PH26153A - Alkoxy-substituted dihydro-benzopyran-2-carboxylate derivatives pharmaceutical composition containing said compound and method of use thereof - Google Patents
Alkoxy-substituted dihydro-benzopyran-2-carboxylate derivatives pharmaceutical composition containing said compound and method of use thereof Download PDFInfo
- Publication number
- PH26153A PH26153A PH36982A PH36982A PH26153A PH 26153 A PH26153 A PH 26153A PH 36982 A PH36982 A PH 36982A PH 36982 A PH36982 A PH 36982A PH 26153 A PH26153 A PH 26153A
- Authority
- PH
- Philippines
- Prior art keywords
- benzopyran
- compound
- dihydro
- acetyl
- methoxy
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 159
- 238000000034 method Methods 0.000 title claims description 48
- 239000008194 pharmaceutical composition Substances 0.000 title claims 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 56
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 56
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 40
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 24
- -1 propoxyl-1,2,3,4-tetrahydro-8-propyl-2-naphthalene- carboxylate Chemical compound 0.000 claims description 22
- 208000027866 inflammatory disease Diseases 0.000 claims description 21
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 17
- 241000124008 Mammalia Species 0.000 claims description 16
- 150000002617 leukotrienes Chemical class 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 9
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 7
- 150000002431 hydrogen Chemical group 0.000 claims description 7
- HMXJOWDZAJWLTF-UHFFFAOYSA-N 2h-chromene-2-carboxylic acid Chemical compound C1=CC=C2C=CC(C(=O)O)OC2=C1 HMXJOWDZAJWLTF-UHFFFAOYSA-N 0.000 claims description 6
- 125000004450 alkenylene group Chemical group 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 6
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- 201000004681 Psoriasis Diseases 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 125000000304 alkynyl group Chemical group 0.000 claims description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
- 201000005569 Gout Diseases 0.000 claims description 4
- 125000004419 alkynylene group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- QRAOZQGIUIDZQZ-UHFFFAOYSA-N 4-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1,4-benzoxazine Chemical compound C=1C=C2N(C)CCOC2=CC=1B1OC(C)(C)C(C)(C)O1 QRAOZQGIUIDZQZ-UHFFFAOYSA-N 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- 125000001589 carboacyl group Chemical group 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 41
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- YEESKJGWJFYOOK-IJHYULJSSA-N leukotriene D4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@H](N)C(=O)NCC(O)=O YEESKJGWJFYOOK-IJHYULJSSA-N 0.000 description 8
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 7
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- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 5
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5713687A | 1987-05-29 | 1987-05-29 | |
| US07/188,708 US4889871A (en) | 1987-05-29 | 1988-05-12 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26153A true PH26153A (en) | 1992-03-18 |
Family
ID=26736113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH36982A PH26153A (en) | 1987-05-29 | 1988-05-26 | Alkoxy-substituted dihydro-benzopyran-2-carboxylate derivatives pharmaceutical composition containing said compound and method of use thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4889871A (es) |
| EP (1) | EP0292977B1 (es) |
| JP (1) | JP2758902B2 (es) |
| KR (1) | KR880013914A (es) |
| AU (1) | AU611153B2 (es) |
| CA (1) | CA1337660C (es) |
| DE (1) | DE3864582D1 (es) |
| DK (1) | DK290188A (es) |
| ES (1) | ES2051796T3 (es) |
| FI (1) | FI882505A (es) |
| GR (1) | GR3003177T3 (es) |
| IE (1) | IE60687B1 (es) |
| IL (1) | IL86502A (es) |
| NO (1) | NO171063C (es) |
| NZ (1) | NZ224807A (es) |
| PH (1) | PH26153A (es) |
| PT (1) | PT87603B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300404A3 (en) * | 1987-07-20 | 1990-07-18 | G.D. Searle & Co. | Di-and tetrahydronapthyl anti-allergy agents |
| FI94342C (fi) * | 1988-03-29 | 1995-08-25 | Ciba Geigy Ag | Menetelmä uusien alkanofenonien valmistamiseksi |
| IL89840A (en) * | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
| US5219883A (en) * | 1988-05-20 | 1993-06-15 | G. D. Searle & Co. | 2,2-di-substituted benzopyran leukotriene-D4 antagonists |
| US4931574A (en) * | 1988-08-23 | 1990-06-05 | Hoffmann-La Roche Inc. | Process for the preparation of benzopyrans |
| WO1990012010A1 (en) * | 1989-04-07 | 1990-10-18 | Pfizer Inc. | Substituted chromans in the treatment of asthma, arthritis and related diseases |
| US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5212198A (en) * | 1990-05-10 | 1993-05-18 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5192782A (en) * | 1990-05-10 | 1993-03-09 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| FR2665159B1 (fr) * | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| JP3334087B2 (ja) * | 1990-09-10 | 2002-10-15 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 選択的ロイコトリエンｂ▲４▼拮抗剤活性を示す置換された二環式アリール化合物 |
| US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| US5273999A (en) * | 1991-09-10 | 1993-12-28 | Hoffmann-La Roche Inc. | Carboxylic acid leukotriene B4 antagonists |
| WO1993012783A1 (en) * | 1991-12-27 | 1993-07-08 | Kureha Chemical Industry Co., Ltd. | Oleaginous ointment |
| ES2098547T3 (es) * | 1992-01-23 | 1997-05-01 | Pfizer | Benzopirano y otros antagonistas de ltb4 relacionados. |
| EP0625138B1 (de) * | 1992-02-05 | 1999-06-02 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonistischer wirkung |
| US5352690A (en) * | 1992-07-01 | 1994-10-04 | Eli Lilly And Company | 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists |
| JPH0625764A (ja) * | 1992-07-08 | 1994-02-01 | Sumitomo Metal Ind Ltd | フェロスクラップ中の銅の除去・回収方法 |
| US5324743A (en) * | 1992-12-10 | 1994-06-28 | Eli Lilly And Company | Leukotriene B4 antagonists |
| DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
| US5380740A (en) * | 1993-04-28 | 1995-01-10 | G. D. Searle & Co. | Anti-inflammatory compounds, compositions and method of use thereof |
| ES2084547B1 (es) * | 1993-07-12 | 1997-01-16 | Pfizer | Antagonistas benzopiranicos y relacionados de leucotrieno b4. |
| US5457124A (en) * | 1993-12-07 | 1995-10-10 | Hoffmann-La Roche Inc. | Carboxylic acid Leukotriene B4 antagonists |
| WO1995032201A1 (en) * | 1994-05-25 | 1995-11-30 | G.D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists |
| US5516917A (en) * | 1994-06-08 | 1996-05-14 | G. D. Searle & Co. | Leukotriene B4 antagonists |
| WO1996006604A2 (en) | 1994-08-31 | 1996-03-07 | Eli Lilly And Company | Methods for identifying and treating resistant tumors |
| US5543428A (en) * | 1994-08-31 | 1996-08-06 | Eli Lilly And Company | Method for treating resistant tumors |
| KR100232340B1 (ko) * | 1994-10-13 | 1999-12-01 | 디. 제이. 우드, 스피겔 알렌 제이 | 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물 |
| US6051601A (en) * | 1994-10-13 | 2000-04-18 | Pfizer Inc. | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists |
| EP0836850A3 (en) * | 1996-10-17 | 2000-11-29 | Pfizer Inc. | Method of preventing allograft rejection |
| WO2000012086A1 (en) | 1998-08-28 | 2000-03-09 | Biomedicines, Inc. | Method of mitigating the adverse effects of interleukin-2 |
| US6436987B1 (en) | 2000-06-08 | 2002-08-20 | Pfizer Inc. | Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid |
| AU9287401A (en) * | 2000-09-27 | 2002-04-08 | Merck & Co Inc | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
| CA2427610A1 (en) | 2000-10-31 | 2002-08-08 | Merck & Co., Inc. | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
| US20040242676A1 (en) * | 2003-05-30 | 2004-12-02 | Alessi Thomas R. | Method of mitigating the adverse effects of IL-2 |
| US8093253B2 (en) * | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4006245A (en) * | 1971-07-29 | 1977-02-01 | Fisons Limited | Chemical compounds |
| GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
| DE3070912D1 (en) * | 1979-03-20 | 1985-09-05 | Fisons Plc | Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them |
| ATE25251T1 (de) * | 1981-11-12 | 1987-02-15 | Fisons Plc | Anti srs-a carbonsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische formulierungen. |
| ZA844519B (en) * | 1983-06-24 | 1985-02-27 | Hoffmann La Roche | Dihydrobenzopyran derivatives |
| US4665203A (en) * | 1983-08-08 | 1987-05-12 | G. D. Searle & Co. | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors |
| AU548450B2 (en) * | 1983-08-08 | 1985-12-12 | G.D. Searle & Co. | Substituted dihydrobenzopyrans |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| US4546194A (en) * | 1984-05-29 | 1985-10-08 | G. D. Searle & Co. | Substituted chromanon-2-yl alkanols and derivatives thereof |
| EP0205699B1 (en) * | 1985-06-28 | 1989-03-22 | International Business Machines Corporation | Shadow mask colour crt with enhanced resolution and/or brightness |
| ZA873745B (en) * | 1986-06-04 | 1988-10-26 | Daiichi Seiyaku Co | Benzopyran derivatives |
| US4885309A (en) * | 1986-08-01 | 1989-12-05 | Hoffmann-La Roche Inc. | Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives |
-
1988
- 1988-05-12 US US07/188,708 patent/US4889871A/en not_active Expired - Lifetime
- 1988-05-26 NZ NZ224807A patent/NZ224807A/xx unknown
- 1988-05-26 IL IL8650288A patent/IL86502A/en unknown
- 1988-05-26 NO NO882317A patent/NO171063C/no unknown
- 1988-05-26 CA CA000567806A patent/CA1337660C/en not_active Expired - Fee Related
- 1988-05-26 PH PH36982A patent/PH26153A/en unknown
- 1988-05-26 AU AU16681/88A patent/AU611153B2/en not_active Ceased
- 1988-05-27 EP EP88108449A patent/EP0292977B1/en not_active Expired - Lifetime
- 1988-05-27 JP JP63130037A patent/JP2758902B2/ja not_active Expired - Fee Related
- 1988-05-27 ES ES88108449T patent/ES2051796T3/es not_active Expired - Lifetime
- 1988-05-27 DE DE8888108449T patent/DE3864582D1/de not_active Expired - Fee Related
- 1988-05-27 PT PT87603A patent/PT87603B/pt not_active IP Right Cessation
- 1988-05-27 DK DK290188A patent/DK290188A/da not_active Application Discontinuation
- 1988-05-27 IE IE161188A patent/IE60687B1/en not_active IP Right Cessation
- 1988-05-27 KR KR1019880006263A patent/KR880013914A/ko not_active Application Discontinuation
- 1988-05-27 FI FI882505A patent/FI882505A/fi not_active IP Right Cessation
-
1991
- 1991-11-22 GR GR91401338T patent/GR3003177T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK290188A (da) | 1988-11-30 |
| NO171063C (no) | 1993-01-20 |
| US4889871A (en) | 1989-12-26 |
| NO882317L (no) | 1988-11-30 |
| IL86502A0 (en) | 1988-11-15 |
| PT87603B (pt) | 1992-12-31 |
| IE881611L (en) | 1988-11-29 |
| NO882317D0 (no) | 1988-05-26 |
| NO171063B (no) | 1992-10-12 |
| NZ224807A (en) | 1991-03-26 |
| ES2051796T3 (es) | 1994-07-01 |
| JP2758902B2 (ja) | 1998-05-28 |
| PT87603A (pt) | 1988-06-01 |
| GR3003177T3 (en) | 1993-02-17 |
| JPS6438045A (en) | 1989-02-08 |
| CA1337660C (en) | 1995-11-28 |
| DK290188D0 (da) | 1988-05-27 |
| FI882505A (fi) | 1988-11-30 |
| IE60687B1 (en) | 1994-08-10 |
| EP0292977B1 (en) | 1991-09-04 |
| AU1668188A (en) | 1988-12-01 |
| IL86502A (en) | 1994-07-31 |
| AU611153B2 (en) | 1991-06-06 |
| EP0292977A1 (en) | 1988-11-30 |
| KR880013914A (ko) | 1988-12-22 |
| DE3864582D1 (de) | 1991-10-10 |
| FI882505A0 (fi) | 1988-05-27 |
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