ES2082059T3 - Uso de reactivos para precipitar proteinas. - Google Patents

Uso de reactivos para precipitar proteinas.

Info

Publication number
ES2082059T3
ES2082059T3 ES91113331T ES91113331T ES2082059T3 ES 2082059 T3 ES2082059 T3 ES 2082059T3 ES 91113331 T ES91113331 T ES 91113331T ES 91113331 T ES91113331 T ES 91113331T ES 2082059 T3 ES2082059 T3 ES 2082059T3
Authority
ES
Spain
Prior art keywords
precipitation reagent
analytes
determination
test sample
specific binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113331T
Other languages
English (en)
Inventor
Victoria P Meucci
Mariola B Zajac
Elizabeth A Simpson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2082059T3 publication Critical patent/ES2082059T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

UN REACTIVO DE PRECIPITACION PARA SER UTILIZADO EN SISTEMAS ANALITICOS PARA LA DETERMINACION DE ANALITAS HIDROFOBICAS EN UNA MUESTRA DE ENSAYO BIOLOGICO, EN PARTICULAR, SISTEMAS ANALITICOS QUE UTILIZAN PROTEINAS ENLAZANTES ESPECIFICAS PARA DICHAS ANALITAS. EL REACTIVO DE PRECIPITACION PRECIPITA PROTEINAS PERTURBADORAS, HEMOGLOBINA Y OTRA SUSTANCIAS PERTURBADORAS DE UNA MUESTRA DE ENSAYO BIOLOGICO MIENTRAS QUE, AL MISMO TIEMPO, MANTIENE LAS ANALITAS HIDROFOBICAS EN DISOLUCION Y MINIMIZA LA DESNATURACION DE PROTEINAS ENLAZANTES ESPECIFICAS TALES COMO ANTICUERPOS , POR EJEMPLO, QUE PUEDEN ESTAR PRESENTES EN UN SISTEMA DE INMUNOENSAYO. EL REACTIVO DE PRECIPITACION CONTIENE UNA SAL DE ZINC, UN GLICOL Y UN ALCOHOL DE CADENA EN LINEA O RAMIFICADA CON DE 1 A 4 ATOMOS DE CARBONO APROXIMADAMENTE Y PUEDE CONTENER OPCIONALMENTE UN ACIDO. UN REACTIVO DE PRECIPITACION PREFERENTE CONTIENE SULFATO DE ZINC, METANOL Y ETILERGLICOL Y ES PARTICULARMENTE UTIL EN UN INMUNOENSAYO DE POLARIZACION FLUORESCENTE PARALA DETERMINACION DE ANALITAS HIDROFOBICAS, ESPECIALMENTE CICLOSPORINA.
ES91113331T 1990-08-15 1991-08-08 Uso de reactivos para precipitar proteinas. Expired - Lifetime ES2082059T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/567,853 US5135875A (en) 1990-08-15 1990-08-15 Protein precipitation reagent

Publications (1)

Publication Number Publication Date
ES2082059T3 true ES2082059T3 (es) 1996-03-16

Family

ID=24268905

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113331T Expired - Lifetime ES2082059T3 (es) 1990-08-15 1991-08-08 Uso de reactivos para precipitar proteinas.

Country Status (10)

Country Link
US (1) US5135875A (es)
EP (1) EP0471295B1 (es)
JP (1) JPH04233460A (es)
AT (1) ATE130095T1 (es)
AU (1) AU642522B2 (es)
CA (1) CA2048314A1 (es)
DE (1) DE69114403T2 (es)
DK (1) DK0471295T3 (es)
ES (1) ES2082059T3 (es)
GR (1) GR3018907T3 (es)

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Also Published As

Publication number Publication date
CA2048314A1 (en) 1992-02-16
JPH04233460A (ja) 1992-08-21
EP0471295A1 (en) 1992-02-19
GR3018907T3 (en) 1996-05-31
EP0471295B1 (en) 1995-11-08
AU642522B2 (en) 1993-10-21
DE69114403T2 (de) 1996-06-05
DE69114403D1 (de) 1995-12-14
US5135875A (en) 1992-08-04
AU8247291A (en) 1992-02-20
ATE130095T1 (de) 1995-11-15
DK0471295T3 (da) 1996-04-09

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