ZA873028B - 1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same - Google Patents

1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same

Info

Publication number
ZA873028B
ZA873028B ZA873028A ZA873028A ZA873028B ZA 873028 B ZA873028 B ZA 873028B ZA 873028 A ZA873028 A ZA 873028A ZA 873028 A ZA873028 A ZA 873028A ZA 873028 B ZA873028 B ZA 873028B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical compositions
compositions containing
piperazine derivatives
general formula
disubstituted piperazine
Prior art date
Application number
ZA873028A
Other languages
English (en)
Inventor
Toth Edit
Kiss Bela
Toerley Jozsef
Palosi Eva
Hajdu Istvan
Szporny Laszlo
Groo Dora
Lapis Erzsebet
Laszlovszky Istvan
Original Assignee
Richter Gedeon Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar filed Critical Richter Gedeon Vegyeszeti Gyar
Publication of ZA873028B publication Critical patent/ZA873028B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ZA873028A 1986-04-28 1987-04-28 1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same ZA873028B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU861750A HU196195B (en) 1986-04-28 1986-04-28 Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds

Publications (1)

Publication Number Publication Date
ZA873028B true ZA873028B (en) 1987-10-21

Family

ID=10956006

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA873028A ZA873028B (en) 1986-04-28 1987-04-28 1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same

Country Status (14)

Country Link
US (1) US4866062A (xx)
EP (1) EP0243904B1 (xx)
JP (1) JPS62294674A (xx)
AT (1) ATE57922T1 (xx)
AU (1) AU595026B2 (xx)
CA (1) CA1277986C (xx)
DE (1) DE3765827D1 (xx)
DK (1) DK213087A (xx)
ES (1) ES2004409A6 (xx)
FI (1) FI85267C (xx)
GR (1) GR870662B (xx)
HU (1) HU196195B (xx)
IL (1) IL82358A (xx)
ZA (1) ZA873028B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
ES2052890T3 (es) * 1988-10-10 1994-07-16 Akzo Nv Un metodo para la sintesis de compuestos aromaticos di- y trisubstituidos.
AU658134B2 (en) * 1989-12-28 1995-04-06 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5252586A (en) * 1990-09-28 1993-10-12 The Du Pont Merck Pharmaceutical Company Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
EP0714292A4 (en) * 1993-06-23 1996-10-09 Cambridge Neuroscience Inc SIGMA RECEPTOR LIGANDS AND THEIR USE
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6799637B2 (en) 2000-10-20 2004-10-05 Schlumberger Technology Corporation Expandable tubing and method
NO335594B1 (no) 2001-01-16 2015-01-12 Halliburton Energy Serv Inc Ekspanderbare anordninger og fremgangsmåte for disse
US8404330B2 (en) * 2004-08-23 2013-03-26 E I Du Pont De Nemours And Company Breathable low-emissivity metallized sheets
US8216600B2 (en) * 2007-11-14 2012-07-10 Cordis Corporation Polymeric materials for medical devices
WO2014138518A2 (en) 2013-03-08 2014-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
US11365195B2 (en) 2017-11-13 2022-06-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE530796A (xx) *
BE530797A (xx) *
BE530795A (xx) *
US2988551A (en) * 1954-07-30 1961-06-13 Union Chimique Belge Sa Piperazine derivatives
CH396007A (fr) * 1961-06-12 1965-07-31 Pharma Yptor S A Lab Procédé de fabrication de nouveaux dérivés de la pipérazine
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Also Published As

Publication number Publication date
ES2004409A6 (es) 1989-01-01
EP0243904A1 (de) 1987-11-04
DK213087A (da) 1987-10-29
JPS62294674A (ja) 1987-12-22
IL82358A (en) 1991-03-10
GR870662B (en) 1987-09-02
CA1277986C (en) 1990-12-18
US4866062A (en) 1989-09-12
AU7215987A (en) 1987-10-29
ATE57922T1 (de) 1990-11-15
HUT45038A (en) 1988-05-30
DE3765827D1 (de) 1990-12-06
AU595026B2 (en) 1990-03-22
DK213087D0 (da) 1987-04-27
FI871875A (fi) 1987-10-29
IL82358A0 (en) 1987-10-30
FI85267B (fi) 1991-12-13
FI871875A0 (fi) 1987-04-28
FI85267C (fi) 1992-03-25
HU196195B (en) 1988-10-28
EP0243904B1 (de) 1990-10-31

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