ES2064727T3 - Derivados de pirimidina. - Google Patents
Derivados de pirimidina.Info
- Publication number
- ES2064727T3 ES2064727T3 ES90906289T ES90906289T ES2064727T3 ES 2064727 T3 ES2064727 T3 ES 2064727T3 ES 90906289 T ES90906289 T ES 90906289T ES 90906289 T ES90906289 T ES 90906289T ES 2064727 T3 ES2064727 T3 ES 2064727T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cycloalkyl
- alkenyl
- carbon atoms
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
EL INVENTO CONCIERNE A LAS NUEVAS SALES AMINOPIRIMIDINO DE LA FORMULA (I), EN LA QUE R1 ES ALQUIL, ALQUENIL, CICLOALQUIL, FENIL, FENILALQUIL O CICLOALQUIL-ALQUIL; UNO DE R2 Y R6 ES UN GRUPO BASICO SELECCIONADO DE AMINO, ALQUILAMINO, DIALQUILAMINO DE MAS DE 8 CARBONOS, PIRROLIDINO, PIPERRIDINO Y MORFOLINO; Y EL OTRO DE R2 Y R6 ES HIDROGENO, ALQUIL, ALQUENIL, ALCOXIALQUIL, FENIL, FENILALQUIL, CICLOALQUIL O CICLOALQUIL-ALQUIL; O AMBOS DE R2 Y R6 SON GRUPOS BASICOS COMO SE MENCIONO ANTES; Y R5 ES HIDROGENO, ALQUIL(C1-4) O ALQUIL(C3-6); O R2 ES UN GRUPO BASICO COMO SE MENCIONO ANTES, Y R5 Y R6 JUNTOS FORMAN ALQUILENO, O JUNTO CON LOS CARBONOS ANEXOS DEL ANILLO PIRIMIDINE, COMPLETAN UN ANILLO BENCENO; R4 ES HIDROGENO, ALQUIL, CICLOALQUIL-ALQUIL, ALQUENIL, ALQUINIL O FENILALQUIL; O R4 ES UN ALQUILENO OPCIONALMENTE SUSTITUIDO O ALQUENILEN LIGADO AL NITROGENO DEL GRUPO Q.A.N.-, O DE LOS QUE LOS GRUPOS ENLAZANTES DEBEN POR LO CUAL COMPLETAR UN ANILLO QUE INCLUYA DOS CARBONOS ADYACENTES DE Q, LOS CARBONOS DE A Y LOS NITROGENOS ADYACENTES DEL GRUPO -A.N-; A ES UN ENLACE DIRECTO AL GRUPO -N(R4) OXIALQUILENO; Q ES PARTE DE PIRIDIL, FURIL, TIENIL O FENIL; E Y ES UN ANION ACEPTABLE FISIOLOGICAMENTE; PERO EXCLUYENDO UN NUMERO DE COMPONENTES ESPECIFICADOS MAS ADELANTE. EL INVENTO TAMBIEN INCLUYE CIERTOS DERIVADOS DE BASE ANHIDRO RELACIONADOS PROXIMOS QUE, COMO LOS COMPONENTES DE LA FORMULA (I), POSEEN EFECTOS BENEFICIOSOS EN EL SISTEMA CARDIOVASCULAR ( Y EN PARTICULAR EFECTOS BENEFICIOSOS MODULADOS EN EL NUDO SINO-ATRIAL). TAMBIEN SON INCLUIDAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN COMPONENTES DE LA FORMULA (I) (O UNA RELACION BASE-ANHIDRO) COMO INGREDIENTE ACTIVO, Y PROCESOS PARA LA MANUFACTURA DE VARIOS COMPONENTES NUEVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898909054A GB8909054D0 (en) | 1989-04-21 | 1989-04-21 | Amino heterocycles |
GB898910548A GB8910548D0 (en) | 1989-05-08 | 1989-05-08 | Heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064727T3 true ES2064727T3 (es) | 1995-02-01 |
Family
ID=26295250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90906289T Expired - Lifetime ES2064727T3 (es) | 1989-04-21 | 1990-04-19 | Derivados de pirimidina. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5223505A (es) |
EP (1) | EP0422178B1 (es) |
JP (1) | JP2528218B2 (es) |
KR (1) | KR920700203A (es) |
CN (1) | CN1024793C (es) |
AT (1) | ATE112561T1 (es) |
AU (1) | AU635260B2 (es) |
CA (1) | CA2014457C (es) |
DE (1) | DE69013112T2 (es) |
DK (1) | DK0422178T3 (es) |
ES (1) | ES2064727T3 (es) |
FI (1) | FI95377C (es) |
GB (1) | GB2230527B (es) |
GR (1) | GR1000371B (es) |
HR (1) | HRP930793A2 (es) |
HU (1) | HU209586B (es) |
IE (1) | IE63502B1 (es) |
IL (1) | IL94062A (es) |
MW (1) | MW9090A1 (es) |
MY (1) | MY105637A (es) |
NO (1) | NO177054C (es) |
NZ (1) | NZ233292A (es) |
PL (2) | PL165502B1 (es) |
PT (1) | PT93823B (es) |
RU (1) | RU2108329C1 (es) |
