AR004655A1 - Un compuesto derivado de aminoacido, una composicion farmaceutica que lo contiene, un proceso para su sintesis y su uso para la fabricacion de un medicamento - Google Patents
Un compuesto derivado de aminoacido, una composicion farmaceutica que lo contiene, un proceso para su sintesis y su uso para la fabricacion de un medicamentoInfo
- Publication number
- AR004655A1 AR004655A1 ARP950100046A AR10004695A AR004655A1 AR 004655 A1 AR004655 A1 AR 004655A1 AR P950100046 A ARP950100046 A AR P950100046A AR 10004695 A AR10004695 A AR 10004695A AR 004655 A1 AR004655 A1 AR 004655A1
- Authority
- AR
- Argentina
- Prior art keywords
- straight
- branched
- alkyl
- substituted
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto derivado de aminoácido de fórmula (I) o fórmula (XXXI) caracterizado porque R1, B y D son independientemente: Ar, alquilo recto oramificado (C1-C6), alquenilo o alquinilo recto o ramificado (C2-C6), alquilo recto o ramificado( C1-C6) sustituido con cicloalquilo (C5-C7), alquenilo oalquinilo recto o ramificado (C3-C6), sustituido con cicloalquilo (C5-C7), alquilo recto o ramificado (C1-C6) sustituido con cicloalquenilo (C5-C7),alquenilo o alquinilo (C3-C6), recto oram ificado sustituido con cicloalquilo (C5-C7), alquilo (C1-C6) recto o ramificado Ar sustituido, alquenilo oalquinilo recto o ramificado (C3-C6) Ar sustituido; en donde cualquiera de los grupos CH2 de dichas cadenas alquilo puede serreemplazado opc ionalmente por unheteroátomo seleccionado del grupo consistente en O, S, SO, SO2 y NR, en donde R es seleccionado del grupo consistente en hidrógeno, alquilo recto oramificado (C1-C4), alquenilo o alquinilo recto o ramificado (C3-C4) y alquilo de e nlace (C1-C4) en donde se forma un puente entre el nitrógeno y un átomo decarbono de dicha cadena que contiene un heteroátomo para formar un anillo, y en donde dicho anillo está fusionado opcionalmente a un grupo Ar; B y Dtambiénpueden ser hidrógeno ; siempre que R1 no sea nitrógeno; J es seleccinado del grupo consistente en alquilo recto o ramificado (C1-C6), alquenilo recto oramificado (C3-C6), alquilo recto o ramificado (C1-C6) Ar sustituido, yalquenilo o alquinilo recto o ramifi cado (C3-C6) AR sustituido; K esseleccionado del grupo consistente en alquilo recto o ramificado (C1-C6), alquilo recto o ramificado (C1-C6) Ar sustituido, alquenilo o alquinilo rectoo ramificado (C2-C6) Arsustituido, y ciclohexilmetilo; X es seleccionado del grupo consistente en Ar, -OR2, y -NR3R4; en donde R2 tiene la misma definición
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34083094A | 1994-11-16 | 1994-11-16 | |
US08/377,285 US5543423A (en) | 1994-11-16 | 1995-01-23 | Amino acid derivatives with improved multi-drug resistance activity |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004655A1 true AR004655A1 (es) | 1999-03-10 |
Family
ID=23335106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP950100046A AR004655A1 (es) | 1994-11-16 | 1995-11-03 | Un compuesto derivado de aminoacido, una composicion farmaceutica que lo contiene, un proceso para su sintesis y su uso para la fabricacion de un medicamento |
Country Status (8)
Country | Link |
---|---|
US (1) | US5543423A (es) |
EP (1) | EP1420009A3 (es) |
KR (1) | KR100404717B1 (es) |
CN (1) | CN1099407C (es) |
AR (1) | AR004655A1 (es) |
PE (1) | PE52396A1 (es) |
RU (1) | RU2165410C2 (es) |
ZA (1) | ZA959304B (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5846981A (en) * | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US7056935B2 (en) * | 1995-06-07 | 2006-06-06 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US6037370A (en) | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5804578A (en) * | 1996-04-03 | 1998-09-08 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
US6093816A (en) * | 1996-06-27 | 2000-07-25 | Isis Pharmaceuticals, Inc. | Cationic lipids |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US6103698A (en) | 1997-03-13 | 2000-08-15 | Basf Aktiengesellschaft | Dolastatin-15 derivatives in combination with taxanes |
US6162616A (en) * | 1997-04-16 | 2000-12-19 | Millennium Pharmaceuticals, Inc. | Multidrug resistance-associated polypeptide |
US20010049381A1 (en) * | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US6187796B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Sulfone hair growth compositions and uses |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6187784B1 (en) | 1998-06-03 | 2001-02-13 | Gpi Nil Holdings, Inc. | Pipecolic acid derivative hair growth compositions and uses |
US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US6271244B1 (en) | 1998-06-03 | 2001-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
US6852496B1 (en) | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US6268384B1 (en) | 1997-08-29 | 2001-07-31 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
US6172087B1 (en) | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
AU770459B2 (en) * | 1998-06-03 | 2004-02-19 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6395758B1 (en) | 1998-08-14 | 2002-05-28 | Gpi Nil Holdings, Inc. | Small molecule carbamates or ureas for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6261693B1 (en) * | 1999-05-03 | 2001-07-17 | Guardian Industries Corporation | Highly tetrahedral amorphous carbon coating on glass |
EP1196386A2 (en) * | 1999-07-06 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | N-substituted glycine derivatives |
US6734211B1 (en) * | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
JP2001031635A (ja) | 1999-07-14 | 2001-02-06 | Ajinomoto Co Inc | 光学活性n−保護−n−メチル−フェニルアラニン誘導体の製造方法 |
AU6387500A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent exocyclic diketo compounds |
US6734192B1 (en) * | 1999-08-23 | 2004-05-11 | Mp-1 Inc. | Treatment of viral infections |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
EP1244670B1 (en) | 1999-12-21 | 2006-03-08 | MGI GP, Inc. | Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
US6258526B1 (en) * | 2000-01-19 | 2001-07-10 | M.D.R. Test Ltd | Ex-vivo test kit for testing the effectiveness of reversers of multidrug resistance |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
MXPA03011095A (es) * | 2001-05-29 | 2005-04-28 | Guilford Pharm Inc | Metodo para tratar una lesion nerviosa causada por cirugia. |
CA2465886A1 (en) * | 2001-11-07 | 2003-05-15 | Kathleen S. Crowley | Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells |
US7294701B2 (en) * | 2003-04-02 | 2007-11-13 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
WO2005007162A1 (en) * | 2003-07-10 | 2005-01-27 | Vertex Pharmaceuticals Incorporated | Compounds augmenting the activity of antibacterial agents |
WO2009006431A2 (en) * | 2007-06-29 | 2009-01-08 | Florida Atlantic University Board Of Trustees | Biologically active aphrocallistin compounds |
JP2013504591A (ja) | 2009-09-11 | 2013-02-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | N−ベンジル−3−(4−クロロフェニル)−2−[メチル−[2−オキソ−2−(3,4,5−トリメトキシフェニル)アセチル]アミノ]−n−[3−(4−ピリジル)−1−[2−(4−ピリジル)エチル]プロピル]プロパンアミドの組成物およびその使用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2447587A (en) * | 1942-12-18 | 1948-08-24 | Geigy Ag J R | Acyl glycine amides |
DE2328391A1 (de) * | 1972-06-19 | 1974-01-10 | Degussa | Trialkoxycinnamoylaminocarbonsaeuren |
US4296113A (en) * | 1980-01-14 | 1981-10-20 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of keto substituted proline and pipecolic acid |
US4376124A (en) * | 1982-03-08 | 1983-03-08 | American Home Products Corporation | Method for modulating the immune response with dibenzocycloheptenylidenes |
US4579840A (en) * | 1983-08-12 | 1986-04-01 | Immunetech Pharmaceuticals | Method of blocking immune complex binding to immunoglobulin Fc receptors |
JPS6137764A (ja) * | 1984-07-31 | 1986-02-22 | Suntory Ltd | 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物 |
CN86101850A (zh) * | 1985-03-22 | 1987-02-04 | 森得克斯(美国)有限公司 | N,n′-二烷基胍基二肽的制造方法与用途 |
US4920218A (en) * | 1988-10-12 | 1990-04-24 | Merck & Co., Inc. | Novel hydroxide mediated FK-506 rearrangement process |
US5135915A (en) * | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
JP2691442B2 (ja) * | 1989-02-20 | 1997-12-17 | 株式会社ヤクルト本社 | 新規なプロリン誘導体 |
DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
GB2247456A (en) * | 1990-09-03 | 1992-03-04 | Fujisawa Pharmaceutical Co | Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same |
US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
CA2074061A1 (en) * | 1991-08-26 | 1993-02-27 | Ivo Monkovic | Benzamide multidrug resistance reversing agents |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
-
1995
- 1995-01-23 US US08/377,285 patent/US5543423A/en not_active Expired - Lifetime
- 1995-11-03 AR ARP950100046A patent/AR004655A1/es active IP Right Grant
- 1995-11-03 ZA ZA959304A patent/ZA959304B/xx unknown
- 1995-11-13 CN CN95196279A patent/CN1099407C/zh not_active Expired - Fee Related
- 1995-11-13 EP EP03029635A patent/EP1420009A3/en not_active Withdrawn
- 1995-11-13 KR KR1019970703249A patent/KR100404717B1/ko not_active IP Right Cessation
- 1995-11-13 RU RU97110114/04A patent/RU2165410C2/ru not_active IP Right Cessation
- 1995-11-16 PE PE1995284732A patent/PE52396A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR100404717B1 (ko) | 2004-03-30 |
US5543423A (en) | 1996-08-06 |
PE52396A1 (es) | 1996-12-12 |
RU2165410C2 (ru) | 2001-04-20 |
EP1420009A3 (en) | 2004-05-26 |
EP1420009A2 (en) | 2004-05-19 |
CN1163605A (zh) | 1997-10-29 |
ZA959304B (en) | 1996-05-29 |
CN1099407C (zh) | 2003-01-22 |
KR970707077A (ko) | 1997-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR004655A1 (es) | Un compuesto derivado de aminoacido, una composicion farmaceutica que lo contiene, un proceso para su sintesis y su uso para la fabricacion de un medicamento | |
PE20040479A1 (es) | Inhibidores de proteasa del vih y composiciones que los contienen | |
ES2174989T3 (es) | Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion. | |
ES2153841T3 (es) | Antagonistas de la taciquinina. | |
ES2095942T3 (es) | Derivados de bencenoacetamida inhibidores del vih. | |
ES8500229A1 (es) | Procedimiento para preparar derivados de aminoacidos triciclicos | |
PT99849A (pt) | Processo para a preparacao de novos compostos triciclicos comportando grupos amino e nitro e de composicoes farmaceuticas que os contem | |
HUT57758A (en) | Process for producing new sulphonamides consisting of benzene-cyclic or benzene-heterocyclic acids and pharmaceutical preparatives containing said sulphonamides | |
ES2059688T3 (es) | Derivados de aminoacidos inhibidores de enzimas, procedimiento para su preparacion, agentes que los contienen y su utilizacion. | |
IT1241674B (it) | Acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono. | |
ES2063465T3 (es) | Nuevos derivados n-sustituidos de alfa-mercapto-alquilaminas, su procedimiento de preparacion y los productos intermedios obtenidos, su aplicacion como medicamentos y composiciones que los contienen. | |
ES2093267T3 (es) | Procedimiento para la preparacion de productos intermedios de cefalosporinas. | |
ES2057802T3 (es) | Nuevos derivados de 3-amino-cromano, procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
ES2029879T3 (es) | Procedimiento para producir derivados de aminas sustituidas. | |
MX9400165A (es) | Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen. | |
PT90814A (pt) | Processo de preparacao de derivados da fenotiazina | |
ES2045197T3 (es) | N-substituidos-n-nitroso-aminoacetonitrilos, procedimiento para su fabricacion y utilizacion. | |
ES2028902T3 (es) | Procedimiento de preparacion de derivados del indano. | |
AR241015A2 (es) | "procedimiento para preparar acidos 16-fenoxiprostatrienoicos" | |
PT99360A (pt) | Processo para a preparacao de carbamatos de oxi-sulfonilo e de composicoes farmaceuticas que os contem | |
ATE26258T1 (de) | Herstellung von phenylalaninen durch hydrierung von phenylserinen. | |
ATE35261T1 (de) | 4-ethyl-2-hydroxy-3-methyl-2-phenylmorpholin und dessen additionssalze. | |
IT1164389B (it) | Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo | |
ES2085323T3 (es) | Compuestos de espiro-indolin-oxazina con caracteristicas fotocromaticas y fotosensibilizantes y el procedimiento para su preparacion. | |
GB1350458A (en) | 2-formyl-propylthio compounds and their use as vulcanisation re tarders |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |