ES2003064T3 - Metodos de diagnostico para detectar linfomas en el hombre. - Google Patents
Metodos de diagnostico para detectar linfomas en el hombre.Info
- Publication number
- ES2003064T3 ES2003064T3 ES87305863T ES87305863T ES2003064T3 ES 2003064 T3 ES2003064 T3 ES 2003064T3 ES 87305863 T ES87305863 T ES 87305863T ES 87305863 T ES87305863 T ES 87305863T ES 2003064 T3 ES2003064 T3 ES 2003064T3
- Authority
- ES
- Spain
- Prior art keywords
- detect
- lymphomas
- man
- diagnostic methods
- chromosomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA SECUENCIA DE LAS REGIONES DE CODIFICACION DE PROTEINAS DEL GEN BCL-2 ESTA PROVISTAS AL IGUAL QUE CLONES DE BACTERIAS QUE PRODUCEN LAS PROTEINAS. SE HAN HECHO INTENTOS PARA DETECTAR UNA CLASE DE CELULA-B NEOPLASMAS ASOCIADOS CON UNA RECOLOCACION DE CROMOSOMAS ENTRE LOS CROMOSOMAS 14 Y 18. ESTA RECOLECCION ESTA PRESENTE EN LA MAYORIA DE LOS CASOS DE LINFOSOMAS FOLICULARES DE PERSONAS. UN INTENTO EMPLEA UN ANTICUERPO QUE ES INMUNOREACTIVO CON UNA PROTEINA HUMANA QUE ESTA SOBRECOMPRIMIDA DEBIDO A UNA RECOLECCION DE CROMOSOMAS. OTRO INTENTO INCLUYE LA MEDIDA DE LA CANTIDAD DE MRNA QUE HIBRIDIZA UN GEN PROXIMO PARA RECOLOCAR UN PUNTO DE RUPTURA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/883,687 US5015568A (en) | 1986-07-09 | 1986-07-09 | Diagnostic methods for detecting lymphomas in humans |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2003064A4 ES2003064A4 (es) | 1988-10-16 |
ES2003064T3 true ES2003064T3 (es) | 1994-09-01 |
Family
ID=25383120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87305863T Expired - Lifetime ES2003064T3 (es) | 1986-07-09 | 1987-07-02 | Metodos de diagnostico para detectar linfomas en el hombre. |
Country Status (9)
Country | Link |
---|---|
US (5) | US5015568A (es) |
EP (1) | EP0252685B1 (es) |
JP (1) | JPS63100379A (es) |
AT (1) | ATE90792T1 (es) |
AU (1) | AU602704B2 (es) |
CA (1) | CA1340827C (es) |
DE (2) | DE252685T1 (es) |
ES (1) | ES2003064T3 (es) |
GR (1) | GR880300131T1 (es) |
Families Citing this family (90)
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---|---|---|---|---|
US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
US6841541B1 (en) | 1992-02-21 | 2005-01-11 | The Trustees Of The University Of Pennsylvania | Regulation of BCL-2-gene expression |
EP0480970A1 (en) * | 1989-07-03 | 1992-04-22 | Temple University - Of The Commonwealth System Higher Education | Tcl-5 gene rearrangement involved in t-cell leukemia and melanoma |
WO1991009974A1 (en) * | 1989-12-27 | 1991-07-11 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Diagnostic probe for detecting human stomach cancer |
WO1991013172A1 (en) * | 1990-02-23 | 1991-09-05 | The Board Of Trustees Of The Leland Stanford Junior University | Transcription factors having a pathogenetic role in human neoplasias |
IT1255770B (it) * | 1992-05-22 | 1995-11-15 | Consiglio Nazionale Ricerche | Oligonucleotidi antisenso ad attivita' antitumorale, composizioni farmaceutiche che li comprendono, e loro impieghi |
US6902732B2 (en) | 1992-06-12 | 2005-06-07 | Massachusetts Institute Of Technology | Identification and characterization of a gene which protects cells from programmed cell death and uses therefor |
WO1993025683A1 (en) | 1992-06-12 | 1993-12-23 | Massachusetts Institute Of Technology | A gene which prevents programmed cell death |
US5501952A (en) * | 1992-07-17 | 1996-03-26 | Aprogenex, Inc. | Analogues of reporter groups as background reducers in hybridization assays |
US5641672A (en) * | 1993-06-09 | 1997-06-24 | The Trustees Of Columbia University In The City Of New York | Cloning and uses of the genetic locus bcl-6 |
US5646008A (en) * | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
US5622852A (en) * | 1994-10-31 | 1997-04-22 | Washington University | Bcl-x/Bcl-2 associated cell death regulator |
US6696548B2 (en) | 1993-12-03 | 2004-02-24 | St. Jude Children's Research Hospital | Antibodies for recognition of alk protein tyrosine/kinase receptor |
US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
US5672686A (en) * | 1994-08-09 | 1997-09-30 | Immunogen, Inc. | Bcl-Y - specific antibodies |
US7175995B1 (en) | 1994-10-27 | 2007-02-13 | Thomas Jefferson University | TCL-1 protein and related methods |
US5985598A (en) * | 1994-10-27 | 1999-11-16 | Thomas Jefferson University | TCL-1 gene and protein and related methods and compositions |
US5789389A (en) * | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
US5695944A (en) * | 1995-05-05 | 1997-12-09 | Thomas Jefferson University | Modulation of bcl-2 phosphorylation |
US6221615B1 (en) | 1995-05-12 | 2001-04-24 | Apoptosis Technology, Inc. | Peptides and compositions which modulate apoptosis |
US5656725A (en) * | 1995-05-12 | 1997-08-12 | Apoptosis Technology, Inc. | Peptides and compositions which modulate apoptosis |
US5789201A (en) * | 1996-02-23 | 1998-08-04 | Cocensys, Inc. | Genes coding for bcl-y a bcl-2 homologue |
AUPN896596A0 (en) * | 1996-03-27 | 1996-04-26 | Walter And Eliza Hall Institute Of Medical Research, The | Therapeutic molecules |
AU728863B2 (en) * | 1996-03-27 | 2001-01-18 | Walter And Eliza Hall Institute Of Medical Research, The | A novel mammalian gene, bcl-w, belongs to the bcl-2 family of apoptosis-controlling genes |
US5821082A (en) | 1996-05-23 | 1998-10-13 | St. Louis University Health Sciences Center | Anti-proliferation domain of a human Bcl-2 and DNA encoding the same |
US6977244B2 (en) * | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US5837838A (en) | 1997-03-14 | 1998-11-17 | The Burnham Institute | Bax inhibitor proteins |
WO1998044142A1 (en) | 1997-04-01 | 1998-10-08 | The General Hospital Corporation | Molecular marker for muscle stem cells |
EP0878552A1 (en) * | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
US6849400B1 (en) | 1997-07-23 | 2005-02-01 | Gen-Probe Incorporated | Methods for detecting and measuring spliced nucleic acids |
US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
US20010041342A1 (en) * | 1998-04-01 | 2001-11-15 | The General Hospital Corporation, A Massachusetts Corporation | Molecular marker for muscle stem cells |
CA2327542C (en) * | 1998-05-04 | 2011-11-22 | Dako A/S | Method and probes for the detection of chromosome aberrations |
WO2001051923A2 (en) * | 2000-01-14 | 2001-07-19 | Mitokor | Screening assays using intramitochondrial calcium |
US20010053769A1 (en) * | 2000-01-21 | 2001-12-20 | Christiane Ferran | Use of pro-apoptotic factors in treatment of atherosclerosis |
US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
US20030044803A1 (en) * | 2000-09-22 | 2003-03-06 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of JAK1 |
US20030077590A1 (en) * | 2000-09-22 | 2003-04-24 | Pedersen Finn Skou | Methods for diagnosis and treatment of diseases associated with altered expression of neurogranin |
US20040147473A1 (en) * | 2000-11-10 | 2004-07-29 | Warrell Raymond P. | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
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CN105902559A (zh) * | 2005-08-01 | 2016-08-31 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
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ES2562077T3 (es) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Regiones ultraconservadas que codifican ARNnc |
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CN104364390B (zh) | 2011-10-14 | 2016-08-24 | 俄亥俄州立大学 | 与卵巢癌相关的方法和材料 |
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CN105936932A (zh) | 2012-01-20 | 2016-09-14 | 俄亥俄州立大学 | 浸润性和预后的乳腺癌生物标志物标签 |
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US3755086A (en) * | 1971-02-09 | 1973-08-28 | Hoffmann La Roche | Diagnostic method utilizing synthetic deoxyrilionucleotide oligomer template |
US4535058A (en) * | 1982-10-01 | 1985-08-13 | Massachusetts Institute Of Technology | Characterization of oncogenes and assays based thereon |
US4661586A (en) * | 1981-11-17 | 1987-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal anti-idiotype antibodies |
US4582788A (en) * | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
US4513088A (en) * | 1983-03-30 | 1985-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Assay for monoclonal antibody against surface Ig of a human B cell tumor |
US4798787A (en) * | 1984-09-19 | 1989-01-17 | Cetus Corporation | Peptide antibodies and their use in detecting oncogene products |
US4679918A (en) * | 1984-10-23 | 1987-07-14 | Ace Ronald S | Ophthalmic glass/plastic laminated lens having photochromic characteristics and assembly thereof |
US4701409A (en) * | 1984-11-15 | 1987-10-20 | The Wistar Institute | Detection of B-cell neoplasms |
US4692405A (en) * | 1985-03-05 | 1987-09-08 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies to antigen on activated human B-cells and assay therefor, protein antigenic determinant therefor and method of making same |
IL79755A0 (en) * | 1985-08-21 | 1986-11-30 | Oncogene Science Inc | Immunoassay for detection of ras encoded protein |
US5015568A (en) * | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
IT1244983B (it) * | 1991-04-29 | 1994-09-13 | Raggio Italgene Spa | Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione. |
-
1986
- 1986-07-09 US US06/883,687 patent/US5015568A/en not_active Expired - Lifetime
-
1987
- 1987-07-02 AT AT87305863T patent/ATE90792T1/de not_active IP Right Cessation
- 1987-07-02 DE DE198787305863T patent/DE252685T1/de active Pending
- 1987-07-02 EP EP87305863A patent/EP0252685B1/en not_active Expired - Lifetime
- 1987-07-02 ES ES87305863T patent/ES2003064T3/es not_active Expired - Lifetime
- 1987-07-02 DE DE87305863T patent/DE3786200T2/de not_active Expired - Lifetime
- 1987-07-08 CA CA000541606A patent/CA1340827C/en not_active Expired - Lifetime
- 1987-07-08 AU AU75328/87A patent/AU602704B2/en not_active Expired
- 1987-07-09 JP JP62172023A patent/JPS63100379A/ja active Pending
-
1988
- 1988-12-16 GR GR88300131T patent/GR880300131T1/el unknown
-
1992
- 1992-12-23 US US07/994,941 patent/US5595869A/en not_active Expired - Lifetime
-
1994
- 1994-04-18 US US08/228,704 patent/US5459251A/en not_active Expired - Lifetime
-
1995
- 1995-05-05 US US08/435,181 patent/US5523393A/en not_active Expired - Lifetime
- 1995-05-05 US US08/435,193 patent/US5506344A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2003064A4 (es) | 1988-10-16 |
GR880300131T1 (en) | 1988-12-16 |
AU7532887A (en) | 1988-02-18 |
DE3786200D1 (de) | 1993-07-22 |
US5595869A (en) | 1997-01-21 |
US5459251A (en) | 1995-10-17 |
US5506344A (en) | 1996-04-09 |
US5015568A (en) | 1991-05-14 |
AU602704B2 (en) | 1990-10-25 |
EP0252685B1 (en) | 1993-06-16 |
ATE90792T1 (de) | 1993-07-15 |
JPS63100379A (ja) | 1988-05-02 |
EP0252685A2 (en) | 1988-01-13 |
DE252685T1 (de) | 1988-06-30 |
EP0252685A3 (en) | 1990-07-11 |
CA1340827C (en) | 1999-11-23 |
DE3786200T2 (de) | 1993-10-07 |
US5523393A (en) | 1996-06-04 |
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