ES2043596T3 - Feniloxazolonas cardiotonicas. - Google Patents

Feniloxazolonas cardiotonicas.

Info

Publication number
ES2043596T3
ES2043596T3 ES86115562T ES86115562T ES2043596T3 ES 2043596 T3 ES2043596 T3 ES 2043596T3 ES 86115562 T ES86115562 T ES 86115562T ES 86115562 T ES86115562 T ES 86115562T ES 2043596 T3 ES2043596 T3 ES 2043596T3
Authority
ES
Spain
Prior art keywords
phenyloxazolones
cardiotonic
oxazolones
infarcts
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86115562T
Other languages
English (en)
Inventor
Richard A Schnettler
George P Claxton
Winton D Jones Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2043596T3 publication Critical patent/ES2043596T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

CONSISTE EN EL EMPLEO DE FENIL OXAZOLONAS PARA EL TRATAMIENTO DE INFARTOS Y MEJORA DE LAS FUNCIONES CARDIACAS.
ES86115562T 1985-11-13 1986-11-10 Feniloxazolonas cardiotonicas. Expired - Lifetime ES2043596T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/797,578 US4728661A (en) 1985-11-13 1985-11-13 Cardiotonic phenyl oxazolones

Publications (1)

Publication Number Publication Date
ES2043596T3 true ES2043596T3 (es) 1994-01-01

Family

ID=25171228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86115562T Expired - Lifetime ES2043596T3 (es) 1985-11-13 1986-11-10 Feniloxazolonas cardiotonicas.

Country Status (6)

Country Link
US (2) US4728661A (es)
EP (1) EP0223177B1 (es)
JP (1) JPS62135422A (es)
AT (1) ATE79615T1 (es)
DE (1) DE3686472T2 (es)
ES (1) ES2043596T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4866182A (en) * 1988-02-18 1989-09-12 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoyl and aroyl oxazolones
US4999431A (en) * 1988-10-24 1991-03-12 Merrell Dow Pharmaceuticals Process for preparing quinoline aldehyde and ketone derivatives
US4990519A (en) * 1988-10-24 1991-02-05 Merrell Dow Pharmaceuticals Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
US4886811A (en) * 1988-10-24 1989-12-12 Merrell Dow Pharmaceuticals Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
ES2106874T3 (es) * 1991-05-14 1997-11-16 Merrell Pharma Inc Inhibicion de metastasis en pacientes que padecen un cancer con la ayuda de piridiniloxazol-2-onas.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
FR2156486A1 (en) * 1971-10-22 1973-06-01 Roussel Uclaf Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories
SU427015A1 (ru) * 1972-04-21 1974-05-05 В. М. Дзиомко , А. В. Иващенко Способ получения замещенных 4-оксазолин-2-онов
US3930008A (en) * 1972-10-16 1975-12-30 Luso Farmaco Inst 4-Aryl-5-aminoalkyl-4-oxazolin-2-ones
US3897410A (en) * 1973-06-04 1975-07-29 Dow Chemical Co Rapid setting non-elastomeric polyurethane compositions prepared in the presence of a mixture of liquid modifiers
JPS5111763A (en) * 1974-07-16 1976-01-30 Sankyo Co 55 chikan 44 okisazorin 22 onno seizoho
JPS5811867B2 (ja) * 1974-11-06 1983-03-04 東京田辺製薬株式会社 ５，５−ジメチル−４−フエニルオキサゾリジン−２−オン誘導体の製造方法
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
DE2935902A1 (de) * 1979-09-05 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln Oxazolinalkansaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones

Also Published As

Publication number Publication date
EP0223177B1 (en) 1992-08-19
JPS62135422A (ja) 1987-06-18
DE3686472T2 (de) 1993-01-21
US4866085A (en) 1989-09-12
ATE79615T1 (de) 1992-09-15
EP0223177A1 (en) 1987-05-27
US4728661A (en) 1988-03-01
DE3686472D1 (de) 1992-09-24

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