ES2093701T3 - Procedimiento para la preparacion de suspensiones acuosas de liposomas que contienen sustancias activas. - Google Patents
Procedimiento para la preparacion de suspensiones acuosas de liposomas que contienen sustancias activas.Info
- Publication number
- ES2093701T3 ES2093701T3 ES91906756T ES91906756T ES2093701T3 ES 2093701 T3 ES2093701 T3 ES 2093701T3 ES 91906756 T ES91906756 T ES 91906756T ES 91906756 T ES91906756 T ES 91906756T ES 2093701 T3 ES2093701 T3 ES 2093701T3
- Authority
- ES
- Spain
- Prior art keywords
- aqueous
- preparation
- active substances
- containing active
- suspensions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA LA PREPARACION DE SUSPENSIONES DE LIPOSOMA ACUOSO CONTENIENDO SUSTANCIAS ACTIVAS, PREPARANDOSE ESTAS SUSPENSIONES A PARTIR DE SOLUCIONES DE UNA SUSTANCIA FORMADORA DE LIPOSOMA, O UNA MEZCLA DE DICHAS SUSTANCIAS, EN UN ALCOHOL INFERIOR CON UN MAXIMO DE TRES ATOMOS DE CARBONO Y UNA FASE ACUOSA, ESTANDO EL INGREDIENTE ACTIVO DISUELTO O SUSPENDIDO EN LA SOLUCION LIPIDA Y/O LA FASE ACUOSA. EL PROCESO SE CARACTERIZA PORQUE SE INCORPORA LA FASE ACUOSA, MEDIANTE MEZCLA, EN LA SOLUCION ALCOHOLICA Y SE EXTRAE EL ALCOHOL INFERIOR MEDIANTE DESTILACION AL VACIO Y, SI ES NECESARIO, SE CONGELA-DESECA LA SUSPENSION DEL LIPOSOMA .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4013580A DE4013580A1 (de) | 1990-04-24 | 1990-04-24 | Verfahren zur herstellung von wirkstoffhaltigen waessrigen liposomensuspensionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2093701T3 true ES2093701T3 (es) | 1997-01-01 |
Family
ID=6405285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91906756T Expired - Lifetime ES2093701T3 (es) | 1990-04-24 | 1991-04-04 | Procedimiento para la preparacion de suspensiones acuosas de liposomas que contienen sustancias activas. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0478727B1 (es) |
| JP (1) | JPH04506814A (es) |
| AT (1) | ATE141503T1 (es) |
| AU (1) | AU651969B2 (es) |
| CA (1) | CA2041075A1 (es) |
| DE (2) | DE4013580A1 (es) |
| DK (1) | DK0478727T3 (es) |
| ES (1) | ES2093701T3 (es) |
| FI (1) | FI103178B (es) |
| HU (1) | HU215960B (es) |
| IE (1) | IE911350A1 (es) |
| NO (1) | NO303481B1 (es) |
| PT (1) | PT97468B (es) |
| WO (1) | WO1991016039A1 (es) |
| ZA (1) | ZA913091B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0660714B1 (en) * | 1991-06-18 | 2003-07-02 | ImaRx Pharmaceutical Corp. | Novel liposomal drug delivery systems |
| ES2113119T3 (es) * | 1993-08-06 | 1998-04-16 | Opperbas Holding Bv | Un metodo para la preparacion de vesiculas cargadas con estructuras biologicas, biopolimeros y/o oligomeros. |
| ATE219688T1 (de) * | 1994-03-28 | 2002-07-15 | Nycomed Imaging As | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
| WO1997035559A2 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation |
| AU773515B2 (en) * | 1999-02-08 | 2004-05-27 | Alza Corporation | Method for controlling liposome size |
| EP1519714B1 (en) * | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| WO2007012191A1 (en) | 2005-07-27 | 2007-02-01 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
| CN114344291B (zh) * | 2022-02-16 | 2023-09-29 | 中南大学湘雅医院 | 4-苯基-1h-吡咯-3-羧酸在制备治疗骨质疏松药物中的应用、脂质体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3416978A1 (de) * | 1983-05-12 | 1984-12-06 | Stauffer Chemical Co., Westport, Conn. | Durch liposom vermittelte transformation eukaryotischer zellen |
| JPS607932A (ja) * | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソーム懸濁液およびその製法 |
| JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| FR2634375B3 (fr) * | 1988-06-30 | 1991-07-05 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques |
| JP2554880B2 (ja) * | 1987-05-07 | 1996-11-20 | ポーラ化成工業株式会社 | 皮膚化粧料 |
-
1990
- 1990-04-24 DE DE4013580A patent/DE4013580A1/de not_active Withdrawn
-
1991
- 1991-04-04 ES ES91906756T patent/ES2093701T3/es not_active Expired - Lifetime
- 1991-04-04 DK DK91906756.1T patent/DK0478727T3/da active
- 1991-04-04 EP EP91906756A patent/EP0478727B1/de not_active Expired - Lifetime
- 1991-04-04 JP JP3506736A patent/JPH04506814A/ja active Pending
- 1991-04-04 WO PCT/DE1991/000294 patent/WO1991016039A1/de active IP Right Grant
- 1991-04-04 DE DE59108097T patent/DE59108097D1/de not_active Expired - Fee Related
- 1991-04-04 HU HU9200235A patent/HU215960B/hu not_active IP Right Cessation
- 1991-04-04 AT AT91906756T patent/ATE141503T1/de not_active IP Right Cessation
- 1991-04-23 IE IE135091A patent/IE911350A1/en unknown
- 1991-04-24 PT PT97468A patent/PT97468B/pt not_active IP Right Cessation
- 1991-04-24 CA CA002041075A patent/CA2041075A1/en not_active Abandoned
- 1991-04-24 AU AU75933/91A patent/AU651969B2/en not_active Ceased
- 1991-04-24 ZA ZA913091A patent/ZA913091B/xx unknown
- 1991-12-18 NO NO915012A patent/NO303481B1/no unknown
- 1991-12-23 FI FI916120A patent/FI103178B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| IE911350A1 (en) | 1991-11-06 |
| DK0478727T3 (es) | 1997-01-20 |
| AU7593391A (en) | 1991-11-07 |
| ATE141503T1 (de) | 1996-09-15 |
| PT97468A (pt) | 1992-01-31 |
| AU651969B2 (en) | 1994-08-11 |
| JPH04506814A (ja) | 1992-11-26 |
| FI103178B1 (fi) | 1999-05-14 |
| DE59108097D1 (de) | 1996-09-26 |
| ZA913091B (en) | 1992-12-30 |
| CA2041075A1 (en) | 1991-10-25 |
| DE4013580A1 (de) | 1991-10-31 |
| FI103178B (fi) | 1999-05-14 |
| FI916120A0 (fi) | 1991-12-23 |
| NO915012L (no) | 1991-12-18 |
| HUT62457A (en) | 1993-05-28 |
| NO303481B1 (no) | 1998-07-20 |
| NO915012D0 (no) | 1991-12-18 |
| EP0478727B1 (de) | 1996-08-21 |
| HU215960B (hu) | 1999-03-29 |
| PT97468B (pt) | 1999-12-31 |
| WO1991016039A1 (de) | 1991-10-31 |
| HU9200235D0 (en) | 1992-04-28 |
| EP0478727A1 (de) | 1992-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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