NO882317L - Alkoksy-substituerte dihydrobenzopyran-2-karboksylat-derivater. - Google Patents
Alkoksy-substituerte dihydrobenzopyran-2-karboksylat-derivater.Info
- Publication number
- NO882317L NO882317L NO882317A NO882317A NO882317L NO 882317 L NO882317 L NO 882317L NO 882317 A NO882317 A NO 882317A NO 882317 A NO882317 A NO 882317A NO 882317 L NO882317 L NO 882317L
- Authority
- NO
- Norway
- Prior art keywords
- dihydrobenzopyrane
- alcoxy
- substituted
- derivates
- carboxylate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5713687A | 1987-05-29 | 1987-05-29 | |
US07/188,708 US4889871A (en) | 1987-05-29 | 1988-05-12 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
Publications (4)
Publication Number | Publication Date |
---|---|
NO882317D0 NO882317D0 (no) | 1988-05-26 |
NO882317L true NO882317L (no) | 1988-11-30 |
NO171063B NO171063B (no) | 1992-10-12 |
NO171063C NO171063C (no) | 1993-01-20 |
Family
ID=26736113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO882317A NO171063C (no) | 1987-05-29 | 1988-05-26 | Analogifremgangsmaate til fremstilling av terapeutisk akseptable, alkoksy-substituerte dihydrobenzopyran-2-karboksylatderivater |
Country Status (17)
Country | Link |
---|---|
US (1) | US4889871A (no) |
EP (1) | EP0292977B1 (no) |
JP (1) | JP2758902B2 (no) |
KR (1) | KR880013914A (no) |
AU (1) | AU611153B2 (no) |
CA (1) | CA1337660C (no) |
DE (1) | DE3864582D1 (no) |
DK (1) | DK290188A (no) |
ES (1) | ES2051796T3 (no) |
FI (1) | FI882505A (no) |
GR (1) | GR3003177T3 (no) |
IE (1) | IE60687B1 (no) |
IL (1) | IL86502A (no) |
NO (1) | NO171063C (no) |
NZ (1) | NZ224807A (no) |
PH (1) | PH26153A (no) |
PT (1) | PT87603B (no) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0300404A3 (en) * | 1987-07-20 | 1990-07-18 | G.D. Searle & Co. | Di-and tetrahydronapthyl anti-allergy agents |
FI94342C (fi) * | 1988-03-29 | 1995-08-25 | Ciba Geigy Ag | Menetelmä uusien alkanofenonien valmistamiseksi |
IL89840A (en) * | 1988-04-06 | 1996-10-31 | Lipha | Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them |
US5219883A (en) * | 1988-05-20 | 1993-06-15 | G. D. Searle & Co. | 2,2-di-substituted benzopyran leukotriene-D4 antagonists |
US4931574A (en) * | 1988-08-23 | 1990-06-05 | Hoffmann-La Roche Inc. | Process for the preparation of benzopyrans |
WO1990012010A1 (en) * | 1989-04-07 | 1990-10-18 | Pfizer Inc. | Substituted chromans in the treatment of asthma, arthritis and related diseases |
US5212198A (en) * | 1990-05-10 | 1993-05-18 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
US5192782A (en) * | 1990-05-10 | 1993-03-09 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
FR2665159B1 (fr) * | 1990-07-24 | 1992-11-13 | Rhone Poulenc Sante | Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent. |
JP3334087B2 (ja) * | 1990-09-10 | 2002-10-15 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 選択的ロイコトリエンb▲4▼拮抗剤活性を示す置換された二環式アリール化合物 |
US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
US5273999A (en) * | 1991-09-10 | 1993-12-28 | Hoffmann-La Roche Inc. | Carboxylic acid leukotriene B4 antagonists |
AU3172993A (en) * | 1991-12-27 | 1993-07-28 | Kureha Chemical Industry Co., Ltd. | Oleaginous ointment |
DK0623122T3 (da) * | 1992-01-23 | 1997-04-21 | Pfizer | Benzopyran og beslægtede LTB4-antagonister |
SK281016B6 (sk) * | 1992-02-05 | 2000-10-09 | Boehringer Ingelheim Kg | Amidínové deriváty, spôsob ich výroby, použitie a farmaceutické prostriedky s ich obsahom |
US5352690A (en) * | 1992-07-01 | 1994-10-04 | Eli Lilly And Company | 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists |
JPH0625764A (ja) * | 1992-07-08 | 1994-02-01 | Sumitomo Metal Ind Ltd | フェロスクラップ中の銅の除去・回収方法 |
US5324743A (en) * | 1992-12-10 | 1994-06-28 | Eli Lilly And Company | Leukotriene B4 antagonists |
DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
US5380740A (en) * | 1993-04-28 | 1995-01-10 | G. D. Searle & Co. | Anti-inflammatory compounds, compositions and method of use thereof |
ES2084547B1 (es) * | 1993-07-12 | 1997-01-16 | Pfizer | Antagonistas benzopiranicos y relacionados de leucotrieno b4. |
US5457124A (en) * | 1993-12-07 | 1995-10-10 | Hoffmann-La Roche Inc. | Carboxylic acid Leukotriene B4 antagonists |
AU2585595A (en) * | 1994-05-25 | 1995-12-18 | G.D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists |
US5516917A (en) * | 1994-06-08 | 1996-05-14 | G. D. Searle & Co. | Leukotriene B4 antagonists |
US5543428A (en) * | 1994-08-31 | 1996-08-06 | Eli Lilly And Company | Method for treating resistant tumors |
EP1129707A3 (en) * | 1994-08-31 | 2002-02-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Methods for identifying and treating resistant tumors |
