ES2005588A6 - Un procedimiento para la preparacion de nuevos derivados de eteres dew 2,3-dihidro-2-oxo-1h-imidiazo (4,5-b) quinolinicos. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de eteres dew 2,3-dihidro-2-oxo-1h-imidiazo (4,5-b) quinolinicos.

Info

Publication number
ES2005588A6
ES2005588A6 ES8701506A ES8701506A ES2005588A6 ES 2005588 A6 ES2005588 A6 ES 2005588A6 ES 8701506 A ES8701506 A ES 8701506A ES 8701506 A ES8701506 A ES 8701506A ES 2005588 A6 ES2005588 A6 ES 2005588A6
Authority
ES
Spain
Prior art keywords
imidazoquinolinylether
phosphodiesterase
derivatives useful
aggregation inhibitors
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701506A
Other languages
English (en)
Spanish (es)
Inventor
Nicholas A Meanwell
John J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2005588A6 publication Critical patent/ES2005588A6/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES8701506A 1986-05-23 1987-05-22 Un procedimiento para la preparacion de nuevos derivados de eteres dew 2,3-dihidro-2-oxo-1h-imidiazo (4,5-b) quinolinicos. Expired ES2005588A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/866,813 US4775674A (en) 1986-05-23 1986-05-23 Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors

Publications (1)

Publication Number Publication Date
ES2005588A6 true ES2005588A6 (es) 1989-03-16

Family

ID=25348473

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701506A Expired ES2005588A6 (es) 1986-05-23 1987-05-22 Un procedimiento para la preparacion de nuevos derivados de eteres dew 2,3-dihidro-2-oxo-1h-imidiazo (4,5-b) quinolinicos.

Country Status (24)

Country Link
US (1) US4775674A (cg-RX-API-DMAC7.html)
JP (1) JPS62283972A (cg-RX-API-DMAC7.html)
KR (1) KR900008567B1 (cg-RX-API-DMAC7.html)
AT (1) AT392790B (cg-RX-API-DMAC7.html)
AU (1) AU603577B2 (cg-RX-API-DMAC7.html)
BE (1) BE1002033A4 (cg-RX-API-DMAC7.html)
CA (1) CA1289137C (cg-RX-API-DMAC7.html)
CH (1) CH675246A5 (cg-RX-API-DMAC7.html)
DE (1) DE3717291A1 (cg-RX-API-DMAC7.html)
DK (1) DK166084C (cg-RX-API-DMAC7.html)
ES (1) ES2005588A6 (cg-RX-API-DMAC7.html)
FI (1) FI86723C (cg-RX-API-DMAC7.html)
FR (1) FR2603586B1 (cg-RX-API-DMAC7.html)
GB (1) GB2190676B (cg-RX-API-DMAC7.html)
GR (1) GR870803B (cg-RX-API-DMAC7.html)
HU (1) HU197570B (cg-RX-API-DMAC7.html)
IL (1) IL82612A0 (cg-RX-API-DMAC7.html)
IT (1) IT1205031B (cg-RX-API-DMAC7.html)
LU (1) LU86896A1 (cg-RX-API-DMAC7.html)
NL (1) NL8701226A (cg-RX-API-DMAC7.html)
NZ (1) NZ220345A (cg-RX-API-DMAC7.html)
PT (1) PT84938B (cg-RX-API-DMAC7.html)
SE (1) SE465163B (cg-RX-API-DMAC7.html)
ZA (1) ZA873583B (cg-RX-API-DMAC7.html)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1306260C (en) * 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
JPH01189791A (ja) * 1988-01-26 1989-07-28 New Japan Radio Co Ltd 非接触idカード
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
US5262540A (en) * 1989-12-20 1993-11-16 Bristol-Myers Squibb Company [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and esters
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5187188A (en) * 1992-04-03 1993-02-16 Bristol-Myers Squibb Company Oxazole carboxylic acid derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
TW593317B (en) 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
US6573273B1 (en) 1999-06-10 2003-06-03 3M Innovative Properties Company Urea substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6756382B2 (en) 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
JP4767429B2 (ja) * 2001-03-02 2011-09-07 株式会社クラレ 架橋剤および架橋性重合体
MXPA05005661A (es) * 2002-11-27 2005-11-23 Artesian Therapeutics Inc Compuestos con actividad antagonista o antagonista parcial mixta inhibidora de fosfodiesterasa y beta-adrenergica para el tratamiento de insuficiencia cardiaca.
CA2535120A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
KR101106812B1 (ko) 2003-08-27 2012-01-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 아릴옥시 및 아릴알킬렌옥시 치환된 이미다조퀴놀린
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
WO2005032484A2 (en) 2003-10-03 2005-04-14 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CN1906193A (zh) 2003-11-14 2007-01-31 3M创新有限公司 肟取代的咪唑环化合物
EP1682544A4 (en) 2003-11-14 2009-05-06 3M Innovative Properties Co HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS
SG148201A1 (en) 2003-11-25 2008-12-31 3M Innovative Properties Co Substituted imidazo ring systems and methods
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
CA2559863A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7943609B2 (en) 2004-12-30 2011-05-17 3M Innovative Proprerties Company Chiral fused [1,2]imidazo[4,5-C] ring compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合[1,2]イミダゾ[4,5−c]環状化合物
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
WO2006086634A2 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275096A3 (en) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenesis via modulation of the muscarinic receptors
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
PL2583970T3 (pl) 2006-08-02 2016-05-31 Cytokinetics Inc Określone cząstki chemiczne, kompozycje i sposoby zawierające imidazopirymidyny
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
PH12014500094A1 (en) 2011-07-13 2014-03-17 Cytokinetics Inc Combination als therapy
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
IL62402A0 (en) * 1980-03-24 1981-05-20 Sterling Drug Inc Imidazo(4,5-b)pyridines,their preparation and pharmaceutical compositions containing them
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
ES8607299A1 (es) * 1984-02-15 1986-06-01 Syntex Inc Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents

Also Published As

Publication number Publication date
DK263587D0 (da) 1987-05-22
DK263587A (da) 1987-11-24
GB2190676B (en) 1990-05-30
NL8701226A (nl) 1987-12-16
GB2190676A (en) 1987-11-25
FR2603586B1 (fr) 1990-12-28
IL82612A0 (en) 1987-11-30
FI86723B (fi) 1992-06-30
FI872220L (fi) 1987-11-24
CH675246A5 (cg-RX-API-DMAC7.html) 1990-09-14
DK166084C (da) 1993-08-02
BE1002033A4 (fr) 1990-05-29
FI872220A0 (fi) 1987-05-20
PT84938A (en) 1987-06-01
SE465163B (sv) 1991-08-05
GB8711839D0 (en) 1987-06-24
AU603577B2 (en) 1990-11-22
IT1205031B (it) 1989-03-10
DE3717291A1 (de) 1987-11-26
CA1289137C (en) 1991-09-17
ATA132087A (de) 1990-11-15
IT8720650A0 (it) 1987-05-22
FR2603586A1 (fr) 1988-03-11
HU197570B (en) 1989-04-28
FI86723C (fi) 1992-10-12
SE8702158L (sv) 1987-11-24
HUT43602A (en) 1987-11-30
KR900008567B1 (ko) 1990-11-24
ZA873583B (en) 1988-04-27
NZ220345A (en) 1990-10-26
GR870803B (en) 1987-09-24
DK166084B (da) 1993-03-08
PT84938B (pt) 1990-02-08
LU86896A1 (fr) 1988-01-20
AT392790B (de) 1991-06-10
US4775674A (en) 1988-10-04
KR870011137A (ko) 1987-12-21
SE8702158D0 (sv) 1987-05-22
JPS62283972A (ja) 1987-12-09
AU7299387A (en) 1987-11-26

Similar Documents

Publication Publication Date Title
ES2005588A6 (es) Un procedimiento para la preparacion de nuevos derivados de eteres dew 2,3-dihidro-2-oxo-1h-imidiazo (4,5-b) quinolinicos.
ES8801829A1 (es) Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas
NO905608L (no) Fremgangsmaate for fremstilling av a-nor-steroid-3-karboksylsyrederivater.
ATE90676T1 (de) Dioxyalkylenaryl-dihydropyridine zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung.
ZA868630B (en) New 3-oxadiazole and 3-carboxylic acid beta-carboline derivatives,their production and their use as drugs
YU142679A (en) Process for preparing sulfophthaleine esters
DE3363593D1 (en) 2-nitro-ethene diamines, process for their preparation and their use as medicines
ATE50407T1 (de) Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
ATE55132T1 (de) Substituierte 6-hydroxymethylcarbapenemantibiotika, verfahren zu ihrer herstellung und ihre verwendung.
ATE42292T1 (de) Imidazo(1,2-c)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
IE882552L (en) Novel benzimidazole derivatives
ATE36853T1 (de) Beta-carbolin-3-carbonsaeurederivate und methode zu ihrer herstellung.
DE59309380D1 (de) Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
SE8405430D0 (sv) 7-acylindolforeningar, lempade som mellanprodukter vid synteser av 7-acylindolin-2-oner
FI823732A0 (fi) Nya 1-furyl-3,4-dihydroisokinoliner, laekemedel innehaollande dessa samt deras framstaellningsfoerfaranden och deras anvaendning
NO865121L (no) Fremgangsmaate for fremstilling av 5- eller 6-substituerte-beta-carbolin-3-carboxylsyreestere.
DE68910931D1 (de) Verfahren zur Herstellung von Propionsäurederivaten.
ATE4536T1 (de) Indan-4-yl-n-alkyl-carbaminsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide.
NO885811D0 (no) Fremgangsmaate for fremstilling av 2-amino-tetrahydroisokinolinderivater.
HUT57779A (en) Process for producing new thiazetoquinoline-3-carboxylic acid derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000503