ES2061802T3 - Derivados de 19-fluor- o ciano-21-hidroxiprogesterona utiles como inhibidores de 19-hidroxilasa. - Google Patents

Derivados de 19-fluor- o ciano-21-hidroxiprogesterona utiles como inhibidores de 19-hidroxilasa.

Info

Publication number
ES2061802T3
ES2061802T3 ES89111699T ES89111699T ES2061802T3 ES 2061802 T3 ES2061802 T3 ES 2061802T3 ES 89111699 T ES89111699 T ES 89111699T ES 89111699 T ES89111699 T ES 89111699T ES 2061802 T3 ES2061802 T3 ES 2061802T3
Authority
ES
Spain
Prior art keywords
useful
hydroxyprogesterone
derivatives
ciano
fluorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89111699T
Other languages
English (en)
Inventor
Gene W Holbert
J O'neal Johnston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2061802T3 publication Critical patent/ES2061802T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Organic Insulating Materials (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

DERIVADOS 19-FLUORO Y CIANO-SUSTITUIDOS 21-HIDROXIPROGESTERONA Y COMPONENTES RELACIONADOS LOS CUALES SON ACTIVOS COMO INHIBIDORES 19-HIDROXILASO Y UTILES COMO AGENTES ANTIHIPERTENSIVOS SON DESCRITAS AQUI, LOS COMPONENTES ESTAN PREPARADOS USANDO APROPIADA DIRECCION DE TRAYECTORIA LA CUAL VARIARA DE ACUERDO A LA NATURALEZA DE LA ESPECIFICA PROGESTERONA 19-SUSTITUIDA O COMPONENTE RELACIONADO DESEADO.
ES89111699T 1988-06-28 1989-06-27 Derivados de 19-fluor- o ciano-21-hidroxiprogesterona utiles como inhibidores de 19-hidroxilasa. Expired - Lifetime ES2061802T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/212,410 US4920114A (en) 1988-06-28 1988-06-28 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors

Publications (1)

Publication Number Publication Date
ES2061802T3 true ES2061802T3 (es) 1994-12-16

Family

ID=22790899

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111699T Expired - Lifetime ES2061802T3 (es) 1988-06-28 1989-06-27 Derivados de 19-fluor- o ciano-21-hidroxiprogesterona utiles como inhibidores de 19-hidroxilasa.

Country Status (19)

Country Link
US (1) US4920114A (es)
EP (1) EP0348911B1 (es)
JP (1) JP2727466B2 (es)
KR (1) KR0140885B1 (es)
CN (1) CN1039424A (es)
AT (1) ATE100462T1 (es)
AU (1) AU610413B2 (es)
CA (1) CA1321579C (es)
DE (1) DE68912422T2 (es)
DK (1) DK318489A (es)
ES (1) ES2061802T3 (es)
FI (1) FI893162A (es)
HU (1) HUT51289A (es)
IL (1) IL90728A0 (es)
NO (1) NO892679L (es)
NZ (1) NZ229694A (es)
PH (1) PH25771A (es)
PT (1) PT90989B (es)
ZA (1) ZA894753B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US6787530B1 (en) 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124574A (en) * 1964-03-10 Iz-halo pregnenes
IT1051705B (it) * 1962-05-12 1981-05-20 Vismara Spa F Metodo per la preparazione di intermedi steroidali
US3154569A (en) * 1961-10-10 1964-10-27 Vismara Francesco Spa 19-nitrilosteroids and process for producing 19-norsteroids
GB984093A (en) * 1962-02-19 1965-02-24 Syntex Corp Improvements in or relating to 19-halo-pregnane compounds
US3257435A (en) * 1962-09-21 1966-06-21 Syntex Corp 19-bisdifluoro pregnanes
US3257389A (en) * 1962-09-21 1966-06-21 Syntex Corp 19-bisdifluoro-pregnanes
US3205228A (en) * 1963-03-01 1965-09-07 Syntex Corp 19-substituted pregnenes
US3159620A (en) * 1963-05-22 1964-12-01 Vismara Francesco Spa Process for the preparation of 17 alpha-ethynyl-19-norandrostene compounds
US3394128A (en) * 1964-09-26 1968-07-23 Syntex Corp 19-halo-androstane and pregnane derivatives and processes for the preparation thereof
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
US4293548A (en) * 1980-09-02 1981-10-06 Merrell Dow Pharmaceuticals Inc. 18-Substituted pregn-4-ene-3,20-diones

Also Published As

Publication number Publication date
EP0348911A3 (en) 1990-03-28
US4920114A (en) 1990-04-24
JPH0248597A (ja) 1990-02-19
HUT51289A (en) 1990-04-28
EP0348911A2 (en) 1990-01-03
PT90989A (pt) 1989-12-29
NO892679L (no) 1989-12-29
AU3712689A (en) 1990-01-04
AU610413B2 (en) 1991-05-16
EP0348911B1 (en) 1994-01-19
ZA894753B (en) 1990-03-28
CN1039424A (zh) 1990-02-07
ATE100462T1 (de) 1994-02-15
IL90728A0 (en) 1990-01-18
DK318489D0 (da) 1989-06-27
DE68912422D1 (de) 1994-03-03
KR900000321A (ko) 1990-01-30
KR0140885B1 (ko) 1998-06-15
FI893162A0 (fi) 1989-06-28
PH25771A (en) 1991-10-18
JP2727466B2 (ja) 1998-03-11
NZ229694A (en) 1992-03-26
FI893162A (fi) 1989-12-29
CA1321579C (en) 1993-08-24
DE68912422T2 (de) 1994-08-18
NO892679D0 (no) 1989-06-27
DK318489A (da) 1989-12-29
PT90989B (pt) 1994-11-30

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