ATE135369T1 - Chemisches verfahren zur herstellung des antibiotikums l 17392 (deglukoteicoplanin) und dessen salze - Google Patents
Chemisches verfahren zur herstellung des antibiotikums l 17392 (deglukoteicoplanin) und dessen salzeInfo
- Publication number
- ATE135369T1 ATE135369T1 AT89122875T AT89122875T ATE135369T1 AT E135369 T1 ATE135369 T1 AT E135369T1 AT 89122875 T AT89122875 T AT 89122875T AT 89122875 T AT89122875 T AT 89122875T AT E135369 T1 ATE135369 T1 AT E135369T1
- Authority
- AT
- Austria
- Prior art keywords
- deglucoteicoplanin
- salts
- chemical process
- antibiotic
- producing
- Prior art date
Links
- 238000001311 chemical methods and process Methods 0.000 title abstract 2
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 title abstract 2
- DKVBOUDTNWVDEP-ZCVCDMNQSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)C2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-ZCVCDMNQSA-N 0.000 title abstract 2
- 108010053950 Teicoplanin Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960001608 teicoplanin Drugs 0.000 abstract 1
- -1 teicoplanin compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88121707 | 1988-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE135369T1 true ATE135369T1 (de) | 1996-03-15 |
Family
ID=8199721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89122875T ATE135369T1 (de) | 1988-12-27 | 1989-12-12 | Chemisches verfahren zur herstellung des antibiotikums l 17392 (deglukoteicoplanin) und dessen salze |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5594102A (de) |
| EP (1) | EP0376042B1 (de) |
| JP (1) | JPH02221297A (de) |
| KR (1) | KR900009652A (de) |
| AT (1) | ATE135369T1 (de) |
| CA (1) | CA2006381A1 (de) |
| DE (1) | DE68925951T2 (de) |
| DK (1) | DK640589A (de) |
| ES (1) | ES2084595T3 (de) |
| HU (1) | HU209314B (de) |
| IL (1) | IL92826A (de) |
| ZA (1) | ZA899773B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8621912D0 (en) * | 1986-09-11 | 1986-10-15 | Lepetit Spa | Increasing ratio of components of anti-biotic complex |
| EP0912604B1 (de) | 1996-04-23 | 2001-11-14 | Biosearch Italia S.p.A. | Chemisches Verfahren zur Herstellung von Amidderivaten von A 40926 Antibiotikum |
| WO2007039194A1 (en) | 2005-09-29 | 2007-04-12 | Roche Diagnostics Gmbh | Release reagent for vitamin d compounds |
| ES2795849T3 (es) | 2010-05-20 | 2020-11-25 | Hoffmann La Roche | Reactivo de liberación para compuestos de vitamina D |
| CA2852275C (en) | 2011-11-18 | 2021-06-29 | F. Hoffmann-La Roche Ag | Release reagent for vitamin d compounds |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1496386A (en) * | 1975-03-05 | 1977-12-30 | Lepetit Spa | Antibiotics |
| US4604239A (en) * | 1982-03-24 | 1986-08-05 | Eli Lilly And Company | Antibiotics |
| GB8307847D0 (en) * | 1983-03-22 | 1983-04-27 | Lepetit Spa | Antibiotics l 17054 and l 17046 |
| US4521335A (en) * | 1983-07-13 | 1985-06-04 | Smithkline Beckman Corporation | Aglycone and pseudo-aglycones of the AAD 216 antibiotics |
| AU579120B2 (en) * | 1983-12-16 | 1988-11-17 | Gruppo Lepetit S.P.A. | Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts |
| IT1173329B (it) * | 1984-02-21 | 1987-06-24 | Lepetit Spa | Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3 |
| GB8415093D0 (en) * | 1984-06-13 | 1984-07-18 | Lepetit Spa | Antibiotic l 17392 |
| GB8420405D0 (en) * | 1984-08-10 | 1984-09-12 | Lepetit Spa | Preparing antibiotic l 17046 |
| GB8531846D0 (en) * | 1985-12-30 | 1986-02-05 | Lepetit Spa | Antibiotic a 40926 mannosyl aglycon |
| GB8608809D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Antibiotic |
| EP0255299A3 (de) * | 1986-07-30 | 1988-07-20 | Smithkline Beecham Corporation | Glykopeptid-Antibiotika |
| US4742045A (en) * | 1986-07-30 | 1988-05-03 | Smithkline Beckman Corporation | Glycopeptide antibiotics |
| GB8715735D0 (en) * | 1987-07-03 | 1987-08-12 | Lepetit Spa | De-mannosyl teicoplanin derivatives |
| GB8720980D0 (en) * | 1987-09-07 | 1987-10-14 | Lepetit Spa | Derivatives |
-
1989
- 1989-12-12 ES ES89122875T patent/ES2084595T3/es not_active Expired - Lifetime
- 1989-12-12 DE DE68925951T patent/DE68925951T2/de not_active Expired - Fee Related
- 1989-12-12 EP EP89122875A patent/EP0376042B1/de not_active Expired - Lifetime
- 1989-12-12 AT AT89122875T patent/ATE135369T1/de not_active IP Right Cessation
- 1989-12-18 DK DK640589A patent/DK640589A/da not_active Application Discontinuation
- 1989-12-20 IL IL9282689A patent/IL92826A/xx unknown
- 1989-12-20 ZA ZA899773A patent/ZA899773B/xx unknown
- 1989-12-21 CA CA002006381A patent/CA2006381A1/en not_active Abandoned
- 1989-12-22 HU HU896773A patent/HU209314B/hu not_active IP Right Cessation
- 1989-12-26 KR KR1019890019475A patent/KR900009652A/ko not_active Withdrawn
- 1989-12-27 JP JP1336812A patent/JPH02221297A/ja active Pending
-
1995
- 1995-05-30 US US08/453,114 patent/US5594102A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL92826A0 (en) | 1990-09-17 |
| HU209314B (en) | 1994-04-28 |
| KR900009652A (ko) | 1990-07-05 |
| DE68925951D1 (de) | 1996-04-18 |
| HU896773D0 (en) | 1990-03-28 |
| DE68925951T2 (de) | 1996-07-25 |
| EP0376042B1 (de) | 1996-03-13 |
| ES2084595T3 (es) | 1996-05-16 |
| IL92826A (en) | 1994-06-24 |
| HUT53377A (en) | 1990-10-28 |
| US5594102A (en) | 1997-01-14 |
| EP0376042A1 (de) | 1990-07-04 |
| ZA899773B (en) | 1991-02-27 |
| CA2006381A1 (en) | 1990-06-27 |
| DK640589D0 (da) | 1989-12-18 |
| JPH02221297A (ja) | 1990-09-04 |
| DK640589A (da) | 1990-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |