ES8506316A1 - Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico. - Google Patents

Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico.

Info

Publication number
ES8506316A1
ES8506316A1 ES536878A ES536878A ES8506316A1 ES 8506316 A1 ES8506316 A1 ES 8506316A1 ES 536878 A ES536878 A ES 536878A ES 536878 A ES536878 A ES 536878A ES 8506316 A1 ES8506316 A1 ES 8506316A1
Authority
ES
Spain
Prior art keywords
dioxide
dehalogenation
acid
dibromopenicillanic acid
dibromopenicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536878A
Other languages
English (en)
Other versions
ES536878A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES536878A0 publication Critical patent/ES536878A0/es
Publication of ES8506316A1 publication Critical patent/ES8506316A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE 1,1-DIOXIDO DEL ACIDO PENICILANICO.MEDIANTE DESHALOGENACION DE 1,1-DIOXIDO DEL ACIDO 6,6-DIBROMOPENICILANICO CON MAGNESIO EN ASOCIACION CON UN ACIDO COMO EL CLORHIDRICO, BROMHIDRICO, SULFURICO, BORICO, PERCLORICO; O ACIDOS ARIL-SULFONICOS, COMO EL P-TOLISULFONICO, Y ACIDOS Y DIACIDOS SUFICIENTEMENTE ACIDOS. PREFERIBLEMENTE SE UTILIZAN EL ACIDO CLORHIDRICO, BROMHIDRICO Y EL SULFURICO. LA REACCION SE LLEVA A CABO CON UN PH PREFERENTE ENTRE 4 Y 6 Y SE EFECTUA EN MEZCLA CON AGUA Y DISOLVENTE ORGANICO INERTE COMO EL ACETATO ETILICO, ACETATO BUTILICO O ACETONITRILO. LA TEMPERATURA SE SITUA PREFERENTEMENTE ENTRE C3JC Y 10JC Y EL MAGNESIO SE EMPLEA EN FORMA DE POLVO.DE APLICACION COMO INHIBIDOR DE LA BETA-LACTAMASA.
ES536878A 1983-10-18 1984-10-18 Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico. Expired ES8506316A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP83201500A EP0139048A1 (en) 1983-10-18 1983-10-18 Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide

Publications (2)

Publication Number Publication Date
ES536878A0 ES536878A0 (es) 1985-07-01
ES8506316A1 true ES8506316A1 (es) 1985-07-01

Family

ID=8191002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536878A Expired ES8506316A1 (es) 1983-10-18 1984-10-18 Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico.

Country Status (15)

Country Link
US (1) US4554104A (es)
EP (2) EP0139048A1 (es)
JP (1) JPS60120883A (es)
KR (1) KR870001067B1 (es)
AU (1) AU572898B2 (es)
CA (1) CA1243299A (es)
DE (1) DE3466540D1 (es)
DK (1) DK157758C (es)
ES (1) ES8506316A1 (es)
FI (1) FI79114C (es)
GR (1) GR80673B (es)
HU (1) HU192609B (es)
NL (1) NL179822C (es)
NZ (1) NZ209824A (es)
PT (1) PT79316B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987006230A1 (en) * 1986-04-10 1987-10-22 Leo Pharmaceutical Products Ltd. A/S Method for preparing penicillanic acid derivatives
JP2603082B2 (ja) * 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
AR247212A1 (es) * 1991-09-13 1994-11-30 Bago Sa Labor Procedimiento de preparacion de acido 1,1-dioxo penicilanico, sus sales y esteres.
US5537807A (en) * 1994-07-22 1996-07-23 The Patriot Company Yard-care machine
ATE288438T1 (de) * 1999-03-03 2005-02-15 Astur Pharma Sa Verfahren zur herstellung von dioxopenicillansäurederivaten
WO2005023821A1 (ja) 2003-09-03 2005-03-17 Otsuka Chemical Co., Ltd. ペニシラン酸化合物の製造方法
JP4125658B2 (ja) * 2003-09-30 2008-07-30 Ｊｆｅケミカル株式会社 炭化水素の製造方法
JP4847204B2 (ja) * 2006-04-28 2011-12-28 ゼブラ株式会社 複式筆記具
CN104132899B (zh) * 2014-06-30 2017-01-25 华北制药集团先泰药业有限公司 青霉素类抗生素的外观评定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
PT76526B (en) * 1982-04-19 1986-01-21 Gist Brocades Nv Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives

Also Published As

Publication number Publication date
DK157758B (da) 1990-02-12
FI79114B (fi) 1989-07-31
FI79114C (fi) 1989-11-10
GR80673B (en) 1985-02-18
DK496184D0 (da) 1984-10-17
ES536878A0 (es) 1985-07-01
NL179822B (nl) 1986-06-16
PT79316A (en) 1984-11-01
US4554104A (en) 1985-11-19
KR850002984A (ko) 1985-05-28
EP0138282A3 (en) 1985-06-19
DK157758C (da) 1990-07-09
FI844051A0 (fi) 1984-10-15
AU572898B2 (en) 1988-05-19
NL179822C (nl) 1986-11-17
JPH0250116B2 (es) 1990-11-01
CA1243299A (en) 1988-10-18
EP0138282B1 (en) 1987-09-30
EP0138282A2 (en) 1985-04-24
PT79316B (en) 1986-09-08
KR870001067B1 (ko) 1987-05-27
NZ209824A (en) 1988-04-29
AU3382984A (en) 1985-04-26
HUT35682A (en) 1985-07-29
DK496184A (da) 1985-04-19
FI844051L (fi) 1985-04-19
EP0139048A1 (en) 1985-05-02
JPS60120883A (ja) 1985-06-28
DE3466540D1 (en) 1987-11-05
HU192609B (en) 1987-06-29
NL8403146A (nl) 1985-05-17

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20020506