ES2052599T3 - Derivados de 1,4,7,10-tetra-aza-ciclododecano. - Google Patents

Derivados de 1,4,7,10-tetra-aza-ciclododecano.

Info

Publication number
ES2052599T3
ES2052599T3 ES87730085T ES87730085T ES2052599T3 ES 2052599 T3 ES2052599 T3 ES 2052599T3 ES 87730085 T ES87730085 T ES 87730085T ES 87730085 T ES87730085 T ES 87730085T ES 2052599 T3 ES2052599 T3 ES 2052599T3
Authority
ES
Spain
Prior art keywords
carbon atoms
groups
group
chain
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87730085T
Other languages
English (en)
Spanish (es)
Inventor
Heinz Dr Gries
Bernd Dr Raduchel
Ulrich Dr Speck
Hans-Joachim Dr Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2052599T3 publication Critical patent/ES2052599T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
ES87730085T 1986-07-28 1987-07-24 Derivados de 1,4,7,10-tetra-aza-ciclododecano. Expired - Lifetime ES2052599T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3625417A DE3625417C2 (de) 1986-07-28 1986-07-28 Tetraazacyclododecan-Derivate

Publications (1)

Publication Number Publication Date
ES2052599T3 true ES2052599T3 (es) 1994-07-16

Family

ID=6306101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87730085T Expired - Lifetime ES2052599T3 (es) 1986-07-28 1987-07-24 Derivados de 1,4,7,10-tetra-aza-ciclododecano.

Country Status (13)

Country Link
EP (1) EP0255471B1 (de)
JP (1) JPH0753720B2 (de)
AT (1) ATE80391T1 (de)
CA (1) CA1341176C (de)
DE (2) DE3625417C2 (de)
DK (1) DK171574B1 (de)
ES (1) ES2052599T3 (de)
GR (1) GR3005808T3 (de)
IE (1) IE60677B1 (de)
NO (1) NO174048C (de)
NZ (1) NZ221225A (de)
PT (1) PT85410B (de)
ZA (1) ZA875561B (de)

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US5342936A (en) * 1989-02-10 1994-08-30 David Parker Tetra-aza macrocycles and processes for their preparation
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US5972307A (en) * 1989-10-23 1999-10-26 Nycomed Salutar, Inc. Dichelants
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DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
KR930019648A (ko) * 1992-03-27 1993-10-18 도키 가츠유키 테트라아자시클로도덴칸 유도체 및 그의 용도
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
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DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
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DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
DE19744003B4 (de) * 1997-09-26 2004-07-08 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
DE19849465A1 (de) * 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
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US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10556873B2 (en) 2008-02-22 2020-02-11 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
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CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
ES2899033T3 (es) * 2016-12-12 2022-03-09 Bracco Imaging Spa Agentes de contraste diméricos
CN108358954B (zh) * 2018-01-17 2019-10-29 南开大学 一种手性稀土-氮氧自由基单链磁体及其制备方法
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CN110357828B (zh) * 2019-08-13 2021-03-19 牡丹江医学院 一种核磁共振造影剂及其制备方法和用途

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DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
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Also Published As

Publication number Publication date
DK171574B1 (da) 1997-01-20
NO174048B (no) 1993-11-29
AU604249B2 (en) 1990-12-13
EP0255471B1 (de) 1992-09-09
ZA875561B (en) 1989-03-29
IE872038L (en) 1988-01-28
NZ221225A (en) 1990-09-26
DE3625417C2 (de) 1998-10-08
CA1341176C (en) 2001-01-30
NO873132L (no) 1988-01-29
IE60677B1 (en) 1994-08-10
ATE80391T1 (de) 1992-09-15
DK393387A (da) 1988-01-29
AU7621787A (en) 1988-02-04
EP0255471A1 (de) 1988-02-03
NO873132D0 (no) 1987-07-27
PT85410B (pt) 1990-06-29
PT85410A (de) 1987-08-01
JPH0753720B2 (ja) 1995-06-07
GR3005808T3 (de) 1993-06-07
DE3781620D1 (de) 1992-10-15
DK393387D0 (da) 1987-07-28
DE3625417A1 (de) 1988-02-11
NO174048C (no) 1994-03-09
JPS6341468A (ja) 1988-02-22

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