FR2642650B1 - Nouvelles compositions pharmaceutiques a base de cyclosporines - Google Patents

Nouvelles compositions pharmaceutiques a base de cyclosporines

Info

Publication number
FR2642650B1
FR2642650B1 FR9001389A FR9001389A FR2642650B1 FR 2642650 B1 FR2642650 B1 FR 2642650B1 FR 9001389 A FR9001389 A FR 9001389A FR 9001389 A FR9001389 A FR 9001389A FR 2642650 B1 FR2642650 B1 FR 2642650B1
Authority
FR
France
Prior art keywords
cyclosporins
pharmaceutical compositions
compositions based
new pharmaceutical
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9001389A
Other languages
English (en)
French (fr)
Other versions
FR2642650A1 (fr
Inventor
Hauer Birgit
Posanski Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898902901A external-priority patent/GB8902901D0/en
Priority claimed from GB898902898A external-priority patent/GB8902898D0/en
Priority claimed from GB898903147A external-priority patent/GB8903147D0/en
Priority claimed from GB898903663A external-priority patent/GB8903663D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2642650A1 publication Critical patent/FR2642650A1/fr
Application granted granted Critical
Publication of FR2642650B1 publication Critical patent/FR2642650B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
FR9001389A 1989-02-09 1990-02-05 Nouvelles compositions pharmaceutiques a base de cyclosporines Expired - Lifetime FR2642650B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898902901A GB8902901D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898902898A GB8902898D0 (en) 1989-02-09 1989-02-09 Improvements in or relating to organic compounds
GB898903147A GB8903147D0 (en) 1989-02-13 1989-02-13 Improvements in or relating to organic compounds
GB898903663A GB8903663D0 (en) 1989-02-17 1989-02-17 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
FR2642650A1 FR2642650A1 (fr) 1990-08-10
FR2642650B1 true FR2642650B1 (fr) 1994-12-09

Family

ID=27450262

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9001389A Expired - Lifetime FR2642650B1 (fr) 1989-02-09 1990-02-05 Nouvelles compositions pharmaceutiques a base de cyclosporines

Country Status (25)

Country Link
JP (3) JP3484190B2 (enExample)
KR (1) KR0170769B1 (enExample)
AT (1) AT404552B (enExample)
AU (1) AU630413B2 (enExample)
BE (1) BE1003009A5 (enExample)
CA (1) CA2009533C (enExample)
CH (1) CH679277A5 (enExample)
CY (1) CY1903A (enExample)
DE (1) DE4003844B4 (enExample)
DK (1) DK176209B1 (enExample)
ES (1) ES2021942A6 (enExample)
FI (1) FI97524C (enExample)
FR (1) FR2642650B1 (enExample)
GB (1) GB2230440B (enExample)
HK (1) HK37296A (enExample)
HU (1) HU213394B (enExample)
IT (1) IT1240758B (enExample)
LU (1) LU87675A1 (enExample)
MY (1) MY107377A (enExample)
NL (1) NL195028C (enExample)
NO (1) NO301576B1 (enExample)
NZ (1) NZ232401A (enExample)
PH (1) PH30917A (enExample)
PT (1) PT93079B (enExample)
SE (1) SE511398C2 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
MX9201782A (es) † 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
JP3631490B2 (ja) 1992-05-13 2005-03-23 ノバルティス ファーマ株式会社 シクロスポリン含有眼科用組成物
US5759566A (en) * 1992-07-28 1998-06-02 Poli Industria Chimica Spa Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
PT589843E (pt) 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
HUT72738A (en) * 1993-04-20 1996-05-28 Rentschler Arzneimittel New cyclosporine-containing pharmaceutical compositions for oral administration
DE4412201A1 (de) * 1993-04-20 1994-11-10 Rentschler Arzneimittel Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
KR970704464A (ko) 1994-11-03 1997-09-06 가이슐러 에리히, 데커 카를-루드빅 간단한 조성 및 높은 생물 유효성을 갖는 경구 투여용의 신규 사이클로스포린 제형 및 이의 제조방법(Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them)
US5679566A (en) * 1995-01-20 1997-10-21 University Of Massachusetts Medical Center Yeast NMD2 gene
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
ES2229473T3 (es) * 1997-01-30 2005-04-16 Novartis Ag Composiciones farmaceuticas sin aceite que contienen ciclosporina a.
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
ATE286403T1 (de) * 1997-03-12 2005-01-15 Abbott Lab Hydrophile binäre systeme zur verabreichung von cyclosporin
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
US6447806B1 (en) 1999-02-25 2002-09-10 Novartis Ag Pharmaceutical compositions comprised of stabilized peptide particles
WO2003032949A1 (en) 2001-10-19 2003-04-24 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
JP4521554B2 (ja) * 2004-03-31 2010-08-11 マイラン製薬株式会社 シクロスポリン製剤
WO2007050975A2 (en) * 2005-10-26 2007-05-03 Banner Pharmacaps, Inc. Hydrophilic vehicle-based dual controlled release matrix system as capsule fill
WO2007112272A2 (en) * 2006-03-28 2007-10-04 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
DE102008059201A1 (de) 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ präzipitierende Arzneistofflösungen
KR102146704B1 (ko) 2018-04-13 2020-08-21 가천대학교 산학협력단 사이클로스포린 A (CsA) 경피 및 피내 약물전달용 마이크로구조체
DK4166133T3 (da) * 2021-10-13 2025-09-01 Chugai Pharmaceutical Co Ltd Sammensætning indeholdende peptidforbindelse og overfladeaktivt stof
CN118354782A (zh) * 2022-05-02 2024-07-16 中外制药株式会社 用于与表面活性剂联用的包含肽化合物的组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445174B (sv) * 1978-03-07 1986-06-09 Sandoz Ag Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
NL8600050A (nl) * 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
GB8602372D0 (en) * 1986-01-31 1986-03-05 Sandoz Ltd Organic compounds
CA1290249C (en) * 1986-04-09 1991-10-08 Cetus Corporation COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
IE873057L (en) * 1986-11-13 1988-05-13 Tretorn Ab Compositions and method for treatment of cancer using¹monoclonal antibody against gd3 ganglioside together eith¹il-2
EP0296122B1 (en) * 1987-06-17 1993-09-29 Sandoz Ag Cyclosporins and their use as pharmaceuticals
JP2536876B2 (ja) * 1987-07-31 1996-09-25 寛治 高田 シクロスポリンの溶解性粉末状製剤
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
DE3830494B4 (de) * 1987-09-15 2006-05-18 Novartis Ag Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
JP2792862B2 (ja) * 1988-07-30 1998-09-03 寛治 高田 経口腸溶製剤
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
JPH1038029A (ja) * 1996-07-26 1998-02-13 Ebara Corp 制振機能付き円板状構造物
JPH10280435A (ja) * 1997-04-03 1998-10-20 Sekisui Chem Co Ltd 地下室の構築方法

Also Published As

Publication number Publication date
JPH02235817A (ja) 1990-09-18
MY107377A (en) 1995-11-30
JP2001302538A (ja) 2001-10-31
IT9047609A0 (it) 1990-02-08
SE9000441D0 (sv) 1990-02-07
NO900577L (no) 1990-08-10
HU213394B (en) 1997-06-30
DK32790A (da) 1990-08-10
CA2009533C (en) 2002-11-12
FR2642650A1 (fr) 1990-08-10
JP4073641B2 (ja) 2008-04-09
FI97524C (fi) 1997-01-10
PT93079B (pt) 1996-04-30
HU900701D0 (en) 1990-04-28
IT9047609A1 (it) 1991-08-08
DK176209B1 (da) 2007-02-05
GB2230440B (en) 1993-05-19
KR900012625A (ko) 1990-09-01
CA2009533A1 (en) 1990-08-09
KR0170769B1 (ko) 1999-02-01
SE511398C2 (sv) 1999-09-20
CH679277A5 (enExample) 1992-01-31
AU4925290A (en) 1990-08-16
AT404552B (de) 1998-12-28
DE4003844B4 (de) 2007-09-20
NL9000299A (nl) 1990-09-03
FI900604A0 (fi) 1990-02-07
FI97524B (fi) 1996-09-30
NZ232401A (en) 1992-10-28
ES2021942A6 (es) 1991-11-16
PT93079A (pt) 1990-08-31
HK37296A (en) 1996-03-15
LU87675A1 (fr) 1991-10-08
SE9000441L (sv) 1991-08-08
DK32790D0 (da) 1990-02-07
JP2006001947A (ja) 2006-01-05
IT1240758B (it) 1993-12-17
GB9002504D0 (en) 1990-04-04
CY1903A (en) 1996-11-22
NL195028C (nl) 2003-12-02
BE1003009A5 (fr) 1991-10-22
PH30917A (en) 1997-12-23
AU630413B2 (en) 1992-10-29
JP3484190B2 (ja) 2004-01-06
GB2230440A (en) 1990-10-24
NO301576B1 (no) 1997-11-17
NO900577D0 (no) 1990-02-07
NL195028B (nl) 2003-08-01
ATA27290A (de) 1998-05-15
DE4003844A1 (de) 1990-08-16

Similar Documents

Publication Publication Date Title
FR2642650B1 (fr) Nouvelles compositions pharmaceutiques a base de cyclosporines
FR2643262B1 (fr) Compositions pharmaceutiques a base de cyclosporines
FR2636534B1 (fr) Compositions pharmaceutiques a base de cyclosporines
IT8947949A0 (it) Composizione farmaceutica a base di ciclosporina per applicazioni topiche
FI922364L (fi) Farmaceutiska kompositioner.
DE68900991D1 (de) Cyclosporin-zusammensetzungen.
IT1243398B (it) Composizioni di sostanze a base di dichetopirrolopirroli
IT8920486A0 (it) Composizioni farmaceutiche.
FR2643263B1 (fr) Composition pharmaceutique a base de ranitidine
FR2600253B1 (fr) Nouvelles compositions pharmaceutiques a base de ketotifene
FR2645022B1 (fr) Compositions therapeutiques a base de derives de la thieno-triazolo-diazepine
BR9002396A (pt) Composicao estabilizada a base de 3-isotiazolonas
FR2742053B1 (fr) Compositions pharmaceutiques a base de mequitazine
IT1223695B (it) Composizioni farmaceutiche e cosmetiche a base di piridone e di agenti antibatterici
FR2665835B1 (fr) Nouvelles compositions pharmaceutiques a base de clozapine.
FR2661830B1 (fr) Nouvelle compositions pharmaceutiques a base de flavonoside.
IT1229231B (it) Aminoimidazopiridine farmacologicamente attive
IT8921722A0 (it) Composizioni farmaceutiche stabili a base di calcitonina.
IT9021735A0 (it) Composizioni farmaceutiche a base di calcitonine
IT1222510B (it) Composizioni farmaceutiche a base di ottreotide
IT8820026A0 (it) Composizioni farmaceutiche adattivita' antineoplastica.
FR2605225B1 (fr) Compositions pharmaceutiques a base d'urokinase
IT8720701A0 (it) Composizioni farmaceutiche adattivita' immunomodulante.
IT8621925A0 (it) Composizioni farmaceutiche adattivita' antineoplastica.
ITMI920364A0 (it) Composizioni farmaceutiche a base di calcitonine

Legal Events

Date Code Title Description
TP Transmission of property