ES2195397T3 - Quinazolin-2,4-dionas sustituidas en posicion 7 utiles como agentes antibacterianos. - Google Patents
Quinazolin-2,4-dionas sustituidas en posicion 7 utiles como agentes antibacterianos.Info
- Publication number
- ES2195397T3 ES2195397T3 ES98948473T ES98948473T ES2195397T3 ES 2195397 T3 ES2195397 T3 ES 2195397T3 ES 98948473 T ES98948473 T ES 98948473T ES 98948473 T ES98948473 T ES 98948473T ES 2195397 T3 ES2195397 T3 ES 2195397T3
- Authority
- ES
- Spain
- Prior art keywords
- useful
- quinazolin
- antibacterial agents
- dionas
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 7-substituted quinazolin-2,4-diones Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de Fórmula I **fórmula** o una de sus sales farmacéuticamente aceptable, en la que: R1 es H, un alquilo lineal o ramificado de 1 a 6 átomos de carbono, cicloalquilo de 3 a 6 átomos de carbono, un heterociclo de 4 a 6 átomos que posee 1 a 2 heteroátomos seleccionado entre 2- ó 3-tienilo, 2- ó 3- furanilo, 2- ó 3-pirrolilo, 2-, 4-, ó 5-imidazolilo, 3-, 4- ó 5-pirazolilo, 2- 4- ó 5-tiazolilo, 3-, 4- ó 5- isotiazolilo, 2-, 4- ó 5-oxazolilo, 3-, 4- ó 5-isoxazolilo, 2-, 3- ó 4-piridinilo, 3-, 4- ó 5-piridazinilo, 2- pirazinilo, 2-, 4- ó 5-pirimidinilo, 1- ó 2-piperazinilo, 2- , 3- ó 4-morfolinilo, 2-, 3- ó 4-tiomorfolinilo, 1-, 2- ó 3- pirrolidinilo, 2- ó 3-tetrahidrofuranilo, 2-, 3- ó 4- tetrahidropiranilo, 2-, 3- ó 4-piperidinilo, 1-, 2-, 4-, 5- ó 6-tetrahidropirimidinilo, 2-dioxolinilo, 2-, 4- ó 5- imidazolidinilo, incluyendo los heterociclos anteriores que contienen azufre oxidado a grupos SO ó SO2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6355697P | 1997-10-28 | 1997-10-28 | |
| US9858898P | 1998-08-31 | 1998-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2195397T3 true ES2195397T3 (es) | 2003-12-01 |
Family
ID=26743531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98948473T Expired - Lifetime ES2195397T3 (es) | 1997-10-28 | 1998-09-23 | Quinazolin-2,4-dionas sustituidas en posicion 7 utiles como agentes antibacterianos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6331538B1 (es) |
| EP (1) | EP1028950B1 (es) |
| AT (1) | ATE239000T1 (es) |
| AU (1) | AU9503998A (es) |
| DE (1) | DE69814135T2 (es) |
| DK (1) | DK1028950T3 (es) |
| ES (1) | ES2195397T3 (es) |
| PT (1) | PT1028950E (es) |
| SI (1) | SI1028950T1 (es) |
| WO (1) | WO1999021840A1 (es) |
| ZA (1) | ZA989783B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000041505A2 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Anthranilic acid derivatives |
| OA12316A (en) | 2000-01-24 | 2006-05-15 | Warner Lambert Co | 3-Aminoquinazolin-2,4-dione antibacterial agents. |
| US7105682B2 (en) * | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| ATE315038T1 (de) | 2001-05-30 | 2006-02-15 | Warner Lambert Co | Antibakterielle mittel |
| AU2002302894A1 (en) * | 2001-06-19 | 2003-01-02 | Warner-Lambert Company Llc | Quinazolinediones as antibacterial agents |
| DOP2003000556A (es) | 2002-01-23 | 2003-10-31 | Warner Lambert Co | Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico. |
| JP2005515253A (ja) | 2002-01-23 | 2005-05-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Ｎ−（４−置換フェニル）−アントラニル酸ヒドロキサメートエステル |
| CA2538420A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| US20050124562A1 (en) * | 2003-09-23 | 2005-06-09 | Joseph Guiles | Bis-quinazoline compounds for the treatment of bacterial infections |
| AU2005205016B2 (en) | 2004-01-16 | 2010-07-15 | F. Hoffmann-La Roche Ag | 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1H-quinazolin-2-one derivatives and the respective 1H-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(D) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-HT) for the treatment of diseases of the central nervous system |
| WO2006019965A2 (en) * | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| EP1828186A1 (en) * | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| US7973022B2 (en) * | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
| WO2008061866A1 (en) * | 2006-11-20 | 2008-05-29 | Bayer Cropscience Sa | New benzamide derivatives |
| NZ596123A (en) * | 2009-05-19 | 2014-08-29 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
| EP2440204B1 (en) | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
| CN108430978B (zh) * | 2015-09-25 | 2022-11-22 | 路德维格癌症研究所有限责任公司 | 3-羟基-喹唑啉-2,4-二酮衍生物及其作为核酸酶调节剂的用途 |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| BR112022022338A2 (pt) | 2020-05-04 | 2023-01-10 | Amgen Inc | Compostos heterocíclicos como receptor desencadeador expresso em agonistas de células mieloides 2 e métodos de uso |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068263B (es) | 1959-11-05 | |||
| US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
| US5283248A (en) | 1989-11-21 | 1994-02-01 | Hoffmann-La Roche Inc. | Amino substituted pyrimido[1,6-2]benzimidazoles |
| JP3002507B2 (ja) | 1990-08-03 | 2000-01-24 | 大日本製薬株式会社 | 四環式化合物 |
-
1998
- 1998-09-23 AU AU95039/98A patent/AU9503998A/en not_active Abandoned
- 1998-09-23 SI SI9830412T patent/SI1028950T1/xx unknown
- 1998-09-23 AT AT98948473T patent/ATE239000T1/de not_active IP Right Cessation
- 1998-09-23 DK DK98948473T patent/DK1028950T3/da active
- 1998-09-23 WO PCT/US1998/019877 patent/WO1999021840A1/en not_active Ceased
- 1998-09-23 PT PT98948473T patent/PT1028950E/pt unknown
- 1998-09-23 US US09/508,796 patent/US6331538B1/en not_active Expired - Fee Related
- 1998-09-23 EP EP98948473A patent/EP1028950B1/en not_active Expired - Lifetime
- 1998-09-23 ES ES98948473T patent/ES2195397T3/es not_active Expired - Lifetime
- 1998-09-23 DE DE69814135T patent/DE69814135T2/de not_active Expired - Fee Related
- 1998-10-27 ZA ZA989783A patent/ZA989783B/xx unknown
-
2001
- 2001-10-04 US US09/971,343 patent/US6825199B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6331538B1 (en) | 2001-12-18 |
| AU9503998A (en) | 1999-05-17 |
| SI1028950T1 (en) | 2003-08-31 |
| WO1999021840A1 (en) | 1999-05-06 |
| DE69814135T2 (de) | 2004-04-01 |
| EP1028950A1 (en) | 2000-08-23 |
| US6825199B2 (en) | 2004-11-30 |
| DK1028950T3 (da) | 2003-09-01 |
| US20020115674A1 (en) | 2002-08-22 |
| ATE239000T1 (de) | 2003-05-15 |
| DE69814135D1 (de) | 2003-06-05 |
| EP1028950B1 (en) | 2003-05-02 |
| PT1028950E (pt) | 2003-09-30 |
| ZA989783B (en) | 1999-04-28 |
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