ES8604514A1 - Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina - Google Patents

Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina

Info

Publication number
ES8604514A1
ES8604514A1 ES542122A ES542122A ES8604514A1 ES 8604514 A1 ES8604514 A1 ES 8604514A1 ES 542122 A ES542122 A ES 542122A ES 542122 A ES542122 A ES 542122A ES 8604514 A1 ES8604514 A1 ES 8604514A1
Authority
ES
Spain
Prior art keywords
proline
propanoyl
mercapto
mercapto methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542122A
Other languages
English (en)
Other versions
ES542122A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Farmhispania SA
Original Assignee
Bioiberica SA
Farmhispania SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA, Farmhispania SA filed Critical Bioiberica SA
Priority to ES542122A priority Critical patent/ES8604514A1/es
Publication of ES542122A0 publication Critical patent/ES542122A0/es
Publication of ES8604514A1 publication Critical patent/ES8604514A1/es
Expired legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA 1-3-MERCAPTO-2-D(-)-METILPROPANOIL-L(-)-PROLINA. CONSISTE EN LA REACCION DEL CLORURO DEL ACIDO D-(-)-S-ACETIL-B-MERCAPTOISOBUTIRICO, DE FORMULA (I), CON LA L-(-)-PROLINA, DE FORMULA (II). LA REACCION SE LLEVA A CABO EN DISOLUCION ACUOSA DE HIDROXIDO SODICO O POTASICO, A LA TEMPERATURA AMBIENTE. EL PRODUCTO OBTENIDO SE ENFRIA A LA TEMPERATURA DE C5JC, SE TRATA CON ACIDO CLORHIDRICO CONCENTRADO HASTA PH 1 Y SE EXTRAE CON CLORURO DE METILENO; EL EXTRACTO SE SECA, SE CONCENTRA A TEMPERATURA INFERIOR A 40JC Y SE RECRISTALIZA EN ACETATO DE TERBUTILO. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTIHIPERTENSOR.
ES542122A 1985-04-10 1985-04-10 Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina Expired ES8604514A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES542122A ES8604514A1 (es) 1985-04-10 1985-04-10 Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES542122A ES8604514A1 (es) 1985-04-10 1985-04-10 Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina

Publications (2)

Publication Number Publication Date
ES542122A0 ES542122A0 (es) 1986-02-01
ES8604514A1 true ES8604514A1 (es) 1986-02-01

Family

ID=8488989

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542122A Expired ES8604514A1 (es) 1985-04-10 1985-04-10 Procedimiento para la sintesis de la 1-(3-mercapto-2-d(-)- metilo-propanol)-2(-) prolina

Country Status (1)

Country Link
ES (1) ES8604514A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2035798A1 (es) * 1990-09-21 1993-04-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento para la preparacion de 1-(2s)-3-mercapto-metil-1-oxopropil)-l-prolina.
ES2058030A1 (es) * 1992-03-13 1994-10-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de preparar acido 1-( (2s)-metil-3-mercaptopropionil-pirrolidina-(2s)-carboxilico.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2035798A1 (es) * 1990-09-21 1993-04-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento para la preparacion de 1-(2s)-3-mercapto-metil-1-oxopropil)-l-prolina.
ES2058030A1 (es) * 1992-03-13 1994-10-16 Egyt Gyogyszervegyeszeti Gyar Procedimiento de preparar acido 1-( (2s)-metil-3-mercaptopropionil-pirrolidina-(2s)-carboxilico.

Also Published As

Publication number Publication date
ES542122A0 (es) 1986-02-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001026