KR900001373A - 지용성 비타민k 함유 수용액 - Google Patents

지용성 비타민k 함유 수용액 Download PDF

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Publication number
KR900001373A
KR900001373A KR1019890009859A KR890009859A KR900001373A KR 900001373 A KR900001373 A KR 900001373A KR 1019890009859 A KR1019890009859 A KR 1019890009859A KR 890009859 A KR890009859 A KR 890009859A KR 900001373 A KR900001373 A KR 900001373A
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KR
South Korea
Prior art keywords
oil
fat
aqueous solution
vitamin
soluble vitamin
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Application number
KR1019890009859A
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English (en)
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KR920002326B1 (ko
Inventor
가쓰미 이다
다까유끼 이께우찌
마사노리 가야노
Original Assignee
나이또오 하루오
에자이 가부시끼가이샤
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Publication of KR900001373A publication Critical patent/KR900001373A/ko
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Publication of KR920002326B1 publication Critical patent/KR920002326B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

지용성 비타민K 함유 수용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 식물성유, 글리세롤 지방산 에스테르 또는 소르비탄지방산 에스테르를 전수용액을 기준으로, 0.004 내지 5중량%의 양으로, 메나테트레논(비타민 K2) 또는 피토나디온(비타민 K1) 및 수소화 레시틴을 함유하는 수용액에 가하여 제조하는 것을 특징으로 하는 지용성 비타민 K함유 수용액.
  2. 제 1항에 있어서, 상기 식물성유가 대두유, 참기름, 올리브유, 면실유, 추바키유, 평지씨유, 낙화생유 및 옥수수유중에서 선택되는 것을 특징으로 하는 지용성 비타민 K함유 수용액.
  3. 제 1항에 있어서, 상기 글리세롤 지방산 에스테르가 글리세롤과 올레산, 스테아르산 또는 팔미트산의 모노- 또는 트리에스테르이거나 글리세롤과 8 내지 12탄소원자를 가지는 지방산의 트리에스테르로 이루어지는 것을 특징으로 하는 지용성 비타민 K함유 수용액.
  4. 제 1항에 있어서, 상기 소르비탄 지방산 에스테르가 소르비탄과 올레산, 스테아르산 또는 팔미트산의 모노-, 쉐스퀴- 또는 트리에스테르로 이루어지는 것을 특징으로 하는 지용성 비타민 K함유 수용액.
  5. 제 1항에 있어서, 0.1 내지 1.0중량%의 비타민 K1과 K2및 0.05 내지 3중량%의 수소화 레시틴으로 이루어지는 것을 특징으로 하는, 지용성 비타민 K함유 수용액.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009859A 1988-07-11 1989-07-11 지용성 비타민 k 함유 수용액 KR920002326B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP63-172,463 1988-07-11
JP63172463A JPH0681739B2 (ja) 1988-07-11 1988-07-11 脂溶性ビタミンｋ含有水性液
JP88-172,463 1988-07-11

Publications (2)

Publication Number Publication Date
KR900001373A true KR900001373A (ko) 1990-02-27
KR920002326B1 KR920002326B1 (ko) 1992-03-21

Family

ID=15942461

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890009859A KR920002326B1 (ko) 1988-07-11 1989-07-11 지용성 비타민 k 함유 수용액

Country Status (7)

Country Link
US (1) US5021570A (ko)
EP (1) EP0350864B1 (ko)
JP (1) JPH0681739B2 (ko)
KR (1) KR920002326B1 (ko)
AT (1) ATE74754T1 (ko)
CA (1) CA1340171C (ko)
DE (1) DE68901222D1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175232A (en) * 1992-05-22 1992-12-29 The United States Of America As Represented By The Secretary Of The Air Force Rigid-rod benzobisazole copolymer containing cyclic phosphate ester
DE4405545A1 (de) * 1994-02-22 1995-08-31 Dietl Hans Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation
DE19645657A1 (de) * 1996-11-06 1998-05-28 Rhone Poulenc Rorer Gmbh Phospholipidische Zusammensetzung, Verfahren zur Herstellung einer derartigen Zusammensetzung und Verwendung derselben
US7138433B2 (en) * 2002-09-16 2006-11-21 Eisai Co., Ltd. Quinone-based therapeutic agent for hepatopathy
US20060194883A1 (en) * 2003-04-23 2006-08-31 Eisai Co., Ltd Mmp expression inhibitor
KR20060111666A (ko) * 2004-01-06 2006-10-27 에자이 가부시키가이샤 퀴논계 화합물을 유효 성분으로 하는 간암의 발암 예방제
JP5103608B2 (ja) * 2006-02-10 2012-12-19 国立大学法人名古屋大学 肝癌治療又は予防用医薬組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356315A (en) 1976-11-01 1978-05-22 Eisai Co Ltd Emulsified solution of fat soluble drugs
JPS5562010A (en) 1978-10-31 1980-05-10 Ajinomoto Co Inc Fat emulsion for intravenous injection
JPS5955818A (ja) * 1982-09-22 1984-03-31 Mohan Yakuhin Kenkyusho:Kk 安定なビタミンｋ注射剤の製造法
JPS59104313A (ja) 1982-12-06 1984-06-16 Ajinomoto Co Inc 脂溶性ビタミン含有水性液
JPS6025918A (ja) 1983-07-25 1985-02-08 Ajinomoto Co Inc 脂溶性薬物含有水性液
JPS61151132A (ja) * 1984-12-24 1986-07-09 Kanebo Ltd ビタミンｋ↓２経口剤の製造法
US5023271A (en) * 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions

Also Published As

Publication number Publication date
CA1340171C (en) 1998-12-08
DE68901222D1 (de) 1992-05-21
KR920002326B1 (ko) 1992-03-21
JPH0681739B2 (ja) 1994-10-19
ATE74754T1 (de) 1992-05-15
US5021570A (en) 1991-06-04
EP0350864B1 (en) 1992-04-15
EP0350864A1 (en) 1990-01-17
JPH0222241A (ja) 1990-01-25

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