DE3686472T2 - Cardiotonische phenyloxazolone. - Google Patents

Cardiotonische phenyloxazolone.

Info

Publication number
DE3686472T2
DE3686472T2 DE8686115562T DE3686472T DE3686472T2 DE 3686472 T2 DE3686472 T2 DE 3686472T2 DE 8686115562 T DE8686115562 T DE 8686115562T DE 3686472 T DE3686472 T DE 3686472T DE 3686472 T2 DE3686472 T2 DE 3686472T2
Authority
DE
Germany
Prior art keywords
phenyloxazolone
cardiotonic
phenyloxazolones
cardiotonics
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686115562T
Other languages
English (en)
Other versions
DE3686472D1 (de
Inventor
Richard A Schnettler
George P Claxton
Jones, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3686472D1 publication Critical patent/DE3686472D1/de
Publication of DE3686472T2 publication Critical patent/DE3686472T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8686115562T 1985-11-13 1986-11-10 Cardiotonische phenyloxazolone. Expired - Fee Related DE3686472T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/797,578 US4728661A (en) 1985-11-13 1985-11-13 Cardiotonic phenyl oxazolones

Publications (2)

Publication Number Publication Date
DE3686472D1 DE3686472D1 (de) 1992-09-24
DE3686472T2 true DE3686472T2 (de) 1993-01-21

Family

ID=25171228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686115562T Expired - Fee Related DE3686472T2 (de) 1985-11-13 1986-11-10 Cardiotonische phenyloxazolone.

Country Status (6)

Country Link
US (2) US4728661A (de)
EP (1) EP0223177B1 (de)
JP (1) JPS62135422A (de)
AT (1) ATE79615T1 (de)
DE (1) DE3686472T2 (de)
ES (1) ES2043596T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4866182A (en) * 1988-02-18 1989-09-12 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoyl and aroyl oxazolones
US4990519A (en) * 1988-10-24 1991-02-05 Merrell Dow Pharmaceuticals Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
US4999431A (en) * 1988-10-24 1991-03-12 Merrell Dow Pharmaceuticals Process for preparing quinoline aldehyde and ketone derivatives
US4886811A (en) * 1988-10-24 1989-12-12 Merrell Dow Pharmaceuticals Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
ATE155686T1 (de) * 1991-05-14 1997-08-15 Merrell Pharma Inc Hemmung von metastasen bei krebspatienten mit pyridyloxazol-2-onen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
FR2156486A1 (en) * 1971-10-22 1973-06-01 Roussel Uclaf Oxazolyl oxy or thio acetic acids - analgesics antipyretics and anti-inflammatories
SU427015A1 (ru) * 1972-04-21 1974-05-05 В. М. Дзиомко , А. В. Иващенко Способ получения замещенных 4-оксазолин-2-онов
US3930008A (en) * 1972-10-16 1975-12-30 Luso Farmaco Inst 4-Aryl-5-aminoalkyl-4-oxazolin-2-ones
US3897410A (en) * 1973-06-04 1975-07-29 Dow Chemical Co Rapid setting non-elastomeric polyurethane compositions prepared in the presence of a mixture of liquid modifiers
JPS5111763A (en) * 1974-07-16 1976-01-30 Sankyo Co 55 chikan 44 okisazorin 22 onno seizoho
JPS5811867B2 (ja) * 1974-11-06 1983-03-04 東京田辺製薬株式会社 ５，５−ジメチル−４−フエニルオキサゾリジン−２−オン誘導体の製造方法
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
DE2935902A1 (de) * 1979-09-05 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln Oxazolinalkansaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones

Also Published As

Publication number Publication date
EP0223177A1 (de) 1987-05-27
ES2043596T3 (es) 1994-01-01
US4866085A (en) 1989-09-12
US4728661A (en) 1988-03-01
EP0223177B1 (de) 1992-08-19
ATE79615T1 (de) 1992-09-15
DE3686472D1 (de) 1992-09-24
JPS62135422A (ja) 1987-06-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee