KR910004798A - 효소의 수성 제형 - Google Patents

효소의 수성 제형 Download PDF

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Publication number
KR910004798A
KR910004798A KR1019900012715A KR900012715A KR910004798A KR 910004798 A KR910004798 A KR 910004798A KR 1019900012715 A KR1019900012715 A KR 1019900012715A KR 900012715 A KR900012715 A KR 900012715A KR 910004798 A KR910004798 A KR 910004798A
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KR
South Korea
Prior art keywords
enzyme
enzymes
xanthan
aqueous medium
aqueous liquid
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Application number
KR1019900012715A
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English (en)
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KR0174263B1 (ko
Inventor
크리스트너 위르겐
플라이너 헤르만
라이너 롤란트
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헤틀러, 부크
룀 게엠베하
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Application filed by 헤틀러, 부크, 룀 게엠베하 filed Critical 헤틀러, 부크
Publication of KR910004798A publication Critical patent/KR910004798A/ko
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Publication of KR0174263B1 publication Critical patent/KR0174263B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음.

Description

효소의 수성 제형
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 수성 매질중에서 세분형으로 존재하는 효소를 침전시키고 이어서 동일한 수성 매질에서 밀도를 조절하여 효소의 침강-내성, 미세하게 분산된 상태를 성취함을 특징으로 하는, 적당한 안정성을 갖는 단백질 분해 효소의 수성 액체 제형을 제조하는 방법.
  2. 제1항에 있어서, 단백질 분해 효소가 프로테아제 (EC 3,4)인 방법.
  3. 제2항에 있어서, 효소가 미생물 기원인 방법.
  4. 제1항에 있어서, 효소를 보조 프로테아제 활성을 갖는 아밀라제 (EC 3.2.1) 및 리파아제(EC 3.1.1.3) 그룹 중에서 선택하는 방법.
  5. 제1항에 있어서, 효소가 췌장 복합체에 속하는 방법.
  6. 제1항에 있어서, 효소가 통상의 효소 생성물로부터 추출물의 형태로 사용되는 방법.
  7. 제1항에 있어서, 상기 효소를 포함하는 수성 매질에 불활성 염을 가하여 효소를 세분형으로 침전시키는 방법.
  8. 제7항에 있어서, 침전을 황산 암모늄 또는 황산 나트륨으로 수행하는 방법.
  9. 제1항에 있어서, 수성 매질의 밀도를 1.22 내지 1.23으로 조절하는 방법.
  10. 제1항에 있어서, 크산탄-기본 농조화제를 미세하게 분산된 효소 현탁액에 가하여 이의 침강에 대한 내성을 증진시키는 방법.
  11. 제10항에 있어서, 크산탄-기본 농조화제를 황산 암모늄 또는 황산 나트륨을 함유하는 수성 등장 용액 형태로 가하는 방법.
  12. 제11항에 있어서, 크산탄-기본 농조화제 용액을 전단력으로 교반하여 제조하는 방법.
  13. 제12항에 있어서, 크산탄-기본 농조화제가 용액중 0.1 내지 1중량%인 방법.
  14. 제1항에 있어서, 상이한 근원으로부터 수득한 효소의 혼합물을 침전시키고 함께 후처리하는 방법.
  15. 제1항에 있어서, 상이한 효소의 현탁액을 따로 제조하고 이어서 혼합하여 안정한 제형을 수득하는 방법.
  16. 제1항에 따른 안정한 수성 액체 효소 제형.
  17. 제14항에 따른 안정한 수성 액체 효소 제형.
  18. 제15항에 따른 안정한 수성 액체 효소 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012715A 1989-08-18 1990-08-18 수성 액상 효소 제형 및 이를 제조하는 방법 KR0174263B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP39272869 1989-08-18
DE3927286A DE3927286C2 (de) 1989-08-18 1989-08-18 Wäßrige Enzym-Flüssigformulierungen
DEP3927286.9 1989-08-18

Publications (2)

Publication Number Publication Date
KR910004798A true KR910004798A (ko) 1991-03-29
KR0174263B1 KR0174263B1 (ko) 1999-02-01

Family

ID=6387365

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900012715A KR0174263B1 (ko) 1989-08-18 1990-08-18 수성 액상 효소 제형 및 이를 제조하는 방법

Country Status (14)

