EP4219765A3 - Prostatakrebsprognose unter verwendung von biomarkern - Google Patents

Prostatakrebsprognose unter verwendung von biomarkern Download PDF

Info

Publication number
EP4219765A3
EP4219765A3 EP23156159.8A EP23156159A EP4219765A3 EP 4219765 A3 EP4219765 A3 EP 4219765A3 EP 23156159 A EP23156159 A EP 23156159A EP 4219765 A3 EP4219765 A3 EP 4219765A3
Authority
EP
European Patent Office
Prior art keywords
biomarkers
cancer
prostate cancer
subject
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23156159.8A
Other languages
English (en)
French (fr)
Other versions
EP4219765A2 (de
Inventor
Christine Buerki
Anamaria CRISAN
Elai Davicioni
Nicholas George Erho
Mercedeh GHADESSI
Robert B. JENKINS
Ismael A. Vergara Correa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Veracyte SD Inc
Original Assignee
Mayo Foundation for Medical Education and Research
Decipher Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, Decipher Biosciences Inc filed Critical Mayo Foundation for Medical Education and Research
Publication of EP4219765A2 publication Critical patent/EP4219765A2/de
Publication of EP4219765A3 publication Critical patent/EP4219765A3/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
EP23156159.8A 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern Pending EP4219765A3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261684066P 2012-08-16 2012-08-16
US201361764365P 2013-02-13 2013-02-13
US201361783124P 2013-03-14 2013-03-14
EP13829137.2A EP2885640B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognostik mittels biomarkern
EP18179289.6A EP3435084B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern
PCT/US2013/055429 WO2014028884A2 (en) 2012-08-16 2013-08-16 Cancer diagnostics using biomarkers

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP13829137.2A Division EP2885640B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognostik mittels biomarkern
EP18179289.6A Division EP3435084B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern

Publications (2)

Publication Number Publication Date
EP4219765A2 EP4219765A2 (de) 2023-08-02
EP4219765A3 true EP4219765A3 (de) 2023-09-20

Family

ID=50101621

Family Applications (3)

Application Number Title Priority Date Filing Date
EP23156159.8A Pending EP4219765A3 (de) 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern
EP13829137.2A Active EP2885640B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognostik mittels biomarkern
EP18179289.6A Active EP3435084B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP13829137.2A Active EP2885640B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognostik mittels biomarkern
EP18179289.6A Active EP3435084B1 (de) 2012-08-16 2013-08-16 Prostatakrebsprognose unter verwendung von biomarkern

Country Status (8)

Country Link
US (2) US11035005B2 (de)
EP (3) EP4219765A3 (de)
AU (3) AU2013302365B2 (de)
CA (1) CA2881627A1 (de)
DK (1) DK3435084T3 (de)
ES (1) ES2945036T3 (de)
HK (1) HK1210832A1 (de)
WO (1) WO2014028884A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
EP2294216A4 (de) 2008-05-14 2011-11-23 Dermtech Int Diagnose von melanom und sonnenpigmentflecken mittels nukleinsäureanalyse
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
AU2012352153B2 (en) 2011-12-13 2018-07-26 Veracyte, Inc. Cancer diagnostics using non-coding transcripts
EP4219765A3 (de) 2012-08-16 2023-09-20 Decipher Biosciences, Inc. Prostatakrebsprognose unter verwendung von biomarkern
WO2016183414A1 (en) * 2015-05-14 2016-11-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing granulomatous diseases
EP3359689B1 (de) * 2015-10-08 2021-04-14 Decipher Biosciences, Inc. Diagnostische verwendung eines einer genetischen signatur zur bewertung von behandlungsstrategien für prostatakrebs
CN108463727B (zh) * 2015-10-23 2021-06-18 诺华股份有限公司 用于得到细胞间空间接近度的计算机方法和系统
WO2018039490A1 (en) * 2016-08-24 2018-03-01 Genomedx Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
GB201616912D0 (en) 2016-10-05 2016-11-16 University Of East Anglia Classification of cancer
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3593140A4 (de) * 2017-03-09 2021-01-06 Decipher Biosciences, Inc. Subtypisierung von prostatakrebs zur vorhersage der reaktion auf eine hormontherapie
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
WO2018210275A1 (en) * 2017-05-16 2018-11-22 The Chinese University Of Hong Kong Integrative single-cell and cell-free plasma rna analysis
EP3879535A1 (de) * 2017-06-13 2021-09-15 BostonGene Corporation Systeme und verfahren zur identifizierung von krebsbehandlungen aus normierten biomarker-scores
CA3090785A1 (en) 2018-02-14 2019-08-22 John Daniel Dobak Iii Novel gene classifiers and uses thereof in non-melanoma skin cancers
CN108830039A (zh) * 2018-03-19 2018-11-16 青岛理工大学 一种pcr控制系统控制节点计算方法
CA3115922A1 (en) 2018-10-09 2020-04-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
EP3636779A1 (de) 2018-10-11 2020-04-15 Koninklijke Philips N.V. Präoperative risikostratifizierung auf basis von pde4d7- und dhx9-expression
CN111139298B (zh) * 2018-11-05 2023-04-11 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 4-LncRNA分子标签在肺癌预后评估中的应用
CA3134936A1 (en) 2019-03-26 2020-10-01 Dermtech, Inc. Novel gene classifiers and uses thereof in skin cancers
GB201915464D0 (en) * 2019-10-24 2019-12-11 Uea Enterprises Ltd Novel biomarkers and diagnostic profiles for prostate cancer
CN112086145B (zh) * 2020-09-02 2024-04-16 腾讯科技（深圳）有限公司 一种化合物活性预测方法、装置、电子设备和存储介质
US20240002944A1 (en) * 2020-11-20 2024-01-04 Decipher Biosciences, Inc. Methods and genomic classifiers for identifying homologous recombination deficiency prostate cancer
WO2024026103A1 (en) * 2022-07-28 2024-02-01 Univeristy Of Pittsburgh - Of The Commonwealth System Of Higher Education Systems and methods for predicting prostate cancer recurrence

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091776A2 (en) * 2005-02-25 2006-08-31 The Brigham And Women's Hospital, Inc. Biomarkers for predicting prostate cancer progression
WO2006110264A2 (en) * 2005-03-16 2006-10-19 Sidney Kimmel Cancer Center Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures
WO2007056049A2 (en) * 2005-11-02 2007-05-18 The Regents Of The University Of Michigan Molecular profiling of cancer
WO2009143603A1 (en) * 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
US7914988B1 (en) * 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer

Family Cites Families (290)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT277936B (de) 1968-02-27 1970-01-12 Guenter Dipl Ing Knapp Verfahren zur quantitativen Bestimmung von Jod und von Schilddrüsenhormonen sowie Vorrichtung zur Durchführung des Verfahrens
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4323546A (en) 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
DE3785591T2 (de) 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5225326A (en) 1988-08-31 1993-07-06 Research Development Foundation One step in situ hybridization assay
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
DK0408295T3 (da) 1989-07-11 1996-09-16 Gen Probe Inc Fremgangsmåder til opformering af nukleinsyresekvenser
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5798257A (en) 1990-07-09 1998-08-25 Research Corporation Technologies, Inc. Nucleic acid encoding human MTS-1 protein
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix Inc Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
WO1993009668A1 (en) 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5545524A (en) 1991-12-04 1996-08-13 The Regents Of The University Of Michigan Compositions and methods for chromosome region-specific probes
US6204370B1 (en) 1992-03-11 2001-03-20 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US6027887A (en) 1992-03-11 2000-02-22 Institute Of Virology, Solvak Academy Of Sciences MN gene and protein
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5989815A (en) 1994-03-18 1999-11-23 University Of Utah Research Foundation Methods for detecting predisposition to cancer at the MTS gene
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
JP3189000B2 (ja) 1994-12-01 2001-07-16 東ソー株式会社 特定核酸配列の検出方法
US5710029A (en) 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5705365A (en) 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5854206A (en) 1995-08-25 1998-12-29 Corixa Corporation Compounds and methods for treatment and diagnosis of prostate cancer
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6121489A (en) 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
WO1997033909A2 (en) 1996-03-15 1997-09-18 Corixa Corporation Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer
EP0892808B1 (de) 1996-04-12 2008-05-14 PHRI Properties, Inc. Sonden, kits und assays
CA2224970C (en) 1996-04-16 2002-04-02 Kishimoto, Tadamitsu Method of detecting solid cancer cells and tissue atypia and method of testing tissues for use in bone marrow transplantation and peripheral blood stem cell transplantation
US6136182A (en) 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US5711029A (en) 1996-06-21 1998-01-27 Visco; Raymond D. Protective apparatus for dispersing pressure applied at a joint
TR199902053T2 (xx) 1997-02-25 2000-04-21 Corixa Corporation Prostat kanserinin immunoterapisine y�nelik bile�ikler ve bunlar�n kullan�lmas�na matuf metodlar.
US20030185830A1 (en) 1997-02-25 2003-10-02 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
ATE363652T1 (de) 1997-03-07 2007-06-15 Clare Chemical Res Inc Fluorometrischer nachweis mit sichtbarem light
AU6451798A (en) 1997-03-07 1998-09-22 Reprogen, Inc. Prostate cancer-specific marker
WO1998045420A1 (en) 1997-04-10 1998-10-15 Diagnocure Inc. Pca3, pca3 genes, and methods of use
GB9711040D0 (en) 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
US20020076735A1 (en) 1998-09-25 2002-06-20 Williams Lewis T. Diagnostic and therapeutic methods using molecules differentially expressed in cancer cells
US8101349B2 (en) 1997-12-23 2012-01-24 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells and their methods of use II
GB9805918D0 (en) * 1998-03-19 1998-05-13 Nycomed Amersham Plc Sequencing by hybridisation
EP1460132A1 (de) 1998-06-08 2004-09-22 Fuso Pharmaceutical Industries Ltd. Antikörper mit spezifischer Immunreaktivität gegen Thyroid Krebszellen
CA2333253C (en) 1998-07-02 2010-09-07 Gen-Probe Incorporated Molecular torches
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20060204989A1 (en) 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6468476B1 (en) 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
DE69937223T3 (de) 1998-11-09 2011-05-05 Eiken Kagaku K.K. Verfahren zur synthese von nukleinsäuren
US6828429B1 (en) 1999-03-26 2004-12-07 Henry M. Jackson Foundation For The Advancement Of Military Medicine Prostate-specific gene, PCGEM1, and the methods of using PCGEM1 to detect, treat, and prevent prostate cancer
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
US6436642B1 (en) 1999-04-20 2002-08-20 Curagen Corporation Method of classifying a thyroid carcinoma using differential gene expression
EP1055734B1 (de) 1999-05-24 2004-10-13 Tosoh Corporation Methode zum Nachweis von Ribonukleinsäuren
EP1218542B1 (de) 1999-09-13 2004-03-24 Nugen Technologies, Inc. Methoden und zusammensetzungen zur linearen isothermalen amplifikation von polynukleotidsequenzen
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6723506B2 (en) 2000-01-20 2004-04-20 Brigham And Women's Hospital Method of identifying PAX8-PPAR gamma-nucleic acid molecules
US20020168638A1 (en) 2000-01-24 2002-11-14 Robert Schlegel Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
AU2001241541A1 (en) 2000-02-17 2001-08-27 Millennium Predictive Medicine, Inc. Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
WO2001066753A2 (en) 2000-03-09 2001-09-13 Chiron Corporation Human genes and gene expression products
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
FR2810677B1 (fr) 2000-06-27 2004-10-01 Urogene Procede de diagnostic in vitro du cancer de la prostate et kit de mise en oeuvre
US6673545B2 (en) 2000-07-28 2004-01-06 Incyte Corporation Prostate cancer markers
US20070037165A1 (en) 2000-09-08 2007-02-15 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US6988040B2 (en) 2001-01-11 2006-01-17 Affymetrix, Inc. System, method, and computer software for genotyping analysis and identification of allelic imbalance
US20040029114A1 (en) 2001-01-24 2004-02-12 Eos Technology, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
US20020169137A1 (en) 2001-02-09 2002-11-14 Active Pass Pharmaceuticals, Inc. Regulation of amyloid precursor protein expression by modification of ABC transporter expression or activity
US7026163B1 (en) 2001-02-23 2006-04-11 Mayo Foundation For Medical Education And Research Sulfotransferase sequence variants
WO2002068677A2 (en) 2001-02-27 2002-09-06 Eos Biotechnology, Inc. Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer
US20030190602A1 (en) 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US20040009481A1 (en) 2001-06-11 2004-01-15 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
DE60230787D1 (de) 2001-08-31 2009-02-26 Gen Probe Inc Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden
ES2253533T3 (es) 2001-09-06 2006-06-01 Adnagen Ag Procedimiento para la deteccion cualitativa y/o cuantitativa de celulas.
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20050202442A1 (en) 2003-12-15 2005-09-15 Morris David W. Novel therapeutic targets in cancer
ATE458003T1 (de) 2001-12-07 2010-03-15 Novartis Vaccines & Diagnostic Bei prostatakrebs hochreguliertes endogenes retrovirus
US6949342B2 (en) 2001-12-21 2005-09-27 Whitehead Institute For Biomedical Research Prostate cancer diagnosis and outcome prediction by expression analysis
US7704700B2 (en) 2002-02-12 2010-04-27 Burnham Institute For Medical Research Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides
US20030194734A1 (en) 2002-03-29 2003-10-16 Tim Jatkoe Selection of markers
US20030186248A1 (en) 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
US20050143933A1 (en) 2002-04-23 2005-06-30 James Minor Analyzing and correcting biological assay data using a signal allocation model
US20050032065A1 (en) 2002-06-24 2005-02-10 Afar Daniel E. H. Methods of prognosis of prostate cancer
EP2385139A1 (de) 2002-07-31 2011-11-09 University of Southern California Polymorphismen zur Vorhersage des Krankheits- und Behandlungsausgangs
JP4632788B2 (ja) 2002-09-20 2011-02-16 ニュー・イングランド・バイオラブズ・インコーポレイティッド 核酸のヘリカーゼ依存性増幅
US7300788B2 (en) 2002-10-08 2007-11-27 Affymetrix, Inc. Method for genotyping polymorphisms in humans
US20050266443A1 (en) 2002-10-11 2005-12-01 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
JP4425142B2 (ja) 2002-11-07 2010-03-03 洋一 松原 遺伝子変異検出法
DE602004024034D1 (de) 2003-01-29 2009-12-24 454 Corp Nukleinsäureamplifikation auf basis von kügelchenemulsion
JP4568716B2 (ja) 2003-02-20 2010-10-27 ジェノミック ヘルス， インコーポレイテッド 遺伝子発現を測定するためのイントロンｒｎａの使用
US7378233B2 (en) 2003-04-12 2008-05-27 The Johns Hopkins University BRAF mutation T1796A in thyroid cancers
US20070275915A1 (en) 2003-04-15 2007-11-29 Cell Genesys, Inc. Tmprss2 Regulatory Sequences and Uses Thereof
AU2004235747B2 (en) 2003-05-01 2009-05-28 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
CA2527285A1 (en) 2003-05-28 2004-12-23 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
WO2005001132A2 (en) 2003-05-30 2005-01-06 The Board Of Trustees Of The University Of Illinois Gene expression profiles that identify genetically elite ungulate mammals
JP2007516693A (ja) 2003-06-09 2007-06-28 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 癌の治療および診断のための組成物および方法
WO2005008213A2 (en) 2003-07-10 2005-01-27 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
WO2005007830A2 (en) 2003-07-14 2005-01-27 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20050118625A1 (en) 2003-10-02 2005-06-02 Mounts William M. Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