MX9702734A (es) * | 1994-10-13 | 1997-06-28 | Pfizer | Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4). |
WO1996011920A1 (en) * | 1994-10-13 | 1996-04-25 | Pfizer Inc. | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists |
EP0836850A3 (en) * | 1996-10-17 | 2000-11-29 | Pfizer Inc. | Method of preventing allograft rejection |
NZ509715A (en) * | 1998-08-28 | 2005-01-28 | Biomedicines Inc | Method of mitigating the adverse effects of interleukin-2 by administering a leukotriene receptor antagonist |
US6436987B1 (en) | 2000-06-08 | 2002-08-20 | Pfizer Inc. | Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid |
CA2423141A1 (en) * | 2000-09-27 | 2002-04-04 | Merck & Co., Inc. | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
AU2002248221B2 (en) | 2000-10-31 | 2006-08-17 | Merck & Co., Inc. | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
US20040242676A1 (en) * | 2003-05-30 | 2004-12-02 | Alessi Thomas R. | Method of mitigating the adverse effects of IL-2 |
US8093253B2 (en) * | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4006245A (en) * | 1971-07-29 | 1977-02-01 | Fisons Limited | Chemical compounds |
GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
ATE14579T1 (de) * | 1979-03-20 | 1985-08-15 | Fisons Plc | Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen. |
ATE25251T1 (de) * | 1981-11-12 | 1987-02-15 | Fisons Plc | Anti srs-a carbonsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische formulierungen. |
ZA844519B (en) * | 1983-06-24 | 1985-02-27 | Hoffmann La Roche | Dihydrobenzopyran derivatives |
US4665203A (en) * | 1983-08-08 | 1987-05-12 | G. D. Searle & Co. | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors |
AU548450B2 (en) * | 1983-08-08 | 1985-12-12 | G.D. Searle & Co. | Substituted dihydrobenzopyrans |
US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
US4546194A (en) * | 1984-05-29 | 1985-10-08 | G. D. Searle & Co. | Substituted chromanon-2-yl alkanols and derivatives thereof |
EP0205699B1 (en) * | 1985-06-28 | 1989-03-22 | International Business Machines Corporation | Shadow mask colour crt with enhanced resolution and/or brightness |
ZA873745B (en) * | 1986-06-04 | 1988-10-26 | Daiichi Seiyaku Co | Benzopyran derivatives |
US4885309A (en) * | 1986-08-01 | 1989-12-05 | Hoffmann-La Roche Inc. | Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives |
-
1988
- 1988-05-12 US US07/188,708 patent/US4889871A/en not_active Expired - Lifetime
- 1988-05-26 NZ NZ224807A patent/NZ224807A/xx unknown
- 1988-05-26 PH PH36982A patent/PH26153A/en unknown
- 1988-05-26 CA CA000567806A patent/CA1337660C/en not_active Expired - Fee Related
- 1988-05-26 NO NO882317A patent/NO171063C/no unknown
- 1988-05-26 AU AU16681/88A patent/AU611153B2/en not_active Ceased
- 1988-05-26 IL IL8650288A patent/IL86502A/en unknown
- 1988-05-27 JP JP63130037A patent/JP2758902B2/ja not_active Expired - Fee Related
- 1988-05-27 IE IE161188A patent/IE60687B1/en not_active IP Right Cessation
- 1988-05-27 DK DK290188A patent/DK290188A/da not_active Application Discontinuation
- 1988-05-27 KR KR1019880006263A patent/KR880013914A/ko not_active Application Discontinuation
- 1988-05-27 FI FI882505A patent/FI882505A/fi not_active IP Right Cessation
- 1988-05-27 PT PT87603A patent/PT87603B/pt not_active IP Right Cessation
- 1988-05-27 ES ES88108449T patent/ES2051796T3/es not_active Expired - Lifetime
- 1988-05-27 DE DE8888108449T patent/DE3864582D1/de not_active Expired - Fee Related
- 1988-05-27 EP EP88108449A patent/EP0292977B1/en not_active Expired - Lifetime
-
1991
- 1991-11-22 GR GR91401338T patent/GR3003177T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3003177T3 (en) | 1993-02-17 |
FI882505A (fi) | 1988-11-30 |
IE881611L (en) | 1988-11-29 |
ES2051796T3 (es) | 1994-07-01 |
DK290188D0 (da) | 1988-05-27 |
IL86502A (en) | 1994-07-31 |
IL86502A0 (en) | 1988-11-15 |
AU611153B2 (en) | 1991-06-06 |
NO171063B (no) | 1992-10-12 |
FI882505A0 (fi) | 1988-05-27 |
JP2758902B2 (ja) | 1998-05-28 |
PT87603B (pt) | 1992-12-31 |
EP0292977A1 (en) | 1988-11-30 |
US4889871A (en) | 1989-12-26 |
DK290188A (da) | 1988-11-30 |
NO171063C (no) | 1993-01-20 |
NZ224807A (en) | 1991-03-26 |
KR880013914A (ko) | 1988-12-22 |
PH26153A (en) | 1992-03-18 |
AU1668188A (en) | 1988-12-01 |
EP0292977B1 (en) | 1991-09-04 |
NO882317D0 (no) | 1988-05-26 |
PT87603A (pt) | 1988-06-01 |
IE60687B1 (en) | 1994-08-10 |
JPS6438045A (en) | 1989-02-08 |
CA1337660C (en) | 1995-11-28 |
DE3864582D1 (de) | 1991-10-10 |
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