Country Link
US (1) US5169771A (ko)
JP (1) JP3004327B2 (ko)
KR (1) KR0174263B1 (ko)
AR (1) AR243602A1 (ko)
BR (1) BR9004059A (ko)
CH (1) CH681809A5 (ko)
DE (1) DE3927286C2 (ko)
DK (1) DK197190A (ko)
ES (1) ES2020889A6 (ko)
FR (1) FR2651006B1 (ko)
GB (1) GB2234973B (ko)
IT (1) IT1240976B (ko)
NL (1) NL9001731A (ko)
SE (1) SE9002623L (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221747B2 (en) 2007-02-20 2012-07-17 Aptalis Pharma Limited Stable pancreatic enzyme compositions
SI2621476T1 (sl) 2010-10-01 2014-12-31 Aptalis Pharma Limited Gastrorezistentne obloĹľene pankrelipazne formulacije z nizko trdnostjo
ES2558756T3 (es) 2011-08-08 2016-02-08 Aptalis Pharma Limited Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas
ES2784227T3 (es) 2013-08-09 2020-09-23 Allergan Pharmaceuticals Int Ltd Composición de enzimas digestivos adecuada para la administración entérica
BR112016000658A2 (pt) * 2013-11-05 2018-03-20 Allergan Pharmaceuticals International Limited pancreatina de alta atividade, processo para a preparação de pancreatina de aa tendo atividade lipásica específica de pelo menos aproximadamente 120 usp iu/mg e método de tratamento de um paciente sujeito a uma condição patológica associada com a insuficiência enzimática pandreática
CA2947998A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts
KR20170045408A (ko) * 2015-10-16 2017-04-27 대한민국(농촌진흥청장) 산 생성능이 우수한 토착 종균, 아스퍼질러스 루추엔시스 74-5를 이용한 탁주용 고체종국 제조방법
WO2019038412A1 (en) 2017-08-24 2019-02-28 Novo Nordisk A/S GLP-1 COMPOSITIONS AND USES THEREOF
AU2021207313A1 (en) 2020-02-18 2022-07-28 Novo Nordisk A/S Pharmaceutical formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2001M (fr) * 1961-11-06 1963-09-09 Felix Amour Nouveau procédé de préparation de solutions aqueuses stables d'enzymes et cristallisation. solution-type : solution isotonique stable de papaine.
US3557002A (en) * 1967-11-15 1971-01-19 Procter & Gamble Stabilized aqueous enzyme preparation
US3741902A (en) * 1971-05-24 1973-06-26 Purex Corp Laundry prespotter composition
DE2234412B2 (de) * 1972-07-13 1980-07-03 Henkel Kgaa, 4000 Duesseldorf Verfahren zur Stabilisierung und Fällung konzentrierter Protease-Lösungen
SU659613A1 (ru) * 1976-09-24 1979-04-30 Всесоюзный Научно-Исследовательский Биотехнический Институт Способ получени комплекса пектолитических ферментов
US4923981A (en) * 1982-09-03 1990-05-08 Sbp, Inc. Use of parenchymal cell cellulose to improve comestibles
US4540506A (en) * 1983-04-15 1985-09-10 Genex Corporation Composition for cleaning drains clogged with deposits containing hair
US4517101A (en) * 1983-08-22 1985-05-14 David Williams Reduced biodegradability in a polymer flood process
US4806479A (en) * 1985-05-13 1989-02-21 Miles Inc. Use of stabilizing agents in culture media for growing acid producing bacteria
DE3704465C2 (de) * 1987-02-13 1995-11-02 Roehm Gmbh Flüssig-Formulierungen von Enzymen
JPH01104173A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol アミラーゼの安定化法
JPH01104170A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol 安定なα−１，６−グルコシダーゼ組成物
JPH01104171A (ja) * 1987-10-16 1989-04-21 Agency Of Ind Science & Technol α−１・６−グルコシダーゼの安定化法

Also Published As

Publication number Publication date
GB2234973A (en) 1991-02-20
DE3927286A1 (de) 1991-02-21
AR243602A1 (es) 1993-08-31
DK197190A (da) 1991-02-19
KR0174263B1 (ko) 1999-02-01
IT9067649A0 (it) 1990-08-17
SE9002623L (sv) 1991-02-19
FR2651006A1 (fr) 1991-02-22
JP3004327B2 (ja) 2000-01-31
US5169771A (en) 1992-12-08
SE9002623D0 (sv) 1990-08-10
DE3927286C2 (de) 1997-07-24
CH681809A5 (ko) 1993-05-28
ES2020889A6 (es) 1991-10-01
GB2234973B (en) 1993-05-19
GB9018065D0 (en) 1990-10-03
IT1240976B (it) 1993-12-27
BR9004059A (pt) 1991-09-03
NL9001731A (nl) 1991-03-18
JPH0398580A (ja) 1991-04-24
DK197190D0 (da) 1990-08-17
FR2651006B1 (fr) 1993-03-26
IT9067649A1 (it) 1992-02-17

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