US20050095634A1 (en) 2003-10-16 2005-05-05 Genomic Health Inc. qRT-PCR assay system for gene expression profiling
WO2005059108A2 (en) * 2003-12-12 2005-06-30 Bayer Pharmaceuticals Corporation Gene expression profiles and methods of use
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US20050250125A1 (en) 2003-12-19 2005-11-10 Novakoff James L Method for conducting pharmacogenomics-based studies
US20090020433A1 (en) 2003-12-31 2009-01-22 Microfabrica Inc. Electrochemical Fabrication Methods for Producing Multilayer Structures Including the use of Diamond Machining in the Planarization of Deposits of Material
US7407755B2 (en) 2004-01-15 2008-08-05 Lubinski Jan Determining a predisposition to cancer
EP1713938A2 (de) 2004-02-09 2006-10-25 Thomas Jefferson University Diagnose und behandlung von krebserkrankungen mit oder nahe mit krebs in zusammenhang stehenden chromosomalen merkmalen lokalisierter microrna
WO2005085471A2 (de) 2004-03-03 2005-09-15 Universität Leipzig Verfahren und mittel zur differentiellen diagnose von schilddrüsentumoren
US8426126B2 (en) 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
US20100075384A1 (en) 2004-03-25 2010-03-25 New England Biolabs, Inc. Helicase-dependent amplification of circular nucleic acids
US7319011B2 (en) 2004-04-08 2008-01-15 Duke University Method for distinguishing follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC)
WO2005100608A2 (en) 2004-04-09 2005-10-27 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health Diagnostic tool for diagnosing benign versus malignant thyroid lesions
ES2550614T3 (es) 2004-04-09 2015-11-11 Genomic Health, Inc. Marcadores de expresión génica para predecir la respuesta a la quimioterapia
US20050240357A1 (en) 2004-04-26 2005-10-27 Minor James M Methods and systems for differential clustering
EP1745156A2 (de) 2004-05-04 2007-01-24 Dako Denmark A/S Verfahren für den nachweis von chromosomenaberrationen
EP2471924A1 (de) 2004-05-28 2012-07-04 Asuragen, INC. Verfahren und Zusammensetzungen mit microRNA
CA2569698A1 (en) 2004-06-04 2006-01-12 Mark G. Erlander The importance of the gene hoxb13 for cancer
US20060019615A1 (en) 2004-07-24 2006-01-26 Ditmer Larry R Wireless keying for a continuous wave (CW) amateur radio transmitter
WO2006014013A1 (ja) 2004-08-04 2006-02-09 Riken 骨・関節疾患感受性遺伝子およびその用途
BRPI0514265A (pt) 2004-08-11 2008-06-10 Cleveland Clinic Foundation método para detectar cáncer da tireóide em um paciente, e, ensaio pré-operatório para determinar se a neoplasia da tireóide em um paciente é benigna ou maligna
EP1975242B1 (de) 2004-08-27 2011-03-02 Gen-Probe Incorporated Einfach-Primernukleinsäuren-Erweiterungsverfahren
US20060046253A1 (en) 2004-09-02 2006-03-02 Suntory Limited Method for analyzing genes of industrial yeasts
US7642348B2 (en) 2004-10-04 2010-01-05 Rosetta Genomics Ltd Prostate cancer-related nucleic acids
JP5303146B2 (ja) 2004-10-06 2013-10-02 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Ｂ７−ｈ１ならびに癌の診断、予後診断および処置の方法
ITBZ20040048A1 (it) 2004-10-06 2005-01-06 Genprofiler Metodo per l'identificazione della trasformazione neoplastica, con particolare riferimento al cancro prostatico
US7629325B2 (en) 2004-10-11 2009-12-08 Technion Research & Development Foundation Ltd. Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US20060141497A1 (en) 2004-10-22 2006-06-29 Finkelstein Sydney D Molecular analysis of cellular fluid and liquid cytology specimens for clinical diagnosis, characterization, and integration with microscopic pathology evaluation
CA2586201A1 (en) * 2004-11-03 2006-05-11 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
US20120122718A1 (en) 2005-03-01 2012-05-17 Reisman David N BRM Expression and Related Diagnostics
US20070037186A1 (en) 2005-05-20 2007-02-15 Yuqiu Jiang Thyroid fine needle aspiration molecular assay
US20070020657A1 (en) 2005-05-20 2007-01-25 Grebe Stefan K Methods for detecting circulating tumor cells
WO2006135596A2 (en) 2005-06-06 2006-12-21 The Regents Of The University Of Michigan Prognostic meta signatures and uses thereof
US20070099209A1 (en) 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
JP2008546387A (ja) 2005-06-13 2008-12-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
IL177006A0 (en) 2005-08-02 2006-12-10 Veridex Llc Predicting bone relapse of breast cancer
CA2619577A1 (en) 2005-08-15 2007-02-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
US9957569B2 (en) 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
CA2814598A1 (en) 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
BRPI0616139A2 (pt) 2005-09-22 2011-06-07 China Synthetic Rubber Corp método para avaliar o risco de metástase à distáncia, microestrutura de ácido nucléico útil na determinação do risco de metástase à distáncia e coleção em meio ou kit
US20070172844A1 (en) 2005-09-28 2007-07-26 University Of South Florida Individualized cancer treatments
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
US20080254470A1 (en) 2005-10-03 2008-10-16 Epigenomics Ag Methods and Nucleic Acids For the Analysis of Gene Expression Associated With the Prognosis of Cell Proliferative Disorders
US7598052B2 (en) 2005-10-11 2009-10-06 The Regents Of The University Of Michigan Expression profile of thyroid cancer
US20070220621A1 (en) 2005-10-31 2007-09-20 Clarke Michael F Genetic characterization and prognostic significance of cancer stem cells in cancer
US20090215054A1 (en) 2005-12-13 2009-08-27 Carter Scott L Prognosis indicators for solid human tumors
EP2487257B1 (de) 2006-01-05 2015-07-01 The Ohio State University Research Foundation Verfahren und Zusammensetzungen auf Mikro-RNA-Basis zur Diagnose und Behandlung von festen Krebsen
CA2633674A1 (en) 2006-01-05 2007-07-19 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US20070172841A1 (en) 2006-01-25 2007-07-26 Hui Wang Probe/target stabilization with add-in oligo
FR2896881B1 (fr) 2006-01-31 2008-04-18 Biomerieux Sa Procede de dosage du prongf pour le diagnostic in vitro du cancer du sein et utilisation du prongf en therapie
US7670775B2 (en) 2006-02-15 2010-03-02 The Ohio State University Research Foundation Method for differentiating malignant from benign thyroid tissue
JP4867018B2 (ja) 2006-03-22 2012-02-01 富士フイルム株式会社 癌の検出方法および抑制方法
US20100279327A1 (en) 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080076674A1 (en) 2006-07-06 2008-03-27 Thomas Litman Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer
US20080028302A1 (en) 2006-07-31 2008-01-31 Steffen Meschkat Method and apparatus for incrementally updating a web page
FI20060751A0 (fi) 2006-08-23 2006-08-23 Valtion Teknillinen Menetelmä prostatasyövän hoitoon ja mainitusta menetelmästä hyödyntävien potilaiden seulonta
WO2008039774A1 (en) 2006-09-25 2008-04-03 Mayo Foundation For Medical Education And Research Extracellular and membrane-associated prostate cancer markers
WO2008063769A2 (en) 2006-10-10 2008-05-29 The Henry M.Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations
WO2008046911A2 (en) 2006-10-20 2008-04-24 Exiqon A/S Novel human micrornas associated with cancer
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
WO2008069906A2 (en) 2006-11-14 2008-06-12 The Regents Of The University Of California Digital expression of gene analysis
US8470534B2 (en) 2006-12-01 2013-06-25 Erik S. Knudsen Methods of predicting resistance or sensitivity to therapies for cancer
US20110045464A1 (en) 2007-01-10 2011-02-24 Henry Ford Health System Methods and compositions for identification of prostate cancer markers
WO2008112283A2 (en) 2007-03-12 2008-09-18 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
US20100273172A1 (en) 2007-03-27 2010-10-28 Rosetta Genomics Ltd. Micrornas expression signature for determination of tumors origin
WO2008117278A2 (en) 2007-03-27 2008-10-02 Rosetta Genomics Ltd. Gene expression signature for classification of cancers
US8802599B2 (en) 2007-03-27 2014-08-12 Rosetta Genomics, Ltd. Gene expression signature for classification of tissue of origin of tumor samples
EP1975252A1 (de) 2007-03-29 2008-10-01 INSERM (Institut National de la Santé et de la Recherche Medicale) Verfahren zur Vorhersage oder Diagnose einer Schilddrüsenkrankheit
US20090062144A1 (en) 2007-04-03 2009-03-05 Nancy Lan Guo Gene signature for prognosis and diagnosis of lung cancer
US7901888B2 (en) 2007-05-09 2011-03-08 The Regents Of The University Of California Multigene diagnostic assay for malignant thyroid neoplasm
CA2814246A1 (en) 2007-07-06 2009-01-15 The Regents Of The University Of Michigan Solute carrier family 45 member 3 (slc45a3) and erg family gene fusions in prostate cancer
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
WO2009020521A2 (en) 2007-08-03 2009-02-12 The Brigham And Women's Hospital, Inc. Identification and treatment of estrogen responsive prostate tumors
US9234244B2 (en) 2007-08-27 2016-01-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic tool for diagnosing benign versus malignant thyroid lesions
AT505726A2 (de) 2007-08-30 2009-03-15 Arc Austrian Res Centers Gmbh Set von tumor-markern
NZ562237A (en) 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
WO2009074968A2 (en) 2007-12-12 2009-06-18 Ecole Polytechnique Federale De Lausanne (Epfl) Method for predicting the efficacy of cancer therapy
US20090191535A1 (en) 2007-12-22 2009-07-30 Mark Carle Connelly Method of assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
CA2711396A1 (en) 2008-01-04 2009-07-16 Centre National De La Recherche Scientifique Molecular in vitro diagnosis of breast cancer
US20100021538A1 (en) 2008-02-29 2010-01-28 Youngro Byun Pharmaceutical compositions containing heparin derivatives
WO2009120800A2 (en) 2008-03-25 2009-10-01 University Of Southern California Prognostic panel for urinary bladder cancer
WO2009140542A1 (en) 2008-05-14 2009-11-19 Dnar, Inc. Biomarkers for the identification, monitoring, and treatment of head and neck cancer
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
US20090298082A1 (en) * 2008-05-30 2009-12-03 Klee George G Biomarker panels for predicting prostate cancer outcomes
US20110077168A1 (en) 2008-06-17 2011-03-31 Nitzan Rosenfeld Methods for distinguishing between specific types of lung cancers
EP2313523A2 (de) 2008-07-07 2011-04-27 Decode Genetics EHF Genetische varianten als vorhersage des krebsrisikos beim menschen
CA2734123A1 (en) 2008-08-15 2010-02-18 Decode Genetics Ehf Genetic variants predictive of cancer risk
WO2010030365A2 (en) 2008-09-12 2010-03-18 Cornell Research Foundation, Inc. Wmc Thyroid tumors identified
AU2009299862B2 (en) 2008-10-01 2016-02-04 Noviogendix Research B.V. Molecular markers in prostate cancer
WO2010045318A2 (en) 2008-10-14 2010-04-22 Caris Mpi, Inc. Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
WO2010056351A2 (en) 2008-11-14 2010-05-20 Stc.Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and out come prediction in pedeatric b-precursor acute lymphoblastic leukemia
US8877445B2 (en) 2008-11-14 2014-11-04 Intelligent Oncotherapeutics, Inc. Methods for identification of tumor phenotype and treatment
CA3153682A1 (en) 2008-11-17 2010-05-20 Veracyte, Inc. Methods and compositions of molecular profiling for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
EP2367939A4 (de) * 2008-11-20 2012-07-04 Oncotherapy Science Inc Verfahren zur diagnose oder behandlung von prostatakrebs
WO2010061407A1 (en) 2008-11-26 2010-06-03 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
US9090943B2 (en) 2008-11-30 2015-07-28 Rosetta Genomics Ltd. Methods for detecting an increased susceptibility to cancer
EP2370813A4 (de) 2008-12-04 2012-05-23 Univ California Materialien und verfahren zur diagnose- und prognosestellung von prostatakrebs
CN102333888B (zh) 2008-12-24 2013-07-10 姜桥 用于肿瘤样本起源组织分类的基因表达签名
US20120041274A1 (en) 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
JP2012514475A (ja) 2009-01-09 2012-06-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌における再現性の遺伝子融合物
WO2010091049A2 (en) 2009-02-03 2010-08-12 Children's Medical Center Corporation Diagnosis and treatment of cancer
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
US8697275B2 (en) 2009-03-04 2014-04-15 Samsung Sdi Co., Ltd. Rechargeable battery having an extendable case region
WO2010123625A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms predict clinical outcome in patients with cancer
US9206482B2 (en) 2009-04-29 2015-12-08 Genomedx Biosciences Inc. Systems and methods for expression-based classification of thyroid tissue
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
EP2473628A1 (de) 2009-08-31 2012-07-11 Alcedo Biotech GmbH Mirna-basierte verfahren und zusammensetzungen zur diagnose, prognose und behandlung von tumor mit chromosomaler neuanordnung
US9110065B2 (en) 2009-09-21 2015-08-18 Paul Walfish Methods and compositions for the diagnosis and treatment of thyroid cancer
US8999648B2 (en) 2009-10-01 2015-04-07 Signal Genetics, Inc. System and method for classification of patients
US8975019B2 (en) 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
GB0922085D0 (en) 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
US9642821B2 (en) 2010-01-14 2017-05-09 Dana-Farber Cancer Institute, Inc. MiR-182 in the diagnosis and treatment of cancer
EP2366800A1 (de) 2010-03-01 2011-09-21 Centrum Onkologii-Instytut im M. Sklodowskiej-Curie Oddzial w Gliwicach Kit, Methode und Verwendung eines Genexpressionsprofils zur Diagnose von papillären Schilddrüsenkrebs
WO2011116380A2 (en) 2010-03-19 2011-09-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Hybrid model for the classification of carcinoma subtypes
WO2011133424A2 (en) 2010-04-20 2011-10-27 The Johns Hopkins University Genetic amplification of iqgap1 in cancer
CN106498076A (zh) 2010-05-11 2017-03-15 威拉赛特公司 用于诊断病状的方法和组合物
WO2011150453A1 (en) 2010-06-01 2011-12-08 The University Of Queensland Diagnostic, prognostic and therapeutic use of a long non-coding rna
WO2012012225A2 (en) 2010-07-22 2012-01-26 Mayo Foundation For Medical Education And Research Predicting cancer outcome
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
US10150999B2 (en) 2010-11-17 2018-12-11 Interpace Diagnostics, Llc miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
CA2818486C (en) 2010-11-19 2018-09-11 The Regents Of The University Of Michigan Ncrna and uses thereof
US20130273543A1 (en) 2010-12-21 2013-10-17 Decode Genetics Ehf. Genetic variants useful for risk assessment of thyroid cancer
EP2663672A1 (de) 2011-01-11 2013-11-20 University Health Network Prognosesignatur zur behandlung von plattenepithelkarzinomen in der mundhöhle
US20140087961A1 (en) 2011-03-17 2014-03-27 Illumina Inc. Genetic variants useful for risk assessment of thyroid cancer
US8945829B2 (en) 2011-03-22 2015-02-03 Cornell University Distinguishing benign and malignant indeterminate thyroid lesions
WO2012135008A1 (en) 2011-03-26 2012-10-04 Oregon Health And Science University Gene expression predictors of cancer prognosis
EP2505664B1 (de) 2011-03-30 2014-12-03 Universität Leipzig Verfahren und Mittel zur Unterscheidung von gut- und bösartigen Tumorproben, insbesondere bei der FNAB
