ES2035798B1 - Procedimiento para la preparacion de 1-(2s)-3-mercapto-metil-1-oxopropil)-l-prolina. - Google Patents
Procedimiento para la preparacion de 1-(2s)-3-mercapto-metil-1-oxopropil)-l-prolina.Info
- Publication number
- ES2035798B1 ES2035798B1 ES9102086A ES9102086A ES2035798B1 ES 2035798 B1 ES2035798 B1 ES 2035798B1 ES 9102086 A ES9102086 A ES 9102086A ES 9102086 A ES9102086 A ES 9102086A ES 2035798 B1 ES2035798 B1 ES 2035798B1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- formula
- procedure
- oxopropil
- proline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU905998A HU208954B (en) | 1990-09-21 | 1990-09-21 | Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2035798A1 ES2035798A1 (es) | 1993-04-16 |
| ES2035798B1 true ES2035798B1 (es) | 1994-02-16 |
Family
ID=10971099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9102086A Expired - Fee Related ES2035798B1 (es) | 1990-09-21 | 1991-09-20 | Procedimiento para la preparacion de 1-(2s)-3-mercapto-metil-1-oxopropil)-l-prolina. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5202443A (forum.php) |
| KR (1) | KR930005973A (forum.php) |
| AT (1) | AT395148B (forum.php) |
| AU (1) | AU637719B2 (forum.php) |
| CA (1) | CA2051985A1 (forum.php) |
| CH (1) | CH683099A5 (forum.php) |
| DE (1) | DE4123172A1 (forum.php) |
| DK (1) | DK162191A (forum.php) |
| ES (1) | ES2035798B1 (forum.php) |
| FI (1) | FI914426A7 (forum.php) |
| FR (1) | FR2667065B1 (forum.php) |
| GB (1) | GB2248060B (forum.php) |
| GR (1) | GR1002173B (forum.php) |
| HU (1) | HU208954B (forum.php) |
| IL (1) | IL99535A (forum.php) |
| IT (1) | IT1251845B (forum.php) |
| NL (1) | NL9101582A (forum.php) |
| NO (1) | NO176141C (forum.php) |
| PL (1) | PL291789A1 (forum.php) |
| PT (1) | PT99022A (forum.php) |
| RU (1) | RU2026286C1 (forum.php) |
| SE (1) | SE501501C2 (forum.php) |
| TW (1) | TW203042B (forum.php) |
| ZA (1) | ZA917517B (forum.php) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
| KR100507816B1 (ko) * | 1996-04-10 | 2006-01-27 | 이.아이,듀우판드네모아앤드캄파니 | 유기티오시아네이트및디술파이드의티올로의접촉가수소분해 |
| US5728887A (en) * | 1996-04-10 | 1998-03-17 | E. I. Du Pont De Nemours And Company | Catalytic hydrogenolysis of organic thiocyanates and disulfides to thiols |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998808A (en) * | 1968-05-22 | 1976-12-21 | Velsicol Chemical Corporation | Compositions of matter D-hetero-1,1-(α-thiocyanoacetyl) compounds |
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4241076A (en) * | 1978-02-21 | 1980-12-23 | E. R. Squibb & Sons, Inc. | Halogenated substituted mercaptoacylamino acids |
| US4192945A (en) * | 1978-12-07 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Process for preparing proline and homoproline derivatives |
| US4684660A (en) * | 1979-04-02 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Mercaptoacyldepeptides |
| ES486217A0 (es) * | 1979-11-21 | 1980-12-16 | Farmaceutico Quimico Lab | Procedimiento de obtencion de un derivado de prolina |
| HU184082B (en) * | 1979-12-29 | 1984-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
| ES8105280A1 (es) * | 1980-04-24 | 1981-05-16 | Inke Sa | Procedimiento para la obtencion de la n-(d-3-mercapto-2-me tilpropionil) l-prolina. |
| SE8203245L (sv) * | 1981-05-27 | 1982-11-28 | Crc Ricerca Chim | Forfarande for enantioselektiv framstellning av n-substituerade prolinderivat |
| JPS58124764A (ja) * | 1982-01-20 | 1983-07-25 | Kanegafuchi Chem Ind Co Ltd | 光学活性チオ−ル化合物の製造法 |
| KR860001391B1 (ko) * | 1984-07-23 | 1986-09-22 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
| KR870001569B1 (ko) * | 1985-02-11 | 1987-09-04 | 보령제약 주식회사 | 피롤리딘 유도체의 제조방법 |
| ES8604514A1 (es) * | 1985-04-10 | 1986-02-01 | Farmhispania | Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina |
| ES544509A0 (es) * | 1985-06-25 | 1986-01-01 | Inke Sa | Procedimiento para la obtencion de la 1-(n-(1-etoxicarbonil-3-fenilpropil)-l-alanil)-l-prolina |
| AT395012B (de) * | 1986-06-27 | 1992-08-25 | Richter Gedeon Vegyeszet | Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen |
| US5002964A (en) * | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
| US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| IL91581A (en) * | 1988-09-13 | 1993-07-08 | Sepracor Inc | Methods for preparing optically active captopril and its analogues |
| US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
| HU206198B (en) * | 1990-09-21 | 1992-09-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing rhodanidoisobutyric acid |
-
1990
- 1990-09-21 HU HU905998A patent/HU208954B/hu not_active IP Right Cessation
-
1991
- 1991-01-18 AT AT0010591A patent/AT395148B/de not_active IP Right Cessation
- 1991-07-12 DE DE4123172A patent/DE4123172A1/de not_active Withdrawn
- 1991-09-17 CH CH2749/91A patent/CH683099A5/de not_active IP Right Cessation
- 1991-09-20 TW TW080107464A patent/TW203042B/zh active
- 1991-09-20 KR KR1019910016570A patent/KR930005973A/ko not_active Withdrawn
- 1991-09-20 GB GB9120150A patent/GB2248060B/en not_active Expired - Fee Related
- 1991-09-20 US US07/762,688 patent/US5202443A/en not_active Expired - Fee Related
- 1991-09-20 AU AU84611/91A patent/AU637719B2/en not_active Ceased
- 1991-09-20 RU SU915001836A patent/RU2026286C1/ru active
- 1991-09-20 NO NO913720A patent/NO176141C/no unknown
- 1991-09-20 PT PT99022A patent/PT99022A/pt not_active Application Discontinuation
- 1991-09-20 FI FI914426A patent/FI914426A7/fi not_active Application Discontinuation
- 1991-09-20 IT ITMI912520A patent/IT1251845B/it active IP Right Grant
- 1991-09-20 GR GR910100391A patent/GR1002173B/el unknown
- 1991-09-20 PL PL29178991A patent/PL291789A1/xx unknown
- 1991-09-20 ZA ZA917517A patent/ZA917517B/xx unknown
- 1991-09-20 CA CA002051985A patent/CA2051985A1/en not_active Abandoned
- 1991-09-20 FR FR9111605A patent/FR2667065B1/fr not_active Expired - Fee Related
- 1991-09-20 DK DK162191A patent/DK162191A/da not_active IP Right Cessation
- 1991-09-20 NL NL9101582A patent/NL9101582A/nl not_active Application Discontinuation
- 1991-09-20 IL IL9953591A patent/IL99535A/en not_active IP Right Cessation
- 1991-09-20 ES ES9102086A patent/ES2035798B1/es not_active Expired - Fee Related
- 1991-09-20 SE SE9102722A patent/SE501501C2/sv unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001009 |