FI871875A - Foerfarande foer framstaellning av nya 1,4-disubstituerade piperazin-derivat. - Google Patents

Foerfarande foer framstaellning av nya 1,4-disubstituerade piperazin-derivat. Download PDF

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Publication number
FI871875A
FI871875A FI871875A FI871875A FI871875A FI 871875 A FI871875 A FI 871875A FI 871875 A FI871875 A FI 871875A FI 871875 A FI871875 A FI 871875A FI 871875 A FI871875 A FI 871875A
Authority
FI
Finland
Prior art keywords
preparation
general formula
piperazine derivatives
disubstitutes
framework
Prior art date
Application number
FI871875A
Other languages
English (en)
Other versions
FI871875A0 (fi
FI85267B (fi
FI85267C (fi
Inventor
Edit Toth
Bela Kiss
Jozsef Torley
Eva Palosi
Istvan Hajdu
Laszlo Szporny
Dora Groo
Erzsebet Lapis
Istvan Laszlovszky
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI871875A0 publication Critical patent/FI871875A0/fi
Publication of FI871875A publication Critical patent/FI871875A/fi
Publication of FI85267B publication Critical patent/FI85267B/fi
Application granted granted Critical
Publication of FI85267C publication Critical patent/FI85267C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
FI871875A 1986-04-28 1987-04-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,4-disubstituerade piperazinderivat. FI85267C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU175086 1986-04-28
HU861750A HU196195B (en) 1986-04-28 1986-04-28 Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds

Publications (4)

Publication Number Publication Date
FI871875A0 FI871875A0 (fi) 1987-04-28
FI871875A true FI871875A (fi) 1987-10-29
FI85267B FI85267B (fi) 1991-12-13
FI85267C FI85267C (fi) 1992-03-25

Family

ID=10956006

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871875A FI85267C (fi) 1986-04-28 1987-04-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,4-disubstituerade piperazinderivat.

Country Status (14)

Country Link
US (1) US4866062A (fi)
EP (1) EP0243904B1 (fi)
JP (1) JPS62294674A (fi)
AT (1) ATE57922T1 (fi)
AU (1) AU595026B2 (fi)
CA (1) CA1277986C (fi)
DE (1) DE3765827D1 (fi)
DK (1) DK213087A (fi)
ES (1) ES2004409A6 (fi)
FI (1) FI85267C (fi)
GR (1) GR870662B (fi)
HU (1) HU196195B (fi)
IL (1) IL82358A (fi)
ZA (1) ZA873028B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
EP0365064B1 (en) * 1988-10-10 1992-10-21 Akzo N.V. Substituted aromatic compounds having an action on the central nervous system
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5252586A (en) * 1990-09-28 1993-10-12 The Du Pont Merck Pharmaceutical Company Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6799637B2 (en) 2000-10-20 2004-10-05 Schlumberger Technology Corporation Expandable tubing and method
NO335594B1 (no) 2001-01-16 2015-01-12 Halliburton Energy Serv Inc Ekspanderbare anordninger og fremgangsmåte for disse
US8404330B2 (en) * 2004-08-23 2013-03-26 E I Du Pont De Nemours And Company Breathable low-emissivity metallized sheets
US8216600B2 (en) * 2007-11-14 2012-07-10 Cordis Corporation Polymeric materials for medical devices
AU2014225550C1 (en) 2013-03-08 2017-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
US11266395B2 (en) 2014-06-17 2022-03-08 Ganihand, LLC Devices and methods to provide hands free scleral depression during ophthalmic procedures
WO2019094856A1 (en) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE530797A (fi) *
BE530795A (fi) *
BE530796A (fi) *
US2988551A (en) * 1954-07-30 1961-06-13 Union Chimique Belge Sa Piperazine derivatives
CH396007A (fr) * 1961-06-12 1965-07-31 Pharma Yptor S A Lab Procédé de fabrication de nouveaux dérivés de la pipérazine
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Also Published As

Publication number Publication date
IL82358A (en) 1991-03-10
JPS62294674A (ja) 1987-12-22
HUT45038A (en) 1988-05-30
EP0243904A1 (de) 1987-11-04
HU196195B (en) 1988-10-28
FI871875A0 (fi) 1987-04-28
DK213087A (da) 1987-10-29
AU595026B2 (en) 1990-03-22
FI85267B (fi) 1991-12-13
CA1277986C (en) 1990-12-18
ATE57922T1 (de) 1990-11-15
ES2004409A6 (es) 1989-01-01
IL82358A0 (en) 1987-10-30
US4866062A (en) 1989-09-12
FI85267C (fi) 1992-03-25
AU7215987A (en) 1987-10-29
GR870662B (en) 1987-09-02
ZA873028B (en) 1987-10-21
EP0243904B1 (de) 1990-10-31
DE3765827D1 (de) 1990-12-06
DK213087D0 (da) 1987-04-27

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Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR RT