ES2070806A1 - Syrup containing n-acetyl-cysteine - Google Patents

Syrup containing n-acetyl-cysteine

Info

Publication number
ES2070806A1
ES2070806A1 ES9450021A ES9450021A ES2070806A1 ES 2070806 A1 ES2070806 A1 ES 2070806A1 ES 9450021 A ES9450021 A ES 9450021A ES 9450021 A ES9450021 A ES 9450021A ES 2070806 A1 ES2070806 A1 ES 2070806A1
Authority
ES
Spain
Prior art keywords
cysteine
acetyl
syrup containing
agent
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9450021A
Other languages
Spanish (es)
Other versions
ES2070806B1 (en
Inventor
Federico Stroppolo
Daniele Bonadeo
Alessandro Saudino
Annibale Gazzaniga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of ES2070806A1 publication Critical patent/ES2070806A1/en
Application granted granted Critical
Publication of ES2070806B1 publication Critical patent/ES2070806B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Abstract

A syrup containing N-acetyl-cysteine, stable for at least two years, having pleasant taste and smell, consists of an aqueous solution of NAC, a sweetening agent and a thickening agent. The solution can also contain a flavouring agent and a preservative. The pH is between 5 and 8.
ES09450021A 1992-12-02 1993-11-23 SYRUP CONTAINING N-ACETYL-CYSTEINE. Expired - Fee Related ES2070806B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922758A IT1256616B (en) 1992-12-02 1992-12-02 SYRUP CONTAINING N-ACETYL-CISTEIN

Publications (2)

Publication Number Publication Date
ES2070806A1 true ES2070806A1 (en) 1995-06-01
ES2070806B1 ES2070806B1 (en) 1996-01-01

Family

ID=11364395

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09450021A Expired - Fee Related ES2070806B1 (en) 1992-12-02 1993-11-23 SYRUP CONTAINING N-ACETYL-CYSTEINE.

Country Status (23)

Country Link
JP (1) JPH08503703A (en)
AT (1) AT407113B (en)
AU (1) AU667611B2 (en)
BE (1) BE1006799A3 (en)
CA (1) CA2150462C (en)
CH (1) CH685371A5 (en)
CZ (1) CZ282550B6 (en)
DE (2) DE4396086T1 (en)
DK (1) DK176247B1 (en)
ES (1) ES2070806B1 (en)
FR (1) FR2698545B1 (en)
GB (1) GB2288977B (en)
HU (2) HU221484B (en)
IT (1) IT1256616B (en)
LU (1) LU88618A1 (en)
MD (1) MD1714G2 (en)
NL (1) NL194957C (en)
NO (1) NO314018B1 (en)
NZ (1) NZ258544A (en)
RU (1) RU2108777C1 (en)
SE (1) SE520834C2 (en)
UA (1) UA27142C2 (en)
WO (1) WO1994012168A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0766557B1 (en) * 1994-06-23 2001-12-19 The Procter & Gamble Company Topical compositions comprising n-acetyl-l-cysteine
JP4501024B2 (en) * 2002-11-14 2010-07-14 小林製薬株式会社 Composition with reduced bitterness and odor of cysteines
JP4501023B2 (en) * 2002-11-14 2010-07-14 小林製薬株式会社 Composition with reduced bitterness and odor of cysteines
US8148356B2 (en) * 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
CN102233139B (en) * 2010-04-21 2012-09-05 重庆健能医药开发有限公司 Acetylcysteine effervescent tablet and preparation method and application thereof
RU2611411C1 (en) * 2016-01-11 2017-02-21 Общество с ограниченной ответственностью "Трейдсервис" Dispersible in water acetylcysteine tablet and method of manufacturing thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192789A (en) * 1986-07-24 1988-01-27 Inpharzam Int Sa Acetylcysteine compositions
GB2192790A (en) * 1986-07-24 1988-01-27 Inpharzam Int Sa Acetylcysteine compositions
FR2631831A1 (en) * 1988-05-31 1989-12-01 Calco Anstalt Syrups based on xylitol, ribitol or arabitol
GB2234171A (en) * 1989-07-27 1991-01-30 Zambon Spa Composition containing N-acetyl-cysteine of enhanced bioavailability

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB905197A (en) * 1960-01-01 1962-09-05 Lab Francais Chimiotherapie Anti-viral compositions comprising 1-phenyl-2-amino-propane-1,3-diol derivatives
CA1239349A (en) * 1983-10-10 1988-07-19 Eberhard F. Gottwald Pharmaceutical composition containing cimetidine
BE901885A (en) * 1985-03-06 1985-07-01 Bruschettini Srl Stable ophthalmic soln. contg. N-acetyl-cysteine - prepd. in nitrogen satd. aq. buffer free of metal ions
US4861797A (en) * 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
CH674940A5 (en) * 1988-05-05 1990-08-15 Ibsa Inst Biochimique Sa
ES2054089T3 (en) * 1988-11-10 1994-08-01 Ciba Geigy Ag LIQUID ORAL FORMULATIONS.
IT1248998B (en) * 1990-06-26 1995-02-11 Iscofar Sas COMPOSITION OF RUBBER TO BE CHEWED FOR THE PREVENTION AND TREATMENT OF DENTAL PLATE
EP0481294B2 (en) * 1990-10-19 2001-04-11 Spirig Ag Pharmazeutische Präparate Solid fast-dissolving pharmaceutical preparation containing N-acetyl-cysteine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192789A (en) * 1986-07-24 1988-01-27 Inpharzam Int Sa Acetylcysteine compositions
GB2192790A (en) * 1986-07-24 1988-01-27 Inpharzam Int Sa Acetylcysteine compositions
FR2631831A1 (en) * 1988-05-31 1989-12-01 Calco Anstalt Syrups based on xylitol, ribitol or arabitol
GB2234171A (en) * 1989-07-27 1991-01-30 Zambon Spa Composition containing N-acetyl-cysteine of enhanced bioavailability

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FARM. TIJDSCHR. BELG., Vol. 61, n‘ 4, 1984; I. THIELENS: "Stability of N-Acetil-L-cisteine in pharmaceutical syrups" pßg. 445-448 *

Also Published As

Publication number Publication date
AU5626694A (en) 1994-06-22
DK176247B1 (en) 2007-04-16
MD1714G2 (en) 2002-03-31
GB9509822D0 (en) 1995-07-19
GB2288977A (en) 1995-11-08
NL194957C (en) 2003-09-02
NO952183D0 (en) 1995-06-01
CH685371A5 (en) 1995-06-30
BE1006799A3 (en) 1994-12-13
NO952183L (en) 1995-06-01
ITMI922758A0 (en) 1992-12-02
AT407113B (en) 2000-12-27
DE4396086T1 (en) 1995-12-07
SE9502001L (en) 1995-07-21
RU2108777C1 (en) 1998-04-20
GB2288977B (en) 1996-09-04
UA27142C2 (en) 2000-02-28
CZ282550B6 (en) 1997-08-13
HUT72668A (en) 1996-05-28
CA2150462C (en) 2005-04-19
NO314018B1 (en) 2003-01-20
WO1994012168A1 (en) 1994-06-09
DK61495A (en) 1995-05-31
ITMI922758A1 (en) 1994-06-02
CA2150462A1 (en) 1994-06-09
ATA906093A (en) 2000-05-15
SE520834C2 (en) 2003-09-02
MD1714F2 (en) 2001-08-31
AU667611B2 (en) 1996-03-28
LU88618A1 (en) 1995-12-01
ES2070806B1 (en) 1996-01-01
SE9502001D0 (en) 1995-06-01
IT1256616B (en) 1995-12-12
HU9501586D0 (en) 1995-08-28
JPH08503703A (en) 1996-04-23
HU221484B (en) 2002-10-28
FR2698545A1 (en) 1994-06-03
NL9320052A (en) 1995-08-01
FR2698545B1 (en) 1995-08-04
CZ136795A3 (en) 1995-11-15
DE4396086B3 (en) 2013-02-28
HU211912A9 (en) 1996-01-29
NZ258544A (en) 1996-11-26
NL194957B (en) 2003-05-01

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20141120