ES2001950A6 - Procedimiento de obtencion de composiciones en emulsion para la administracion de farmacos hidrofobos ionizables escasamente hidrosolubles. - Google Patents

Procedimiento de obtencion de composiciones en emulsion para la administracion de farmacos hidrofobos ionizables escasamente hidrosolubles.

Info

Publication number
ES2001950A6
ES2001950A6 ES8601758A ES8601758A ES2001950A6 ES 2001950 A6 ES2001950 A6 ES 2001950A6 ES 8601758 A ES8601758 A ES 8601758A ES 8601758 A ES8601758 A ES 8601758A ES 2001950 A6 ES2001950 A6 ES 2001950A6
Authority
ES
Spain
Prior art keywords
administration
water soluble
sparingly water
emulsion compositions
hydrophobic drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601758A
Other languages
English (en)
Inventor
Narendra Raghun Desai
Madurai Ganesan
Eugene Albert Carpentier
Edward Charles Shinal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES2001950A6 publication Critical patent/ES2001950A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Colloid Chemistry (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPOSICIONES EN EMULSION PARA LA ADMINISTRACION DE FARMACOS HIDROFOBOS IONIZABLES ESCASAMENTE HIDROSOLUBLES, MEDIANTE REACCION DEL FARMACO HIDROFOBO CON UN FORMADOR DE PAR IONICO Y FORMACION DE UNA EMULSION, ACEITE EN AGUA DEL PAR IONICO RESULTANTE, ELIGIENDOSE EL FORMADOR DE PAR IONICO ENTRE ACIDOS ALIFATICOS O AROMATICOS SATURADOS O INSATURADOS C6-C20, CUANDO EL FARMACO HIDROFOBO SEA BASICO Y UNA AMINA ALIFATICA O AROMATICA ACEPTABLE CUANDO EL FARMACO HIDROFOBO SEA ACIDO.
ES8601758A 1985-09-11 1986-09-10 Procedimiento de obtencion de composiciones en emulsion para la administracion de farmacos hidrofobos ionizables escasamente hidrosolubles. Expired ES2001950A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/774,762 US4816247A (en) 1985-09-11 1985-09-11 Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs

Publications (1)

Publication Number Publication Date
ES2001950A6 true ES2001950A6 (es) 1988-07-01

Family

ID=25102201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601758A Expired ES2001950A6 (es) 1985-09-11 1986-09-10 Procedimiento de obtencion de composiciones en emulsion para la administracion de farmacos hidrofobos ionizables escasamente hidrosolubles.

Country Status (18)

Country Link
US (1) US4816247A (es)
EP (1) EP0214501B1 (es)
JP (1) JPS62111915A (es)
KR (1) KR900000211B1 (es)
AT (1) ATE80795T1 (es)
AU (1) AU593014B2 (es)
CA (1) CA1272685A (es)
DE (1) DE3686797T2 (es)
DK (1) DK432586A (es)
ES (1) ES2001950A6 (es)
FI (1) FI86142C (es)
GR (1) GR862316B (es)
HU (1) HU196700B (es)
IE (1) IE59828B1 (es)
NO (1) NO171145C (es)
NZ (1) NZ217483A (es)
PH (1) PH24313A (es)
ZA (1) ZA866899B (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs
US6759057B1 (en) * 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5229422A (en) * 1987-09-07 1993-07-20 Teijin Limited Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion
US5244925A (en) * 1987-12-18 1993-09-14 Kabi Pharmacia Aktiebolag Emulsion for parenteral administration
JP2643217B2 (ja) * 1988-01-22 1997-08-20 エーザイ株式会社 脂溶性物質水性液
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
GB2217596A (en) * 1988-04-26 1989-11-01 American Cyanamid Co Anti-arthritic liposome composition
DE68914929T2 (de) * 1988-09-29 1994-08-11 Shiseido Co Ltd Emulgierte Zusammensetzung.
US4971788A (en) * 1989-01-27 1990-11-20 Medicontrol Corporation Oral cavity and dental microemulsion products
DE3908047A1 (de) * 1989-03-13 1990-09-20 Desitin Arzneimittel Gmbh Hochdisperse pharmazeutische zusammensetzung
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
GB8919172D0 (en) * 1989-08-23 1989-10-04 Univ Nottingham Useful composition
US5221535A (en) * 1989-11-13 1993-06-22 Nova Pharmaceutical Corporation Sustained release formulations of insect repellent
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5227165A (en) * 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
IE904098A1 (en) * 1989-11-13 1991-05-22 Nova Pharm Corp Lipospheres for controlled delivery of substances
JPH0714872B2 (ja) * 1990-02-06 1995-02-22 昭和薬品化工株式会社 シロップ剤組成物
DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
DE4124252A1 (de) * 1991-07-22 1993-01-28 Knoll Ag Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung
GB2260079B (en) * 1991-10-01 1995-08-09 American Cyanamid Co Pharmaceutical composition containing felbinac
JPH06157294A (ja) * 1992-11-19 1994-06-03 Tanabe Seiyaku Co Ltd 脂肪微粒子製剤
SG65599A1 (en) * 1993-03-24 1999-06-22 Collaborative Lab Inc Cosmetic delivery system for salicylic acid and process for preparation of same
US5969004A (en) * 1993-10-15 1999-10-19 The Gillette Company Aqueous inks
US5851510A (en) * 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion
WO1996003113A1 (en) * 1994-07-22 1996-02-08 G.D. Searle & Co. Self-emulsifying drug delivery system
US5616342A (en) * 1995-04-11 1997-04-01 Pdt, Inc. Emulsioin suitable for administering a poorly water-soluble photosensitizing compound and use thereof
GB9625589D0 (en) 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
US6054421A (en) * 1997-09-23 2000-04-25 Scimed Life Systems, Inc. Medical emulsion lubricant
US6281175B1 (en) 1997-09-23 2001-08-28 Scimed Life Systems, Inc. Medical emulsion for lubrication and delivery of drugs
CN1239158C (zh) * 1997-09-30 2006-02-01 伊莱利利公司 2－甲基－噻吩并－苯并二氮杂䓬制剂
TWI241915B (en) 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
WO2001085142A1 (en) 2000-05-05 2001-11-15 Wisconsin Alumni Research Foundation Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
MXPA03000720A (es) * 2000-07-24 2004-11-01 Upjohn Co Sistemas auto-emulsificantes de suministro de medicamentos para medicamentos lipofilicos extremadamente insolubles en agua.
AU2002363959B2 (en) * 2001-12-03 2007-12-13 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
WO2003097026A1 (fr) * 2002-05-22 2003-11-27 Nihon Pharmaceutical Co., Ltd. Inhibiteur du peristaltisme de muscles lisses
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
JP5475215B2 (ja) 2003-02-24 2014-04-16 ファーマシューティカル プロダクションズ， インコーポレイテッド 経粘膜薬物送達システム
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US7871632B2 (en) * 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
WO2006073886A1 (en) 2005-01-05 2006-07-13 Eli Lilly And Company Olanzapine pamoate dihydrate
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
BRPI0801417B8 (pt) * 2008-03-13 2021-05-25 Univ Minas Gerais processo para obtenção de composição farmacêutica de retinóides, produto derivado de retinóides e uso
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
JP5468221B2 (ja) * 2008-08-04 2014-04-09 株式会社 メドレックス 難溶性薬物の静注用分散製剤
JP5619780B2 (ja) 2009-02-26 2014-11-05 テイコク ファーマ ユーエスエー インコーポレーテッド 癌性疼痛の治療のための麻薬性エマルション製剤
GB201009676D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process
WO2015013581A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Combinatorial methods to improve the therapeutic benefit of bisantrene

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172816A (en) * 1963-01-28 1965-03-09 Smith Kline French Lab Method of increasing the oil solubility of compounds and products thereof
US3647624A (en) * 1969-07-24 1972-03-07 Wisconsin Alumni Res Found Treatment of blood with oleaginous substance
JPS5021334B1 (es) * 1970-11-04 1975-07-22
US4124720A (en) * 1970-11-09 1978-11-07 Wenmaekers Georges E J Therapeutic hydrodispersible emulsion
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
FR2313078A1 (fr) * 1975-02-07 1976-12-31 Anvar Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention
US3991206A (en) * 1976-01-15 1976-11-09 American Cyanamid Company Alleviation of eye inflammation by topical application of p-biphenylacetic acid
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
IN150729B (es) * 1978-09-22 1982-11-27 Lever Hindustan Ltd
US4340054A (en) * 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
GB2105589B (en) * 1981-09-11 1985-10-23 Wellcome Found Injectable suspensions containing maleic acid or a salt thereof as a stabilising agent
JPS5859912A (ja) * 1981-10-06 1983-04-09 Green Cross Corp:The 鎮痛消炎物質脂肪乳剤
FR2520253A1 (fr) * 1982-01-28 1983-07-29 Oreal Nouveau systeme emulsionnant a base d'un condensat de proteines, d'un sterol polyoxyethylene et de phosphatide et son utilisation en cosmetique
JPS59134710A (ja) * 1983-01-21 1984-08-02 Suntory Ltd 発酵養毛化粧料
US4563354A (en) * 1983-10-26 1986-01-07 Kabivitrum Ab Oil-in-water emulsion for parenteral administration
US4703062A (en) * 1984-01-16 1987-10-27 Baxter Travenol Laboratories, Inc. Parenteral nutrition with medium and long chain triglycerides
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
NZ213008A (en) * 1984-08-22 1989-04-26 Mobil Oil Corp Grease compositions containing diol/boron compound reaction products
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4784845A (en) * 1985-09-16 1988-11-15 American Cyanamid Company Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs

Also Published As

Publication number Publication date
AU593014B2 (en) 1990-02-01
NO171145C (no) 1993-02-03
EP0214501A3 (en) 1987-09-09
KR900000211B1 (ko) 1990-01-23
NO863620L (no) 1987-03-12
NO171145B (no) 1992-10-26
DE3686797D1 (de) 1992-10-29
ZA866899B (en) 1987-05-27
EP0214501A2 (en) 1987-03-18
KR870002834A (ko) 1987-04-13
ATE80795T1 (de) 1992-10-15
NZ217483A (en) 1990-08-28
NO863620D0 (no) 1986-09-10
IE59828B1 (en) 1994-04-06
PH24313A (en) 1990-05-29
FI863664A0 (fi) 1986-09-10
DE3686797T2 (de) 1993-03-25
HU196700B (en) 1989-01-30
DK432586A (da) 1987-03-12
FI863664A (fi) 1987-03-12
IE862408L (en) 1987-03-11
DK432586D0 (da) 1986-09-10
AU6253886A (en) 1987-03-12
EP0214501B1 (en) 1992-09-23
FI86142C (fi) 1992-07-27
JPS62111915A (ja) 1987-05-22
US4816247A (en) 1989-03-28
CA1272685A (en) 1990-08-14
HUT43948A (en) 1988-01-28
GR862316B (en) 1987-01-13
FI86142B (fi) 1992-04-15

Similar Documents

Publication Publication Date Title
ES2001950A6 (es) Procedimiento de obtencion de composiciones en emulsion para la administracion de farmacos hidrofobos ionizables escasamente hidrosolubles.
MX171191B (es) Composiciones farmaceuticas de glipizida
MX9700081A (es) Composiciones farmaceuticas de tacrina.
EP1033981A4 (en) FORMULATIONS AND METHODS FOR REDUCING THE TOXICITY OF ANTINEOPLASTIC AGENTS
EP0724885A4 (en) COMPOSITION ADMINISTERED BY NASAL AND PREPARATION CONTAINING THE SAME
NO306377B1 (no) Doseform for avgivelse av et medikament
ZA867009B (en) Emulsion compositions for the parenteral and/or oral administration of sparingly water soluble ionizable hydrophobic drugs
GEP20053473B (en) High Potency Dihydroergotamine Compositions
KR910019618A (ko) 발기부전증 치료용 제약 조성물
WO2003049694A3 (en) Methods of therapy for non-hodgkin's lymphoma
KR970025615A (ko) 암 전이 억제제
ES2119748T3 (es) Composicion farmaceutica que contiene un farmaco ligeramente soluble en agua.
IL78336A (en) Compositions for delivery of orally administered fat-soluble drugs
ATE234082T1 (de) Adenosin enthaltendes arzneimittel
DE3263832D1 (en) Gallium chloride, an anti-cancer drug
MY100780A (en) Azumolene dosage form.
ES2062763T3 (es) Preparacion farmaceutica de 1-octadecil-2-metil-glicero-3-fosfocolina administrable por via intravenosa.
SE7708622L (sv) 2-bensyl-perhydroazepiner, sett for framstellning derav och lekemedel, innehallande dem
KR870005642A (ko) 디플루니살과 트로메타민의 혼합물
RU94020614A (ru) Противоопухолевое средство
IT1262929B (it) Impiego terapeutico del monosialodiesosil ganglioside gm3 e derivati come agenti anti-angiogenici
UA30251A (uk) Спосіб лікування гіпертонії сфінктера одді у хворих на хронічний безкам'яний холецистит при поєднанні з підвищенням тонусу симпатичної нервової системи

Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-10