ES2005160A6 - Un metodo para preparar derivados de moranolina. - Google Patents

Un metodo para preparar derivados de moranolina.

Info

Publication number
ES2005160A6
ES2005160A6 ES8701085A ES8701085A ES2005160A6 ES 2005160 A6 ES2005160 A6 ES 2005160A6 ES 8701085 A ES8701085 A ES 8701085A ES 8701085 A ES8701085 A ES 8701085A ES 2005160 A6 ES2005160 A6 ES 2005160A6
Authority
ES
Spain
Prior art keywords
manufacturing
methanol
moranoline derivatives
moranoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701085A
Other languages
English (en)
Inventor
Yoji Ezure
Masaji Yamamoto
Shigeaki Maruo
Makoto Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ES2005160A6 publication Critical patent/ES2005160A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN METODO PARA PREPARAR DERIVADOS DE MORANOLINA DE FORMULAEN EL QUE SE CALIENTA EN AGUA, O SE DISUELVE EN AGUA A TEMPERATURA AMBIENTE, UNA MEZCLA DEL DERIVADO DE FORMULA (I), OLIGOGLUCOSILMORANOLINA DE FORMULAEN LA QUE N ES 1 A 5, Y MORANOLINA DE FORMULASE AÑADE METANOL EN UNA CANTIDAD DE 1 A 1.000 VECES EL VOLUMEN DE LA MEZCLA, SE MANTIENE ESTA A UNA TEMPERATURA DE 5 A 40GC CON AGITACION A UNA VELOCIDAD DE 50 A 1.000 RPM DURANTE 30 MINUTOS A 72 HORAS, Y SE APLICA CRISTALIZACION FRACCIONADA A LA MEZCLA PARA SEPARAR EL COMPUESTO BUSCADO. EL DERIVADO DE GLUCOSILMORANOLINA CON MATANOL RESULTANTE PUEDE TRATARSE SEGUIDAMENTE CON ETANOL, PROPORCIONANDO OTRO DERIVADO DE MORANOLINA. LOS DERIVADOS OBTENIDOS SON ESPECIALMENTE UTILES COMO AGENTES TERAPEUTICOS PARA LA DIABETES MELITUS.
ES8701085A 1986-04-15 1987-04-14 Un metodo para preparar derivados de moranolina. Expired ES2005160A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61087509A JPS62242692A (ja) 1986-04-15 1986-04-15 モラノリン誘導体の製造法

Publications (1)

Publication Number Publication Date
ES2005160A6 true ES2005160A6 (es) 1989-03-01

Family

ID=13916951

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701085A Expired ES2005160A6 (es) 1986-04-15 1987-04-14 Un metodo para preparar derivados de moranolina.

Country Status (13)

Country Link
US (1) US4806633A (es)
JP (1) JPS62242692A (es)
KR (1) KR950004899B1 (es)
AT (1) AT392474B (es)
BE (1) BE1000157A5 (es)
CH (1) CH671766A5 (es)
DE (1) DE3712799A1 (es)
ES (1) ES2005160A6 (es)
FR (1) FR2601019B1 (es)
GB (1) GB2190081B (es)
IT (1) IT1206061B (es)
NL (1) NL8700731A (es)
SE (1) SE469941B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
AU8069891A (en) * 1990-06-08 1991-12-31 Merrell Dow Pharmaceuticals Inc. Novel alpha-glucosidase inhibitors
ATE193551T1 (de) * 1991-03-18 2000-06-15 Scripps Research Inst Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen
CA2129140A1 (en) * 1992-01-31 1993-08-05 Akira Hasegawa Lewis-type sugar chain derivative
US8579029B2 (en) * 2008-12-31 2013-11-12 Schlumberger Technology Corporation System, method and treatment fluid for controlling fines migration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2832268A1 (de) * 1978-07-22 1980-01-31 Bayer Ag Pseudotrisaccharide
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
JPS602038B2 (ja) * 1980-09-22 1985-01-18 日本新薬株式会社 グルコシルモラノリン誘導体の製法
JPS5681595A (en) * 1979-12-08 1981-07-03 Nippon Shinyaku Co Ltd Moranoline derivative and its preparation
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
JPS6055078B2 (ja) * 1980-12-01 1985-12-03 日本新薬株式会社 モラノリンの誘導体
US4526784A (en) * 1981-05-05 1985-07-02 Bayer Aktiengesellschaft Amino-cyclitol derivatives and medicaments containing them
JPS61115093A (ja) * 1984-11-09 1986-06-02 Nippon Shinyaku Co Ltd モラノリン誘導体の製法
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents

Also Published As

Publication number Publication date
GB2190081B (en) 1990-03-21
IT8747798A0 (it) 1987-03-31
BE1000157A5 (fr) 1988-06-28
SE8701317L (sv) 1987-10-16
GB2190081A (en) 1987-11-11
SE469941B (sv) 1993-10-11
CH671766A5 (es) 1989-09-29
ATA95587A (de) 1990-09-15
KR870010070A (ko) 1987-11-30
SE8701317D0 (sv) 1987-03-30
GB8708193D0 (en) 1987-05-13
DE3712799A1 (de) 1987-10-22
JPS62242692A (ja) 1987-10-23
DE3712799C2 (es) 1989-04-06
IT1206061B (it) 1989-04-14
FR2601019B1 (fr) 1989-05-05
US4806633A (en) 1989-02-21
AT392474B (de) 1991-04-10
NL8700731A (nl) 1987-11-02
FR2601019A1 (fr) 1988-01-08
KR950004899B1 (ko) 1995-05-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201