ES2001519A6 - Procedimiento para preparar compuestos aromaticos triciclicos y su empleo en composiciones farmaceuticas. - Google Patents

Procedimiento para preparar compuestos aromaticos triciclicos y su empleo en composiciones farmaceuticas.

Info

Publication number
ES2001519A6
ES2001519A6 ES8601122A ES8601122A ES2001519A6 ES 2001519 A6 ES2001519 A6 ES 2001519A6 ES 8601122 A ES8601122 A ES 8601122A ES 8601122 A ES8601122 A ES 8601122A ES 2001519 A6 ES2001519 A6 ES 2001519A6
Authority
ES
Spain
Prior art keywords
nitrogen
tricyclic compounds
chem
amide
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601122A
Other languages
English (en)
Inventor
O William Lever
Harry Jefferson Leighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES2001519A6 publication Critical patent/ES2001519A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EL PROCEDIMIENTO DESCRITO PREPARA COMPUESTOS DE FORMULA: O SUS SALES, ESTERES O AMIDAS, DONDE R1 ES -CH2-CH2-, -CH2-O- O -CH2-, R2 Y R3, IGUALES O DIFERENTES, SON HIDROGENO, ALQUILO C1-4 O, TOMADOS JUNTAMENTE CON EL NITROGENO, CONSTITUYEN UN ANILLO HETEROCICLICO DE 4 A 6 MIEMBROS QUE CONTIENE NITROGENO, R4 ES UN ENLACE SIMPLE O UN GRUPO DE HIDROCARBURO ALIFATICO BIVALENTE C1-7 Y PUEDE ESTAR UNIDO AL SISTEMA DE ANILLO AROMATICO EN POSICIONES 2, 3, 8 O 9, Y N ES 0 A 3, HACIENDO REACCIONAR UN COMPUESTO DE FORMULA: DONDE R1 Y R4 SON COMO ANTES, CON UN REACTIVO DE WITTIG O DE GRIGNARD, SEGUIDO POR DESHIDRATACION. EXISTEN OTRAS VIAS DE OBTENCION ALTERNATIVAS QUE SE DESCRIBEN EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS TIENEN POTENTES PROPIEDADES ANTIHISTAMINICAS Y ANTIASMATICAS Y SON UTILES PARA FORMULAR COMPOSICIONES FARMACEUTICAS.
ES8601122A 1985-08-17 1986-08-14 Procedimiento para preparar compuestos aromaticos triciclicos y su empleo en composiciones farmaceuticas. Expired ES2001519A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858520662A GB8520662D0 (en) 1985-08-17 1985-08-17 Tricyclic aromatic compounds

Publications (1)

Publication Number Publication Date
ES2001519A6 true ES2001519A6 (es) 1988-06-01

Family

ID=10583945

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601122A Expired ES2001519A6 (es) 1985-08-17 1986-08-14 Procedimiento para preparar compuestos aromaticos triciclicos y su empleo en composiciones farmaceuticas.

Country Status (13)

Country Link
US (1) US4871865A (es)
EP (3) EP0316022B1 (es)
JP (2) JPH0739346B2 (es)
AT (3) ATE51867T1 (es)
DE (3) DE3650357T2 (es)
ES (1) ES2001519A6 (es)
GB (1) GB8520662D0 (es)
GR (1) GR862137B (es)
HK (1) HK97593A (es)
HU (1) HU201520B (es)
IL (1) IL79729A (es)
PT (1) PT83202B (es)
SG (1) SG38393G (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2344242A1 (es) * 2007-02-16 2010-08-20 Sumitomo Chemical Company, Limited Metodo para la produccion de un compuesto de dibenzoxepina.

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ES2344242A1 (es) * 2007-02-16 2010-08-20 Sumitomo Chemical Company, Limited Metodo para la produccion de un compuesto de dibenzoxepina.

Also Published As

Publication number Publication date
JPH0739346B2 (ja) 1995-05-01
DE3689311D1 (de) 1993-12-23
IL79729A (en) 1990-11-05
EP0214779A1 (en) 1987-03-18
ATE51867T1 (de) 1990-04-15
DE3670290D1 (de) 1990-05-17
PT83202B (pt) 1989-03-30
JPH07165749A (ja) 1995-06-27
JPS6245557A (ja) 1987-02-27
EP0316022A3 (en) 1989-10-11
DE3650357D1 (de) 1995-08-31
US4871865A (en) 1989-10-03
EP0316022A2 (en) 1989-05-17
HUT41761A (en) 1987-05-28
GB8520662D0 (en) 1985-09-25
HK97593A (en) 1993-09-24
HU201520B (en) 1990-11-28
EP0351887B1 (en) 1995-07-26
ATE97401T1 (de) 1993-12-15
DE3650357T2 (de) 1996-01-04
EP0351887A1 (en) 1990-01-24
IL79729A0 (en) 1986-11-30
GR862137B (en) 1986-12-30
SG38393G (en) 1993-06-11
DE3689311T2 (de) 1994-03-10
JP2556821B2 (ja) 1996-11-27
EP0316022B1 (en) 1993-11-18
EP0214779B1 (en) 1990-04-11
PT83202A (en) 1986-09-01
ATE125535T1 (de) 1995-08-15

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Effective date: 20060816