ES2004409A6 - Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos - Google Patents
Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidosInfo
- Publication number
- ES2004409A6 ES2004409A6 ES8701261A ES8701261A ES2004409A6 ES 2004409 A6 ES2004409 A6 ES 2004409A6 ES 8701261 A ES8701261 A ES 8701261A ES 8701261 A ES8701261 A ES 8701261A ES 2004409 A6 ES2004409 A6 ES 2004409A6
- Authority
- ES
- Spain
- Prior art keywords
- methoxy
- bis
- phenyl
- preparation
- piperazines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
LA INVENCION SE RELACIONA CON NUEVOS DERIVADOS PIPERAZINAS 1,4-DISUSTITUIDOS DE FORMULA GENERAL (I), CON SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, CON COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y CON UN PROCEDIMIENTO PARA SU PREPARACION.EN LA FORMULA GENERAL IR1 Y R2 SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO O HALOGENO O UN GRUPO ALQUILO INFERIOR, TRIHALOMETILO O ALCOXILO INFERIOR.LOS COMPUESTOS DE FORMULA GENERAL (I) SON TERAPEUTICAMENTE UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DERIVADAS DE UNA HIPOFUNCION DEL SISTEMA DOPAMINERGICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU861750A HU196195B (en) | 1986-04-28 | 1986-04-28 | Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2004409A6 true ES2004409A6 (es) | 1989-01-01 |
Family
ID=10956006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8701261A Expired ES2004409A6 (es) | 1986-04-28 | 1987-04-28 | Procedimiento parala preparacion de nuevos derivados piperazinas 1,4-disustituidos |
Country Status (14)
Country | Link |
---|---|
US (1) | US4866062A (es) |
EP (1) | EP0243904B1 (es) |
JP (1) | JPS62294674A (es) |
AT (1) | ATE57922T1 (es) |
AU (1) | AU595026B2 (es) |
CA (1) | CA1277986C (es) |
DE (1) | DE3765827D1 (es) |
DK (1) | DK213087A (es) |
ES (1) | ES2004409A6 (es) |
FI (1) | FI85267C (es) |
GR (1) | GR870662B (es) |
HU (1) | HU196195B (es) |
IL (1) | IL82358A (es) |
ZA (1) | ZA873028B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
ES2052890T3 (es) * | 1988-10-10 | 1994-07-16 | Akzo Nv | Un metodo para la sintesis de compuestos aromaticos di- y trisubstituidos. |
EP0507863A4 (en) * | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
DK178490D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
US5252586A (en) * | 1990-09-28 | 1993-10-12 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
FR2673182A1 (fr) * | 1991-02-22 | 1992-08-28 | Univ Caen | Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique. |
WO1993000811A1 (en) * | 1991-07-01 | 1993-01-21 | The General Hospital Corporation | Invertebrate phenylethanolamine transporter and the use thereof |
WO1995000131A1 (en) * | 1993-06-23 | 1995-01-05 | Cambridge Neuroscience, Incorporated | Sigma receptor ligands and the use thereof |
US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US6799637B2 (en) | 2000-10-20 | 2004-10-05 | Schlumberger Technology Corporation | Expandable tubing and method |
NO335594B1 (no) | 2001-01-16 | 2015-01-12 | Halliburton Energy Serv Inc | Ekspanderbare anordninger og fremgangsmåte for disse |
US8404330B2 (en) * | 2004-08-23 | 2013-03-26 | E I Du Pont De Nemours And Company | Breathable low-emissivity metallized sheets |
US8216600B2 (en) * | 2007-11-14 | 2012-07-10 | Cordis Corporation | Polymeric materials for medical devices |
WO2014138518A2 (en) * | 2013-03-08 | 2014-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof |
WO2019094856A1 (en) | 2017-11-13 | 2019-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Atypical inhibitors of monoamine transporters; method of making; and use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE530795A (es) * | ||||
BE530797A (es) * | ||||
BE530796A (es) * | ||||
US2988551A (en) * | 1954-07-30 | 1961-06-13 | Union Chimique Belge Sa | Piperazine derivatives |
CH396007A (fr) * | 1961-06-12 | 1965-07-31 | Pharma Yptor S A Lab | Procédé de fabrication de nouveaux dérivés de la pipérazine |
GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
NL8202636A (nl) * | 1982-06-29 | 1984-01-16 | Gist Brocades Nv | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
-
1986
- 1986-04-28 HU HU861750A patent/HU196195B/hu not_active IP Right Cessation
-
1987
- 1987-04-22 US US07/041,234 patent/US4866062A/en not_active Expired - Fee Related
- 1987-04-27 DK DK213087A patent/DK213087A/da not_active Application Discontinuation
- 1987-04-28 CA CA000535730A patent/CA1277986C/en not_active Expired - Fee Related
- 1987-04-28 ZA ZA873028A patent/ZA873028B/xx unknown
- 1987-04-28 FI FI871875A patent/FI85267C/fi not_active IP Right Cessation
- 1987-04-28 EP EP87106033A patent/EP0243904B1/de not_active Expired - Lifetime
- 1987-04-28 AU AU72159/87A patent/AU595026B2/en not_active Ceased
- 1987-04-28 GR GR870662A patent/GR870662B/el unknown
- 1987-04-28 AT AT87106033T patent/ATE57922T1/de not_active IP Right Cessation
- 1987-04-28 IL IL82358A patent/IL82358A/xx unknown
- 1987-04-28 JP JP62106157A patent/JPS62294674A/ja active Pending
- 1987-04-28 ES ES8701261A patent/ES2004409A6/es not_active Expired
- 1987-04-28 DE DE8787106033T patent/DE3765827D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE57922T1 (de) | 1990-11-15 |
HU196195B (en) | 1988-10-28 |
FI85267C (fi) | 1992-03-25 |
EP0243904B1 (de) | 1990-10-31 |
FI871875A0 (fi) | 1987-04-28 |
DK213087A (da) | 1987-10-29 |
AU7215987A (en) | 1987-10-29 |
JPS62294674A (ja) | 1987-12-22 |
HUT45038A (en) | 1988-05-30 |
FI85267B (fi) | 1991-12-13 |
AU595026B2 (en) | 1990-03-22 |
GR870662B (en) | 1987-09-02 |
US4866062A (en) | 1989-09-12 |
CA1277986C (en) | 1990-12-18 |
IL82358A (en) | 1991-03-10 |
FI871875A (fi) | 1987-10-29 |
IL82358A0 (en) | 1987-10-30 |
DK213087D0 (da) | 1987-04-27 |
DE3765827D1 (de) | 1990-12-06 |
ZA873028B (en) | 1987-10-21 |
EP0243904A1 (de) | 1987-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |