ES2001522A6 - Procedimiento para la preparacion de una modificacion estable de (1-isopropil-3- (4-m-toluidino-3-piridil) sulfonil-urea. - Google Patents
Procedimiento para la preparacion de una modificacion estable de (1-isopropil-3- (4-m-toluidino-3-piridil) sulfonil-urea.Info
- Publication number
- ES2001522A6 ES2001522A6 ES8601131A ES8601131A ES2001522A6 ES 2001522 A6 ES2001522 A6 ES 2001522A6 ES 8601131 A ES8601131 A ES 8601131A ES 8601131 A ES8601131 A ES 8601131A ES 2001522 A6 ES2001522 A6 ES 2001522A6
- Authority
- ES
- Spain
- Prior art keywords
- torasemide
- modification
- preparation
- medicaments containing
- stable modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 title abstract 6
- 230000004048 modification Effects 0.000 title abstract 6
- 238000012986 modification Methods 0.000 title abstract 6
- 229960005461 torasemide Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000002844 melting Methods 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 2
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853529529 DE3529529A1 (de) | 1985-08-17 | 1985-08-17 | Verfahren zur herstellung einer stabilen modifikation von torasemid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2001522A6 true ES2001522A6 (es) | 1988-06-01 |
Family
ID=6278766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8601131A Expired ES2001522A6 (es) | 1985-08-17 | 1986-08-14 | Procedimiento para la preparacion de una modificacion estable de (1-isopropil-3- (4-m-toluidino-3-piridil) sulfonil-urea. |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US4743693A (en:Method) |
| EP (1) | EP0212537B1 (en:Method) |
| JP (2) | JPS6245576A (en:Method) |
| KR (1) | KR930009818B1 (en:Method) |
| AU (1) | AU573454B2 (en:Method) |
| CA (1) | CA1307277C (en:Method) |
| CS (2) | CS259891B2 (en:Method) |
| DD (1) | DD259858A5 (en:Method) |
| DE (2) | DE3529529A1 (en:Method) |
| DK (1) | DK162518C (en:Method) |
| ES (1) | ES2001522A6 (en:Method) |
| FI (1) | FI82189C (en:Method) |
| GR (1) | GR862139B (en:Method) |
| HK (1) | HK59994A (en:Method) |
| HU (1) | HU195778B (en:Method) |
| IE (1) | IE59237B1 (en:Method) |
| IL (1) | IL79672A (en:Method) |
| LT (1) | LT3596B (en:Method) |
| NO (1) | NO170079C (en:Method) |
| NZ (1) | NZ217172A (en:Method) |
| PL (1) | PL146086B1 (en:Method) |
| PT (1) | PT83186B (en:Method) |
| SU (1) | SU1480766A3 (en:Method) |
| UA (1) | UA7080A1 (en:Method) |
| ZA (1) | ZA866151B (en:Method) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623620A1 (de) * | 1986-07-12 | 1988-01-21 | Boehringer Mannheim Gmbh | Spritzfertige, waessrige, alkalische injektionsloesungen von torasemid und verfahren zu ihrer herstellung |
| US5166162A (en) * | 1990-03-02 | 1992-11-24 | Adir Et Compagnie | Pyridylsulfonylurea and pyridylsulfonylthiourea compounds |
| JP3586471B2 (ja) * | 1991-06-25 | 2004-11-10 | 三菱ウェルファーマ株式会社 | トラセミド含有医薬組成物 |
| TW257757B (en:Method) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| HRP980532B1 (en) | 1998-10-02 | 2005-06-30 | Pliva | Novel crystalline torasemide modification |
| US6166045A (en) | 1998-06-02 | 2000-12-26 | Roche Diagnostics Gmbh | Torasemide of modification III |
| US5914336A (en) | 1998-06-02 | 1999-06-22 | Boehringer Mannheim Gmbh | Method of controlling the serum solubility of orally administered torasemide and composition relating thereto |
| US20030026835A1 (en) * | 1999-02-15 | 2003-02-06 | Sumitomo Pharmaceuticals Company Limited | Tablets disintegrating rapidly in the oral cavity |
| HRP20020120A2 (en) | 1999-08-11 | 2003-10-31 | Teva Pharma | Torsemide polymorphs |
| EP1292303B1 (en) * | 2000-02-17 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical formulation comprising torsemide modification ii |
