KR900002767A - 항암활성 증강제 - Google Patents

항암활성 증강제 Download PDF

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Publication number
KR900002767A
KR900002767A KR1019890011470A KR890011470A KR900002767A KR 900002767 A KR900002767 A KR 900002767A KR 1019890011470 A KR1019890011470 A KR 1019890011470A KR 890011470 A KR890011470 A KR 890011470A KR 900002767 A KR900002767 A KR 900002767A
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KR
South Korea
Prior art keywords
fat emulsion
emulsion according
carbon atoms
phospholipid
fatty acid
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Application number
KR1019890011470A
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English (en)
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KR0132439B1 (ko
Inventor
오사무 오가와
이꾸오 기시
요시유끼 다하라
마사노리 스기다
Original Assignee
고니시 신베에,히사나가 쇼이찌로
니혼 레다리가부시기가이샤
마사다 오사무
닛신세이훈 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 고니시 신베에,히사나가 쇼이찌로, 니혼 레다리가부시기가이샤, 마사다 오사무, 닛신세이훈 가부시끼가이샤 filed Critical 고니시 신베에,히사나가 쇼이찌로
Publication of KR900002767A publication Critical patent/KR900002767A/ko
Application granted granted Critical
Publication of KR0132439B1 publication Critical patent/KR0132439B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
    • H01L2224/01—Means for bonding being attached to, or being formed on, the surface to be connected, e.g. chip-to-package, die-attach, "first-level" interconnects; Manufacturing methods related thereto
    • H01L2224/42—Wire connectors; Manufacturing methods related thereto
    • H01L2224/47—Structure, shape, material or disposition of the wire connectors after the connecting process
    • H01L2224/48—Structure, shape, material or disposition of the wire connectors after the connecting process of an individual wire connector
    • H01L2224/4805—Shape
    • H01L2224/4809—Loop shape
    • H01L2224/48091—Arched
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2224/00—Indexing scheme for arrangements for connecting or disconnecting semiconductor or solid-state bodies and methods related thereto as covered by H01L24/00
    • H01L2224/01—Means for bonding being attached to, or being formed on, the surface to be connected, e.g. chip-to-package, die-attach, "first-level" interconnects; Manufacturing methods related thereto
    • H01L2224/42—Wire connectors; Manufacturing methods related thereto
    • H01L2224/47—Structure, shape, material or disposition of the wire connectors after the connecting process
    • H01L2224/48—Structure, shape, material or disposition of the wire connectors after the connecting process of an individual wire connector
    • H01L2224/481—Disposition
    • H01L2224/48151—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive
    • H01L2224/48221—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked
    • H01L2224/48245—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked the item being metallic
    • H01L2224/48247—Connecting between a semiconductor or solid-state body and an item not being a semiconductor or solid-state body, e.g. chip-to-substrate, chip-to-passive the body and the item being stacked the item being metallic connecting the wire to a bond pad of the item

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

항암활성 증강제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. (a) 하기식 (Ⅰ):
    으로 표시되는 N-소라네실-N,N′-비스(3, 4-디메톡시벤질)에틸렌디아민 말산염 0.1∼10%(W/V), (b)식물유, 탄소원자수 8∼12개의 중쇄지방산의 트리글리세리드 및 탄소원자수 6∼18개의 지방산의 디 및 모노 글리세리드로부터 선택되는 적어도 1종의 지방유제기재 5∼50%(W/V), (c) 인지질 및 비이온계 계면활성제로부터 선택되는 적어도 1종의 유화제 0.05∼25%(W/V)및, (d) 물로 구성된 항암활성 증강 작용을 가지는 지방유제.
  2. 제1항에 있어서, 식물유가 대두유인 지방유제.
  3. 제1항에 있어서, 인지질이 대두인지질인 지방유제.
  4. 제1항에 있어서, 글리세린, 당알코올, 단당류, 이당류 및 아미노산으로 부터 선택되는 적어도 1종의 등장화제를 또한 함유하는 지방유제.
  5. 제1항에 있어서, 탄소수 10∼20개의 지방산 및 그 염, 포스파티딜에탄올아민, 포스파티딜세린 및 스테아릴아민으로부터 선택되는 적어도 1종의 유화조제를 또한 함유하는 지방유제.
  6. 제1항에 있어서, 콜레스테롤 및 토코페롤로부터 선택되는 안정화제를 또한 함유하는 지방유제.
  7. 제1항에 있어서, 알부민 및 그 지방산 아미드 유도체, 및 다당류 및 그 지방산 에스테르 유도체로부터 선택되는 적어도 1종의 안정화제를 또한 함유하는 지방유제.
  8. 제1항에 있어서, (a) 식 (Ⅰ)으로 표시되는 말산염 0.3∼3%(W/V) (b)대두유 5∼30%(W/V) (c) 대두인지질 0.5∼25%(W/V) (d) D-소르비톨 5∼20%(W/V) 및 (e) 물로 구성된 지방유제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011470A 1988-08-11 1989-08-11 항암활성 증강제 KR0132439B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19879588 1988-08-11
JP63-198,795 1988-08-11
JP63-198795 1988-08-11

Publications (2)

Publication Number Publication Date
KR900002767A true KR900002767A (ko) 1990-03-23
KR0132439B1 KR0132439B1 (ko) 1998-04-17

Family

ID=16397032

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890011470A KR0132439B1 (ko) 1988-08-11 1989-08-11 항암활성 증강제

Country Status (8)

Country Link
US (1) US5004756A (ko)
EP (1) EP0355604B1 (ko)
JP (1) JP2847783B2 (ko)
KR (1) KR0132439B1 (ko)
AT (1) ATE101036T1 (ko)
CA (1) CA1339502C (ko)
DE (1) DE68912850T2 (ko)
ES (1) ES2061831T3 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
US5620703A (en) * 1991-10-11 1997-04-15 Max-Delbruck-Centrum Fur Molekulare Medizin Stimulating hematopoietic activity with carboplatin or lobaplatin
GB9126209D0 (en) * 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
EP0626850B1 (en) * 1992-02-18 2002-05-15 Pharmos Corporation Dry compositions for preparing submicron emulsions
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
BR9201168A (pt) * 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
JPH06157294A (ja) * 1992-11-19 1994-06-03 Tanabe Seiyaku Co Ltd 脂肪微粒子製剤
IL107471A (en) * 1993-11-02 1997-09-30 Yissum Res Dev Co Pharmaceutical preparation comprising a self- emulsifying formulation and process for its production
US5851510A (en) * 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
WO1996033697A1 (fr) * 1995-04-24 1996-10-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Formulation auto-emulsionnable formant une emulsion huile dans l'eau
US6011069A (en) * 1995-12-26 2000-01-04 Nisshin Flour Milling Co., Ltd. Multidrug resistance inhibitors
US5756475A (en) * 1996-01-31 1998-05-26 Nisshin Flour Milling Co., Ltd. Isoprene derivatives
US20040191297A1 (en) * 1997-05-22 2004-09-30 Lance Schlipalius Carotenoid formulation
US8034823B2 (en) * 2005-02-22 2011-10-11 Savvipharm Inc Method of increasing drug oral bioavailability and compositions of less toxic orotate salts
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192339A (en) * 1981-05-18 1982-11-26 Nisshin Flour Milling Co Ltd Isoprenylamine derivative
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
JPS61200913A (ja) * 1985-03-01 1986-09-05 Nisshin Flour Milling Co Ltd 制癌剤

Also Published As

Publication number Publication date
EP0355604A2 (en) 1990-02-28
EP0355604B1 (en) 1994-02-02
DE68912850T2 (de) 1994-06-16
US5004756A (en) 1991-04-02
ATE101036T1 (de) 1994-02-15
DE68912850D1 (de) 1994-03-17
ES2061831T3 (es) 1994-12-16
EP0355604A3 (en) 1991-06-05
JP2847783B2 (ja) 1999-01-20
JPH02138211A (ja) 1990-05-28
KR0132439B1 (ko) 1998-04-17
CA1339502C (en) 1997-10-21

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