DE3686221D1 - Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe. - Google Patents
Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe.Info
- Publication number
- DE3686221D1 DE3686221D1 DE8686111470T DE3686221T DE3686221D1 DE 3686221 D1 DE3686221 D1 DE 3686221D1 DE 8686111470 T DE8686111470 T DE 8686111470T DE 3686221 T DE3686221 T DE 3686221T DE 3686221 D1 DE3686221 D1 DE 3686221D1
- Authority
- DE
- Germany
- Prior art keywords
- parenteral
- emulsions
- oral administration
- heavy water
- medicinal substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/776,306 US4784845A (en) | 1985-09-16 | 1985-09-16 | Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3686221D1 true DE3686221D1 (de) | 1992-09-03 |
DE3686221T2 DE3686221T2 (de) | 1993-02-25 |
Family
ID=25107019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686111470T Expired - Fee Related DE3686221T2 (de) | 1985-09-16 | 1986-08-19 | Emulsionen zur parenteralen und/oder oralen verabreichung schwer wasserloeslicher ionisierbarer hydrophober arzneistoffe. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4784845A (de) |
EP (1) | EP0215313B1 (de) |
JP (1) | JPS6267018A (de) |
KR (1) | KR890004684B1 (de) |
AR (1) | AR242716A1 (de) |
AT (1) | ATE78683T1 (de) |
AU (1) | AU591705B2 (de) |
CA (1) | CA1272447A (de) |
DE (1) | DE3686221T2 (de) |
DK (1) | DK165730C (de) |
ES (1) | ES2002750A6 (de) |
FI (1) | FI863728A (de) |
GR (1) | GR862354B (de) |
HU (1) | HU199282B (de) |
NO (1) | NO863670L (de) |
NZ (1) | NZ217484A (de) |
PH (1) | PH23736A (de) |
ZA (1) | ZA867009B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
US4820724A (en) * | 1986-03-31 | 1989-04-11 | University Of Southern California | Dual phase solvent carrier system |
GB8714652D0 (en) * | 1987-06-23 | 1987-07-29 | Davis S S | Drug emulsion |
US5229422A (en) * | 1987-09-07 | 1993-07-20 | Teijin Limited | Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion |
NZ227813A (en) * | 1988-02-10 | 1990-03-27 | Richardson Vicks Inc | Oil in water emulsion having 3-40% oil and an amphipathic emulsifying agent in the range 0.02-2% and method of forming such emulsions |
EP0406275A4 (en) * | 1988-03-21 | 1992-05-06 | Daratech Pty. Ltd. | Teat dip |
AU622664B2 (en) * | 1988-03-21 | 1992-04-16 | Daratech Pty Ltd | Teat dip |
US5338761A (en) * | 1988-09-29 | 1994-08-16 | Shiseido Company Ltd. | Emulsified composition |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
US5004593A (en) * | 1989-04-17 | 1991-04-02 | Mayo Foundation For Medical Education And Research | Hexamethylmelamine formulation exhibiting reduced neurotoxicity |
CA2017507C (en) * | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
GB8919172D0 (en) * | 1989-08-23 | 1989-10-04 | Univ Nottingham | Useful composition |
US5534502A (en) * | 1990-11-06 | 1996-07-09 | Nippon Shinyaku Co. Ltd. | Process for producing fat emulsion |
EP0556392A4 (de) * | 1990-11-06 | 1994-03-17 | Nippon Shinyaku Co Ltd | Verfahren zur produktion einer fettemulsion. |
DE4124252A1 (de) * | 1991-07-22 | 1993-01-28 | Knoll Ag | Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung |
IL103275A0 (en) * | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
YU87892A (sh) * | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
JPH06245700A (ja) * | 1993-02-23 | 1994-09-06 | Snow Brand Milk Prod Co Ltd | 消化吸収性を低減した油脂組成物 |
WO1994028872A1 (en) * | 1993-06-04 | 1994-12-22 | Warner-Lambert Company | Non-alcoholic cold and sinus medication |
JP3117145B2 (ja) * | 1994-02-04 | 2000-12-11 | スコーツイア・リピツドテクニク・アクチエボラーグ | 水中油エマルジョン |
WO1995022973A1 (en) * | 1994-02-25 | 1995-08-31 | Takeda Chemicals Industries, Ltd. | Injectable emulsions containing antifungal triazole derivatives |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
CA2185803C (en) * | 1994-03-18 | 2006-07-11 | Edward M. Rudnic | Emulsified drug delivery systems |
US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
US5616342A (en) * | 1995-04-11 | 1997-04-01 | Pdt, Inc. | Emulsioin suitable for administering a poorly water-soluble photosensitizing compound and use thereof |
US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
US6013636A (en) * | 1995-09-25 | 2000-01-11 | Ashmont Holdings Limited | Anthelmintic macrocyclic lactone compositions |
CA2259469A1 (en) | 1996-06-05 | 1997-12-11 | Ashmont Holdings Limited | Injectable compositions |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6054421A (en) * | 1997-09-23 | 2000-04-25 | Scimed Life Systems, Inc. | Medical emulsion lubricant |
US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
AU752552C (en) * | 1997-09-30 | 2003-09-11 | Eli Lilly And Company | 2-methyl-thieno-benzodiazepine formulation |
US6036946A (en) * | 1997-12-24 | 2000-03-14 | Shaklee Corporation | Methods for protecting skin from damaging effects of ultraviolet light |
WO1999043301A1 (en) * | 1998-02-24 | 1999-09-02 | The Board Of Trustees Of The University Of Illinois | Lipid emulsions in the treatment of systemic poisoning |
US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6146664A (en) * | 1998-07-10 | 2000-11-14 | Shaklee Corporation | Stable topical ascorbic acid compositions |
US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
US6777450B1 (en) * | 2000-05-26 | 2004-08-17 | Color Access, Inc. | Water-thin emulsions with low emulsifier levels |
CA2469119A1 (en) * | 2001-12-03 | 2003-06-12 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin d compounds |
AU2002353118A1 (en) * | 2001-12-11 | 2003-07-24 | Dor Biopharma, Inc. | Lipid particles and suspensions and uses thereof |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20040062779A1 (en) * | 2002-09-26 | 2004-04-01 | Jerry Whittemore | Dermatologic composition using ultra-fine/micronized 1-ascorbic acid and other antioxidant ingredients in a stabilized anhydrous vehicle |
US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
US20050186230A1 (en) * | 2004-01-23 | 2005-08-25 | Sd Pharmaceuticals, Inc. | Elemene compositions containing liquid oil |
DK1838716T3 (da) | 2005-01-05 | 2011-07-25 | Lilly Co Eli | Olanzapinpamota-dihydrat |
AU2006231967B2 (en) * | 2005-03-31 | 2011-09-15 | Suntory Holdings Limited | Oil-in-water emulsions containing lignan-class compounds and compositions containing the same |
JP2009515990A (ja) * | 2005-11-17 | 2009-04-16 | バイオアバイラビリティ,インク. | 生体適合性潜在的乳化剤 |
CN101511356A (zh) * | 2006-10-04 | 2009-08-19 | 三得利株式会社 | 含有木脂素类化合物的o/w/o型乳液及含有该乳液的组合物 |
EP2200613B1 (de) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazin-derivate und ihre verwendungen |
WO2010008891A2 (en) * | 2008-06-24 | 2010-01-21 | Merial Limited | Anthelminthic formulations |
AU2014293011A1 (en) | 2013-07-26 | 2016-03-17 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene |
EP3079668A1 (de) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit |
US11141398B2 (en) | 2017-01-08 | 2021-10-12 | The United States Government As Represented By The Department Of Veterans Affairs | Methods for decreasing injuries associated with intraoperative hypotension |
EP3661487A4 (de) * | 2017-09-12 | 2021-05-05 | Academic Pharmaceuticals, Inc. | Formulierung einer metolazonemulsion |
US20210401775A1 (en) * | 2018-11-02 | 2021-12-30 | Amaterasu Lifesciences Llp | A liquid injectable composition |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3116203A (en) * | 1962-03-14 | 1963-12-31 | Hoffmann La Roche | Oleaginous systems |
US3172816A (en) * | 1963-01-28 | 1965-03-09 | Smith Kline French Lab | Method of increasing the oil solubility of compounds and products thereof |
US3647624A (en) * | 1969-07-24 | 1972-03-07 | Wisconsin Alumni Res Found | Treatment of blood with oleaginous substance |
US4124720A (en) * | 1970-11-09 | 1978-11-07 | Wenmaekers Georges E J | Therapeutic hydrodispersible emulsion |
US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
FR2313078A1 (fr) * | 1975-02-07 | 1976-12-31 | Anvar | Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention |
DE2526938C2 (de) * | 1975-02-14 | 1982-04-22 | F. Hoffmann-La Roche & Co. AG, 4002 Basel | Vitaminpräparate |
US3991206A (en) * | 1976-01-15 | 1976-11-09 | American Cyanamid Company | Alleviation of eye inflammation by topical application of p-biphenylacetic acid |
US4168308A (en) * | 1976-03-12 | 1979-09-18 | Apoteksvarucentralen Vitrum Ab | Composition for enhancing the administration of pharmacologically active agents |
JPS5822085B2 (ja) * | 1977-07-19 | 1983-05-06 | 株式会社ミドリ十字 | 静注用ガンマ・グロブリン製剤 |
IN150729B (de) * | 1978-09-22 | 1982-11-27 | Lever Hindustan Ltd | |
US4340054A (en) * | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
GB2105589B (en) * | 1981-09-11 | 1985-10-23 | Wellcome Found | Injectable suspensions containing maleic acid or a salt thereof as a stabilising agent |
JPS5859912A (ja) * | 1981-10-06 | 1983-04-09 | Green Cross Corp:The | 鎮痛消炎物質脂肪乳剤 |
JPS59134710A (ja) * | 1983-01-21 | 1984-08-02 | Suntory Ltd | 発酵養毛化粧料 |
US4563354A (en) * | 1983-10-26 | 1986-01-07 | Kabivitrum Ab | Oil-in-water emulsion for parenteral administration |
US4703062A (en) * | 1984-01-16 | 1987-10-27 | Baxter Travenol Laboratories, Inc. | Parenteral nutrition with medium and long chain triglycerides |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | 4−ビフエニリル酢酸系化合物含有脂肪乳剤 |
US4707470A (en) * | 1985-05-17 | 1987-11-17 | Smithkline Beckman Corporation | Polyene antibiotic emulsion formulation |
US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
-
1985
- 1985-09-16 US US06/776,306 patent/US4784845A/en not_active Expired - Fee Related
-
1986
- 1986-08-19 AT AT86111470T patent/ATE78683T1/de active
- 1986-08-19 EP EP86111470A patent/EP0215313B1/de not_active Expired - Lifetime
- 1986-08-19 DE DE8686111470T patent/DE3686221T2/de not_active Expired - Fee Related
- 1986-09-05 NZ NZ217484A patent/NZ217484A/en unknown
- 1986-09-11 PH PH34246A patent/PH23736A/en unknown
- 1986-09-12 DK DK438286A patent/DK165730C/da not_active IP Right Cessation
- 1986-09-12 CA CA000518052A patent/CA1272447A/en not_active Expired - Fee Related
- 1986-09-15 ES ES8601914A patent/ES2002750A6/es not_active Expired
- 1986-09-15 NO NO863670A patent/NO863670L/no unknown
- 1986-09-15 GR GR862354A patent/GR862354B/el unknown
- 1986-09-15 HU HU863944A patent/HU199282B/hu not_active IP Right Cessation
- 1986-09-15 ZA ZA867009A patent/ZA867009B/xx unknown
- 1986-09-15 AU AU62696/86A patent/AU591705B2/en not_active Ceased
- 1986-09-15 FI FI863728A patent/FI863728A/fi not_active Application Discontinuation
- 1986-09-15 AR AR86305237A patent/AR242716A1/es active
- 1986-09-15 KR KR1019860007750A patent/KR890004684B1/ko not_active IP Right Cessation
- 1986-09-16 JP JP61216067A patent/JPS6267018A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US4784845A (en) | 1988-11-15 |
DK165730B (da) | 1993-01-11 |
EP0215313B1 (de) | 1992-07-29 |
HU199282B (en) | 1990-02-28 |
CA1272447A (en) | 1990-08-07 |
NO863670L (no) | 1987-03-17 |
KR890004684B1 (ko) | 1989-11-25 |
KR870002835A (ko) | 1987-04-13 |
NZ217484A (en) | 1990-04-26 |
FI863728A (fi) | 1987-03-17 |
PH23736A (en) | 1989-11-03 |
JPS6267018A (ja) | 1987-03-26 |
NO863670D0 (no) | 1986-09-15 |
DK165730C (da) | 1993-06-07 |
AR242716A1 (es) | 1993-05-31 |
GR862354B (en) | 1987-01-19 |
DK438286D0 (da) | 1986-09-12 |
ZA867009B (en) | 1987-07-29 |
ATE78683T1 (de) | 1992-08-15 |
DK438286A (da) | 1987-03-17 |
EP0215313A3 (en) | 1987-09-09 |
EP0215313A2 (de) | 1987-03-25 |
DE3686221T2 (de) | 1993-02-25 |
HUT43947A (en) | 1988-01-28 |
AU591705B2 (en) | 1989-12-14 |
AU6269686A (en) | 1987-03-19 |
ES2002750A6 (es) | 1988-10-01 |
FI863728A0 (fi) | 1986-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |