FR2375248A1 - Nouveaux derives de sucres amines, leur procede de preparation et medicament les contenant - Google Patents

Nouveaux derives de sucres amines, leur procede de preparation et medicament les contenant

Info

Publication number
FR2375248A1
FR2375248A1 FR7738818A FR7738818A FR2375248A1 FR 2375248 A1 FR2375248 A1 FR 2375248A1 FR 7738818 A FR7738818 A FR 7738818A FR 7738818 A FR7738818 A FR 7738818A FR 2375248 A1 FR2375248 A1 FR 2375248A1
Authority
FR
France
Prior art keywords
derivatives
preparation process
product containing
new derivatives
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738818A
Other languages
English (en)
Other versions
FR2375248B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19762658562 external-priority patent/DE2658562A1/de
Priority claimed from DE19772726207 external-priority patent/DE2726207A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2375248A1 publication Critical patent/FR2375248A1/fr
Application granted granted Critical
Publication of FR2375248B1 publication Critical patent/FR2375248B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouveaux dérivés aminés de sucres de formule II. Elle concerne également un procédé à plusieurs variantes pour la préparation de ces dérivés. Les nouveaux dérivés de l'invention peuvent être utilisés en médecine humaine et en médecine vétérinaire pour combattre le diabète, l'adiposité et l'hyperlipidémie. Ces dérivés inhibent bien mieux les alpha -glucosidases que ne le font les composés de base et représentent donc un enrichissement du domaine pharmaceutique.
FR7738818A 1976-12-23 1977-12-22 Nouveaux derives de sucres amines, leur procede de preparation et medicament les contenant Granted FR2375248A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19762658562 DE2658562A1 (de) 1976-12-23 1976-12-23 Aminozuckerderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE19772726207 DE2726207A1 (de) 1977-06-10 1977-06-10 Aminozuckerderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
FR2375248A1 true FR2375248A1 (fr) 1978-07-21
FR2375248B1 FR2375248B1 (fr) 1982-07-30

Family

ID=25771297

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738818A Granted FR2375248A1 (fr) 1976-12-23 1977-12-22 Nouveaux derives de sucres amines, leur procede de preparation et medicament les contenant

Country Status (11)

Country Link
US (1) US4175123A (fr)
JP (1) JPS5938959B2 (fr)
AT (1) AT357568B (fr)
CA (1) CA1096375A (fr)
CH (1) CH641813A5 (fr)
ES (1) ES465340A1 (fr)
FR (1) FR2375248A1 (fr)
GB (1) GB1556345A (fr)
HK (1) HK23782A (fr)
NL (1) NL7714142A (fr)
SE (1) SE449104B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471387A1 (fr) * 1979-12-08 1981-06-19 Nippon Shinyaku Co Ltd Procede de preparation de derives de moranoline, nouveaux produits ainsi obtenus et leur utilisation pour controler l'augmentation des niveaux de sucre dans le sang
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
EP0064635A1 (fr) * 1981-05-05 1982-11-17 Bayer Ag Dérivés d'aminocyclitols, leur préparation et les médicaments les contenant
EP0067356A1 (fr) * 1981-06-13 1982-12-22 Bayer Ag Dérivés saturés d'aminocyclitols, leur préparation et les médicaments les contenant
EP0089812A1 (fr) * 1982-03-19 1983-09-28 Takeda Chemical Industries, Ltd. Pseudo-aminosucres-N-substitués, leur fabrication et emploi

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953920B2 (ja) * 1977-12-28 1984-12-27 東洋醸造株式会社 新規なアミノ糖化合物およびその製法
JPS5643294A (en) * 1979-09-19 1981-04-21 Meiji Seika Kaisha Ltd Novel antibiotic sf-1130x substance, its preparation, and use
DE3117705A1 (de) * 1981-05-05 1982-12-02 Bayer Ag, 5090 Leverkusen Aminocyclitderivate, ihre herstellung und sie enthaltende arnzeimittel
JPS6185254U (fr) * 1984-11-08 1986-06-04
JPH01502266A (ja) * 1986-12-11 1989-08-10 ジェンジム・コーポレーション １―アミノ―１―デオキシオリゴ糖とその誘導体の製造
US5324828A (en) * 1986-12-11 1994-06-28 Genzyme Corporation 1-amino-1-deoxyoligosaccharides and derivatives thereof
US6297363B1 (en) * 1993-02-12 2001-10-02 Nomura Co., Ltd. Glycoside indoles
DK1157696T3 (da) * 2000-05-24 2007-02-12 Pfizer Behandling af rumen-acidose med alpha-amylaseinhibitorer
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
CA2692417C (fr) 2007-07-03 2017-03-21 Children's Hospital & Research Center At Oakland Derives d'acide polysialique, procedes de production, et utilisations pour ameliorer la production et le ciblage d'antigenes de cancers
CA2690440A1 (fr) 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Derives d'acide oligosialique, procedes de fabrication et utilisations immunologiques
US8999954B2 (en) * 2007-07-03 2015-04-07 Childern's Hospital & Research Center at Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
EP2145538A1 (fr) 2008-07-15 2010-01-20 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Produit de protection des plantes et des matériaux

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (de) * 1973-09-22 1975-04-10 Bayer Ag Aminozuckerderivate, verfahren zu ihrer herstellung, sowie ihre verwendung als arzneimittel
FR2264490A1 (fr) * 1974-03-21 1975-10-17 Bayer Ag
DE2614393A1 (de) * 1976-04-02 1977-10-06 Bayer Ag Aminozucker-derivate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US4076930A (en) * 1968-12-13 1978-02-28 James Ellingboe Polysaccharide polyols
AR204612A1 (es) * 1972-05-30 1976-02-20 Ciba Geigy Ag Procedimiento para obtener nuevos derivados de anhidrofuranosa
US4016261A (en) * 1973-03-01 1977-04-05 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (de) * 1973-09-22 1975-04-10 Bayer Ag Aminozuckerderivate, verfahren zu ihrer herstellung, sowie ihre verwendung als arzneimittel
FR2244536A1 (fr) * 1973-09-22 1975-04-18 Bayer Ag
FR2264490A1 (fr) * 1974-03-21 1975-10-17 Bayer Ag
DE2614393A1 (de) * 1976-04-02 1977-10-06 Bayer Ag Aminozucker-derivate
FR2346368A1 (fr) * 1976-04-02 1977-10-28 Bayer Ag Nouveaux derives de sucres amines et medicament les contenant

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471387A1 (fr) * 1979-12-08 1981-06-19 Nippon Shinyaku Co Ltd Procede de preparation de derives de moranoline, nouveaux produits ainsi obtenus et leur utilisation pour controler l'augmentation des niveaux de sucre dans le sang
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
EP0051023A1 (fr) * 1980-10-29 1982-05-05 SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: Nouveaux composés appartenant à la famille des benzoyl- et alpha-hydroxybenzyl-phényl-osides, leur procédé de préparation et leur application en thérapeutique
EP0064635A1 (fr) * 1981-05-05 1982-11-17 Bayer Ag Dérivés d'aminocyclitols, leur préparation et les médicaments les contenant
EP0067356A1 (fr) * 1981-06-13 1982-12-22 Bayer Ag Dérivés saturés d'aminocyclitols, leur préparation et les médicaments les contenant
US4536493A (en) * 1981-06-13 1985-08-20 Baker Aktiengesellschaft Saturated aminocyclitol derivatives, their preparation and medicaments containing these compounds
EP0089812A1 (fr) * 1982-03-19 1983-09-28 Takeda Chemical Industries, Ltd. Pseudo-aminosucres-N-substitués, leur fabrication et emploi

Also Published As

Publication number Publication date
AT357568B (de) 1980-07-25
CH641813A5 (de) 1984-03-15
ES465340A1 (es) 1978-09-16
JPS5938959B2 (ja) 1984-09-20
NL7714142A (nl) 1978-06-27
FR2375248B1 (fr) 1982-07-30
US4175123A (en) 1979-11-20
GB1556345A (en) 1979-11-21
JPS5379841A (en) 1978-07-14
SE7714660L (sv) 1978-06-24
HK23782A (en) 1982-06-11
CA1096375A (fr) 1981-02-24
ATA918577A (de) 1979-12-15
SE449104B (sv) 1987-04-06

Similar Documents

Publication Publication Date Title
FR2375248A1 (fr) Nouveaux derives de sucres amines, leur procede de preparation et medicament les contenant
FR2370723A1 (fr) Nouveaux aryl-acylamides n-(2-aminocycloaliphatiques), leur procede de preparation et medicament les contenant
DE3686797D1 (de) Emulsionen zur verabreichung in wasser schwerloeslicher ionisierbarer basischer hydrophober arzneistoffe.
FR2370722A1 (fr) Nouveaux benzamides trans-n-(2-aminocycloaliphatiques), leur procede de preparation et medicament les contenant
EP0427247A2 (fr) Composition pharmaceutique contenant comme agent actif R-alpha acide lipoique ou S-alpha acide lipoique
FR2362833A1 (fr) Nouveaux derives 5 de prostaglandine, leur procede de preparation et medicament les contenant
FR2378763A1 (fr) Nouveaux derives de 1,4-dihydropyridine substitues en position 2, leur procede de preparation et medicament les contenant
RU94022479A (ru) Применение антиэстрогенных соединений, а также фармацевтически приемлемых солей и сольватов для уменьшения концентрации глюкозы в крови, фармацевтический препарат
FR2404625A1 (fr) Nouveaux 4-aminocyclohexanols et composition pharmaceutique les contenant
FR2359127A1 (fr) Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation
KR950007848A (ko) (S)-(-)-α-에틸-2-옥소-1-피롤리딘아세트아미드를 사용한 불안치료방법
FR2457689A1 (fr) Medicament hypolipemique a base de carnitine
FR2422640A1 (fr) Nouvelles morphinane-6-ones a substituant 8b-alkyle, leur procede de production et medicament les contenant
FR2390424A1 (fr) Nouveaux derives d'amides de l'acide phenylacetique substitues, leur application en tant que medicament et leur application
KR910018348A (ko) 술포닐아미노치환 비시클로환계 히드록삼산 유도체
FR2376128A1 (fr) Nouveaux dehydro-oligopeptides, leur procede de preparation et medicament les contenant
KR920702225A (ko) 약학 조성물
FR2404010A1 (fr) Nouveaux derives de pyrimido-(2,1-a)isoquinoleine, leur procede de production et composition pharmaceutique les contenant
KR880004810A (ko) 소화성 궤양 치료제
FR2359141A1 (fr) Nouvelles benzodiazepines, leur procede de preparation et medicament les contenant
BE900780A (fr) DERIVES DE LA CHLORO-4-FURO (3,4-c)-PYRIDINE, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS THERAPEUTIQUES A BASE DE CES DERIVES.
KR880002535A (ko) 약제로서의 15-데옥시스퍼구알린의 용도
KR880003623A (ko) 시알로실글리세로리피드로 된 신경장해질환 치료제
KR950700063A (ko) 외상후 스트레스 치료제로서의 브로파로민(Brofaromine as an agent for treating post-traumatic stress)
FR2375241A1 (fr) Nouveaux antibiotiques du type b-lactame, leur procede de preparation et medicaments les contenant

Legal Events

Date Code Title Description
ST Notification of lapse