FR2359127A1 - Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation - Google Patents

Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation

Info

Publication number
FR2359127A1
FR2359127A1 FR7721965A FR7721965A FR2359127A1 FR 2359127 A1 FR2359127 A1 FR 2359127A1 FR 7721965 A FR7721965 A FR 7721965A FR 7721965 A FR7721965 A FR 7721965A FR 2359127 A1 FR2359127 A1 FR 2359127A1
Authority
FR
France
Prior art keywords
hydroxyprostanoic
desoxy
substitutes
acids
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721965A
Other languages
English (en)
Other versions
FR2359127B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2359127A1 publication Critical patent/FR2359127A1/fr
Application granted granted Critical
Publication of FR2359127B1 publication Critical patent/FR2359127B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Les nouveaux médicaments répondent à la formule générale :
FR7721965A 1976-07-19 1977-07-18 Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation Granted FR2359127A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/706,343 US4061670A (en) 1976-07-19 1976-07-19 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners

Publications (2)

Publication Number Publication Date
FR2359127A1 true FR2359127A1 (fr) 1978-02-17
FR2359127B1 FR2359127B1 (fr) 1983-12-02

Family

ID=24837152

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721965A Granted FR2359127A1 (fr) 1976-07-19 1977-07-18 Nouveaux acides 15-desoxy-16-hydroxyprostanoiques 16-substitues doues d'activites pharmaceutiques et leur procede de preparation

Country Status (15)

Country Link
US (2) US4061670A (fr)
AU (1) AU512223B2 (fr)
BE (1) BE856949A (fr)
CA (1) CA1173826A (fr)
CH (1) CH636606A5 (fr)
DE (1) DE2731868A1 (fr)
DK (1) DK324777A (fr)
ES (1) ES460873A1 (fr)
FR (1) FR2359127A1 (fr)
GB (1) GB1571641A (fr)
HU (1) HU181840B (fr)
NL (1) NL7708020A (fr)
PL (1) PL121307B1 (fr)
SE (1) SE436741B (fr)
SU (1) SU873877A3 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation
EP0013107A1 (fr) * 1978-12-21 1980-07-09 American Cyanamid Company 16-Hydroxy-16-vinyl (ou cyclopropyl)-prostan-1-ols et compositions pharmaceutiques les contenant

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198521A (en) * 1976-07-19 1980-04-15 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
US4151187A (en) * 1977-02-22 1979-04-24 G. D. Searle & Co. Intermediates for prostaglandin synthesis
GB2009162A (en) * 1977-12-05 1979-06-13 American Cyanamid Co Prostanoic acids and congeners
US4275224A (en) * 1978-02-23 1981-06-23 Miles Laboratories, Inc. 15-Deoxy-16-hydroxy prostaglandins
US4358605A (en) * 1978-03-20 1982-11-09 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
DE2830079A1 (de) * 1978-07-08 1980-01-17 Hoechst Ag Neue prostaglandinderivate der delta 2,4-11-desoxy-pge-reihe
US4254145A (en) * 1978-08-16 1981-03-03 American Cyanamid Company Topical application of prostaglandin hypotensive agents
US4265904A (en) * 1979-06-07 1981-05-05 American Cyanamid Company Prostacyclin analogs of the 1 series and related analogs
US4390711A (en) * 1979-06-07 1983-06-28 American Cyanamid Company 16-Hydroxy-5-iodo-prostacyclin analogs of the 1 series
US4289955A (en) * 1979-11-05 1981-09-15 Emerson Electric Co. Electric heating assemblies with a mounted thermostatic switch
US4291174A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives
US4289910A (en) * 1980-04-03 1981-09-15 American Cyanamid Company 1-Hydroxymethyl-prosten-1-ol derivatives
US4291175A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
US4310700A (en) * 1980-04-03 1982-01-12 American Cyanamid Company 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
US4288630A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives
US4288629A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
US4288633A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
US4288632A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives
US5166369A (en) * 1981-05-21 1992-11-24 American Cyanamid Company Precursors and synthesis of D1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates
CA2147461A1 (fr) * 1992-10-21 1994-04-28 Takehiro Amano Analogues de la prostaglandine e1
SE9401087D0 (sv) * 1994-03-31 1994-03-31 Pharmacia Ab New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
NO317155B1 (no) * 1997-02-04 2004-08-30 Ono Pharmaceutical Co <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965143A (en) * 1974-03-26 1976-06-22 G. D. Searle & Co. 16-Oxygenated prostanoic acid derivatives
JPS50131951A (fr) * 1974-04-05 1975-10-18

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410648A1 (fr) * 1977-12-05 1979-06-29 American Cyanamid Co Nouveaux esters d'alkyle des 15-desoxy-16-vinyl- et 16-cyclopropylprostaglandines e, utiles notamment comme agents hypotenseurs, et leur procede de preparation
EP0013107A1 (fr) * 1978-12-21 1980-07-09 American Cyanamid Company 16-Hydroxy-16-vinyl (ou cyclopropyl)-prostan-1-ols et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
NL7708020A (nl) 1978-01-23
AU2658777A (en) 1979-01-04
DE2731868A1 (de) 1978-02-02
HU181840B (en) 1983-11-28
ES460873A1 (es) 1978-10-01
GB1571641A (en) 1980-07-16
SE436741B (sv) 1985-01-21
DK324777A (da) 1978-01-20
US4131737A (en) 1978-12-26
BE856949A (fr) 1978-01-19
SE7708348L (sv) 1978-01-20
US4061670A (en) 1977-12-06
CA1173826A (fr) 1984-09-04
CH636606A5 (de) 1983-06-15
AU512223B2 (en) 1980-10-02
DE2731868C2 (fr) 1987-06-04
FR2359127B1 (fr) 1983-12-02
PL121307B1 (en) 1982-04-30
SU873877A3 (ru) 1981-10-15

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