ES2021942A6 - Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas. - Google Patents
Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas.Info
- Publication number
- ES2021942A6 ES2021942A6 ES9000397A ES9000397A ES2021942A6 ES 2021942 A6 ES2021942 A6 ES 2021942A6 ES 9000397 A ES9000397 A ES 9000397A ES 9000397 A ES9000397 A ES 9000397A ES 2021942 A6 ES2021942 A6 ES 2021942A6
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporin
- thinner
- vehicle
- compositions
- cyclosporin compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229930182912 cyclosporin Natural products 0.000 title abstract 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 108010036941 Cyclosporins Proteins 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898902901A GB8902901D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB898902898A GB8902898D0 (en) | 1989-02-09 | 1989-02-09 | Improvements in or relating to organic compounds |
| GB898903147A GB8903147D0 (en) | 1989-02-13 | 1989-02-13 | Improvements in or relating to organic compounds |
| GB898903663A GB8903663D0 (en) | 1989-02-17 | 1989-02-17 | Improvements in or relating to organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2021942A6 true ES2021942A6 (es) | 1991-11-16 |
Family
ID=27450262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9000397A Expired - Lifetime ES2021942A6 (es) | 1989-02-09 | 1990-02-09 | Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas. |
Country Status (25)
| Country | Link |
|---|---|
| JP (3) | JP3484190B2 (enExample) |
| KR (1) | KR0170769B1 (enExample) |
| AT (1) | AT404552B (enExample) |
| AU (1) | AU630413B2 (enExample) |
| BE (1) | BE1003009A5 (enExample) |
| CA (1) | CA2009533C (enExample) |
| CH (1) | CH679277A5 (enExample) |
| CY (1) | CY1903A (enExample) |
| DE (1) | DE4003844B4 (enExample) |
| DK (1) | DK176209B1 (enExample) |
| ES (1) | ES2021942A6 (enExample) |
| FI (1) | FI97524C (enExample) |
| FR (1) | FR2642650B1 (enExample) |
| GB (1) | GB2230440B (enExample) |
| HK (1) | HK37296A (enExample) |
| HU (1) | HU213394B (enExample) |
| IT (1) | IT1240758B (enExample) |
| LU (1) | LU87675A1 (enExample) |
| MY (1) | MY107377A (enExample) |
| NL (1) | NL195028C (enExample) |
| NO (1) | NO301576B1 (enExample) |
| NZ (1) | NZ232401A (enExample) |
| PH (1) | PH30917A (enExample) |
| PT (1) | PT93079B (enExample) |
| SE (1) | SE511398C2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
| MX9201782A (es) † | 1991-04-19 | 1992-10-01 | Sandoz Ag | Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene. |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| JP3631490B2 (ja) | 1992-05-13 | 2005-03-23 | ノバルティス ファーマ株式会社 | シクロスポリン含有眼科用組成物 |
| US5759566A (en) * | 1992-07-28 | 1998-06-02 | Poli Industria Chimica Spa | Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents |
| PT589843E (pt) | 1992-09-25 | 2002-04-29 | Novartis Ag | Composicoes farmaceuticas contendo ciclosporinas |
| HUT72738A (en) * | 1993-04-20 | 1996-05-28 | Rentschler Arzneimittel | New cyclosporine-containing pharmaceutical compositions for oral administration |
| DE4412201A1 (de) * | 1993-04-20 | 1994-11-10 | Rentschler Arzneimittel | Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin |
| DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| KR0146671B1 (ko) * | 1994-02-25 | 1998-08-17 | 김충환 | 사이클로스포린-함유 분말 조성물 |
| KR970704464A (ko) | 1994-11-03 | 1997-09-06 | 가이슐러 에리히, 데커 카를-루드빅 | 간단한 조성 및 높은 생물 유효성을 갖는 경구 투여용의 신규 사이클로스포린 제형 및 이의 제조방법(Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them) |
| US5679566A (en) * | 1995-01-20 | 1997-10-21 | University Of Massachusetts Medical Center | Yeast NMD2 gene |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
| US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US5798333A (en) * | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
| ES2229473T3 (es) * | 1997-01-30 | 2005-04-16 | Novartis Ag | Composiciones farmaceuticas sin aceite que contienen ciclosporina a. |
| AU762247B2 (en) * | 1997-01-30 | 2003-06-19 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