SI (1) | SI9010799A (es) |
WO (1) | WO1990012790A1 (es) |
YU (1) | YU79990A (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
GB9022644D0 (en) * | 1990-10-18 | 1990-11-28 | Ici Plc | Heterocyclic compounds |
US5958934A (en) * | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
US5952331A (en) * | 1996-05-23 | 1999-09-14 | Syntex (Usa) Inc. | Aryl pyrimidine derivatives |
NZ506417A (en) | 1998-02-17 | 2003-05-30 | Tularik Inc | Anti-viral pyrimidine derivatives |
ES2361146T3 (es) | 1998-03-27 | 2011-06-14 | Janssen Pharmaceutica Nv | Derivados de la piramidina inhibitatoria de vih. |
DE19851421A1 (de) * | 1998-11-07 | 2000-05-11 | Boehringer Ingelheim Pharma | Neue Pyrimidine, deren Herstellung und Verwendung |
IL148801A0 (en) | 1999-09-24 | 2002-09-12 | Janssen Pharmaceutica Nv | Antiviral compositions |
US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
MXPA03010324A (es) * | 2001-05-14 | 2004-02-17 | Bristol Myers Squibb Pharma Co | PIRAZINONAS, PIRIDINAS Y PIRIMIDINAS SUBSTITUIDAS COMO LIGANDOS DEL FACTOR DE LIBERACIoN DE CORTICOTROPINA. |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
AU2003265336B8 (en) | 2002-07-29 | 2009-04-23 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
US20040242566A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US7618975B2 (en) * | 2003-07-03 | 2009-11-17 | Myriad Pharmaceuticals, Inc. | 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
PL1656372T3 (pl) | 2003-07-30 | 2013-08-30 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym |
CN1867560A (zh) | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4-嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
EP1699777B1 (en) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102127053A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
EP1814878B1 (en) | 2004-11-24 | 2012-01-04 | Rigel Pharmaceuticals, Inc. | Spiro-2, 4-pyrimidinediamine compounds and their uses |
EP2805953B1 (en) | 2004-12-21 | 2016-03-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
ATE451381T1 (de) | 2005-01-19 | 2009-12-15 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
CA2604551A1 (en) * | 2005-05-03 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Jak kinase inhibitors and their uses |
IN2014DN04588A (es) | 2005-05-26 | 2015-07-10 | Tibotec Pharm Ltd | |
ME02005B (me) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Inhibitori dipeptidil peptidaze za lečenje dijabetesa |
CA2622642C (en) | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1993612A4 (en) * | 2006-01-31 | 2010-05-05 | Univ Yale | COMPOSITIONS AND METHODS FOR TREATING COGNITIVE INTERFERENCE |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
US20080217501A1 (en) * | 2007-02-14 | 2008-09-11 | Chad Jensen | Power a-frame |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
TWI401023B (zh) * | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
WO2012135697A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center & Research Institute Inc. | Novel rho kinase inhibitors and methods of use |
US10172856B2 (en) | 2017-04-06 | 2019-01-08 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives as histamine H4 modulators |
AU2018352695A1 (en) | 2017-10-19 | 2020-05-28 | Effector Therapeutics, Inc. | Benzimidazole-indole inhibitors of Mnk1 and Mnk2 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB815833A (en) * | 1956-09-26 | 1959-07-01 | Boots Pure Drug Co Ltd | Phenanthridine compounds |
BE492034A (es) * | 1948-11-05 | |||
US2784124A (en) * | 1953-07-01 | 1957-03-05 | Howard R Moore | Method of coating ferrous metal surface and composition therefor |
US2748124A (en) * | 1954-05-06 | 1956-05-29 | Searle & Co | 1-(4-anilino-2-pyrimidino)-3-alkylureas |
US2845425A (en) * | 1956-10-04 | 1958-07-29 | Lilly Co Eli | Substituted aminopyrimidines |
DE1241832B (de) * | 1963-02-23 | 1967-06-08 | Hoechst Ag | Verfahren zur Herstellung von Pyrimidiniumverbindungen |
DE1445740A1 (de) * | 1963-09-04 | 1968-11-28 | Bayer Ag | Verfahren zur Herstellung von Bispyrimidinium-Verbindungen |
GB1229413A (es) * | 1967-06-14 | 1971-04-21 | ||
IN142539B (es) * | 1974-05-10 | 1977-07-23 | Ciba Geigy India Ltd | |
US4339453A (en) * | 1979-07-23 | 1982-07-13 | Merck & Co., Inc. | Antimicrobial aminopyrimidinium salts |
GR80171B (en) * | 1983-08-29 | 1985-01-02 | Ciba Geigy Ag | N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use |
US4725600A (en) * | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
DE3717480A1 (de) * | 1987-05-23 | 1988-12-01 | Shell Agrar Gmbh & Co Kg | Neue herbizid und mikrobizid wirksame 2,6-diaminopyrimidine |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
-
1990
- 1990-04-06 IE IE125890A patent/IE63502B1/en not_active IP Right Cessation
- 1990-04-09 GB GB9007964A patent/GB2230527B/en not_active Expired - Fee Related
- 1990-04-11 IL IL9406290A patent/IL94062A/en not_active IP Right Cessation
- 1990-04-11 NZ NZ233292A patent/NZ233292A/en unknown
- 1990-04-12 CA CA002014457A patent/CA2014457C/en not_active Expired - Fee Related
- 1990-04-19 RU SU4894489A patent/RU2108329C1/ru active
- 1990-04-19 AT AT90906289T patent/ATE112561T1/de not_active IP Right Cessation
- 1990-04-19 ES ES90906289T patent/ES2064727T3/es not_active Expired - Lifetime
- 1990-04-19 DE DE69013112T patent/DE69013112T2/de not_active Expired - Fee Related
- 1990-04-19 YU YU00799/90A patent/YU79990A/xx unknown
- 1990-04-19 KR KR1019900702652A patent/KR920700203A/ko not_active Application Discontinuation
- 1990-04-19 HU HU903555A patent/HU209586B/hu not_active IP Right Cessation
- 1990-04-19 WO PCT/GB1990/000595 patent/WO1990012790A1/en active IP Right Grant
- 1990-04-19 EP EP90906289A patent/EP0422178B1/en not_active Expired - Lifetime
- 1990-04-19 DK DK90906289.5T patent/DK0422178T3/da active
- 1990-04-19 AU AU54354/90A patent/AU635260B2/en not_active Ceased
- 1990-04-19 JP JP2506034A patent/JP2528218B2/ja not_active Expired - Lifetime
- 1990-04-20 PL PL90284871A patent/PL165502B1/pl unknown
- 1990-04-20 US US07/513,304 patent/US5223505A/en not_active Expired - Fee Related
- 1990-04-20 PT PT93823A patent/PT93823B/pt not_active IP Right Cessation
- 1990-04-20 PL PL90301231A patent/PL165917B1/pl unknown
- 1990-04-20 SI SI9010799A patent/SI9010799A/sl unknown
- 1990-04-21 MY MYPI90000670A patent/MY105637A/en unknown
- 1990-04-21 CN CN90103931A patent/CN1024793C/zh not_active Expired - Fee Related
- 1990-04-23 GR GR900100304A patent/GR1000371B/el not_active IP Right Cessation
- 1990-12-06 MW MW90/90A patent/MW9090A1/xx unknown
- 1990-12-20 NO NO905519A patent/NO177054C/no not_active IP Right Cessation
- 1990-12-20 FI FI906307A patent/FI95377C/fi not_active IP Right Cessation
-
1993
- 1993-04-06 HR HRP-799/90A patent/HRP930793A2/hr not_active Application Discontinuation
Also Published As
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