ES2093267T3 - Procedimiento para la preparacion de productos intermedios de cefalosporinas. - Google Patents
Procedimiento para la preparacion de productos intermedios de cefalosporinas.Info
- Publication number
- ES2093267T3 ES2093267T3 ES92915701T ES92915701T ES2093267T3 ES 2093267 T3 ES2093267 T3 ES 2093267T3 ES 92915701 T ES92915701 T ES 92915701T ES 92915701 T ES92915701 T ES 92915701T ES 2093267 T3 ES2093267 T3 ES 2093267T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- group
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000001681 protective effect Effects 0.000 abstract 2
- -1 HYDROGEN ATOMS Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 abstract 1
- 229960001139 cefazolin Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCESO PARA PREPARAR UN COMPUESTO DE LA FORMULA (I), EN DONDE R ES UN GRUPO HETEROCICLICO QUE COMPRENDE AL MENOS UN ATOMO DE NITROGENO CON O SIN OXIGENO O AZUFRE Y R1 Y R2 SON AMBAS ATOMOS DE HIDROGENO O UNA DE ELLAS ES UN ATOMO DE HIDROGENO Y LA OTRA ES UN GRUPO DE ACIL; EL PROCESO COMPRENDE LA REACCION DE UN COMPUESTO DE LA FORMULA (II), EN DONDE R1 Y R2 SON SEGUN SE HAN DEFINIDO ANTERIORMENTE, Y EN DONDE, SI FUERA NECESARIO, CUALQUIER GRUPO REACTIVO ESTA PROTEGIDO POR UN GRUPO PROTECTOR ADECUADO, O UNA SAL DEL MISMO, CON UN COMPUESTO DE LA FORMULA (III): R-SH, EN DONDE R ES SEGUN SE HA DEFINIDO ANTERIORMENTE, O UNA SAL DEL MISMO, EN LA PRESENCIA DE UN ACIDO O DE UN COMPUESTO DE LA FORMULA (IV), EN DONDE CADA UNA DE R3 Y R4 ES UN GRUPO DE ALQUIL C1-C4 O R3 Y R4 JUNTAS SON UNA CADENA DE ALQUILENO C2 O C3 Y, SI FUERA NECESARIO, LA SEPARACION DE LOS GRUPOS PROTECTORES POSIBLEMENTE PRESENTES. LOS COMPUESTOS DE LA FORMULA (I) SON UTILES COMO INTERMEDIARIOS EN LA SINTESIS DE LA CEFAZOLINA Y DE LA CEFACEDONA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919115287A GB9115287D0 (en) | 1991-07-15 | 1991-07-15 | Process for the preparation of cephalosporins intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2093267T3 true ES2093267T3 (es) | 1996-12-16 |
Family
ID=10698406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92915701T Expired - Lifetime ES2093267T3 (es) | 1991-07-15 | 1992-07-14 | Procedimiento para la preparacion de productos intermedios de cefalosporinas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5387679A (es) |
| EP (1) | EP0548338B1 (es) |
| JP (1) | JPH06501271A (es) |
| KR (1) | KR100234442B1 (es) |
| AT (1) | ATE144516T1 (es) |
| DE (1) | DE69214784T2 (es) |
| DK (1) | DK0548338T3 (es) |
| ES (1) | ES2093267T3 (es) |
| GB (1) | GB9115287D0 (es) |
| TW (1) | TW208014B (es) |
| WO (1) | WO1993002085A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996007435A1 (en) * | 1994-09-07 | 1996-03-14 | The Dow Chemical Company | Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof |
| JPH10101679A (ja) * | 1996-10-02 | 1998-04-21 | Otsuka Chem Co Ltd | セファゾリンの製造法 |
| IT1286520B1 (it) * | 1996-12-03 | 1998-07-15 | Antibioticos Spa | Procedimento per la preparazione di intermedi utili nella sintesi di cefalosporine |
| US6446517B1 (en) * | 2000-11-20 | 2002-09-10 | Samsung Electronics Company | Controlled particle deposition in drives and on media for thermal asperity studies |
| AU2002310863A1 (en) | 2001-04-19 | 2002-11-05 | Bioferma Murcia, S.A. | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
| US20030135041A1 (en) * | 2002-01-04 | 2003-07-17 | Orchid Chemicals & Pharmaceuticals Limited, India | Synthesis of ceftiofur intermediate |
| CN100364998C (zh) * | 2006-07-12 | 2008-01-30 | 黑龙江豪运经贸有限公司 | 三氟化硼碳酸二甲酯络合物的络合方法 |
| CN102321101B (zh) * | 2011-07-28 | 2015-07-15 | 哈药集团制药总厂 | 一种制备头孢唑林钠化合物的方法 |
| CN102633813A (zh) * | 2012-04-17 | 2012-08-15 | 黑龙江豪运精细化工有限公司 | 一种头孢唑林钠中间体tda的制备方法 |
| CN103342708A (zh) * | 2013-07-10 | 2013-10-09 | 中国医药集团总公司四川抗菌素工业研究所 | 一种制备丙二醇头孢曲嗪3-位中间体的方法 |
| CN108727411A (zh) * | 2018-07-25 | 2018-11-02 | 上海上药新亚药业有限公司 | 一种盐酸头孢替安的制备方法 |
| CN109651402B (zh) * | 2018-12-29 | 2021-01-01 | 山东罗欣药业集团股份有限公司 | 一种头孢西酮钠的制备工艺 |
| CN109553630B (zh) * | 2018-12-29 | 2020-06-09 | 山东罗欣药业集团股份有限公司 | 一种头孢西酮钠的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1565941A (en) * | 1977-02-08 | 1980-04-23 | Toyama Chemical Co Ltd | Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids |
| US4472574A (en) * | 1981-05-22 | 1984-09-18 | Hoffman-La Roche Inc. | Process for the manufacture of a cephem carboxylic acid derivative |
-
1991
- 1991-07-15 GB GB919115287A patent/GB9115287D0/en active Pending
-
1992
- 1992-07-13 TW TW081105514A patent/TW208014B/zh active
- 1992-07-14 WO PCT/EP1992/001595 patent/WO1993002085A1/en active IP Right Grant
- 1992-07-14 DK DK92915701.4T patent/DK0548338T3/da active
- 1992-07-14 US US07/988,961 patent/US5387679A/en not_active Expired - Fee Related
- 1992-07-14 AT AT92915701T patent/ATE144516T1/de not_active IP Right Cessation
- 1992-07-14 JP JP5502575A patent/JPH06501271A/ja active Pending
- 1992-07-14 KR KR1019930700754A patent/KR100234442B1/ko not_active IP Right Cessation
- 1992-07-14 ES ES92915701T patent/ES2093267T3/es not_active Expired - Lifetime
- 1992-07-14 DE DE69214784T patent/DE69214784T2/de not_active Expired - Fee Related
- 1992-07-14 EP EP92915701A patent/EP0548338B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB9115287D0 (en) | 1991-08-28 |
| DK0548338T3 (da) | 1996-11-18 |
| EP0548338B1 (en) | 1996-10-23 |
| KR100234442B1 (ko) | 1999-12-15 |
| EP0548338A1 (en) | 1993-06-30 |
| KR930702358A (ko) | 1993-09-08 |
| ATE144516T1 (de) | 1996-11-15 |
| TW208014B (es) | 1993-06-21 |
| DE69214784T2 (de) | 1997-03-13 |
| DE69214784D1 (de) | 1996-11-28 |
| US5387679A (en) | 1995-02-07 |
| WO1993002085A1 (en) | 1993-02-04 |
| JPH06501271A (ja) | 1994-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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