ES2002750A6 - Procedimiento de obtencion de composiciones en emulsion para la administracion parenteral ynu oral de farmacos hidrofobos ionizables, escasamente hidrosolubles. - Google Patents

Procedimiento de obtencion de composiciones en emulsion para la administracion parenteral ynu oral de farmacos hidrofobos ionizables, escasamente hidrosolubles.

Info

Publication number
ES2002750A6
ES2002750A6 ES8601914A ES8601914A ES2002750A6 ES 2002750 A6 ES2002750 A6 ES 2002750A6 ES 8601914 A ES8601914 A ES 8601914A ES 8601914 A ES8601914 A ES 8601914A ES 2002750 A6 ES2002750 A6 ES 2002750A6
Authority
ES
Spain
Prior art keywords
emulsion compositions
parenteral
oral administration
water soluble
hydrophobic drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601914A
Other languages
English (en)
Inventor
Narendra Raghun Desai
Madurai Ganesan
Eugene Albert Carpentier
Edward Charles Shinal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES2002750A6 publication Critical patent/ES2002750A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPOSICIONES EN EMULSION PARA LA ADMINISTRACION PARENTERAL Y/U ORAL DE FARMACOS HIDDROFOBOS IONIZABLES, ESCASAMENTE HIDROSOLUBLES, QUE COMPRENDE COMBINAR UN FARMACO HIDROFOBO QUE PUEDE SER UN SOLIDO IONIZABLE, ESCASAMENTE HIDROSOLUBLE O UN LIQUIDO OLEOSO, VISCOSO, HIDROINSOLUBLE, Y PUEDE SER UN FARMACO BASICO QUE TENGA UN VALOR PKA MENOR O MAS PROXIMO AL PH FISIOLOGICO O UN FARMACO ACIDO QUE TENGA UN VALOR PKA MAYOR O MAS PROXIMO AL PH FISIOLOGICO, CON UN VEHICULO OLEAGINOSO O ACEITE ACEPTABLE FARMACEUTICAMENTE; EN PRESENCIA DE UN AGENTE TENSOACTIVO O EMULSOR AUXILIAR; Y ALCOHOL BENCILICO EN CANTIDAD SUFICIENTE PARA ACTUAR COMO CODISOLVENTE DEL FARMACO EN CUESTION.
ES8601914A 1985-09-16 1986-09-15 Procedimiento de obtencion de composiciones en emulsion para la administracion parenteral ynu oral de farmacos hidrofobos ionizables, escasamente hidrosolubles. Expired ES2002750A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/776,306 US4784845A (en) 1985-09-16 1985-09-16 Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs

Publications (1)

Publication Number Publication Date
ES2002750A6 true ES2002750A6 (es) 1988-10-01

Family

ID=25107019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601914A Expired ES2002750A6 (es) 1985-09-16 1986-09-15 Procedimiento de obtencion de composiciones en emulsion para la administracion parenteral ynu oral de farmacos hidrofobos ionizables, escasamente hidrosolubles.

Country Status (18)

Country Link
US (1) US4784845A (es)
EP (1) EP0215313B1 (es)
JP (1) JPS6267018A (es)
KR (1) KR890004684B1 (es)
AR (1) AR242716A1 (es)
AT (1) ATE78683T1 (es)
AU (1) AU591705B2 (es)
CA (1) CA1272447A (es)
DE (1) DE3686221T2 (es)
DK (1) DK165730C (es)
ES (1) ES2002750A6 (es)
FI (1) FI863728A (es)
GR (1) GR862354B (es)
HU (1) HU199282B (es)
NO (1) NO863670L (es)
NZ (1) NZ217484A (es)
PH (1) PH23736A (es)
ZA (1) ZA867009B (es)

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WO1999043301A1 (en) * 1998-02-24 1999-09-02 The Board Of Trustees Of The University Of Illinois Lipid emulsions in the treatment of systemic poisoning
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
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Also Published As

Publication number Publication date
EP0215313A2 (en) 1987-03-25
DK165730C (da) 1993-06-07
NO863670L (no) 1987-03-17
CA1272447A (en) 1990-08-07
FI863728A0 (fi) 1986-09-15
EP0215313B1 (en) 1992-07-29
DK438286D0 (da) 1986-09-12
PH23736A (en) 1989-11-03
NZ217484A (en) 1990-04-26
NO863670D0 (no) 1986-09-15
AU591705B2 (en) 1989-12-14
ZA867009B (en) 1987-07-29
ATE78683T1 (de) 1992-08-15
FI863728A (fi) 1987-03-17
GR862354B (en) 1987-01-19
AR242716A1 (es) 1993-05-31
DE3686221D1 (de) 1992-09-03
JPS6267018A (ja) 1987-03-26
AU6269686A (en) 1987-03-19
KR890004684B1 (ko) 1989-11-25
EP0215313A3 (en) 1987-09-09
HU199282B (en) 1990-02-28
HUT43947A (en) 1988-01-28
US4784845A (en) 1988-11-15
KR870002835A (ko) 1987-04-13
DK165730B (da) 1993-01-11
DE3686221T2 (de) 1993-02-25
DK438286A (da) 1987-03-17

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-15

FD1A Patent lapsed

Effective date: 20001009