ES2070827T3 - Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion. - Google Patents

Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion.

Info

Publication number
ES2070827T3
ES2070827T3 ES87402747T ES87402747T ES2070827T3 ES 2070827 T3 ES2070827 T3 ES 2070827T3 ES 87402747 T ES87402747 T ES 87402747T ES 87402747 T ES87402747 T ES 87402747T ES 2070827 T3 ES2070827 T3 ES 2070827T3
Authority
ES
Spain
Prior art keywords
phospholipid
phospholipids
active substance
preparation procedure
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87402747T
Other languages
English (en)
Inventor
Roger Baurain
Andre Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8617116A external-priority patent/FR2607719B1/fr
Priority claimed from FR8702137A external-priority patent/FR2611138B2/fr
Priority claimed from FR8712424A external-priority patent/FR2620028B2/fr
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2070827T3 publication Critical patent/ES2070827T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A MICROCRISTALES DE UNA SUSTANCIA INSOLUBLE EN EL AGUA QUE PRESENTA UNA AFINIDAD PARA LOS FOSFOLIPIDOS, ASI COMO UN PROCEDIMIENTO DE PREPARACION. SEGUN LA INVENCION, SE EVAPORA EL O LOS DISOLVENTES ORGANICOS DE UNA SOLUCION DE FOSFOLIPIDOS Y DE DICHA SUSTANCIA, Y SE VUELVE A PONER EL FILM OBTENIDO, DESPUES DE LA EVAPORACION DEL O DE LOS DISOLVENTES, EN SUSPENSION EN UNA SOLUCION ACUOSA POR AGITACION VIGOROSA. LA COMPOSICION SE REFIERE IGUALMENTE A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN COMO PRINCIPIO ACTIVO DICHOS MICROCRISTALES, PARTICULARMENTE A COMPOSICIONES FARMACEUTICAS LIQUIDAS ACONDICIONADAS BAJO FORMA INYECTABLE O BAJO FORMA PULVERIZABLE.
ES87402747T 1986-12-05 1987-12-03 Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion. Expired - Lifetime ES2070827T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8617116A FR2607719B1 (fr) 1986-12-05 1986-12-05 Microcristaux comportant a titre de substance active des ginkgolides et compositions pharmaceutiques les contenant
FR8702137A FR2611138B2 (fr) 1986-12-05 1987-02-19 Microcristaux comportant une substance active presentant une affinite pour les phospholipides
FR8712424A FR2620028B2 (fr) 1986-12-05 1987-09-08 Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant

Publications (1)

Publication Number Publication Date
ES2070827T3 true ES2070827T3 (es) 1995-06-16

Family

ID=27251413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87402747T Expired - Lifetime ES2070827T3 (es) 1986-12-05 1987-12-03 Microcristales que contienen una sustancia activa que presenta afinidad por los fosfolipidos y al menos un fosfolipido, procedimiento de preparacion.

Country Status (8)

Country Link
US (1) US4973465A (es)
EP (1) EP0270460B1 (es)
JP (1) JP2852421B2 (es)
AT (1) ATE121301T1 (es)
CA (1) CA1338736C (es)
DE (1) DE3751258T2 (es)
ES (1) ES2070827T3 (es)
HK (1) HK1007502A1 (es)

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US6676930B2 (en) * 1999-11-28 2004-01-13 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
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Also Published As

Publication number Publication date
CA1338736C (fr) 1996-11-26
EP0270460A3 (en) 1990-09-05
EP0270460B1 (fr) 1995-04-19
ATE121301T1 (de) 1995-05-15
US4973465A (en) 1990-11-27
EP0270460A2 (fr) 1988-06-08
JPS63208515A (ja) 1988-08-30
HK1007502A1 (en) 1999-04-16
DE3751258D1 (de) 1995-05-24
DE3751258T2 (de) 1995-09-07
JP2852421B2 (ja) 1999-02-03

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