ES2075014T3 - Derivados de progesterona 19-sustituidos utiles como inhibidores de 19-hidroxilasa. - Google Patents

Derivados de progesterona 19-sustituidos utiles como inhibidores de 19-hidroxilasa.

Info

Publication number
ES2075014T3
ES2075014T3 ES89111698T ES89111698T ES2075014T3 ES 2075014 T3 ES2075014 T3 ES 2075014T3 ES 89111698 T ES89111698 T ES 89111698T ES 89111698 T ES89111698 T ES 89111698T ES 2075014 T3 ES2075014 T3 ES 2075014T3
Authority
ES
Spain
Prior art keywords
progesterone
hydroxylase inhibitors
derivatives useful
compounds
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89111698T
Other languages
English (en)
Inventor
Gene W Holbert
J O'neal Johnston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2075014T3 publication Critical patent/ES2075014T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Abstract

DERIVADOS DE LA PROGESTERONA 19-SUSTITUIDA Y COMPONENTES RELACIONADOS LOS CUALES SON ACTIVOS COMO INHIBIDORES 19-HIDROSILASO E UTILES COMO AGENTES ANTIHIPERTENSIVOS SON AQUI DESCRITOS. LOS COMPONENTES SON PREPARADOS USANDO LA APROPIADA DIRECCION DE TRAYECTORIA LA CUAL VARIARA DE ACUERDO A LA NATURALEZA DE LA ESPECIFICA PROGESTERONA 19-SUSTITUIDA O COMPONENTE RELACIONADO DESEADO.
ES89111698T 1988-06-28 1989-06-27 Derivados de progesterona 19-sustituidos utiles como inhibidores de 19-hidroxilasa. Expired - Lifetime ES2075014T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/212,409 US4910191A (en) 1988-06-28 1988-06-28 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
ES2075014T3 true ES2075014T3 (es) 1995-10-01

Family

ID=22790892

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111698T Expired - Lifetime ES2075014T3 (es) 1988-06-28 1989-06-27 Derivados de progesterona 19-sustituidos utiles como inhibidores de 19-hidroxilasa.

Country Status (20)

Country Link
US (1) US4910191A (es)
EP (1) EP0348910B1 (es)
JP (1) JP2729320B2 (es)
KR (1) KR0160280B1 (es)
CN (1) CN1033032C (es)
AT (1) ATE122681T1 (es)
AU (1) AU610473B2 (es)
CA (1) CA1321578C (es)
DE (1) DE68922660T2 (es)
DK (1) DK167534B1 (es)
ES (1) ES2075014T3 (es)
FI (1) FI92706C (es)
HU (1) HU204066B (es)
IE (1) IE66338B1 (es)
IL (1) IL90727A (es)
NO (1) NO174511B (es)
NZ (1) NZ229696A (es)
PH (1) PH25714A (es)
PT (1) PT90988B (es)
ZA (1) ZA894754B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
PT1330468E (pt) * 2000-09-18 2007-09-13 Serono Lab Análogos de enxofre de 21-hidroxi-6, 19-oxidoprogesterona ( 21oh-60p) para tratar excesso de glucocorticóides.
DE102006018888A1 (de) * 2006-04-18 2007-10-25 Bayer Schering Pharma Ag Verfahren zur Herstellung von 4-[17beta-Methoxy-17alpha-methoxymethyl-3-oxoestra-4,9-dien-11beta-yl]benzaldehyd-(E)-oxims (Asoprisnil)
US8911777B2 (en) 2007-04-04 2014-12-16 Sigmoid Pharma Limited Pharmaceutical composition of tacrolimus
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
CN102268058B (zh) * 2011-05-24 2012-10-10 湖南诺凯生物医药有限公司 制备17α-羟基孕酮或其类似物的方法
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
KR20170102223A (ko) 2014-11-07 2017-09-08 시그모이드 파마 리미티드 사이클로스포린을 포함하는 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1051693A (es) * 1962-07-09
US3275622A (en) * 1963-12-18 1966-09-27 Syntex Corp 19-alkylidene-delta4-3, 20-keto pregnanes
US3275621A (en) * 1963-12-18 1966-09-27 Syntex Corp 19-amino-delta4-pregnenes and-10alpha-pregnenes and process for their preparation
US3558673A (en) * 1966-10-29 1971-01-26 Ormonoterapia Richter Spa 10beta-amino-19-nor-pregnanes and method for the preparation thereof
US3849402A (en) * 1971-01-06 1974-11-19 Steele Chem Co Ltd 19-oxygenated and 19-nor delta8(14)-steroid compounds
US4041055A (en) * 1975-11-17 1977-08-09 The Upjohn Company Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
US4293548A (en) * 1980-09-02 1981-10-06 Merrell Dow Pharmaceuticals Inc. 18-Substituted pregn-4-ene-3,20-diones
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
US4495102A (en) * 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
US4473564A (en) * 1983-07-12 1984-09-25 Akzo N.V. 19-Thio-androstane derivatives
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
GB8531745D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynyl-4-9(11)-estradiene derivatives

Also Published As

Publication number Publication date
IE892086L (en) 1989-12-28
IL90727A (en) 1993-05-13
PT90988A (pt) 1989-12-29
NO892678L (no) 1989-12-29
KR910000588A (ko) 1991-01-29
EP0348910B1 (en) 1995-05-17
JPH0248598A (ja) 1990-02-19
IE66338B1 (en) 1995-12-27
HU204066B (en) 1991-11-28
DK318589A (da) 1989-12-29
FI92706C (fi) 1994-12-27
PH25714A (en) 1991-09-18
NO892678D0 (no) 1989-06-27
JP2729320B2 (ja) 1998-03-18
NZ229696A (en) 1992-03-26
IL90727A0 (en) 1990-01-18
HUT51288A (en) 1990-04-28
EP0348910A3 (en) 1990-03-21
DK167534B1 (da) 1993-11-15
ATE122681T1 (de) 1995-06-15
US4910191A (en) 1990-03-20
CA1321578C (en) 1993-08-24
CN1033032C (zh) 1996-10-16
FI893163A0 (fi) 1989-06-28
PT90988B (pt) 1994-11-30
ZA894754B (en) 1990-05-30
KR0160280B1 (ko) 1998-11-16
NO174511C (es) 1994-05-18
AU610473B2 (en) 1991-05-16
FI893163A (fi) 1989-12-29
NO174511B (no) 1994-02-07
EP0348910A2 (en) 1990-01-03
DE68922660D1 (de) 1995-06-22
AU3712789A (en) 1990-01-04
FI92706B (fi) 1994-09-15
DK318589D0 (da) 1989-06-27
CN1039593A (zh) 1990-02-14
DE68922660T2 (de) 1996-01-18

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