| NZ521852A (en) | 2000-03-20 | 2004-10-29 | Teva Pharma | Novel processes for preparing torsemide intermediate |
| HRP20000162B1 (en) * | 2000-03-20 | 2004-06-30 | Pliva D D | Amorphous torasemide modification |
| HRP20000765A2 (en) * | 2000-11-10 | 2002-06-30 | Pliva D D | Compositions of n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridylsulfonamide and cyclic oligosaccharides with increased release |
| US20030022921A1 (en) * | 2001-02-21 | 2003-01-30 | Minutza Leibovici | Stable pharmaceutical formulation comprising torsemide modification II |
| IN192178B (en:Method) * | 2001-08-03 | 2004-03-06 | Ranbaxy Lab | |
| JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
| ITMI20020639A1 (it) * | 2002-03-27 | 2003-09-29 | Cosma S P A | Composizioni farmaceutiche comprendenti come principio attivo 1-isopropil-3°(4-m-toluidino-3-pridil)sulfonil!-urea |
| HRP20020603B1 (en) * | 2002-07-19 | 2008-11-30 | Pliva D.D. | New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide |
| DE60312953T2 (de) * | 2002-11-18 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Stabiles lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm wasser und mehr als 200 ppm bis zu 5000 ppm alkohol |
| CA2515130A1 (en) * | 2003-02-05 | 2004-08-26 | Teva Pharmaceutical Industries Ltd. | Method of stabilizing lansoprazole |
| ES2244324B1 (es) * | 2004-03-25 | 2006-11-16 | Ferrer Internacional, S.A. | Composiciones diureticas de liberacion prolongada. |
| AT500576B1 (de) * | 2004-07-28 | 2006-11-15 | Sanochemia Pharmazeutika Ag | Verfahren zur reindarstellung von kristallformen von torsemid |
| US10178893B1 (en) * | 2013-06-14 | 2019-01-15 | Scott Bradley Baker | Shoe |
| FR3018688A1 (fr) * | 2014-03-19 | 2015-09-25 | Virbac | Utilisation de torasemide a faible dose dans une composition veterinaire |
| US12048677B2 (en) | 2014-12-12 | 2024-07-30 | Ceva Sante Animale | Compositions and uses thereof for the treatment of heart failure in domestic animals |
| EP3031471A1 (en) * | 2014-12-12 | 2016-06-15 | Ceva Sante Animale | Veterinary composition for the treatment of pulmonary edema associated with heart failure in domestic animals |
| SI3173075T1 (sl) * | 2015-11-27 | 2019-02-28 | Accupharma Spolka Z Ograniczona Odpowiedzialnoscia | Farmacevtski kombinacijski pripravek inhibitorja ACE in diuretika zanke |
| CN115417810B (zh) * | 2022-09-22 | 2023-10-10 | 南京正科医药股份有限公司 | 一种托拉塞米晶型ⅰ的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US30633A (en) * | 1860-11-13 | Improvement in fire-escapes | ||
| GB1477664A (en) * | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
| GB1593609A (en) * | 1978-01-31 | 1981-07-22 | Christiaens Sa A | Pyridine sulfonamides |
| LU85193A1 (fr) * | 1984-01-31 | 1985-09-12 | Christiaens Sa A | Nouveaux derives de la 4-phenylaminopyridine,leur utilisation et leur preparation |
-
1985
- 1985-08-17 DE DE19853529529 patent/DE3529529A1/de active Granted
-
1986
- 1986-08-10 IL IL79672A patent/IL79672A/xx not_active IP Right Cessation
- 1986-08-11 CS CS865945A patent/CS259891B2/cs not_active IP Right Cessation
- 1986-08-11 CA CA000515676A patent/CA1307277C/en not_active Expired - Lifetime
- 1986-08-11 US US06/895,355 patent/US4743693A/en not_active Ceased
- 1986-08-11 AU AU61055/86A patent/AU573454B2/en not_active Expired
- 1986-08-12 EP EP86111118A patent/EP0212537B1/de not_active Expired - Lifetime
- 1986-08-12 NZ NZ217172A patent/NZ217172A/xx unknown
- 1986-08-12 DE DE8686111118T patent/DE3667970D1/de not_active Expired - Lifetime
- 1986-08-12 PT PT83186A patent/PT83186B/pt unknown
- 1986-08-13 IE IE217986A patent/IE59237B1/en not_active IP Right Cessation
- 1986-08-13 DK DK385586A patent/DK162518C/da not_active IP Right Cessation
- 1986-08-14 DD DD86293655A patent/DD259858A5/de not_active IP Right Cessation
- 1986-08-14 KR KR1019860006689A patent/KR930009818B1/ko not_active Expired - Lifetime
- 1986-08-14 ES ES8601131A patent/ES2001522A6/es not_active Expired
- 1986-08-14 GR GR862139A patent/GR862139B/el unknown
- 1986-08-15 HU HU863598A patent/HU195778B/hu unknown
- 1986-08-15 PL PL1986261052A patent/PL146086B1/pl unknown
- 1986-08-15 SU SU864027953A patent/SU1480766A3/ru active
- 1986-08-15 NO NO863305A patent/NO170079C/no not_active IP Right Cessation
- 1986-08-15 ZA ZA866151A patent/ZA866151B/xx unknown
- 1986-08-15 UA UA4027953A patent/UA7080A1/uk unknown
- 1986-08-15 FI FI863305A patent/FI82189C/fi not_active IP Right Cessation
- 1986-08-18 JP JP61191789A patent/JPS6245576A/ja active Granted
-
1987
- 1987-10-20 US US07/111,439 patent/US4822807A/en not_active Ceased
-
1989
- 1989-10-27 JP JP1278800A patent/JPH0643400B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-31 CS CS914199A patent/CS419991A3/cs unknown
-
1992
- 1992-12-03 US US07/985,053 patent/USRE34580E/en not_active Expired - Lifetime
-
1993
- 1993-04-08 US US08/043,631 patent/USRE34672E/en not_active Expired - Lifetime
- 1993-08-27 LT LTIP898A patent/LT3596B/lt not_active IP Right Cessation
-
1994
- 1994-06-23 HK HK59994A patent/HK59994A/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2001522A6 (es) | Procedimiento para la preparacion de una modificacion estable de (1-isopropil-3- (4-m-toluidino-3-piridil) sulfonil-urea. | |
| CY1955A (en) | Immunomodulatory azaspiranes | |
| JO1502B1 (en) | New pharmacy vehicles | |
| EP0564739A3 (en:Method) | ||
| IL77395A (en) | Pharmaceutical compositions containing 1-benzo-fused heterocyclyl)-piperazine derivatives,certain such novel compounds and their preparation | |
| NZ236589A (en) | A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions | |
| EP0181001A3 (en) | Polypeptide, a process for preparing the same, a pharmaceutical composition containing said polypeptide as well as the use thereof | |
| MY101784A (en) | Novel pharmacological compounds | |
| IE832529L (en) | ß-CARBOLINES, PROCESS FOR THEIR PRODUCTION AND¹PHARMACEUTICAL PREPARATIONS CONTAINING THEM | |
| AU3191293A (en) | New naphthalene amides and sulphonamides, processes for their preparation and pharmaceutical compositions containing them | |
| IL107068A0 (en) | 5-oxo-dibenzo(a,d)cyclohepta-1,4-dienes,their preparation and pharmaceutical compositions containing them | |
| GB1447462A (en) | Alpha-thiolincosaminides and the preparation thereof | |
| AU7414691A (en) | New 3-aminochroman derivatives, process for preparing these and pharmaceutical compositions containing them | |
| HUT43815A (en) | Process for producing new pirrolidine derivatives and pharmaceutical compositions containing the new compounds | |
| ES2001389A6 (es) | Procedimiento para preparar derivados de o-toluidina | |
| HUT41025A (en) | Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients | |
| DE3666223D1 (en) | Anticonvulsant agents | |
| AU568694B2 (en) | N-benzyl-n-phenyl-b-pyrrolidinyl-f-isobutoxy-propylamine | |
| DE3663664D1 (en) | Compounds having antiplatelet aggregation activity, a process for the preparation thereof and pharmaceutical compositions containing them | |
| AU562271B2 (en) | Pharmaceutical composition of corazepam and diphenhydramine | |
| DE3572171D1 (en) | Theophylline-7-acetic acid ester of d,l-trans-sobrerol having mucosecretolytic-fluidizing and antibronchospastic activity, a process for its preparation and pharmaceutical compositions thereof | |
| DK220088D0 (da) | Thiadiasolguanidiner, fremgangsmaade til fremstilling deraf og afrmaceutiske praeparater indeholdende disse forbindelser | |
| AU2601088A (en) | Hypoglycaemic peptides | |
| GEP20022796B (en) | Novel Aryloxy-Alkyl-Dialkylamines | |
| GR850484B (en:Method) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20060816 |