ES2051796T3 - Procedimiento para preparar derivados de dihidrobenzopiran-2-carboxilatos alcoxi-sustituidos. - Google Patents

Procedimiento para preparar derivados de dihidrobenzopiran-2-carboxilatos alcoxi-sustituidos.

Info

Publication number
ES2051796T3
ES2051796T3 ES88108449T ES88108449T ES2051796T3 ES 2051796 T3 ES2051796 T3 ES 2051796T3 ES 88108449 T ES88108449 T ES 88108449T ES 88108449 T ES88108449 T ES 88108449T ES 2051796 T3 ES2051796 T3 ES 2051796T3
Authority
ES
Spain
Prior art keywords
atoms
alkylene
dihydrobenzopiran
alcoxi
carboxylates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88108449T
Other languages
English (en)
Inventor
Stevan Wakefield Djuric
Robert Larry Shone
Stella Siu Tzyy Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2051796T3 publication Critical patent/ES2051796T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES DONDE R1 REPRESENTA ALQUILO CON 2-6 ATOMOS DE CARBONO, R2 REPRESENTA METILO O ETILO, R3 REPRESENTA ALQUILO CON 1 A 5 ATOMOS DE C, W REPRESENTA (CH2)X SIENDO X DE 2 A 7, ALQUILENO TIENE 2 A 7 ATOMOS DE C, ALQUENILENO CON 3 A 7 ATOMOS DE C, ALQUINILENO CON 3 A 7 ATOMOS DE C O CICLOPENTILO, R4, Q, B, R5 Y A TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION. ESTOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DE LEUCOTRIENO B4(LTD4) CON POCO O NINGUN ANTAGONISMO DE LEUCOTRIENO D4 (LTD4) Y SON AGENTES ANTIINFLAMATORIOS UTILES PARA TRATAR ENFERMEDADES DEL INTESTINO, ARTRITIS REUMATOIDE, GOTA Y PSORIASIS.
ES88108449T 1987-05-29 1988-05-27 Procedimiento para preparar derivados de dihidrobenzopiran-2-carboxilatos alcoxi-sustituidos. Expired - Lifetime ES2051796T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5713687A 1987-05-29 1987-05-29
US07/188,708 US4889871A (en) 1987-05-29 1988-05-12 Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

Publications (1)

Publication Number Publication Date
ES2051796T3 true ES2051796T3 (es) 1994-07-01

Family

ID=26736113

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88108449T Expired - Lifetime ES2051796T3 (es) 1987-05-29 1988-05-27 Procedimiento para preparar derivados de dihidrobenzopiran-2-carboxilatos alcoxi-sustituidos.

Country Status (17)

Country Link
US (1) US4889871A (es)
EP (1) EP0292977B1 (es)
JP (1) JP2758902B2 (es)
KR (1) KR880013914A (es)
AU (1) AU611153B2 (es)
CA (1) CA1337660C (es)
DE (1) DE3864582D1 (es)
DK (1) DK290188A (es)
ES (1) ES2051796T3 (es)
FI (1) FI882505A (es)
GR (1) GR3003177T3 (es)
IE (1) IE60687B1 (es)
IL (1) IL86502A (es)
NO (1) NO171063C (es)
NZ (1) NZ224807A (es)
PH (1) PH26153A (es)
PT (1) PT87603B (es)

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EP0300404A3 (en) * 1987-07-20 1990-07-18 G.D. Searle & Co. Di-and tetrahydronapthyl anti-allergy agents
IL89713A0 (en) * 1988-03-29 1989-09-28 Ciba Geigy Ag Novel alkanophenones
MA21528A1 (fr) * 1988-04-06 1989-12-31 Lipha Composants substituants du flavonoide, leurs sels, leurs manufactures et produits contenant ces matieres .
US5219883A (en) * 1988-05-20 1993-06-15 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US4931574A (en) * 1988-08-23 1990-06-05 Hoffmann-La Roche Inc. Process for the preparation of benzopyrans
US5298512A (en) * 1989-04-07 1994-03-29 Pfizer Inc. Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5192782A (en) * 1990-05-10 1993-03-09 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5212198A (en) * 1990-05-10 1993-05-18 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP3334087B2 (ja) * 1990-09-10 2002-10-15 アヴェンティス ファーマシューティカルズ インコーポレイテッド 選択的ロイコトリエンｂ▲４▼拮抗剤活性を示す置換された二環式アリール化合物
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
AU3172993A (en) * 1991-12-27 1993-07-28 Kureha Chemical Industry Co., Ltd. Oleaginous ointment
US5550152A (en) * 1992-01-23 1996-08-27 Pfizer Inc. Benzopyran and related LTB4 antagonists
HU216191B (hu) * 1992-02-05 1999-05-28 Boehringer Ingelheim Kg Eljárás új amidinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
JPH0625764A (ja) * 1992-07-08 1994-02-01 Sumitomo Metal Ind Ltd フェロスクラップ中の銅の除去・回収方法
US5324743A (en) * 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
US5380740A (en) * 1993-04-28 1995-01-10 G. D. Searle & Co. Anti-inflammatory compounds, compositions and method of use thereof
ES2084547B1 (es) * 1993-07-12 1997-01-16 Pfizer Antagonistas benzopiranicos y relacionados de leucotrieno b4.
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
WO1995032201A1 (en) * 1994-05-25 1995-11-30 G.D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists
US5516917A (en) * 1994-06-08 1996-05-14 G. D. Searle & Co. Leukotriene B4 antagonists
WO1996006604A2 (en) * 1994-08-31 1996-03-07 Eli Lilly And Company Methods for identifying and treating resistant tumors
US5543428A (en) * 1994-08-31 1996-08-06 Eli Lilly And Company Method for treating resistant tumors
MX9702731A (es) * 1994-10-13 1997-06-28 Pfizer Compuestos de benzopirano y benzo fusionados, composiciones que los contienen y uso de los mismos.
KR100232340B1 (ko) * 1994-10-13 1999-12-01 디. 제이. 우드, 스피겔 알렌 제이 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
ATE326960T1 (de) * 1998-08-28 2006-06-15 Intarcia Therapeutics Inc Zusammensetzungen zur linderung der nebeneffekte des interleukin-2
US6436987B1 (en) 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
EP1324995A2 (en) * 2000-09-27 2003-07-09 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
EP1347755A2 (en) 2000-10-31 2003-10-01 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
US20040242676A1 (en) * 2003-05-30 2004-12-02 Alessi Thomas R. Method of mitigating the adverse effects of IL-2
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

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GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
US4006245A (en) * 1971-07-29 1977-02-01 Fisons Limited Chemical compounds
DE3070912D1 (en) * 1979-03-20 1985-09-05 Fisons Plc Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them
EP0079637B1 (en) * 1981-11-12 1987-01-28 FISONS plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
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US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
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US4885309A (en) * 1986-08-01 1989-12-05 Hoffmann-La Roche Inc. Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives

Also Published As

Publication number Publication date
US4889871A (en) 1989-12-26
NO171063B (no) 1992-10-12
CA1337660C (en) 1995-11-28
DK290188D0 (da) 1988-05-27
AU1668188A (en) 1988-12-01
FI882505A (fi) 1988-11-30
DE3864582D1 (de) 1991-10-10
EP0292977B1 (en) 1991-09-04
AU611153B2 (en) 1991-06-06
IE881611L (en) 1988-11-29
GR3003177T3 (en) 1993-02-17
NO882317L (no) 1988-11-30
JPS6438045A (en) 1989-02-08
IL86502A0 (en) 1988-11-15
PT87603A (pt) 1988-06-01
IE60687B1 (en) 1994-08-10
EP0292977A1 (en) 1988-11-30
NO171063C (no) 1993-01-20
PT87603B (pt) 1992-12-31
PH26153A (en) 1992-03-18
DK290188A (da) 1988-11-30
JP2758902B2 (ja) 1998-05-28
NO882317D0 (no) 1988-05-26
FI882505A0 (fi) 1988-05-27
NZ224807A (en) 1991-03-26
IL86502A (en) 1994-07-31
KR880013914A (ko) 1988-12-22

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