ES2020889A6 - Procedimiento para la preparacion de formulaciones liquidas acuosas de enzimas proteoliticamente activas con suficiente estabilidad. - Google Patents

Procedimiento para la preparacion de formulaciones liquidas acuosas de enzimas proteoliticamente activas con suficiente estabilidad.

Info

Publication number
ES2020889A6
ES2020889A6 ES9001884A ES9001884A ES2020889A6 ES 2020889 A6 ES2020889 A6 ES 2020889A6 ES 9001884 A ES9001884 A ES 9001884A ES 9001884 A ES9001884 A ES 9001884A ES 2020889 A6 ES2020889 A6 ES 2020889A6
Authority
ES
Spain
Prior art keywords
making
dispersion
enzyme
resistant stable
stable enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9001884A
Other languages
English (en)
Inventor
Jurgen Christner
Hermann Plainer
Roland Reiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roehm GmbH Darmstadt
Original Assignee
Roehm GmbH Darmstadt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Darmstadt filed Critical Roehm GmbH Darmstadt
Publication of ES2020889A6 publication Critical patent/ES2020889A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE FORMULACIONES LIQUIDAS ACUOSAS DE ENZIMAS PROTEOLITICAMENTE ACTIVAS CON SUFICIENTE ESTABILIDAD. PRIMERAMENTE SE PRECIPITAN EN DISTRIBUCION FINA LAS ENZIMAS PRESENTES EN MEDIO ACUOSO, DESPUES DE LO CUAL, ENTONCES POR EQUIPARACION DE DENSIDAD, EN EL MISMO MEDIO ACUOSO, SE PREPARA UN ESTADO DE DISTRIBUCION FINALMENTE DISPERSO, ESTABLE A LA PRECIPITACION, DE LAS ENZIMAS.
ES9001884A 1989-08-18 1990-07-10 Procedimiento para la preparacion de formulaciones liquidas acuosas de enzimas proteoliticamente activas con suficiente estabilidad. Expired - Lifetime ES2020889A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3927286A DE3927286C2 (de) 1989-08-18 1989-08-18 Wäßrige Enzym-Flüssigformulierungen

Publications (1)

Publication Number Publication Date
ES2020889A6 true ES2020889A6 (es) 1991-10-01

Family

ID=6387365

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9001884A Expired - Lifetime ES2020889A6 (es) 1989-08-18 1990-07-10 Procedimiento para la preparacion de formulaciones liquidas acuosas de enzimas proteoliticamente activas con suficiente estabilidad.

Country Status (14)

Country Link
US (1) US5169771A (es)
JP (1) JP3004327B2 (es)
KR (1) KR0174263B1 (es)
AR (1) AR243602A1 (es)
BR (1) BR9004059A (es)
CH (1) CH681809A5 (es)
DE (1) DE3927286C2 (es)
DK (1) DK197190A (es)
ES (1) ES2020889A6 (es)
FR (1) FR2651006B1 (es)
GB (1) GB2234973B (es)
IT (1) IT1240976B (es)
NL (1) NL9001731A (es)
SE (1) SE9002623L (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009008828A (es) 2007-02-20 2009-12-14 Eurand Pharmaceuticals Ltd Composiciones de enzimas digestivas estables.
DK2621476T4 (da) 2010-10-01 2020-10-26 Nestle Sa Enterisk overtrukne pancrelipaseformuleringer med lav styrke
EP2987499B1 (en) 2011-08-08 2019-05-08 Allergan Pharmaceuticals International Limited Method for dissolution testing of solid compositions containing digestive enzymes
MX2016001593A (es) 2013-08-09 2016-09-29 Allergan Pharmaceuticals Int Ltd Composicion de enzima digestiva adecuada para administracion enterica.
BR112016000658A2 (pt) * 2013-11-05 2018-03-20 Allergan Pharmaceuticals International Limited pancreatina de alta atividade, processo para a preparação de pancreatina de aa tendo atividade lipásica específica de pelo menos aproximadamente 120 usp iu/mg e método de tratamento de um paciente sujeito a uma condição patológica associada com a insuficiência enzimática pandreática
WO2015193730A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts
KR20170045408A (ko) * 2015-10-16 2017-04-27 대한민국(농촌진흥청장) 산 생성능이 우수한 토착 종균, 아스퍼질러스 루추엔시스 74-5를 이용한 탁주용 고체종국 제조방법
TWI762706B (zh) 2017-08-24 2022-05-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1組成物及其用途
IL294520A (en) 2020-02-18 2022-09-01 Novo Nordisk As Pharmaceutical formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2001M (fr) * 1961-11-06 1963-09-09 Felix Amour Nouveau procédé de préparation de solutions aqueuses stables d'enzymes et cristallisation. solution-type : solution isotonique stable de papaine.
US3557002A (en) * 1967-11-15 1971-01-19 Procter & Gamble Stabilized aqueous enzyme preparation
US3741902A (en) * 1971-05-24 1973-06-26 Purex Corp Laundry prespotter composition
DE2234412B2 (de) * 1972-07-13 1980-07-03 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Stabilisierung und Fällung konzentrierter Protease-Lösungen
SU659613A1 (ru) * 1976-09-24 1979-04-30 Всесоюзный Научно-Исследовательский Биотехнический Институт Способ получени комплекса пектолитических ферментов
US4923981A (en) * 1982-09-03 1990-05-08 Sbp, Inc. Use of parenchymal cell cellulose to improve comestibles
US4540506A (en) * 1983-04-15 1985-09-10 Genex Corporation Composition for cleaning drains clogged with deposits containing hair
US4517101A (en) * 1983-08-22 1985-05-14 David Williams Reduced biodegradability in a polymer flood process
US4806479A (en) * 1985-05-13 1989-02-21 Miles Inc. Use of stabilizing agents in culture media for growing acid producing bacteria
DE3704465C2 (de) * 1987-02-13 1995-11-02 Roehm Gmbh Flüssig-Formulierungen von Enzymen
JPH01104170A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol 安定なα−１，６−グルコシダーゼ組成物
JPH01104173A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol アミラーゼの安定化法
JPH01104171A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol α−１・６−グルコシダーゼの安定化法

Also Published As

Publication number Publication date
CH681809A5 (es) 1993-05-28
IT9067649A0 (it) 1990-08-17
DK197190A (da) 1991-02-19
NL9001731A (nl) 1991-03-18
GB9018065D0 (en) 1990-10-03
SE9002623L (sv) 1991-02-19
BR9004059A (pt) 1991-09-03
SE9002623D0 (sv) 1990-08-10
AR243602A1 (es) 1993-08-31
IT9067649A1 (it) 1992-02-17
DK197190D0 (da) 1990-08-17
JPH0398580A (ja) 1991-04-24
FR2651006B1 (fr) 1993-03-26
JP3004327B2 (ja) 2000-01-31
DE3927286C2 (de) 1997-07-24
KR0174263B1 (ko) 1999-02-01
DE3927286A1 (de) 1991-02-21
KR910004798A (ko) 1991-03-29
IT1240976B (it) 1993-12-27
FR2651006A1 (fr) 1991-02-22
US5169771A (en) 1992-12-08
GB2234973A (en) 1991-02-20
GB2234973B (en) 1993-05-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601