ES8507569A1 - Un procedimiento de transformar un compuesto de teicoplanina, o un compuesto del tipo de teicoplanina, en desglucoteicoplanina - Google Patents
Un procedimiento de transformar un compuesto de teicoplanina, o un compuesto del tipo de teicoplanina, en desglucoteicoplaninaInfo
- Publication number
- ES8507569A1 ES8507569A1 ES538618A ES538618A ES8507569A1 ES 8507569 A1 ES8507569 A1 ES 8507569A1 ES 538618 A ES538618 A ES 538618A ES 538618 A ES538618 A ES 538618A ES 8507569 A1 ES8507569 A1 ES 8507569A1
- Authority
- ES
- Spain
- Prior art keywords
- deglucoteicoplanin
- salts
- chemical process
- preparing antibiotic
- teicoplanin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001311 chemical methods and process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 title abstract 2
- DKVBOUDTNWVDEP-ZCVCDMNQSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)C2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-ZCVCDMNQSA-N 0.000 title abstract 2
- 108010053950 Teicoplanin Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960001608 teicoplanin Drugs 0.000 abstract 1
- -1 teicoplanin compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA TRANSFORMAR UN COMPUESTO DE TEICOPLANINA, O ANALOGO EN DESGLUCOTICOPLANINA.CONSISTE EN SOMETER A HIDROLISIS ACIDA FUERTE CONTROLADA A UNA SUSTANCIA ELEGIDA ENTRE EL COMPREJO DE TEICOPLANINA, FACTOR A2 DE TEICOPLANINA Y FACTOR A3 DE TEICOPLANINA, EN UN DISOLVENTE PROTONICO ORGANICO, EN PRESENCIA DE UN ACIDO FUERTE Y A UNA TEMPERATURA ENTRE 20J Y 100JC. EL DISOLVENTE PROTONICO SE ELIGE ENTRE ACIDOS ALIFATICOS Y ACIDOS ALIFATICOS HALOGENADOS BAB, ALCANOLES ALIFATICOS Y CICLOALIFATICOS Y ALCANOLES INFERIORES SUSTITUIDOS CON FENILO Y RESTOS DE ALQUILO DE C 1 A 4 O ALCOXILO DE C 1 A 4; Y EL ACIDO FUERTE SE ELIGE ENTRE LOS ACIDOS MINERALES FUERTES, ACIDOS INORGANICOS FUERTES Y RESINAS INTERCAMBIADORAS DE CATIONES ACIDAS FUERTES EN FORMA DE H.SE UTILIZA COMO ANTIBIOTICO CONTRA BACTERIAS GRAM-POSITIVAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838333624A GB8333624D0 (en) | 1983-12-16 | 1983-12-16 | Antibiotics l 17054 and l 17392 |
| GB848415091A GB8415091D0 (en) | 1984-06-13 | 1984-06-13 | Deglutcoteicoplanin and acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES538618A0 ES538618A0 (es) | 1985-09-01 |
| ES8507569A1 true ES8507569A1 (es) | 1985-09-01 |
Family
ID=26287114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES538618A Expired ES8507569A1 (es) | 1983-12-16 | 1984-12-14 | Un procedimiento de transformar un compuesto de teicoplanina, o un compuesto del tipo de teicoplanina, en desglucoteicoplanina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4629781A (es) |
| EP (1) | EP0146053B1 (es) |
| JP (1) | JPH0653746B2 (es) |
| KR (1) | KR920001691B1 (es) |
| AR (1) | AR242224A1 (es) |
| AU (1) | AU579120B2 (es) |
| CA (1) | CA1250093A (es) |
| DE (1) | DE3485386D1 (es) |
| DK (1) | DK584384A (es) |
| ES (1) | ES8507569A1 (es) |
| FI (1) | FI87079C (es) |
| GR (1) | GR81032B (es) |
| HU (1) | HU194281B (es) |
| IE (1) | IE57697B1 (es) |
| IL (1) | IL73805A (es) |
| NO (1) | NO170019C (es) |
| NZ (1) | NZ210543A (es) |
| PH (1) | PH20212A (es) |
| PT (1) | PT79683B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1173329B (it) * | 1984-02-21 | 1987-06-24 | Lepetit Spa | Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3 |
| GB8415092D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Ester derivatives |
| GB8420405D0 (en) * | 1984-08-10 | 1984-09-12 | Lepetit Spa | Preparing antibiotic l 17046 |
| GB8522574D0 (en) * | 1985-09-12 | 1985-10-16 | Lepetit Spa | Amides of teicoplanin compounds |
| GB8608809D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Antibiotic |
| GB8701872D0 (en) * | 1987-01-28 | 1987-03-04 | Lepetit Spa | N15-alkyl & n15,n15-dialkyl derivatives |
| GB8704847D0 (en) * | 1987-03-02 | 1987-04-08 | Lepetit Spa | Substituted alkylamides of teicoplanin compounds |
| GB8711066D0 (en) * | 1987-05-11 | 1987-06-17 | Lepetit Spa | Teicoplanin derivatives |
| GB8715735D0 (en) * | 1987-07-03 | 1987-08-12 | Lepetit Spa | De-mannosyl teicoplanin derivatives |
| ATE135369T1 (de) * | 1988-12-27 | 1996-03-15 | Lepetit Spa | Chemisches verfahren zur herstellung des antibiotikums l 17392 (deglukoteicoplanin) und dessen salze |
| US5500410A (en) * | 1989-03-29 | 1996-03-19 | Gruppo Lepetit S.P.A. | Substituted alkylamide derivatives of teicoplanin |
| US5185320A (en) * | 1989-04-03 | 1993-02-09 | Gruppo Lepetit S.P.A. | O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin |
| ATE158306T1 (de) | 1990-03-28 | 1997-10-15 | Lepetit Spa | Verfahren zur herstellung von mannosylteicoplaninderivaten und mannosylteicoplaninaglykon |
| JPH06503306A (ja) * | 1990-12-05 | 1994-04-14 | グルポ・レペチツト・エス・ピー・エイ | テイコプラニン抗生物質の３８−デカルボキシ−３８−ヒドロキシメチル誘導体およびそれらの製造方法 |
| ATE208791T1 (de) | 1996-04-23 | 2001-11-15 | Biosearch Italia Spa | Chemisches verfahren zur herstellung von amidderivaten von a 40926 antibiotikum |
| KR100554481B1 (ko) * | 2004-06-30 | 2006-03-03 | 씨제이 주식회사 | 반코마이신 염산염의 정제방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1496386A (en) * | 1975-03-05 | 1977-12-30 | Lepetit Spa | Antibiotics |
| US4322406A (en) * | 1980-12-18 | 1982-03-30 | Eli Lilly And Company | Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1 |
| FI75190C (fi) * | 1982-03-24 | 1988-05-09 | Lilly Co Eli | Foerfarande foer framstaellning av ett antibiotikum a41030-komplex eller dess faktorer a, b, c, d, e, f och g. |
| US4462942A (en) * | 1982-07-30 | 1984-07-31 | Eli Lilly And Company | A47934 Antibiotic and process for production thereof |
| GB8307847D0 (en) * | 1983-03-22 | 1983-04-27 | Lepetit Spa | Antibiotics l 17054 and l 17046 |
| US4521335A (en) * | 1983-07-13 | 1985-06-04 | Smithkline Beckman Corporation | Aglycone and pseudo-aglycones of the AAD 216 antibiotics |
| US4497802A (en) * | 1983-10-21 | 1985-02-05 | Eli Lilly And Company | N-Acyl glycopeptide derivatives |
| GB8415092D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Ester derivatives |
| GB8415093D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Antibiotic l 17392 |
-
1984
- 1984-11-21 AU AU35734/84A patent/AU579120B2/en not_active Ceased
- 1984-11-23 GR GR81032A patent/GR81032B/el unknown
- 1984-11-30 EP EP84114558A patent/EP0146053B1/en not_active Expired
- 1984-11-30 DE DE8484114558T patent/DE3485386D1/de not_active Expired - Fee Related
- 1984-12-05 PH PH31530A patent/PH20212A/en unknown
- 1984-12-07 DK DK584384A patent/DK584384A/da not_active Application Discontinuation
- 1984-12-11 US US06/680,435 patent/US4629781A/en not_active Expired - Lifetime
- 1984-12-12 IL IL73805A patent/IL73805A/xx unknown
- 1984-12-13 NZ NZ210543A patent/NZ210543A/xx unknown
- 1984-12-13 NO NO845005A patent/NO170019C/no unknown
- 1984-12-14 JP JP59263081A patent/JPH0653746B2/ja not_active Expired - Lifetime
- 1984-12-14 AR AR84298965A patent/AR242224A1/es active
- 1984-12-14 KR KR1019840007973A patent/KR920001691B1/ko not_active IP Right Cessation
- 1984-12-14 PT PT79683A patent/PT79683B/pt not_active IP Right Cessation
- 1984-12-14 CA CA000470136A patent/CA1250093A/en not_active Expired
- 1984-12-14 ES ES538618A patent/ES8507569A1/es not_active Expired
- 1984-12-14 FI FI844963A patent/FI87079C/fi not_active IP Right Cessation
- 1984-12-14 HU HU844673A patent/HU194281B/hu not_active IP Right Cessation
- 1984-12-14 IE IE3218/84A patent/IE57697B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT79683B (en) | 1986-12-10 |
| DE3485386D1 (de) | 1992-02-06 |
| PH20212A (en) | 1986-10-21 |
| NZ210543A (en) | 1988-07-28 |
| AR242224A1 (es) | 1993-03-31 |
| ES538618A0 (es) | 1985-09-01 |
| NO170019C (no) | 1992-09-02 |
| EP0146053A2 (en) | 1985-06-26 |
| FI844963L (fi) | 1985-06-17 |
| PT79683A (en) | 1985-01-01 |
| CA1250093A (en) | 1989-02-14 |
| US4629781A (en) | 1986-12-16 |
| DK584384A (da) | 1985-06-17 |
| IL73805A0 (en) | 1985-03-31 |
| EP0146053A3 (en) | 1987-05-13 |
| NO170019B (no) | 1992-05-25 |
| IL73805A (en) | 1988-05-31 |
| GR81032B (en) | 1985-02-27 |
| HUT36838A (en) | 1985-10-28 |
| HU194281B (en) | 1988-01-28 |
| AU3573484A (en) | 1985-06-20 |
| FI844963A0 (fi) | 1984-12-14 |
| JPS60243091A (ja) | 1985-12-03 |
| FI87079C (fi) | 1992-11-25 |
| KR920001691B1 (ko) | 1992-02-22 |
| NO845005L (no) | 1985-06-17 |
| JPH0653746B2 (ja) | 1994-07-20 |
| KR850004496A (ko) | 1985-07-15 |
| FI87079B (fi) | 1992-08-14 |
| IE57697B1 (en) | 1993-03-10 |
| DK584384D0 (da) | 1984-12-07 |
| AU579120B2 (en) | 1988-11-17 |
| EP0146053B1 (en) | 1991-12-27 |
| IE843218L (en) | 1985-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000201 |