| ATE286403T1 (de) * | 1997-03-12 | 2005-01-15 | Abbott Lab | Hydrophile binäre systeme zur verabreichung von cyclosporin |
| NZ328751A (en) * | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| US6447806B1 (en) | 1999-02-25 | 2002-09-10 | Novartis Ag | Pharmaceutical compositions comprised of stabilized peptide particles |
| WO2003032949A1 (en) | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| US6979672B2 (en) | 2002-12-20 | 2005-12-27 | Polichem, S.A. | Cyclosporin-based pharmaceutical compositions |
| JP4521554B2 (ja) * | 2004-03-31 | 2010-08-11 | マイラン製薬株式会社 | シクロスポリン製剤 |
| WO2007050975A2 (en) * | 2005-10-26 | 2007-05-03 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system as capsule fill |
| WO2007112272A2 (en) * | 2006-03-28 | 2007-10-04 | Javelin Pharmaceuticals, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
| US7495024B2 (en) | 2006-08-07 | 2009-02-24 | Via Pharmaceuticals, Inc. | Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque |
| DE102008059201A1 (de) | 2008-11-27 | 2010-06-02 | GÖPFERICH, Achim, Prof. Dr. | In situ präzipitierende Arzneistofflösungen |
| KR102146704B1 (ko) | 2018-04-13 | 2020-08-21 | 가천대학교 산학협력단 | 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체 |
| DK4166133T3 (da) * | 2021-10-13 | 2025-09-01 | Chugai Pharmaceutical Co Ltd | Sammensætning indeholdende peptidforbindelse og overfladeaktivt stof |
| CN118354782A (zh) * | 2022-05-02 | 2024-07-16 | 中外制药株式会社 | 用于与表面活性剂联用的包含肽化合物的组合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE445174B (sv) * | 1978-03-07 | 1986-06-09 | Sandoz Ag | Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans |
| JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
| NL8600050A (nl) * | 1986-01-13 | 1987-08-03 | Sanico Nv | Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van. |
| GB8602372D0 (en) * | 1986-01-31 | 1986-03-05 | Sandoz Ltd | Organic compounds |
| CA1290249C (en) * | 1986-04-09 | 1991-10-08 | Cetus Corporation | COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR |
| IE873057L (en) * | 1986-11-13 | 1988-05-13 | Tretorn Ab | Compositions and method for treatment of cancer using¹monoclonal antibody against gd3 ganglioside together eith¹il-2 |
| EP0296122B1 (en) * | 1987-06-17 | 1993-09-29 | Sandoz Ag | Cyclosporins and their use as pharmaceuticals |
| JP2536876B2 (ja) * | 1987-07-31 | 1996-09-25 | 寛治 高田 | シクロスポリンの溶解性粉末状製剤 |
| HU205010B (en) * | 1987-09-15 | 1992-03-30 | Sandoz Ag | Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity |
| DE3830494B4 (de) * | 1987-09-15 | 2006-05-18 | Novartis Ag | Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe |
| US5756450A (en) * | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| JP2792862B2 (ja) * | 1988-07-30 | 1998-09-03 | 寛治 高田 | 経口腸溶製剤 |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| JPH1038029A (ja) * | 1996-07-26 | 1998-02-13 | Ebara Corp | 制振機能付き円板状構造物 |
| JPH10280435A (ja) * | 1997-04-03 | 1998-10-20 | Sekisui Chem Co Ltd | 地下室の構築方法 |
-
1990
- 1990-02-05 CH CH359/90A patent/CH679277A5/de not_active IP Right Cessation
- 1990-02-05 GB GB9002504A patent/GB2230440B/en not_active Expired - Lifetime
- 1990-02-05 BE BE9000133A patent/BE1003009A5/fr not_active IP Right Cessation
- 1990-02-05 FR FR9001389A patent/FR2642650B1/fr not_active Expired - Lifetime
- 1990-02-07 LU LU87675A patent/LU87675A1/fr unknown
- 1990-02-07 CA CA002009533A patent/CA2009533C/en not_active Expired - Lifetime
- 1990-02-07 NZ NZ232401A patent/NZ232401A/en unknown
- 1990-02-07 PH PH40014A patent/PH30917A/en unknown
- 1990-02-07 MY MYPI90000191A patent/MY107377A/en unknown
- 1990-02-07 DK DK199000327A patent/DK176209B1/da not_active IP Right Cessation
- 1990-02-07 PT PT93079A patent/PT93079B/pt not_active IP Right Cessation
- 1990-02-07 HU HU90701A patent/HU213394B/hu unknown
- 1990-02-07 FI FI900604A patent/FI97524C/fi active IP Right Grant
- 1990-02-07 SE SE9000441A patent/SE511398C2/sv not_active Application Discontinuation
- 1990-02-07 NO NO900577A patent/NO301576B1/no not_active IP Right Cessation
- 1990-02-08 JP JP03134890A patent/JP3484190B2/ja not_active Expired - Lifetime
- 1990-02-08 DE DE4003844A patent/DE4003844B4/de not_active Expired - Lifetime
- 1990-02-08 KR KR1019900001492A patent/KR0170769B1/ko not_active Expired - Lifetime
- 1990-02-08 NL NL9000299A patent/NL195028C/nl not_active IP Right Cessation
- 1990-02-08 AT AT0027290A patent/AT404552B/de not_active IP Right Cessation
- 1990-02-08 IT IT47609A patent/IT1240758B/it active IP Right Grant
- 1990-02-08 AU AU49252/90A patent/AU630413B2/en not_active Expired
- 1990-02-09 ES ES9000397A patent/ES2021942A6/es not_active Expired - Lifetime
-
1996
- 1996-03-07 HK HK37296A patent/HK37296A/xx not_active IP Right Cessation
- 1996-11-22 CY CY190396A patent/CY1903A/en unknown
-
2001
- 2001-04-25 JP JP2001127538A patent/JP4073641B2/ja not_active Expired - Lifetime
-
2005
- 2005-09-13 JP JP2005265724A patent/JP2006001947A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2021942A6 (es) | Procedimiento para preparar composiciones farmaceuticas a base de ciclosporinas. | |
| SE7901683L (sv) | Nya resorberbara galeniska kompositioner | |
| RU92016471A (ru) | Твердая непористая микросфера, способ ее получения и применение в фармакологическом препарате | |
| IT8520769A0 (it) | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. | |
| ES2062530T3 (es) | Procedimiento para producir particulas pequeñas de moleculas biologicamente activas. | |
| ES2070322T3 (es) | Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta. | |
| ES2052645T3 (es) | Acidos poliinsaturados con accion vasocinetica y formulaciones farmaceuticas y cosmeticas que los contienen. | |
| ES2147320T3 (es) | Derivados de n-(3-benzofuranil)urea. | |
| ITMI922699A0 (it) | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione | |
| CA2039491A1 (en) | Stable compositions for parenteral administration and method of making same | |
| IT8920170A0 (it) | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. | |
| ES2170259T3 (es) | Empleo de lipidos como agentes auxiliares en la obtencion de formas farmaceuticas solidas segun el procedimiento de extrusion en fusion. | |
| AR240872A1 (es) | Novedosas composiciones tensioactivas con base de esteres fosforicos de derivados polioxialquenados, su procedimiento de preparacion y su aplicacion a la formulacion de materias activas. | |
| IT8920784A0 (it) | 2 alchinilfenoli sostituiti ad azione anti infiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. | |
| IT8620404A0 (it) | Cosmetiche che li contengono. esteri grassi dienici oppure trienici di eritromicina a, loro procedimento di preparazione e composizioni farmaceutiche e | |
| ES2034951T1 (es) | Microgranulados cargados de una substancia activa, constituidos esencialmente por un triglicerido de acidos grasos saturados y su utilizacion por via topica en el campo terapeutico. | |
| TWI255720B (en) | Novel preparation and administration form comprising an acid-labile active compound and process for production thereof | |
| SG64693G (en) | Nicorandil-containing preparation for injection | |
| IT8648208A0 (it) | Saponine triterpeniche ad attivita'antiinfiammatoria, mucolitica ed antiedemigena, procedimento per il loro ottenimento e composizioni farmaceutiche che li comprendono | |
| DE69712055D1 (de) | Pharmazeutische zusammensetzungen enthaltend cyclosporin und einen träger mit mindestens einer ester-alpha-glycerophosphorsäure | |
| DE3786199D1 (de) | Artikel fuer die verabreichung pharmakologisch aktiver substanzen. | |
| IT8921567A0 (it) | Derivati peptidici farmacologicamente attivi e preparazioni farmaceutiche che li contengono. | |
| IT1295290B1 (it) | Composizioni cosmetiche a base di acido azelaico | |
| AR004354A1 (es) | Nuevos antagonistas de lh-rh con efecto mejorado, procedimiento para prepararlos, las composiciones farmaceuticas que los contienen y susaplicaciones para la preparacion de medicamentos. | |
| ES2107525T3 (es) | Peptido trombolitico, su produccion y agente trombolitico. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD2A | Announcement of lapse in spain |
Effective date: 20141120 |