WO2013006495A2 (en) 2011-07-01 2013-01-10 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
WO2013033073A1 (en) 2011-08-31 2013-03-07 Ventana Medical Systems, Inc. Expression of ets related gene (erg) and phosphatase and tensin homolog (pten) correlates with prostate cancer capsular penetration
WO2013066678A1 (en) 2011-10-26 2013-05-10 Georgetown University Microrna expression profiling of thyroid cancer
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
WO2013086524A1 (en) 2011-12-09 2013-06-13 The Johns Hopkins University Compositions and methods for characterizing thyroid neoplasia
GB2511221B (en) 2011-12-09 2020-09-23 Veracyte Inc Methods and compositions for classification of samples
WO2013086522A1 (en) 2011-12-10 2013-06-13 Veracyte, Inc. Methods and compositions for sample identification
WO2013088457A1 (en) 2011-12-13 2013-06-20 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
AU2012352153B2 (en) 2011-12-13 2018-07-26 Veracyte, Inc. Cancer diagnostics using non-coding transcripts
US20130184999A1 (en) 2012-01-05 2013-07-18 Yan Ding Systems and methods for cancer-specific drug targets and biomarkers discovery
WO2013116742A1 (en) 2012-02-01 2013-08-08 Mayo Foundation For Medical Education And Research Predicting responses to androgen deprivation therapy and methods for treating prostate cancer
WO2013138726A1 (en) 2012-03-15 2013-09-19 Sabiosciences Corp. Thyroid cancer biomarker
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
EP4219765A3 (de) 2012-08-16 2023-09-20 Decipher Biosciences, Inc. Prostatakrebsprognose unter verwendung von biomarkern
US9994907B2 (en) 2012-09-20 2018-06-12 Genomedx Biosciences, Inc. Thyroid cancer diagnostics
WO2014058317A1 (en) 2012-10-10 2014-04-17 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Methods and means for predicting resistance to anti-cancer treatment
BR102013027577A2 (pt) 2012-10-25 2016-03-29 Memorialsloan Kettering Cancer Ct método de detecção de um nível aumentado de axl ou gas6 e método de identificação de um paciente com câncer resistente a inibidor de egfr
US20140143188A1 (en) 2012-11-16 2014-05-22 Genformatic, Llc Method of machine learning, employing bayesian latent class inference: combining multiple genomic feature detection algorithms to produce an integrated genomic feature set with specificity, sensitivity and accuracy
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
US20150292030A1 (en) 2012-11-27 2015-10-15 Board Of Regents, The University Of Texas System Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer
WO2014089241A2 (en) 2012-12-04 2014-06-12 Caris Mpi, Inc. Molecular profiling for cancer
EP2971084A1 (de) 2013-03-12 2016-01-20 Cepheid Verfahren zur krebserkennung
EP2971174A4 (de) 2013-03-14 2017-06-14 Genomedx Biosciences Inc. Krebsbiomarker und klassifizierer sowie verwendungen davon
CA2905620A1 (en) 2013-03-15 2014-10-02 Biotheranostics, Inc. Neuroendocrine tumors
US20160032400A1 (en) 2013-03-15 2016-02-04 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Method for the prognosis and treatment of cancer metastasis
CN105378104A (zh) 2013-03-15 2016-03-02 威拉赛特公司 用于样品分类的方法和组合物
US20140315199A1 (en) 2013-04-17 2014-10-23 Life Technologies Corporation Gene fusions and gene variants associated with cancer
EP2993980B1 (de) 2013-05-10 2023-11-01 Memorial Sloan Kettering Cancer Center Lipid-scavenging bei ras-karzinomen
PL406033A1 (pl) 2013-11-14 2015-05-25 Warszawski Uniwersytet Medyczny Sposób diagnozowania raka brodawkowatego tarczycy, zastosowanie markera mikroRNA do diagnozowania nowotworu tarczycy, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
WO2015073949A1 (en) 2013-11-15 2015-05-21 The University Of North Carolina At Chapel Hill Method of subtyping high-grade bladder cancer and uses thereof
US9708667B2 (en) 2014-05-13 2017-07-18 Rosetta Genomics, Ltd. MiRNA expression signature in the classification of thyroid tumors
JP2016031772A (ja) 2014-07-30 2016-03-07 株式会社日立ハイテクファインシステムズ 熱アシスト磁気ヘッド素子の検査方法及びその装置
CN114634985A (zh) 2015-03-04 2022-06-17 威拉赛特公司 使用表达水平和序列变体信息评估疾病发生或复发风险的方法
US20190204322A1 (en) 2015-09-09 2019-07-04 Genomedx Biosciences, Inc. Molecular subtyping, prognosis and treatment of prostate cancer
CA2996426A1 (en) 2015-10-05 2017-04-13 Cedars-Sinai Medical Center Method of classifying and diagnosing cancer
EP3359689B1 (de) 2015-10-08 2021-04-14 Decipher Biosciences, Inc. Diagnostische verwendung eines einer genetischen signatur zur bewertung von behandlungsstrategien für prostatakrebs
JP2019528482A (ja) 2016-08-22 2019-10-10 オストロー、マイケル 投射型ディスプレイ用のレーザｌｅｄハイブリッド光源
WO2018039490A1 (en) 2016-08-24 2018-03-01 Genomedx Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3593140A4 (de) 2017-03-09 2021-01-06 Decipher Biosciences, Inc. Subtypisierung von prostatakrebs zur vorhersage der reaktion auf eine hormontherapie
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
WO2019023517A2 (en) 2017-07-27 2019-01-31 Veracyte, Inc. GENOMIC SEQUENCING CLASSIFIER

