DE69417426T2 - N2s2-chelatoren des hydrazino-typs - Google Patents
N2s2-chelatoren des hydrazino-typsInfo
- Publication number
- DE69417426T2 DE69417426T2 DE69417426T DE69417426T DE69417426T2 DE 69417426 T2 DE69417426 T2 DE 69417426T2 DE 69417426 T DE69417426 T DE 69417426T DE 69417426 T DE69417426 T DE 69417426T DE 69417426 T2 DE69417426 T2 DE 69417426T2
- Authority
- DE
- Germany
- Prior art keywords
- hydrazino
- chelators
- type
- targetting molecules
- conjugation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Amplifiers (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11650493A | 1993-09-03 | 1993-09-03 | |
PCT/CA1994/000479 WO1995006633A1 (en) | 1993-09-03 | 1994-08-31 | Hydrazino-type n2s2 chelators |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69417426D1 DE69417426D1 (de) | 1999-04-29 |
DE69417426T2 true DE69417426T2 (de) | 1999-10-28 |
Family
ID=22367562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69417426T Expired - Lifetime DE69417426T2 (de) | 1993-09-03 | 1994-08-31 | N2s2-chelatoren des hydrazino-typs |
Country Status (8)
Country | Link |
---|---|
US (1) | US5574140A (de) |
EP (1) | EP0716647B1 (de) |
JP (1) | JP3602848B2 (de) |
AT (1) | ATE178053T1 (de) |
AU (1) | AU7528894A (de) |
CA (1) | CA2169269A1 (de) |
DE (1) | DE69417426T2 (de) |
WO (1) | WO1995006633A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5858327A (en) * | 1993-09-03 | 1999-01-12 | Resolutions Pharmaceuticals, Inc. | Hydrazino-type N2 S2 radionuclide chelating compounds |
US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
DE19536783A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle Nicotinamid-Chelatbildner vom Typ N¶2¶S¶2¶ für radioaktive Isotope |
WO1998033809A1 (en) * | 1997-01-31 | 1998-08-06 | The General Hospital Corporation | Compositions and methods for imaging gene expression |
EP1011738A1 (de) * | 1997-09-08 | 2000-06-28 | The General Hospital Corporation | Vorbereitung zur snelle bilddarstellung von cardiovaskulare erkrankungen |
US7060251B1 (en) | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
WO2001039664A1 (en) * | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Method and apparatus for measuring indices of brain activity |
US6907280B2 (en) * | 1999-12-02 | 2005-06-14 | The General Hospital Corporation | Method and apparatus for objectively measuring pain, pain treatment and other related techniques |
EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
WO2003074005A2 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP2284180B1 (de) | 2003-03-03 | 2015-09-09 | Dyax Corp. | Verwendungen von Spezifisch an HGF-Rezeptor (cMET) bindenden Peptiden |
JP5364589B2 (ja) | 2006-12-11 | 2013-12-11 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 診断および治療適用用フィブリン結合ペプチドコンジュゲート |
EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
US20150344523A1 (en) | 2014-05-05 | 2015-12-03 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
CN108290927B (zh) | 2015-07-15 | 2022-06-24 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
KR20180104166A (ko) | 2016-02-09 | 2018-09-19 | 브라코 스위스 에스.에이. | 셀렉틴 표적화를 위한 재조합 키메라 단백질 |
EP3519425B1 (de) | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Zusammensetzungen zum nachweis, zur hemmung und zur bildgebung von indolamin 2,3-dioxygenase 1 (ido1) und verfahren zur herstellung und verwendung davon |
WO2018085375A1 (en) | 2016-11-01 | 2018-05-11 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
US11638764B2 (en) | 2018-11-08 | 2023-05-02 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60184571A (ja) * | 1984-03-01 | 1985-09-20 | Miyoshi Kasei:Kk | 水素添加レシチンにより表面処理した化粧料用顔料 |
US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
US5037630A (en) * | 1985-01-14 | 1991-08-06 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5120526A (en) * | 1985-01-14 | 1992-06-09 | Neorx Corporation | Method of producing metal radionuclide labeled proteins for diagnosis and therapy |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
JPS63113082A (ja) * | 1985-07-29 | 1988-05-18 | Shiseido Co Ltd | 改質粉体 |
US5187264A (en) * | 1986-05-28 | 1993-02-16 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
ES2017088B3 (es) * | 1986-05-28 | 1991-01-01 | Mallinckrodt Inc (A Missouri Corporation) | Quelatos de tecnecio a utilizar para determinar la funcion renal. |
US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
US5091514A (en) * | 1987-03-26 | 1992-02-25 | Neorx Corporation | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy |
US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
IL89222A (en) * | 1988-02-09 | 1995-03-30 | Mallinckrodt Inc | Preparation of metal-radionuclide-labelled proteins, certain novel compounds used therein and radiopharmaceutical compositions containing the labelled proteins |
US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
JPH01224309A (ja) * | 1988-03-03 | 1989-09-07 | Pola Chem Ind Inc | 化粧料 |
US5089249A (en) * | 1988-06-10 | 1992-02-18 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
US5196515A (en) * | 1989-03-17 | 1993-03-23 | The Johns Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
JP2801639B2 (ja) * | 1989-05-11 | 1998-09-21 | 株式会社三光生物科学研究所 | メイクアップ用皮膚化粧料組成物 |
DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
US5175257A (en) * | 1989-12-29 | 1992-12-29 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
US5112953A (en) * | 1989-12-29 | 1992-05-12 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
CA2080685A1 (en) * | 1990-04-17 | 1991-10-18 | Alfons Verbruggen | Method and kit for preparing technetium-99m complexes |
JP2978989B2 (ja) * | 1990-12-04 | 1999-11-15 | エンジェルハード・コーポレイション | 改良板状顔料 |
WO1992010214A1 (en) * | 1990-12-12 | 1992-06-25 | Mallinckrodt Medical, Inc. | Method of radioactive labelling of blood cells and kit therefor |
US5908931A (en) * | 1990-12-14 | 1999-06-01 | Mallinckrodt Inc. | Preorganized hexadentate ligands useful in radiographic imaging agents |
US5243073A (en) * | 1990-12-14 | 1993-09-07 | Mallinckrodt Medical, Inc. | Hexadentate ligands useful in radiographic imaging agents |
US5112594A (en) * | 1991-04-04 | 1992-05-12 | Mallinckrodt Medical, Inc. | Kit for preparing a technetium-99m myocardial imaging agent |
US5112595A (en) * | 1990-12-21 | 1992-05-12 | Mallinckrodt Medical, Inc. | 99MTC(III) myocardial imaging agents and method of use |
WO1992019274A1 (en) * | 1991-05-08 | 1992-11-12 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
EP0588905A1 (de) * | 1991-06-03 | 1994-03-30 | Mallinckrodt Medical, Inc. | Radioaktiv markierte somatostatinderivate, ihre herstellung und verwendung |
ATE203416T1 (de) * | 1991-08-05 | 2001-08-15 | Mallinckrodt Inc | Schwermetallcluster zur verwendung als abbildungsmittel |
-
1994
- 1994-07-14 US US08/274,850 patent/US5574140A/en not_active Expired - Lifetime
- 1994-08-31 AT AT94925320T patent/ATE178053T1/de not_active IP Right Cessation
- 1994-08-31 WO PCT/CA1994/000479 patent/WO1995006633A1/en active IP Right Grant
- 1994-08-31 AU AU75288/94A patent/AU7528894A/en not_active Abandoned
- 1994-08-31 JP JP50784895A patent/JP3602848B2/ja not_active Expired - Fee Related
- 1994-08-31 CA CA002169269A patent/CA2169269A1/en not_active Abandoned
- 1994-08-31 DE DE69417426T patent/DE69417426T2/de not_active Expired - Lifetime
- 1994-08-31 EP EP94925320A patent/EP0716647B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE178053T1 (de) | 1999-04-15 |
US5574140A (en) | 1996-11-12 |
WO1995006633A1 (en) | 1995-03-09 |
EP0716647A1 (de) | 1996-06-19 |
DE69417426D1 (de) | 1999-04-29 |
JP3602848B2 (ja) | 2004-12-15 |
AU7528894A (en) | 1995-03-22 |
EP0716647B1 (de) | 1999-03-24 |
JPH09503496A (ja) | 1997-04-08 |
CA2169269A1 (en) | 1995-03-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |