ES8506316A1 - Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico. - Google Patents
Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico.Info
- Publication number
- ES8506316A1 ES8506316A1 ES536878A ES536878A ES8506316A1 ES 8506316 A1 ES8506316 A1 ES 8506316A1 ES 536878 A ES536878 A ES 536878A ES 536878 A ES536878 A ES 536878A ES 8506316 A1 ES8506316 A1 ES 8506316A1
- Authority
- ES
- Spain
- Prior art keywords
- dioxide
- dehalogenation
- acid
- dibromopenicillanic acid
- dibromopenicillanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE 1,1-DIOXIDO DEL ACIDO PENICILANICO.MEDIANTE DESHALOGENACION DE 1,1-DIOXIDO DEL ACIDO 6,6-DIBROMOPENICILANICO CON MAGNESIO EN ASOCIACION CON UN ACIDO COMO EL CLORHIDRICO, BROMHIDRICO, SULFURICO, BORICO, PERCLORICO; O ACIDOS ARIL-SULFONICOS, COMO EL P-TOLISULFONICO, Y ACIDOS Y DIACIDOS SUFICIENTEMENTE ACIDOS. PREFERIBLEMENTE SE UTILIZAN EL ACIDO CLORHIDRICO, BROMHIDRICO Y EL SULFURICO. LA REACCION SE LLEVA A CABO CON UN PH PREFERENTE ENTRE 4 Y 6 Y SE EFECTUA EN MEZCLA CON AGUA Y DISOLVENTE ORGANICO INERTE COMO EL ACETATO ETILICO, ACETATO BUTILICO O ACETONITRILO. LA TEMPERATURA SE SITUA PREFERENTEMENTE ENTRE C3JC Y 10JC Y EL MAGNESIO SE EMPLEA EN FORMA DE POLVO.DE APLICACION COMO INHIBIDOR DE LA BETA-LACTAMASA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP83201500A EP0139048A1 (en) | 1983-10-18 | 1983-10-18 | Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide |
Publications (2)
Publication Number | Publication Date |
---|---|
ES536878A0 ES536878A0 (es) | 1985-07-01 |
ES8506316A1 true ES8506316A1 (es) | 1985-07-01 |
Family
ID=8191002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536878A Expired ES8506316A1 (es) | 1983-10-18 | 1984-10-18 | Procedimiento de preparacion de1,1-dioxido del acido penicilanico por deshalogenacion de 1,1-dioxido del acido 6,6-dibromopenicilanico. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4554104A (es) |
EP (2) | EP0139048A1 (es) |
JP (1) | JPS60120883A (es) |
KR (1) | KR870001067B1 (es) |
AU (1) | AU572898B2 (es) |
CA (1) | CA1243299A (es) |
DE (1) | DE3466540D1 (es) |
DK (1) | DK157758C (es) |
ES (1) | ES8506316A1 (es) |
FI (1) | FI79114C (es) |
GR (1) | GR80673B (es) |
HU (1) | HU192609B (es) |
NL (1) | NL179822C (es) |
NZ (1) | NZ209824A (es) |
PT (1) | PT79316B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987006230A1 (en) * | 1986-04-10 | 1987-10-22 | Leo Pharmaceutical Products Ltd. A/S | Method for preparing penicillanic acid derivatives |
JP2603082B2 (ja) * | 1987-09-07 | 1997-04-23 | 大塚化学株式会社 | ペニシラン酸誘導体の製造法 |
AR247212A1 (es) * | 1991-09-13 | 1994-11-30 | Bago Sa Labor | Procedimiento de preparacion de acido 1,1-dioxo penicilanico, sus sales y esteres. |
US5537807A (en) * | 1994-07-22 | 1996-07-23 | The Patriot Company | Yard-care machine |
ATE288438T1 (de) * | 1999-03-03 | 2005-02-15 | Astur Pharma Sa | Verfahren zur herstellung von dioxopenicillansäurederivaten |
WO2005023821A1 (ja) | 2003-09-03 | 2005-03-17 | Otsuka Chemical Co., Ltd. | ペニシラン酸化合物の製造方法 |
JP4125658B2 (ja) * | 2003-09-30 | 2008-07-30 | Jfeケミカル株式会社 | 炭化水素の製造方法 |
JP4847204B2 (ja) * | 2006-04-28 | 2011-12-28 | ゼブラ株式会社 | 複式筆記具 |
CN104132899B (zh) * | 2014-06-30 | 2017-01-25 | 华北制药集团先泰药业有限公司 | 青霉素类抗生素的外观评定方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE449103B (sv) * | 1979-03-05 | 1987-04-06 | Pfizer | Sett att framstella penicillansyra-1,1-dioxid samt estrar derav |
US4419284A (en) * | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
PT76526B (en) * | 1982-04-19 | 1986-01-21 | Gist Brocades Nv | Preparation of 6-alpha-bromo- and/or 6,6-dibromopenicillanic acid 1,1-dioxides |
US4468351A (en) * | 1983-06-06 | 1984-08-28 | Pfizer Inc. | Process for debromination of dibromopenicillanic acid and derivatives |
-
1983
- 1983-10-18 EP EP83201500A patent/EP0139048A1/en not_active Withdrawn
-
1984
- 1984-10-03 PT PT79316A patent/PT79316B/pt not_active IP Right Cessation
- 1984-10-04 AU AU33829/84A patent/AU572898B2/en not_active Ceased
- 1984-10-09 NZ NZ209824A patent/NZ209824A/en unknown
- 1984-10-10 US US06/659,088 patent/US4554104A/en not_active Expired - Lifetime
- 1984-10-12 KR KR1019840006322A patent/KR870001067B1/ko not_active IP Right Cessation
- 1984-10-15 FI FI844051A patent/FI79114C/fi not_active IP Right Cessation
- 1984-10-16 NL NLAANVRAGE8403146,A patent/NL179822C/xx not_active IP Right Cessation
- 1984-10-16 GR GR80673A patent/GR80673B/el unknown
- 1984-10-17 DK DK496184A patent/DK157758C/da not_active IP Right Cessation
- 1984-10-17 CA CA000465599A patent/CA1243299A/en not_active Expired
- 1984-10-17 HU HU843884A patent/HU192609B/hu not_active IP Right Cessation
- 1984-10-18 EP EP84201514A patent/EP0138282B1/en not_active Expired
- 1984-10-18 ES ES536878A patent/ES8506316A1/es not_active Expired
- 1984-10-18 DE DE8484201514T patent/DE3466540D1/de not_active Expired
- 1984-10-18 JP JP59219334A patent/JPS60120883A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DK157758B (da) | 1990-02-12 |
FI79114B (fi) | 1989-07-31 |
FI79114C (fi) | 1989-11-10 |
GR80673B (en) | 1985-02-18 |
DK496184D0 (da) | 1984-10-17 |
ES536878A0 (es) | 1985-07-01 |
NL179822B (nl) | 1986-06-16 |
PT79316A (en) | 1984-11-01 |
US4554104A (en) | 1985-11-19 |
KR850002984A (ko) | 1985-05-28 |
EP0138282A3 (en) | 1985-06-19 |
DK157758C (da) | 1990-07-09 |
FI844051A0 (fi) | 1984-10-15 |
AU572898B2 (en) | 1988-05-19 |
NL179822C (nl) | 1986-11-17 |
JPH0250116B2 (es) | 1990-11-01 |
CA1243299A (en) | 1988-10-18 |
EP0138282B1 (en) | 1987-09-30 |
EP0138282A2 (en) | 1985-04-24 |
PT79316B (en) | 1986-09-08 |
KR870001067B1 (ko) | 1987-05-27 |
NZ209824A (en) | 1988-04-29 |
AU3382984A (en) | 1985-04-26 |
HUT35682A (en) | 1985-07-29 |
DK496184A (da) | 1985-04-19 |
FI844051L (fi) | 1985-04-19 |
EP0139048A1 (en) | 1985-05-02 |
JPS60120883A (ja) | 1985-06-28 |
DE3466540D1 (en) | 1987-11-05 |
HU192609B (en) | 1987-06-29 |
NL8403146A (nl) | 1985-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20020506 |