ES2058169T3 - Enkastinas: nuevas glicopeptidos con efecto inhibidor de la encefalinasa, procedimiento para su preparacion y su empleo como preparados farmaceuticos. - Google Patents
Enkastinas: nuevas glicopeptidos con efecto inhibidor de la encefalinasa, procedimiento para su preparacion y su empleo como preparados farmaceuticos.Info
- Publication number
- ES2058169T3 ES2058169T3 ES88106354T ES88106354T ES2058169T3 ES 2058169 T3 ES2058169 T3 ES 2058169T3 ES 88106354 T ES88106354 T ES 88106354T ES 88106354 T ES88106354 T ES 88106354T ES 2058169 T3 ES2058169 T3 ES 2058169T3
- Authority
- ES
- Spain
- Prior art keywords
- rest
- encephalinase
- neutral
- amino acid
- enkastinas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/47—Streptomyces albus
Abstract
LA INVENCION SE REFIERE A NUEVOS GLICOPEPTIDOS BIOLOGICAMENTE ACTIVOS DE FORMULA (I) DONDE SACCH REPRESENTA UN RESTO DE MONOSACARIDO, CON GRUPOS OH OPCIONALMENTE SUSTITUIDOS EN FORMA PARCIAL O TOTAL, A ES UN RESTO DE UN AMINOACIDO NEUTRO L O D, O, EN CASO DE FACTOR B, ES UN RESTO DE UN D-AMINOACIDO NEUTRO, B FALTA O ES UN RESTO DE AMINOACIDO NEUTRO L O D O UN AMINOACIDO ACIDO O BASICO L O D BIFUNCIONAL, OPCIONALMENTE OMEGA-SUSTITUIDO Y R REPRESENTA HIDROXI, ALCOXI C1-C8, UN RESTO AMINO, OPCIONALMENTE SUSTITUIDO CON UNO O DOS RESTOS IGUALES O DIFERENTES DE LA SERIE ALQUILO C1-C8, CICLOALQUILO C5-C8 O HETEROARILO, U OTRO DERIVADO DE ACIDO. ESTOS COMPUESTOS POSEEN PROPIEDADES INHIBIDORAS DE LA ENCEFALINASA Y POR ELLO PUEDEN EMPLEARSE P.E. COMO ANALGESICOS EN MEDICINA Y VETERINARIA. SE DESCRIBE ADEMAS EL AISLAMIENTO DE ESTOS COMPUESTOS A PARTIR DE STREPTOMYCES ALBUS ATCC 21838 ASI COMO OTROS PROCEDIMIENTOS PARA SU OBTENCION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873713873 DE3713873A1 (de) | 1987-04-25 | 1987-04-25 | Enkastine: neue glycopeptide mit enkephalinase-hemmender wirkung, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutische praeparate |
DE19873739376 DE3739376A1 (de) | 1987-11-20 | 1987-11-20 | Enkastine: neue glycopeptide mit enkephalinase-hemmender wirkung, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutische praeparate |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058169T3 true ES2058169T3 (es) | 1994-11-01 |
Family
ID=25854960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88106354T Expired - Lifetime ES2058169T3 (es) | 1987-04-25 | 1988-04-21 | Enkastinas: nuevas glicopeptidos con efecto inhibidor de la encefalinasa, procedimiento para su preparacion y su empleo como preparados farmaceuticos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5302582A (es) |
EP (1) | EP0288897B1 (es) |
JP (1) | JP2610646B2 (es) |
KR (1) | KR880012643A (es) |
CN (1) | CN1030766A (es) |
AU (1) | AU607486B2 (es) |
DE (1) | DE3883055D1 (es) |
DK (1) | DK222488A (es) |
ES (1) | ES2058169T3 (es) |
FI (1) | FI881869A (es) |
HU (1) | HU198953B (es) |
IL (1) | IL86168A (es) |
NO (1) | NO172351C (es) |
NZ (1) | NZ224341A (es) |
PT (1) | PT87306B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE184611T1 (de) * | 1991-11-29 | 1999-10-15 | Hoechst Ag | Peptide mit insulinartiger wirkung |
US5679769A (en) * | 1994-03-15 | 1997-10-21 | Sloan-Kettering Institute For Cancer Research | Synthesis of asparagine-linked glycopeptides on a polymeric solid support |
DK1216707T3 (da) * | 2000-12-22 | 2005-05-09 | Pasteur Institut | Fremgangsmåde til screening af ligandmolekyler, der specifikt binder til NEP-bindingsstederne for QHNPR-pentapeptidet |
CN100412082C (zh) * | 2003-10-16 | 2008-08-20 | 北京北医投资管理有限公司医药科技开发分公司 | 环糖基氨基酸及其制备方法和防治重金属中毒的用途 |
JP4616928B2 (ja) * | 2003-11-19 | 2011-01-19 | 花王株式会社 | フルクトシルジペプチド又はその塩 |
JP4542874B2 (ja) * | 2003-11-19 | 2010-09-15 | 花王株式会社 | フルクトシルジペプチド又はその塩 |
JP4589823B2 (ja) * | 2005-06-22 | 2010-12-01 | 花王株式会社 | 化粧料 |
JP4589824B2 (ja) * | 2005-06-22 | 2010-12-01 | 花王株式会社 | 化粧料 |
JP4584784B2 (ja) * | 2005-06-22 | 2010-11-24 | 花王株式会社 | 化粧料 |
CN101285046B (zh) * | 2007-04-09 | 2011-08-17 | 天津科技大学 | 一种诱变菌株白色链霉菌TUST2及利用该诱变菌株生产ε-聚赖氨酸及其盐的方法 |
-
1988
- 1988-04-21 ES ES88106354T patent/ES2058169T3/es not_active Expired - Lifetime
- 1988-04-21 EP EP88106354A patent/EP0288897B1/de not_active Expired - Lifetime
- 1988-04-21 FI FI881869A patent/FI881869A/fi not_active Application Discontinuation
- 1988-04-21 DE DE8888106354T patent/DE3883055D1/de not_active Expired - Fee Related
- 1988-04-22 PT PT87306A patent/PT87306B/pt not_active IP Right Cessation
- 1988-04-22 AU AU15098/88A patent/AU607486B2/en not_active Ceased
- 1988-04-22 NO NO881778A patent/NO172351C/no unknown
- 1988-04-22 DK DK222488A patent/DK222488A/da not_active Application Discontinuation
- 1988-04-22 JP JP63098469A patent/JP2610646B2/ja not_active Expired - Lifetime
- 1988-04-22 NZ NZ224341A patent/NZ224341A/en unknown
- 1988-04-22 HU HU882061A patent/HU198953B/hu not_active IP Right Cessation
- 1988-04-23 CN CN88102457A patent/CN1030766A/zh active Pending
- 1988-04-25 KR KR1019880004690A patent/KR880012643A/ko not_active Application Discontinuation
- 1988-04-25 IL IL86168A patent/IL86168A/xx not_active IP Right Cessation
-
1991
- 1991-07-05 US US07/727,388 patent/US5302582A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO172351B (no) | 1993-03-29 |
HU198953B (en) | 1989-12-28 |
NO881778L (no) | 1988-10-26 |
JPS63295598A (ja) | 1988-12-01 |
KR880012643A (ko) | 1988-11-28 |
PT87306A (pt) | 1988-05-01 |
NO881778D0 (no) | 1988-04-22 |
DE3883055D1 (de) | 1993-09-16 |
CN1030766A (zh) | 1989-02-01 |
FI881869A (fi) | 1988-10-26 |
NZ224341A (en) | 1991-05-28 |
US5302582A (en) | 1994-04-12 |
EP0288897A2 (de) | 1988-11-02 |
PT87306B (pt) | 1992-08-31 |
NO172351C (no) | 1993-07-07 |
AU1509888A (en) | 1988-10-27 |
AU607486B2 (en) | 1991-03-07 |
EP0288897A3 (de) | 1991-02-27 |
JP2610646B2 (ja) | 1997-05-14 |
IL86168A0 (en) | 1988-11-15 |
DK222488A (da) | 1988-10-26 |
HUT47600A (en) | 1989-03-28 |
DK222488D0 (da) | 1988-04-22 |
FI881869A0 (fi) | 1988-04-21 |
EP0288897B1 (de) | 1993-08-11 |
IL86168A (en) | 1993-04-04 |
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Legal Events
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FG2A | Definitive protection |
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