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091776A2 (en) * 2005-02-25 2006-08-31 The Brigham And Women's Hospital, Inc. Biomarkers for predicting prostate cancer progression
WO2006110264A2 (en) * 2005-03-16 2006-10-19 Sidney Kimmel Cancer Center Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures
WO2007056049A2 (en) * 2005-11-02 2007-05-18 The Regents Of The University Of Michigan Molecular profiling of cancer
US7914988B1 (en) * 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
WO2009143603A1 (en) * 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer

Also Published As

Publication number Publication date
EP4219765A2 (de) 2023-08-02
EP2885640B1 (de) 2018-07-18
WO2014028884A2 (en) 2014-02-20
EP2885640A4 (de) 2016-05-04
EP3435084A1 (de) 2019-01-30
EP3435084B1 (de) 2023-02-22
AU2013302365B2 (en) 2019-03-21
ES2945036T3 (es) 2023-06-28
AU2019201577B2 (en) 2021-08-26
AU2013302365A1 (en) 2015-02-26
US20140066323A1 (en) 2014-03-06
AU2021273545A1 (en) 2021-12-16
US11035005B2 (en) 2021-06-15
EP2885640A2 (de) 2015-06-24
WO2014028884A3 (en) 2014-05-08
DK3435084T3 (da) 2023-05-30
HK1210832A1 (en) 2016-05-06
AU2019201577A1 (en) 2019-03-28
CA2881627A1 (en) 2014-02-20
US20220349011A1 (en) 2022-11-03

Similar Documents

Publication Publication Date Title
EP4219765A3 (de) Prostatakrebsprognose unter verwendung von biomarkern
MX2017008421A (es) Métodos terapéuticos, diagnósticos y pronósticos para el cáncer de vejiga.
EP2576837A4 (de) Mit prostatakrebs assoziierte zirkulierende nukleinsäure-biomarker
EP4242329A3 (de) Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
GB2545361A (en) Protein biomarker panels for detecting colorectal cancer and advanced adenoma
MX2013005762A (es) Biomarcadores para la prediccion de la eficacia de una inmunoterapia contra el cancer.
MX2013000502A (es) Metodos y kits para el diagnostico de cancer de prostata.
WO2015094995A3 (en) Gene signature biomarkers of tumor response to pd-1 antagonists
MX2013000917A (es) Metodos para detectar las enfermedades o condiciones usando celulas fagociticas.
EP2611941A4 (de) Gensignaturen zur krebsdiagnose und -prognose
MX2020010147A (es) Metodos para predecir el riesgo de neumonia intersticial.
MX2020010947A (es) Metodos de tratamiento de enfermedad de alzheimer.
MX2016012697A (es) Perfiles de marcadores biologicos de proteina para detectar tumores colorrectales.
NZ703411A (en) Use of markers in the diagnosis and treatment of prostate cancer
WO2015094996A3 (en) Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
MX358474B (es) Biomarcadores salivales específicos para detección de riesgo, diagnóstico temprano, pronóstico y vigilancia de las enfermedades de alzheimer y de parkinson.
WO2011112845A3 (en) Methods and compositions related to a multi-methylation assay to predict patient outcome
EP4202441A3 (de) Genexpressionsprofil in makrophagen zur diagnose von krebs
WO2017042625A3 (en) Molecular subtyping, prognosis and treatment of prostate cancer
WO2013028807A3 (en) Renal cell carcinoma biomarkers and uses thereof
WO2013185779A3 (en) Biomarkers for prostate cancer
AU2012236134A8 (en) Biomarkers for predicting sensitivity to cancer treatments
WO2010009171A3 (en) Src activation for determining cancer prognosis and as a target for cancer therapy
EP3693742A3 (de) Verfahren zum nachweis von prostatakrebs
EP3385717A3 (de) Verfahren zum nachweis von prostatakrebs

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2885640

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3435084

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: C12Q0001688600

Ipc: G01N0033574000

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: C40B 30/04 20060101ALI20230816BHEP

Ipc: C12Q 1/68 20180101ALI20230816BHEP

Ipc: G01N 33/574 20060101AFI20230816BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230822

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Owner name: VERACYTE SD, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240311

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR