ES2085465T3 - Lipoesferas para la administracion controlada de sustancias. - Google Patents

Lipoesferas para la administracion controlada de sustancias.

Info

Publication number
ES2085465T3
ES2085465T3 ES91901106T ES91901106T ES2085465T3 ES 2085465 T3 ES2085465 T3 ES 2085465T3 ES 91901106 T ES91901106 T ES 91901106T ES 91901106 T ES91901106 T ES 91901106T ES 2085465 T3 ES2085465 T3 ES 2085465T3
Authority
ES
Spain
Prior art keywords
agent
phospholipid
lipospheres
liquid
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901106T
Other languages
English (en)
Inventor
Abraham J Domb
Manoj Maniar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2085465T3 publication Critical patent/ES2085465T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Abstract

SE PRESENTAN LIPOSFERAS SOLIDAS, INDISOLUBLES EN AGUA FORMADAS DE UN NUCLEO HIDROFOBICO SOLIDO QUE TIENE UNA CAPA DE UN FOSFOLIPIDO EMBEBIDA EN LA SUPERFICIE DEL NUCLEO, QUE CONTIENEN UN AGENTE BIOLOGICAMENTE ACTIVO EN EL NUCLEO, EN EL FOSFOLIPIDO, ADHERIDO AL FOSFOLIPIDO, O UNA COMBINACION DE LOS MISMOS, PARA UTILIZARLAS PARA PROPORCIONAR UNA LIBERACION AMPLIADA DEL AGENTE ACTIVO, INCLUIDAS LAS DROGAS COMO POR EJEMPLO VACUNAS Y ANESTESICOS, LOS AGENTES PARA EL CONTROL DE INSECTOS COMO POR EJEMPLO INSECTICIDAS Y AHUYENTADORES DE INSECTOS Y LOS COMPUESTOS AGRICOLAS COMO POR EJEMPLO FERTILIZANTES, FUNGICIDAS, PESTICIDAS Y HERBICIDAS. LAS LIPOSFERAS SE PUEDEN PREPARAR MEDIANTE UNA TECNICA DE DERRETIMIENTO O UNA TECNICA POR SOLVENTE, QUE DE MANERA RESUMIDA CONSISTE EN: (1) FORMAR UNA SOLUCION LIQUIDA O SUSPENSION DEL AGENTE BIEN A BASE DE DERRETIR EL AGENTE, O DE DISOLVER O DISPERSAR EL AGENTE EN UN MEDIO LIQUIDO, PARA FORMAR UNA MEZCLA DE UN AGENTE LIQUIDO QUE SE SOLIDIFICA A UNA TEMPERATURA AMBIENTE O MAYOR; (2) AÑADIR UN FOSFOLIPIDO Y UNA SOLUCION ACUOSA AL AGENTE LIQUIDO PARA FORMAR UNA SUSPENSION; (3) MEZCLAR LA SUSPENSION A UNA TEMPERATURA SUPERIOR A LA TEMPERATURA DE FUSION HASTA QUE SE OBTENGA UNA DISPERSION SUAVE HOMOGENEA; Y DESPUES (4) ENFRIAR RAPIDAMENTE LA DISPERSION POR DEBAJO DE LA TEMPERATURA DE FUSION DE LA MEZCLA LIQUIDA QUE CONTIENE EL AGENTE. TAMBIEN SE PUEDE AÑADIR EL AGENTE AL FOSFOLIPIDO O MEZCLARLO CON LAS LIPOSFERAS RESULTANTES . LAS LIPOSFERAS QUE CONTIENEN EL AGENTE PRESENTAN GRANDES VENTAJAS EN COMPARACION A OTROS SISTEMAS DE SUMINISTRO, INCLUIDAS LAS EMULSIONES, VESICULAS Y LIPOSOMAS, QUE INCLUYEN UNA ESTABILIDAD, UN BAJO COSTE DE LOS REAGENTES, UNA FACILIDAD DE FABRICACION, UNA ALTA DISPERSABILIDAD EN UN MEDIO ACUOSO, UNA VELOCIDAD DE LIBERACION PARA LA SUSTANCIA ATRAPADA QUE ES CONTROLADA POR EL REVESTIMIENTO DE FOSFOLIPIDOS Y POR LA PORTADORA. UNOS EJEMPLOS DEMUESTRAN LA ADMINISTRACION EFECTIVA DE ANESTESICOS, ANTIGENOS Y PRODUCTOS AHUYENTADORES DEINSECTOS (DEET).
ES91901106T 1989-11-13 1990-11-08 Lipoesferas para la administracion controlada de sustancias. Expired - Lifetime ES2085465T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43554689A 1989-11-13 1989-11-13

Publications (1)

Publication Number Publication Date
ES2085465T3 true ES2085465T3 (es) 1996-06-01

Family

ID=23728827

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901106T Expired - Lifetime ES2085465T3 (es) 1989-11-13 1990-11-08 Lipoesferas para la administracion controlada de sustancias.

Country Status (12)

Country Link
EP (1) EP0502119B1 (es)
JP (1) JP3233402B2 (es)
KR (1) KR960005137B1 (es)
AT (1) ATE133562T1 (es)
AU (1) AU655162B2 (es)
CA (1) CA2068216C (es)
DE (1) DE69025196T2 (es)
DK (1) DK0502119T3 (es)
ES (1) ES2085465T3 (es)
GR (1) GR3019716T3 (es)
WO (1) WO1991007171A1 (es)
ZA (1) ZA909088B (es)

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CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5785976A (en) * 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
ATE199316T1 (de) * 1993-12-23 2001-03-15 Bruno Gander Mit antigen beladene mikropartikel und pharmazeutische zubereitungen, die diese mikropartikel enthalten.
DE69511418T2 (de) 1995-10-28 2000-03-30 Braun Melsungen Ag Lokalanästhetika und/oder Zentralanalgetika enthaltende pharmazeutische Zusammensetzungen
NZ503086A (en) * 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
AU9496798A (en) 1997-09-19 1999-04-05 Shire Laboratories, Inc. Solid solution beadlet
DE69940735D1 (de) * 1998-07-17 2009-05-28 Pacira Pharmaceuticals Inc Biologisch abbaubare anordnungen zur kontrollierten freigabe eingeschlossener substanzen
CA2336879C (en) * 1998-07-20 2010-06-01 Peptech Limited Sustained-release formulations comprising peptides, polypeptides, proteins or nucleic acids as active ingredients
US8052982B2 (en) 1998-07-20 2011-11-08 Peptech Animal Health Pty Limited Bioimplant formulation comprising lecithin and stearin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
DE50110158D1 (de) * 2001-09-06 2006-07-27 Friedrich Wolfgang Verwendung eines Gemisches von Lidocain und Prilocain, sowie Mittel zur Tumeszenz-Lokalanästhesie
US6696490B2 (en) 2002-07-10 2004-02-24 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Slow release insect repellent compounds and process for delivering active
WO2004041247A2 (en) 2002-11-01 2004-05-21 Biodelivery Sciences International, Inc. Geodate delivery vehicles
JP4601311B2 (ja) * 2004-03-12 2010-12-22 ネイチャーテクノロジー株式会社 球状粒子及びその製造方法
JP4533185B2 (ja) * 2005-02-24 2010-09-01 花王株式会社 固体脂質粒子製剤
US8101274B2 (en) 2007-06-11 2012-01-24 Spedden Richard H Solid state membranes with surface-embedded glycosylated amphiphilic molecules and micelles formed therefrom
PL2299953T3 (pl) 2008-07-14 2017-10-31 Polypid Ltd Kompozycja nośnika leku o przedłużonym uwalnianiu
KR20110042107A (ko) 2008-08-07 2011-04-22 바이오엑티브 써지컬, 아이엔씨. 의료 장치 및 이식물을 위한 줄기 세포 포획 및 고정화 코팅
IN2012DN00570A (es) 2009-07-14 2015-06-12 Polypid Ltd
EP2525778B1 (en) 2010-01-19 2018-08-01 Polypid Ltd. Sustained-release nucleic acid matrix compositions
PT2439188E (pt) 2010-09-15 2012-11-14 Selkis Sas Derivados de p-mentano-3,8-diol e meios de proteção contra insetos que os contêm
WO2013171196A1 (en) * 2012-05-15 2013-11-21 Dsm Ip Assets B.V. Antifungal compositions
US10702604B2 (en) 2012-06-01 2020-07-07 Galderma Research & Development Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing the same, process for preparing the same and use thereof in dermatology
EP2823811A1 (en) * 2013-07-09 2015-01-14 OTC GmbH Targeted active release system comprising solid lipid nano-particles
DE102013224627A1 (de) 2013-11-29 2015-06-03 Andreas Lauterbach Pharmazeutische Formulierung mit Lipidmikropartikeln und Herstellungsverfahren
US10857080B2 (en) 2013-12-04 2020-12-08 Galderma Research & Development Lipid microcapsules preferably comprising a lipophilic active substance and composition containing same, method for the production thereof, and use of same in dermatology and in cosmetics
WO2016193588A1 (fr) 2015-05-29 2016-12-08 Galderma Research & Development Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques
JP6530069B2 (ja) 2015-06-17 2019-06-12 臼井国際産業株式会社 燃料噴射管用鋼管およびその製造方法
CN107608422A (zh) * 2017-09-29 2018-01-19 智车优行科技（北京）有限公司 车载温度控制装置
IT201900011436A1 (it) 2019-07-10 2021-01-10 Univ Degli Studi Di Palermo Particelle micrometriche, loro metodo di preparazione e loro usi
KR20220140783A (ko) 2020-02-13 2022-10-18 글리코사이언스 에스엘 휘발성 알코올의 느린 방출을 위한 3'-케토글리코시드 화합물
WO2023057235A1 (en) 2021-10-06 2023-04-13 Glycoscience, S.L. Process for preparing 3'-ketoglycoside compounds
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Also Published As

Publication number Publication date
CA2068216A1 (en) 1991-05-14
DE69025196T2 (de) 1996-11-14
WO1991007171A1 (en) 1991-05-30
KR960005137B1 (ko) 1996-04-22
DE69025196D1 (de) 1996-03-14
JPH05505338A (ja) 1993-08-12
ZA909088B (en) 1991-07-31
EP0502119B1 (en) 1996-01-31
DK0502119T3 (da) 1996-06-03
ATE133562T1 (de) 1996-02-15
EP0502119A1 (en) 1992-09-09
GR3019716T3 (en) 1996-07-31
CA2068216C (en) 1999-04-13
KR920703017A (ko) 1992-12-17
AU655162B2 (en) 1994-12-08
JP3233402B2 (ja) 2001-11-26
AU6950091A (en) 1991-06-13

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