DE3686797T2 - Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe. - Google Patents

Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe.

Info

Publication number
DE3686797T2
DE3686797T2 DE8686111325T DE3686797T DE3686797T2 DE 3686797 T2 DE3686797 T2 DE 3686797T2 DE 8686111325 T DE8686111325 T DE 8686111325T DE 3686797 T DE3686797 T DE 3686797T DE 3686797 T2 DE3686797 T2 DE 3686797T2
Authority
DE
Germany
Prior art keywords
administration
emulsions
water liquid
medicinal products
basic hydrophobic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686111325T
Other languages
English (en)
Other versions
DE3686797D1 (de
Inventor
Narendra Raghunthji Desai
Eugene Albert Carpentier
Madurai Ganesan
Edward Charles Shinal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE3686797D1 publication Critical patent/DE3686797D1/de
Publication of DE3686797T2 publication Critical patent/DE3686797T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Colloid Chemistry (AREA)
DE8686111325T 1985-09-11 1986-08-16 Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe. Expired - Fee Related DE3686797T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/774,762 US4816247A (en) 1985-09-11 1985-09-11 Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs

Publications (2)

Publication Number Publication Date
DE3686797D1 DE3686797D1 (de) 1992-10-29
DE3686797T2 true DE3686797T2 (de) 1993-03-25

Family

ID=25102201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686111325T Expired - Fee Related DE3686797T2 (de) 1985-09-11 1986-08-16 Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe.

Country Status (18)

Country Link
US (1) US4816247A (de)
EP (1) EP0214501B1 (de)
JP (1) JPS62111915A (de)
KR (1) KR900000211B1 (de)
AT (1) ATE80795T1 (de)
AU (1) AU593014B2 (de)
CA (1) CA1272685A (de)
DE (1) DE3686797T2 (de)
DK (1) DK432586A (de)
ES (1) ES2001950A6 (de)
FI (1) FI86142C (de)
GR (1) GR862316B (de)
HU (1) HU196700B (de)
IE (1) IE59828B1 (de)
NO (1) NO171145C (de)
NZ (1) NZ217483A (de)
PH (1) PH24313A (de)
ZA (1) ZA866899B (de)

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US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
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DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
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JPH06157294A (ja) * 1992-11-19 1994-06-03 Tanabe Seiyaku Co Ltd 脂肪微粒子製剤
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US5851510A (en) * 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion
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US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
AU2001259484A1 (en) * 2000-05-05 2001-11-20 Wisconsin Alumni Research Foundation Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
ATE290372T1 (de) * 2000-07-24 2005-03-15 Upjohn Co Selbstemulgierendes system zur abgabe von sehr wasserunlöslichen und lipophilen arzneimitteln
CA2469119A1 (en) * 2001-12-03 2003-06-12 Novacea, Inc. Pharmaceutical compositions comprising active vitamin d compounds
EP1506774B1 (de) * 2002-05-22 2011-08-24 Nihon Pharmaceutical Co., Ltd. Peristolen-hemmer der glatten muskulatur
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
RU2342953C2 (ru) 2003-02-24 2009-01-10 Фармасьютикал Продакшенз, Инк. Трансмукозная система доставки лекарственных средств
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US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US7871632B2 (en) 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
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EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
BRPI0801417B8 (pt) * 2008-03-13 2021-05-25 Univ Minas Gerais processo para obtenção de composição farmacêutica de retinóides, produto derivado de retinóides e uso
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JP5468221B2 (ja) * 2008-08-04 2014-04-09 株式会社 メドレックス 難溶性薬物の静注用分散製剤
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KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법

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Also Published As

Publication number Publication date
NO863620D0 (no) 1986-09-10
IE59828B1 (en) 1994-04-06
ES2001950A6 (es) 1988-07-01
DK432586A (da) 1987-03-12
KR870002834A (ko) 1987-04-13
DK432586D0 (da) 1986-09-10
PH24313A (en) 1990-05-29
NO171145C (no) 1993-02-03
HUT43948A (en) 1988-01-28
EP0214501B1 (de) 1992-09-23
IE862408L (en) 1987-03-11
GR862316B (en) 1987-01-13
JPS62111915A (ja) 1987-05-22
US4816247A (en) 1989-03-28
NO863620L (no) 1987-03-12
EP0214501A2 (de) 1987-03-18
KR900000211B1 (ko) 1990-01-23
EP0214501A3 (en) 1987-09-09
NO171145B (no) 1992-10-26
HU196700B (en) 1989-01-30
AU593014B2 (en) 1990-02-01
FI86142C (fi) 1992-07-27
CA1272685A (en) 1990-08-14
ATE80795T1 (de) 1992-10-15
AU6253886A (en) 1987-03-12
ZA866899B (en) 1987-05-27
FI86142B (fi) 1992-04-15
FI863664A (fi) 1987-03-12
FI863664A0 (fi) 1986-09-10
DE3686797D1 (de) 1992-10-29
NZ217483A (en) 1990-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee