ATE80795T1 - Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe. - Google Patents

Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe.

Info

Publication number
ATE80795T1
ATE80795T1 AT86111325T AT86111325T ATE80795T1 AT E80795 T1 ATE80795 T1 AT E80795T1 AT 86111325 T AT86111325 T AT 86111325T AT 86111325 T AT86111325 T AT 86111325T AT E80795 T1 ATE80795 T1 AT E80795T1
Authority
AT
Austria
Prior art keywords
administration
emulsions
hydrophobic drugs
water slowly
slowly soluble
Prior art date
Application number
AT86111325T
Other languages
English (en)
Inventor
Narendra Raghunthji Desai
Eugene Albert Carpentier
Madurai Ganesan
Edward Charles Shinal
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE80795T1 publication Critical patent/ATE80795T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Colloid Chemistry (AREA)
AT86111325T 1985-09-11 1986-08-16 Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe. ATE80795T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/774,762 US4816247A (en) 1985-09-11 1985-09-11 Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
EP86111325A EP0214501B1 (de) 1985-09-11 1986-08-16 Emulsionen zur Verabreichung in Wasser schwerlöslicher ionisierbarer basischer hydrophober Arzneistoffe

Publications (1)

Publication Number Publication Date
ATE80795T1 true ATE80795T1 (de) 1992-10-15

Family

ID=25102201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86111325T ATE80795T1 (de) 1985-09-11 1986-08-16 Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe.

Country Status (18)

Country Link
US (1) US4816247A (de)
EP (1) EP0214501B1 (de)
JP (1) JPS62111915A (de)
KR (1) KR900000211B1 (de)
AT (1) ATE80795T1 (de)
AU (1) AU593014B2 (de)
CA (1) CA1272685A (de)
DE (1) DE3686797T2 (de)
DK (1) DK432586A (de)
ES (1) ES2001950A6 (de)
FI (1) FI86142C (de)
GR (1) GR862316B (de)
HU (1) HU196700B (de)
IE (1) IE59828B1 (de)
NO (1) NO171145C (de)
NZ (1) NZ217483A (de)
PH (1) PH24313A (de)
ZA (1) ZA866899B (de)

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US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
EP1280556A1 (de) 2000-05-05 2003-02-05 Wisconsin Alumni Research Foundation Zusammensetzungen und verfahren zum schutz von zellen während der chemotherpie und strahlentherapie
EP1303261B1 (de) * 2000-07-24 2005-03-09 Pharmacia & Upjohn Company Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln
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US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
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US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
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US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
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Also Published As

Publication number Publication date
CA1272685A (en) 1990-08-14
KR870002834A (ko) 1987-04-13
JPS62111915A (ja) 1987-05-22
DE3686797D1 (de) 1992-10-29
ZA866899B (en) 1987-05-27
NO863620D0 (no) 1986-09-10
IE59828B1 (en) 1994-04-06
DK432586A (da) 1987-03-12
AU6253886A (en) 1987-03-12
GR862316B (en) 1987-01-13
KR900000211B1 (ko) 1990-01-23
IE862408L (en) 1987-03-11
ES2001950A6 (es) 1988-07-01
EP0214501A3 (en) 1987-09-09
AU593014B2 (en) 1990-02-01
FI86142B (fi) 1992-04-15
FI863664A0 (fi) 1986-09-10
DE3686797T2 (de) 1993-03-25
NO171145B (no) 1992-10-26
DK432586D0 (da) 1986-09-10
HU196700B (en) 1989-01-30
EP0214501B1 (de) 1992-09-23
FI863664L (fi) 1987-03-12
EP0214501A2 (de) 1987-03-18
HUT43948A (en) 1988-01-28
US4816247A (en) 1989-03-28
FI86142C (fi) 1992-07-27
PH24313A (en) 1990-05-29
NO171145C (no) 1993-02-03
NZ217483A (en) 1990-08-28
NO863620L (no) 1987-03-12

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