FR2375248A1 - NEW DERIVATIVES OF AMINO SUGARS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM - Google Patents

NEW DERIVATIVES OF AMINO SUGARS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Info

Publication number
FR2375248A1
FR2375248A1 FR7738818A FR7738818A FR2375248A1 FR 2375248 A1 FR2375248 A1 FR 2375248A1 FR 7738818 A FR7738818 A FR 7738818A FR 7738818 A FR7738818 A FR 7738818A FR 2375248 A1 FR2375248 A1 FR 2375248A1
Authority
FR
France
Prior art keywords
derivatives
preparation process
product containing
new derivatives
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738818A
Other languages
French (fr)
Other versions
FR2375248B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19762658562 external-priority patent/DE2658562A1/en
Priority claimed from DE19772726207 external-priority patent/DE2726207A1/en
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2375248A1 publication Critical patent/FR2375248A1/en
Application granted granted Critical
Publication of FR2375248B1 publication Critical patent/FR2375248B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouveaux dérivés aminés de sucres de formule II. Elle concerne également un procédé à plusieurs variantes pour la préparation de ces dérivés. Les nouveaux dérivés de l'invention peuvent être utilisés en médecine humaine et en médecine vétérinaire pour combattre le diabète, l'adiposité et l'hyperlipidémie. Ces dérivés inhibent bien mieux les alpha -glucosidases que ne le font les composés de base et représentent donc un enrichissement du domaine pharmaceutique.The invention relates to novel amino derivatives of sugars of formula II. It also relates to a process with several variants for the preparation of these derivatives. The new derivatives of the invention can be used in human medicine and in veterinary medicine to combat diabetes, adiposity and hyperlipidemia. These derivatives inhibit alpha -glucosidases much better than the basic compounds and therefore represent an enrichment in the pharmaceutical field.

FR7738818A 1976-12-23 1977-12-22 NEW DERIVATIVES OF AMINO SUGARS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM Granted FR2375248A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19762658562 DE2658562A1 (en) 1976-12-23 1976-12-23 Amino sugar derivs. - useful as glycoside hydrolase inhibitors
DE19772726207 DE2726207A1 (en) 1977-06-10 1977-06-10 Amino sugar derivs. - useful as glycoside hydrolase inhibitors

Publications (2)

Publication Number Publication Date
FR2375248A1 true FR2375248A1 (en) 1978-07-21
FR2375248B1 FR2375248B1 (en) 1982-07-30

Family

ID=25771297

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738818A Granted FR2375248A1 (en) 1976-12-23 1977-12-22 NEW DERIVATIVES OF AMINO SUGARS, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Country Status (11)

Country Link
US (1) US4175123A (en)
JP (1) JPS5938959B2 (en)
AT (1) AT357568B (en)
CA (1) CA1096375A (en)
CH (1) CH641813A5 (en)
ES (1) ES465340A1 (en)
FR (1) FR2375248A1 (en)
GB (1) GB1556345A (en)
HK (1) HK23782A (en)
NL (1) NL7714142A (en)
SE (1) SE449104B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471387A1 (en) * 1979-12-08 1981-06-19 Nippon Shinyaku Co Ltd PROCESS FOR THE PREPARATION OF MORANOLINE DERIVATIVES, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR CONTROLLING THE INCREASE IN SUGAR LEVELS IN BLOOD
FR2492830A1 (en) * 1980-10-29 1982-04-30 Sori Soc Rech Ind NOVEL COMPOUNDS BELONGING TO THE BENZOYL- AND A-HYDROXYBENZYL-PHENYL-OSIDES FAMILY, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
EP0064635A1 (en) * 1981-05-05 1982-11-17 Bayer Ag Aminocyclitol derivatives, their preparation and pharmaceutical preparations containing them
EP0067356A1 (en) * 1981-06-13 1982-12-22 Bayer Ag Saturated derivatives of aminocyclitols, their preparation and pharmaceutical preparations containing them
EP0089812A1 (en) * 1982-03-19 1983-09-28 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars, their production and use

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953920B2 (en) * 1977-12-28 1984-12-27 東洋醸造株式会社 Novel amino sugar compound and its production method
JPS5643294A (en) * 1979-09-19 1981-04-21 Meiji Seika Kaisha Ltd Novel antibiotic sf-1130x substance, its preparation, and use
DE3117705A1 (en) * 1981-05-05 1982-12-02 Bayer Ag, 5090 Leverkusen Aminocyclitol derivatives, their preparation and pharmaceuticals containing them
JPS6185254U (en) * 1984-11-08 1986-06-04
JPH01502266A (en) * 1986-12-11 1989-08-10 ジェンジム・コーポレーション Production of 1-amino-1-deoxyoligosaccharide and its derivatives
US5324828A (en) * 1986-12-11 1994-06-28 Genzyme Corporation 1-amino-1-deoxyoligosaccharides and derivatives thereof
US6297363B1 (en) * 1993-02-12 2001-10-02 Nomura Co., Ltd. Glycoside indoles
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
IL143225A (en) * 2000-05-24 2008-03-20 Pfizer Preparation of medicaments containing alpha-amylase inhibitors for the treatment of rumen acidosis
CA2690440A1 (en) * 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Oligosialic acid derivatives, methods of manufacture, and immunological uses
EP2173166A4 (en) * 2007-07-03 2010-08-11 Childrens Hosp & Res Ct Oak Inhibitors of polysialic acid de-n-acetylase and methods for using the same
AU2008272785B2 (en) 2007-07-03 2014-06-12 Children's Hospital & Research Center At Oakland Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting
EP2145538A1 (en) 2008-07-15 2010-01-20 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Plant and material preservative

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
FR2264490A1 (en) * 1974-03-21 1975-10-17 Bayer Ag
DE2614393A1 (en) * 1976-04-02 1977-10-06 Bayer Ag AMINO SUGAR DERIVATIVES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US4076930A (en) * 1968-12-13 1978-02-28 James Ellingboe Polysaccharide polyols
AR204612A1 (en) * 1972-05-30 1976-02-20 Ciba Geigy Ag PROCEDURE TO OBTAIN NEW DERIVATIVES OF ANHIDROFURANOSE
US4016261A (en) * 1973-03-01 1977-04-05 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2347782A1 (en) * 1973-09-22 1975-04-10 Bayer Ag AMINO SUGAR DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
FR2244536A1 (en) * 1973-09-22 1975-04-18 Bayer Ag
FR2264490A1 (en) * 1974-03-21 1975-10-17 Bayer Ag
DE2614393A1 (en) * 1976-04-02 1977-10-06 Bayer Ag AMINO SUGAR DERIVATIVES
FR2346368A1 (en) * 1976-04-02 1977-10-28 Bayer Ag NEW DERIVATIVES OF AMINO SUGARS AND MEDICINAL PRODUCTS CONTAINING THEM

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471387A1 (en) * 1979-12-08 1981-06-19 Nippon Shinyaku Co Ltd PROCESS FOR THE PREPARATION OF MORANOLINE DERIVATIVES, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR CONTROLLING THE INCREASE IN SUGAR LEVELS IN BLOOD
FR2492830A1 (en) * 1980-10-29 1982-04-30 Sori Soc Rech Ind NOVEL COMPOUNDS BELONGING TO THE BENZOYL- AND A-HYDROXYBENZYL-PHENYL-OSIDES FAMILY, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
EP0051023A1 (en) * 1980-10-29 1982-05-05 SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: Derivatives of the benzoyl and alpha hydroxybenzyl-phenyl osides family, method for their preparation and their therapeutic application
EP0064635A1 (en) * 1981-05-05 1982-11-17 Bayer Ag Aminocyclitol derivatives, their preparation and pharmaceutical preparations containing them
EP0067356A1 (en) * 1981-06-13 1982-12-22 Bayer Ag Saturated derivatives of aminocyclitols, their preparation and pharmaceutical preparations containing them
US4536493A (en) * 1981-06-13 1985-08-20 Baker Aktiengesellschaft Saturated aminocyclitol derivatives, their preparation and medicaments containing these compounds
EP0089812A1 (en) * 1982-03-19 1983-09-28 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars, their production and use

Also Published As

Publication number Publication date
ES465340A1 (en) 1978-09-16
SE7714660L (en) 1978-06-24
HK23782A (en) 1982-06-11
FR2375248B1 (en) 1982-07-30
US4175123A (en) 1979-11-20
CH641813A5 (en) 1984-03-15
GB1556345A (en) 1979-11-21
ATA918577A (en) 1979-12-15
SE449104B (en) 1987-04-06
AT357568B (en) 1980-07-25
CA1096375A (en) 1981-02-24
JPS5938959B2 (en) 1984-09-20
NL7714142A (en) 1978-06-27
JPS5379841A (en) 1978-07-14

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Legal Events

Date Code Title Description
ST Notification of lapse