BR9804648A - Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. - Google Patents
Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos.Info
- Publication number
- BR9804648A BR9804648A BR9804648-9A BR9804648A BR9804648A BR 9804648 A BR9804648 A BR 9804648A BR 9804648 A BR9804648 A BR 9804648A BR 9804648 A BR9804648 A BR 9804648A
- Authority
- BR
- Brazil
- Prior art keywords
- drug
- deproteinization
- body fluids
- monitoring
- present
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9446—Antibacterials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
<B>MONITORIZAçãO DA OBEDIêNCIA DO PACIENTE AO TRATAMENTO E DA BIODISPONIBILIDADE DE DROGAS PELA DESPROTEINIZAçãO DE FLUIDOS CORPóREOS<D>. O objetivo da presente invenção é fornecer um método de determinação quantitativa da concentração de drogas presentes em fluidos corpóreos com a finalidade de monitorizar tanto a obediência ao tratamento com a medicação prescrita com os níveis da droga praticados no tratamento clínico individual e nos programas de Saúde Pública. A monitorização dos níveis da droga é obtida através de ensaios quantitativos que permitem a detecção de drogas presentes em fluidos corpóreos em concentrações abaixo de 0.3 <109>g/ml. O método é caracterizado por uma etapa de desproteinização prévia a qual propicia a recuperação de pelo menos 97% da quantidade da substância em análise presente no fluido corpóreo, isto é, fazendo a desproteinização na presença de ZnSO~ 4~ é possível retirar, com eficiência, a droga que tenha ficado aderida às proteínas contidas no fluido corpóreo. Ressalta-se o fato de que o método da invenção é especialmente útil na determinação da droga presente no sangue pois este contém muito mais proteína do que outros fluidos biológicos tais como urina, saliva ou fluido lacrimal. Uma concretização da presente invenção é um método para a determinação do nível da droga utilizando uma etapa simplificada e efetiva de desproteinização a partir de fluidos corpóreos, tais como o plasma, sangue, urina, saliva ou fluido lacrimal seguida pela extração da droga e sua quantificação usando uma técnica acurada, como por exemplo os ensaios colorimétrico e HPLC. Uma particular concretização refere-se a um método para quantificar rifampicina com a finalidade de monitorizar os níveis dessa droga em fluidos corpóreos bem como a um kit de monitorização do tratamento da tuberculose com base na determinação da concentração da rifampicina em fluidos corpóreos.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9804648-9A BR9804648A (pt) | 1998-11-23 | 1998-11-23 | Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. |
US09/600,594 US6790668B1 (en) | 1998-11-23 | 1999-11-23 | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
CA002318776A CA2318776A1 (en) | 1998-11-23 | 1999-11-23 | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
PCT/BR1999/000096 WO2000031531A1 (en) | 1998-11-23 | 1999-11-23 | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
EP99974266A EP1352239A1 (en) | 1998-11-23 | 1999-11-23 | Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9804648-9A BR9804648A (pt) | 1998-11-23 | 1998-11-23 | Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9804648A true BR9804648A (pt) | 2000-05-30 |
Family
ID=4070929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9804648-9A BR9804648A (pt) | 1998-11-23 | 1998-11-23 | Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. |
Country Status (5)
Country | Link |
---|---|
US (1) | US6790668B1 (pt) |
EP (1) | EP1352239A1 (pt) |
BR (1) | BR9804648A (pt) |
CA (1) | CA2318776A1 (pt) |
WO (1) | WO2000031531A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117092046A (zh) * | 2023-08-03 | 2023-11-21 | 首都医科大学附属北京安定医院 | 一种检测精神病患者口腔是否藏匿药物的方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7790401B2 (en) * | 2007-08-06 | 2010-09-07 | Siemens Healthcare Diagnostics | Methods for detection of immunosuppressant drugs |
US7910378B2 (en) | 2007-12-14 | 2011-03-22 | Siemens Healthcare Diagnostics Inc. | Methods for detection of hydrophobic drugs |
EP2426499A1 (en) * | 2010-09-03 | 2012-03-07 | Bruker Daltonik GmbH | Immunosuppressant monitoring by MALDI mass spectrometry |
US10475142B2 (en) | 2011-12-30 | 2019-11-12 | Elwha Llc | Evidence-based healthcare information management protocols |
US20130173295A1 (en) | 2011-12-30 | 2013-07-04 | Elwha LLC, a limited liability company of the State of Delaware | Evidence-based healthcare information management protocols |
US10679309B2 (en) | 2011-12-30 | 2020-06-09 | Elwha Llc | Evidence-based healthcare information management protocols |
US10340034B2 (en) | 2011-12-30 | 2019-07-02 | Elwha Llc | Evidence-based healthcare information management protocols |
US10559380B2 (en) | 2011-12-30 | 2020-02-11 | Elwha Llc | Evidence-based healthcare information management protocols |
US10528913B2 (en) | 2011-12-30 | 2020-01-07 | Elwha Llc | Evidence-based healthcare information management protocols |
US10552581B2 (en) | 2011-12-30 | 2020-02-04 | Elwha Llc | Evidence-based healthcare information management protocols |
DE102012018234A1 (de) * | 2012-09-17 | 2014-03-20 | Magnamedics Gmbh | Abtrennung von Proteinen |
US20170176475A1 (en) * | 2014-04-11 | 2017-06-22 | Drexel University | Novel methods and kits for detecting a rifamycin, or derivative or analogue thereof |
EA201892347A1 (ru) | 2016-04-15 | 2019-04-30 | Баксалта Инкорпорейтед | Способ и устройство для предоставления фармакокинетической схемы дозирования лекарственных препаратов |
US10896749B2 (en) | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
GB2569397B (en) * | 2017-12-18 | 2021-06-23 | Intelligent Fingerprinting Ltd | Monitoring tuberculosis medication |
CN109580806B (zh) * | 2018-11-09 | 2021-06-29 | 佛山科学技术学院 | 一种用于水产品中利福平药物残留的测定方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8306353D0 (en) | 1983-03-08 | 1983-04-13 | Stuart J F B | Monitoring of drug levels |
US4656141A (en) | 1983-09-27 | 1987-04-07 | University Patents, Inc. | High-performance liquid chromatography process and apparatus and composition of matter therefor |
US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
US5135875A (en) | 1990-08-15 | 1992-08-04 | Abbott Laboratories | Protein precipitation reagent |
US6333061B1 (en) * | 1996-11-22 | 2001-12-25 | Cryovac, Inc. | Packaging article |
-
1998
- 1998-11-23 BR BR9804648-9A patent/BR9804648A/pt not_active Application Discontinuation
-
1999
- 1999-11-23 EP EP99974266A patent/EP1352239A1/en not_active Withdrawn
- 1999-11-23 WO PCT/BR1999/000096 patent/WO2000031531A1/en active Application Filing
- 1999-11-23 CA CA002318776A patent/CA2318776A1/en not_active Abandoned
- 1999-11-23 US US09/600,594 patent/US6790668B1/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117092046A (zh) * | 2023-08-03 | 2023-11-21 | 首都医科大学附属北京安定医院 | 一种检测精神病患者口腔是否藏匿药物的方法 |
CN117092046B (zh) * | 2023-08-03 | 2024-03-08 | 首都医科大学附属北京安定医院 | 一种检测精神病患者口腔是否藏匿药物的方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2000031531A8 (en) | 2002-06-06 |
EP1352239A1 (en) | 2003-10-15 |
WO2000031531A1 (en) | 2000-06-02 |
US6790668B1 (en) | 2004-09-14 |
CA2318776A1 (en) | 2000-06-02 |
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Legal Events
Date | Code | Title | Description |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO DE FOLHAS 99 A 106 PUBLICADO NA RPI N.O 1975, DE 11/11/2008. ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. PORTANTO, INDEFIRO O PRESENTE PEDIDO. |
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B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |