ES2004409A6 - Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos - Google Patents

Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos

Info

Publication number
ES2004409A6
ES2004409A6 ES8701261A ES8701261A ES2004409A6 ES 2004409 A6 ES2004409 A6 ES 2004409A6 ES 8701261 A ES8701261 A ES 8701261A ES 8701261 A ES8701261 A ES 8701261A ES 2004409 A6 ES2004409 A6 ES 2004409A6
Authority
ES
Spain
Prior art keywords
methoxy
bis
phenyl
piperazines
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701261A
Other languages
English (en)
Inventor
Edit Toth
Bela Kiss
Jozsef Torley
Eva Palosi
Istvan Hajdu
Laszlo Szporny
Dora Groo
Erzsebet Lapis
Istvan Laszlovszky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES2004409A6 publication Critical patent/ES2004409A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

LA INVENCION SE RELACIONA CON NUEVOS DERIVADOS PIPERAZINAS 1,4-DISUSTITUIDOS DE FORMULA GENERAL (I), CON SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, CON COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y CON UN PROCEDIMIENTO PARA SU PREPARACION.EN LA FORMULA GENERAL IR1 Y R2 SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO O HALOGENO O UN GRUPO ALQUILO INFERIOR, TRIHALOMETILO O ALCOXILO INFERIOR.LOS COMPUESTOS DE FORMULA GENERAL (I) SON TERAPEUTICAMENTE UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DERIVADAS DE UNA HIPOFUNCION DEL SISTEMA DOPAMINERGICO.
ES8701261A 1986-04-28 1987-04-28 Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos Expired ES2004409A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU861750A HU196195B (en) 1986-04-28 1986-04-28 Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds

Publications (1)

Publication Number Publication Date
ES2004409A6 true ES2004409A6 (es) 1989-01-01

Family

ID=10956006

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701261A Expired ES2004409A6 (es) 1986-04-28 1987-04-28 Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos

Country Status (14)

Country Link
US (1) US4866062A (es)
EP (1) EP0243904B1 (es)
JP (1) JPS62294674A (es)
AT (1) ATE57922T1 (es)
AU (1) AU595026B2 (es)
CA (1) CA1277986C (es)
DE (1) DE3765827D1 (es)
DK (1) DK213087A (es)
ES (1) ES2004409A6 (es)
FI (1) FI85267C (es)
GR (1) GR870662B (es)
HU (1) HU196195B (es)
IL (1) IL82358A (es)
ZA (1) ZA873028B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
DE68903263T2 (de) * 1988-10-10 1993-05-19 Akzo Nv Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung.
AU658134B2 (en) * 1989-12-28 1995-04-06 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5252586A (en) * 1990-09-28 1993-10-12 The Du Pont Merck Pharmaceutical Company Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
AU7177694A (en) * 1993-06-23 1995-01-17 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6799637B2 (en) 2000-10-20 2004-10-05 Schlumberger Technology Corporation Expandable tubing and method
NO335594B1 (no) 2001-01-16 2015-01-12 Halliburton Energy Serv Inc Ekspanderbare anordninger og fremgangsmåte for disse
US8404330B2 (en) * 2004-08-23 2013-03-26 E I Du Pont De Nemours And Company Breathable low-emissivity metallized sheets
US8216600B2 (en) * 2007-11-14 2012-07-10 Cordis Corporation Polymeric materials for medical devices
EP2964611B1 (en) * 2013-03-08 2022-10-19 The United States of America, as represented by The Secretary, Department of Health and Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
WO2015195748A2 (en) 2014-06-17 2015-12-23 Ganiban Gary Devices and methods to provide hands free scleral depression during ophthalmic procedures
WO2019094856A1 (en) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE530797A (es) *
BE530796A (es) *
BE530795A (es) *
US2988551A (en) * 1954-07-30 1961-06-13 Union Chimique Belge Sa Piperazine derivatives
CH396007A (fr) * 1961-06-12 1965-07-31 Pharma Yptor S A Lab Procédé de fabrication de nouveaux dérivés de la pipérazine
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Also Published As

Publication number Publication date
EP0243904A1 (de) 1987-11-04
IL82358A0 (en) 1987-10-30
US4866062A (en) 1989-09-12
DK213087D0 (da) 1987-04-27
HUT45038A (en) 1988-05-30
HU196195B (en) 1988-10-28
CA1277986C (en) 1990-12-18
AU7215987A (en) 1987-10-29
DK213087A (da) 1987-10-29
JPS62294674A (ja) 1987-12-22
GR870662B (en) 1987-09-02
ZA873028B (en) 1987-10-21
DE3765827D1 (de) 1990-12-06
IL82358A (en) 1991-03-10
AU595026B2 (en) 1990-03-22
EP0243904B1 (de) 1990-10-31
FI871875A0 (fi) 1987-04-28
FI85267B (fi) 1991-12-13
FI871875A7 (fi) 1987-10-29
FI85267C (fi) 1992-03-25
ATE57922T1 (de) 1990-11-15

Similar Documents

Publication Publication Date Title
ES2004409A6 (es) Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos
ES2061471T3 (es) Derivados de la piridina, compuestos farmaceuticos que comprenden la misma, su utilizacion para la fabricacion de medicamentos con valor terapeutico o preventivo y procedimiento para su fabricacion.
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
DE3262880D1 (en) Tricyclic ethers, process for their preparation and their use in pharmaceutical preparations
AR005420A1 (es) Compuestos derivados de piperazinas y piperidinas con efecto analgésico, composiciones farmacéuticas que los contienen, uso de los mismos para la fabricación de un medicamento y un proceso para la preparación de dichos compuestos.
AR247733A1 (es) Procedimiento para obtener nuevos derivados de aminoacidos
ES2029812T3 (es) Un procedimiento para preparar alfa-alquil-4-amino-3-quinolina-metanoles y 1-(4-aralquilamino-3-quinolil)alcanonas.
ES2031876T3 (es) Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas.
ES2123652T3 (es) 7-(2-aminoetil)-benzotiazolonas.
BR9802804A (pt) Compostos benzimidazol, benzoxazol e benzotiazol, processo para sua preparação e composições farmacéuticas contendo os mesmos.
AR008291A1 (es) Derivados de tetrahidroisoquinolina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su uso para la preparacionde un medicamento.
ATE74352T1 (de) Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
ES2042593T3 (es) Procedimiento para la obtencion de derivados de la benzhidriloxietil-piperazina.
ES2058449T3 (es) Nuevas piperazinilalquil-3(2h)-piridazinonas, procedimiento para su obtencion y su empleo como agentes reductores de la presion sanguinea.
ES2058177T3 (es) Nuevos derivados de alcanosulfonanilida, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
ES8203352A1 (es) Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina
ES8507529A1 (es) Una piperazinilalcanoilanilida
HUT59393A (en) Process for producing 1-heterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
ATE39692T1 (de) Phenylalkansaeure-derivate.
AR013241A1 (es) Derivados del acido aminoetilfenoxiacetico, composicion farmaceutica que incluye a dicho derivado, medicamento para reducir el dolor y promover la eliminacion de calculos en urolitiasis, utilizacion de dicho derivado para la fabricacion de dicha composicion farmaceutica y procedimiento para la fabri
MX9304190A (es) Derivados novedosos de 4-[3-benzofuranil]piperidinilo y 4-[3-benzotientil]piperidinilo.
ATE37368T1 (de) Benzothiazolon-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES348344A1 (es) Procedimiento para la preparacion de diazepinas y oxa-(tia)xepinas sustituidas.
ES2003758A6 (es) Procedimiento para preparar nuevos derivados de acidos fenilaceticos
BR9101973A (pt) Compostos quimicos,processo para a sua preparacao e composicoes farmaceutica e terapeutica

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102