JPS5681595A - Moranoline derivative and its preparation - Google Patents

Moranoline derivative and its preparation

Info

Publication number
JPS5681595A
JPS5681595A JP15941779A JP15941779A JPS5681595A JP S5681595 A JPS5681595 A JP S5681595A JP 15941779 A JP15941779 A JP 15941779A JP 15941779 A JP15941779 A JP 15941779A JP S5681595 A JPS5681595 A JP S5681595A
Authority
JP
Japan
Prior art keywords
moranoline
cyclodextrin
passed
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15941779A
Other languages
Japanese (ja)
Other versions
JPS612076B2 (en
Inventor
Shingo Matsumura
Hiroshi Enomoto
Yoshiaki Aoyanagi
Yoji Ezure
Yoshiaki Yoshikuni
Masahiro Yagi
Nobutoshi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP15941779A priority Critical patent/JPS5681595A/en
Priority to GB8037691A priority patent/GB2064527B/en
Priority to FR8025953A priority patent/FR2471387A1/en
Priority to IT50321/80A priority patent/IT1188970B/en
Priority to CH9050/80A priority patent/CH649302A5/en
Priority to DE19803046184 priority patent/DE3046184A1/en
Priority to US06/214,009 priority patent/US4338433A/en
Publication of JPS5681595A publication Critical patent/JPS5681595A/en
Publication of JPS612076B2 publication Critical patent/JPS612076B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An oligoglucosymoranoline expressed by formula I (n is an integer 0W3).
EXAMPLE: 4-(α-D-Maltotetraosyl)-moranoline.
USE: A suppersant against hyperglycemia.
PROCESS: A mixed solution of moranoline of formula II with cyclodextrin of soluble starch is reacted with cyclodextrin glycosytransferase preferably at 40°C and pH 5.0W8.5 for 1W3 days. The reaction solution is then passed through a strongly acidic ion exchange resin column to adsorb a basic substance on the resin, and the adsorbed substance is eluted wirh 0.5N. aqueous ammonia. The eluate is then concentrated in vacuo and passed through a Sephadex column to collect a desired fraction.
COPYRIGHT: (C)1981,JPO&Japio
JP15941779A 1979-12-08 1979-12-08 Moranoline derivative and its preparation Granted JPS5681595A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP15941779A JPS5681595A (en) 1979-12-08 1979-12-08 Moranoline derivative and its preparation
GB8037691A GB2064527B (en) 1979-12-08 1980-11-25 Moranoline derivatives and process for preparation thereof
FR8025953A FR2471387A1 (en) 1979-12-08 1980-12-05 PROCESS FOR THE PREPARATION OF MORANOLINE DERIVATIVES, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR CONTROLLING THE INCREASE IN SUGAR LEVELS IN BLOOD
IT50321/80A IT1188970B (en) 1979-12-08 1980-12-05 MORANOLINA DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
CH9050/80A CH649302A5 (en) 1979-12-08 1980-12-08 MORANOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
DE19803046184 DE3046184A1 (en) 1979-12-08 1980-12-08 "MORANOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF"
US06/214,009 US4338433A (en) 1979-12-08 1980-12-08 Moranoline derivatives and process for preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15941779A JPS5681595A (en) 1979-12-08 1979-12-08 Moranoline derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5681595A true JPS5681595A (en) 1981-07-03
JPS612076B2 JPS612076B2 (en) 1986-01-22

Family

ID=15693284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15941779A Granted JPS5681595A (en) 1979-12-08 1979-12-08 Moranoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5681595A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712799A1 (en) * 1986-04-15 1987-10-22 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING MORANOLINE DERIVATIVES
DE3712818A1 (en) * 1986-04-15 1987-10-22 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING MORANOLINE DERIVATIVES
WO1993017100A1 (en) * 1992-02-21 1993-09-02 Nippon Shinyaku Co., Ltd. Specific adsorbent and purification method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH052691U (en) * 1991-05-08 1993-01-19 成行 拝原 Pickles

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712799A1 (en) * 1986-04-15 1987-10-22 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING MORANOLINE DERIVATIVES
DE3712818A1 (en) * 1986-04-15 1987-10-22 Nippon Shinyaku Co Ltd METHOD FOR PRODUCING MORANOLINE DERIVATIVES
WO1993017100A1 (en) * 1992-02-21 1993-09-02 Nippon Shinyaku Co., Ltd. Specific adsorbent and purification method

Also Published As

Publication number Publication date
JPS612076B2 (en) 1986-01-22

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