ES2080821T3 - Nuevos 2,3-dihidro-5-oxi-4,6,7-trimetilbenzofuranos 2-(rs)-sustituidos, utiles como productos farmaceuticos antioxidantes con propiedades mucorreguladoras y antiisquemicas. - Google Patents

Nuevos 2,3-dihidro-5-oxi-4,6,7-trimetilbenzofuranos 2-(rs)-sustituidos, utiles como productos farmaceuticos antioxidantes con propiedades mucorreguladoras y antiisquemicas.

Info

Publication number
ES2080821T3
ES2080821T3 ES90830376T ES90830376T ES2080821T3 ES 2080821 T3 ES2080821 T3 ES 2080821T3 ES 90830376 T ES90830376 T ES 90830376T ES 90830376 T ES90830376 T ES 90830376T ES 2080821 T3 ES2080821 T3 ES 2080821T3
Authority
ES
Spain
Prior art keywords
oxi
dihydro
properties
trimetilbenzofuranos
antiischemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90830376T
Other languages
English (en)
Inventor
Mario Brufani
Patrizia Giannetti
Sergio Zanarella
Stefano Ceccarelli
Agnese Paesano
Vellis Patrizia De
Romolo Scuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomedica Foscama Industria Chimico Farmaceutica SpA
Original Assignee
Biomedica Foscama Industria Chimico Farmaceutica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomedica Foscama Industria Chimico Farmaceutica SpA filed Critical Biomedica Foscama Industria Chimico Farmaceutica SpA
Application granted granted Critical
Publication of ES2080821T3 publication Critical patent/ES2080821T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

LO QUE SE DESCRIBE EN ESTA INVENCION CONCIERNE A NUEVOS SUSTITUTOS 2,3-DIHIDRO-5-OXI-4,6,7-TRIMETILBENZOFURANOS 2-(RS), A PROCEDIMIENTO DE SINTESIS Y AL USO DE TERAPEUTICOS RELACIONADOS COMO ANTI-OXIDANTES Y PRODUCTOS FARMACEUTICOS CON MUCOREGULACION Y PROPIEDADES ANTI-ISQUEMICAS.
ES90830376T 1989-08-18 1990-08-16 Nuevos 2,3-dihidro-5-oxi-4,6,7-trimetilbenzofuranos 2-(rs)-sustituidos, utiles como productos farmaceuticos antioxidantes con propiedades mucorreguladoras y antiisquemicas. Expired - Lifetime ES2080821T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921532A IT1231341B (it) 1989-08-18 1989-08-18 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.

Publications (1)

Publication Number Publication Date
ES2080821T3 true ES2080821T3 (es) 1996-02-16

Family

ID=11183207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90830376T Expired - Lifetime ES2080821T3 (es) 1989-08-18 1990-08-16 Nuevos 2,3-dihidro-5-oxi-4,6,7-trimetilbenzofuranos 2-(rs)-sustituidos, utiles como productos farmaceuticos antioxidantes con propiedades mucorreguladoras y antiisquemicas.

Country Status (21)

Country Link
US (1) US5114966A (es)
EP (1) EP0413668B1 (es)
JP (1) JP2931056B2 (es)
KR (1) KR0167553B1 (es)
CN (1) CN1032135C (es)
AT (1) ATE131164T1 (es)
AU (1) AU634570B2 (es)
CA (1) CA2023522A1 (es)
CS (1) CS277503B6 (es)
DE (1) DE69023980T2 (es)
DK (1) DK0413668T3 (es)
ES (1) ES2080821T3 (es)
FI (1) FI92198C (es)
GR (1) GR3019030T3 (es)
HU (1) HU207059B (es)
IT (1) IT1231341B (es)
NO (1) NO175819C (es)
NZ (1) NZ234934A (es)
PT (1) PT95037B (es)
RU (1) RU2068845C1 (es)
ZA (1) ZA906266B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
JP3246741B2 (ja) * 1992-04-06 2002-01-15 メレルダウファーマス−ティカルズ インコーポレイテッド ２，３−ジヒドロベンゾフラノールの新規な誘導体及びその製法
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
IT1256264B (it) * 1992-12-31 1995-11-29 Lifegroup Spa N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
WO1995029906A1 (fr) * 1994-04-28 1995-11-09 Meiji Milk Products Co., Ltd. Derive de benzofurane et son utilisation
FR2720395B1 (fr) * 1994-05-31 1996-06-28 Oreal Nouveaux composés de la famille des benzohétérocycles.
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
US5798356A (en) * 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US6048891A (en) 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
CN107056707B (zh) * 2017-01-23 2019-08-23 温州医科大学 一种3,4,5-三甲氧基苯类化合物及其在制备抗氧化药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1281325C (en) * 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
JPS6388173A (ja) * 1986-09-30 1988-04-19 Kuraray Co Ltd ２，３−ジヒドロベンゾフラン誘導体
JP2855340B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 ２―置換クマラン誘導体
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
IT1229482B (it) * 1988-08-01 1991-09-03 Foscama Biomed Chim Farma Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici.

Also Published As

Publication number Publication date
US5114966A (en) 1992-05-19
NO175819C (no) 1994-12-14
ATE131164T1 (de) 1995-12-15
IT8921532A0 (it) 1989-08-18
HU207059B (en) 1993-03-01
EP0413668A2 (en) 1991-02-20
GR3019030T3 (en) 1996-05-31
FI903994A0 (fi) 1990-08-13
CN1032135C (zh) 1996-06-26
PT95037A (pt) 1991-04-18
FI92198B (fi) 1994-06-30
NO903640D0 (no) 1990-08-17
NZ234934A (en) 1992-02-25
RU2068845C1 (ru) 1996-11-10
NO175819B (no) 1994-09-05
CA2023522A1 (en) 1991-02-19
IT1231341B (it) 1991-11-28
CS402390A3 (en) 1992-01-15
AU6128090A (en) 1991-02-21
DK0413668T3 (da) 1996-04-22
AU634570B2 (en) 1993-02-25
NO903640L (no) 1991-02-19
ZA906266B (en) 1991-05-29
HUT54669A (en) 1991-03-28
JPH03236383A (ja) 1991-10-22
EP0413668A3 (en) 1991-09-11
DE69023980T2 (de) 1996-08-01
DE69023980D1 (de) 1996-01-18
FI92198C (fi) 1994-10-10
PT95037B (pt) 1997-10-31
JP2931056B2 (ja) 1999-08-09
EP0413668B1 (en) 1995-12-06
KR0167553B1 (ko) 1999-01-15
CS277503B6 (en) 1993-03-17
KR910004588A (ko) 1991-03-29
HU905062D0 (en) 1991-01-28
CN1049499A (zh) 1991-02-27

Similar Documents

Publication Publication Date Title
ES2080821T3 (es) Nuevos 2,3-dihidro-5-oxi-4,6,7-trimetilbenzofuranos 2-(rs)-sustituidos, utiles como productos farmaceuticos antioxidantes con propiedades mucorreguladoras y antiisquemicas.
SV1995000042A (es) Heteroaril-oxazolidinonas de 5 eslabones ref. le a 30523-sv
EE200000320A (et) Uudsed ühendid
ES2185711T3 (es) 1,4-benzotiazepina-1,1-dioxidoshipolipimemicos.
DK0538300T3 (da) O-Glycosyleret IFN-alfa
ES2144239T3 (es) Derivados de vitamina d con sustituyentes en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos.
PT641343E (pt) Derivados de 4-mercaptoacetilamino-¬2|benzazapinona (3) e a sua utilizacao como inibidores de encefalinase
ATE126215T1 (de) Anti-entzündende 4-aminophenol-derivate.
ES2192680T3 (es) Nuevos derivados de vitamina d con sustituyentes carbo- o heterociclicos en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos.
BR9000216A (pt) Composicao de polimero de organossilicio,processo para sua producao e uso da mesma
ES2043665T3 (es) 6,11-dihidro-11-(4-piperidiliden)-5h-benzo-(5,6)-ciclohepta-(1,2-b)-piridinas y composiciones y metodos de uso.
ES2089186T3 (es) Reflectores de pelicula de magnesio.
SV1997000025A (es) Nuevos pirimido /1,2-a/ indoles ref. lea 31544-sv
MX9202763A (es) Nuevos derivados de 2-(1-piperazinil)-4-fenil-cicloalcanopiridina y composicion farmaceutica que los contiene.
ES2105605T3 (es) Antagonistas de taquiquinina, su preparacion y utilizacion en formulaciones farmaceuticas.
ES2091254T3 (es) Mezclas-madre de celulosa-material sintetico, procedimiento para su obtencion y su empleo.
FI925497A (fi) Menetelmä synteettisten isohirudiinien valmistamiseksi, joilla on parantunut stabiilisuus
MX22522A (es) Procedimiento para la elaboracion de una composici on que contiene alfa-interferon y producto obten ido mediante el mismo.
ES2089157T3 (es) Nuevos derivados de la 20,21-dinoreburnamenina, su procedimiento de preparacion y los nuevos productos intermedios asi obtenidos, su aplicacion como medicamentos y composiciones que los contienen.
BR0012622A (pt) Derivados de 3-amino-2-benzil-1-fenil-propano
AR059965A2 (es) Uso de 8,9-dehidroestrona para la preparacion de un medicamento antioxidante
IT8919524A0 (it) Derivati dal 1 arilsolfonil 2 piperidone, loro procedimento di preparazione e loro impiego come farmaci.
ATE147742T1 (de) 8-alpha-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
BR0014612A (pt) Poliamidas termoformáveis
ES2083478T3 (es) Antagonistas de nmda heterociclicos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 413668

Country of ref document: ES